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Themed collection Synthetic methodology in OBC

1000 items - Showing page 1 of 15
Accepted Manuscript - Review Article

Halogen-mediated electrochemical organic synthesis

From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the oxime-participating synthesis of isoxazolines

This review is devoted to highlighting the main achievements in the development of methodologies for the synthesis of isoxazolines.

Graphical abstract: Recent advances in the oxime-participating synthesis of isoxazolines
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the catalytic synthesis of 3-aminooxindoles: an update

3-Substituted-3-aminooxindoles are versatile scaffolds and these motifs constitute the core structure of number of natural products and biologically active compounds.

Graphical abstract: Recent advances in the catalytic synthesis of 3-aminooxindoles: an update
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Recent applications of thiourea-based organocatalysts in asymmetric multicomponent reactions (AMCRs)

From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Synthesis and practical applications of 2-(2-nitroalkyl)pyrroles

Two main approaches can be designed for the synthesis of 2-(2-nitroalkyl)pyrroles using nitroalkenes or nitroalkanes in the reaction with pyrrole derivatives. The obtained nitroalkyl pyrroles can be converted into various bioactive compounds.

Graphical abstract: Synthesis and practical applications of 2-(2-nitroalkyl)pyrroles
From the themed collection: Synthetic methodology in OBC
Review Article

Remote C–C bond formation via visible light photoredox-catalyzed intramolecular hydrogen atom transfer

Visible light photoredox catalysis combined with intramolecular hydrogen atom transfer (HAT) can serve as a unique tool for achieving remote C–C bond formation. Recent advances in photoredox-catalyzed remote C–C bond formation are summarized.

Graphical abstract: Remote C–C bond formation via visible light photoredox-catalyzed intramolecular hydrogen atom transfer
From the themed collection: Synthetic methodology in OBC
Review Article

C–H functionalization of quinazolinones by transition metal catalysis

Quinazolinone and its derivatives are an important class of heterocyclic scaffolds in pharmaceuticals and natural products. This review provides the recent research advances in the transition metal catalyzed selective C–H bond functionalization of quinazolinone.

Graphical abstract: C–H functionalization of quinazolinones by transition metal catalysis
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of indoles from alkynes and a nitrogen source under metal-free conditions

This review deals with the methodologies published in the last ten years, which used metal-free conditions to prepare indoles starting from alkynes and nitrogen compounds.

Graphical abstract: Synthesis of indoles from alkynes and a nitrogen source under metal-free conditions
From the themed collection: Synthetic methodology in OBC
Review Article

Aromatic [b]-fused BODIPY dyes as promising near-infrared dyes

This review describes aromatic [b]-fused BODIPY dyes with the focus on design and synthesis, the relationships between their photophysical/spectroscopic properties and molecular structures, and potential uses in bioassays and optoelectronic devices.

Graphical abstract: Aromatic [b]-fused BODIPY dyes as promising near-infrared dyes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress of transition metal-catalysed regioselective C–H transformations based on noncovalent interactions

Recent advances in the transition metal-catalysed regioselective C–H transformations controlled by noncovalent interactions between substrates and reagents or ligands are summarised.

Graphical abstract: Recent progress of transition metal-catalysed regioselective C–H transformations based on noncovalent interactions
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of imidazoles

The review highlights the recent advances (2018-present) in the regiocontrolled synthesis of substituted imidazoles.

Graphical abstract: Recent advances in the synthesis of imidazoles
From the themed collection: Synthetic methodology in OBC
Review Article

Stereoselective synthesis of 2,6-disubstituted piperidine alkaloids

The synthetic methods to build the 2,6-disubstituted piperidine structural motif were described focusing on stereochemical control of two substituents at C2 and C6 with specific examples of natural products.

Graphical abstract: Stereoselective synthesis of 2,6-disubstituted piperidine alkaloids
From the themed collection: Synthetic methodology in OBC
Review Article

Palladium-catalysed decarboxylative annulations of vinylethylene carbonates leading to diverse functionalised heterocycles

This review provides an overview of the palladium-catalysed diverse cyclisations of VECs over the past five years, which could offer powerful synthetic tools to access various functionalised heterocycles.

Graphical abstract: Palladium-catalysed decarboxylative annulations of vinylethylene carbonates leading to diverse functionalised heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives

β2-Amino acids: recent advances in the synthesis of β2-amino acids and their derivatives from various stereoselective transformations of β-nitroacrylates are summarized.

Graphical abstract: Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic enantioselective decarboxylative nucleophilic addition reactions using chiral organocatalysts

Catalytic decarboxylative reactions are attractive as biomimetic and environmentally friendly reaction processes. This review summarizes recent results for organocatalytic enantioselective decarboxylative reactions from October 2013 to December 2019.

Graphical abstract: Catalytic enantioselective decarboxylative nucleophilic addition reactions using chiral organocatalysts
From the themed collection: Synthetic methodology in OBC
Review Article

Visible light promoted C–H functionalization of imidazoheterocycles

The present review summarizes the visible light mediated direct C–H functionalizations of pharmacologically active imidazo[1,2-a]pyridines and other related heterocycles.

Graphical abstract: Visible light promoted C–H functionalization of imidazoheterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Synthetic and mechanistic aspects of sulfonyl migrations

Sulfonyl migrations, frequently described as ‘unusual’ or ‘unexpected’, from the last 20 years, including 1,2-, 1,3-, 1,4-, 1,5-, 1,6- and 1,7-sulfonyl shifts, through either radical or polar processes, either inter- or intramolecularly are reviewed.

Graphical abstract: Synthetic and mechanistic aspects of sulfonyl migrations
From the themed collection: Synthetic methodology in OBC
Review Article

Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy

In this review, the progress of tandem transformation of nitro, nitrile and azide functionalities is summarised to develop new C–C and C–N bonds as well as multi-component reactions using alcohols.

Graphical abstract: Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Macrocyclization via C–H functionalization: a new paradigm in macrocycle synthesis

The emergence and applications of the C–H activation logic as a new paradigm in macrocyclization reactions are captured in this review.

Graphical abstract: Macrocyclization via C–H functionalization: a new paradigm in macrocycle synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of α-functionalized ketones by visible-light promoted oxygenation of alkenes

This article gives a short review on the visible-light promoted synthesis of α-functionalized ketones from alkenes.

Graphical abstract: Synthesis of α-functionalized ketones by visible-light promoted oxygenation of alkenes
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Sequential conjugation methods based on triazole formation and related reactions using azides

This review highlights recent transformations involving selective triazole formation, allowing efficient preparation of unsymmetric bis- and tris(triazole)s using diverse platform molecules.

Graphical abstract: Sequential conjugation methods based on triazole formation and related reactions using azides
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the direct β-C(sp2)–H functionalization of enamides

Recent advances in the direct β-C(sp2)–H functionalization of enamides, mainly including arylation, alkenylation, alkynylation, alkylation, acylation, sulfonylation, phosphorylation, and others, are reported.

Graphical abstract: Recent advances in the direct β-C(sp2)–H functionalization of enamides
From the themed collection: Synthetic methodology in OBC
Review Article

Chemical transformations of quaternary ammonium salts via C–N bond cleavage

The reaction of quaternary ammonium salts via C–N bond cleavage to construct C–C, C–H and C–heteroatom bonds is summarized.

Graphical abstract: Chemical transformations of quaternary ammonium salts via C–N bond cleavage
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions

This review highlights the different enantioselective catalyst-controlled cascades creating multiple alcohol functions and ensuring through subsequent simple derivatization, the rapid preparation of extended 1,3-polyols.

Graphical abstract: Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions
From the themed collection: Synthetic methodology in OBC
Review Article

The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines

Intramolecular endo-aza-Michael additions are categorised in various ways.

Graphical abstract: The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent trends in catalytic sp3 C–H functionalization of heterocycles

In this mini-review, we attempt to highlight gaps in existing techniques for sp3 C–H activation adjacent to heterocycles.

Graphical abstract: Recent trends in catalytic sp3 C–H functionalization of heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in the chemistry of allenyl sulfones

Allenyl sulfones are versatile building blocks for the construction of various acyclic, carbocyclic and heterocyclic motifs. Recent developments in the preparation and synthetic applications of allenyl sulfones are summarised.

Graphical abstract: Recent developments in the chemistry of allenyl sulfones
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress in transition-metal-catalyzed hydrocyanation of nonpolar alkenes and alkynes

Hydrocyanation is a powerful method for the preparation of nitriles which are versatile building blocks for the synthesis of amines, acids and amides.

Graphical abstract: Recent progress in transition-metal-catalyzed hydrocyanation of nonpolar alkenes and alkynes
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

The reticent tautomer: exploiting the interesting multisite and multitype reactivity of 4-pyrrolin-2-ones

Multisite and multitype reactivities of the highly versatile and valuable synthetic building block 4-pyrrolin-2-one are covered in this review.

Graphical abstract: The reticent tautomer: exploiting the interesting multisite and multitype reactivity of 4-pyrrolin-2-ones
From the themed collection: Synthetic methodology in OBC
Review Article

Developments in the construction of cyclopropanols

This review introduces and discusses the advances in the construction of cyclopropanols; improved synthetic methods are included, as well as the highly stereoselective production of cyclopropanols.

Graphical abstract: Developments in the construction of cyclopropanols
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in cobalt-catalysed C–H functionalizations

Ready availability, low cost and low toxicity of cobalt salts have redirected the attention of researchers away from noble metals, such as Pd, Rh, and Ir, towards Co in the field of C–H functionalisation.

Graphical abstract: Recent advances in cobalt-catalysed C–H functionalizations
From the themed collection: Synthetic methodology in OBC
Review Article

Imidates: an emerging synthon for N-heterocycles

This review highlights the recent application of imidates as building blocks for the synthesis of saturated and un-saturated N-heterocycles via C–N annulation reactions under acid/base/metal-catalyzed/radical-mediated reaction conditions.

Graphical abstract: Imidates: an emerging synthon for N-heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic enantioselective cross dehydrogenative coupling of sp3 C–H of heterocycles

The recent developments in the asymmetric functionalization of heterocycles via the catalytic enantioselective cross dehydrogenative coupling reactions of heterocyclic sp3 C–H bonds are highlighted in this review.

Graphical abstract: Catalytic enantioselective cross dehydrogenative coupling of sp3 C–H of heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent trends and applications of the Cadiot–Chodkiewicz reaction

The Cadiot–Chodkiewicz reaction offers an elegant strategy for the formation of 1,3-diynes via Cu-catalyzed cross-coupling of alkynyl halides with terminal alkynes in the presence of an amine.

Graphical abstract: Recent trends and applications of the Cadiot–Chodkiewicz reaction
From the themed collection: Synthetic methodology in OBC
Review Article

Application of copper(I) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

This review summarises the synthesis of bioactive molecules through the use of Cu(I) salt and fluoride promoted Stille coupling reactions.

Graphical abstract: Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic allylic functionalization via π-allyl palladium chemistry

This review highlights the palladium-catalyzed allylic C–H functionalizations via π-allyl palladium reported from early 2014 to present date.

Graphical abstract: Catalytic allylic functionalization via π-allyl palladium chemistry
From the themed collection: Synthetic methodology in OBC
Review Article

Advances in asymmetric visible-light photocatalysis, 2015–2019

Asymmetric visible-light photocatalysis has recently drawn considerable attention of the scientific community owing to its unique activation modes and significance for the enantioselective green synthesis.

Graphical abstract: Advances in asymmetric visible-light photocatalysis, 2015–2019
From the themed collection: Synthetic methodology in OBC
Review Article

α-Halogenoacetamides: versatile and efficient tools for the synthesis of complex aza-heterocycles

This review presents the use of α-alkyl- and α-alkoxy-halogenoacetamides as powerful partners for domino and 1,3-dipolar cycloaddition reactions resulting in a ring closure.

Graphical abstract: α-Halogenoacetamides: versatile and efficient tools for the synthesis of complex aza-heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Modifications of amino acids using arenediazonium salts

Aryl transfer reactions from arenediazonium salts have started to make their impact in chemical biology with initial forays in the arena of arylative modifications and bio-conjugations of amino acids, peptides and proteins.

Graphical abstract: Modifications of amino acids using arenediazonium salts
From the themed collection: Synthetic methodology in OBC
Review Article

Hypervalent iodine reactions utilized in carbon–carbon bond formations

This review covers recent developments of hypervalent iodine chemistry in dearomatizations, radicals, hypervalent iodine-guided electrophilic substitution, arylations, photoredox, and more.

Graphical abstract: Hypervalent iodine reactions utilized in carbon–carbon bond formations
From the themed collection: Synthetic methodology in OBC
Review Article

Consecutive multicomponent reactions for the synthesis of complex molecules

Consecutive multicomponent reactions (MCRs) combine two or more MCRs to achieve high synthetic efficiency, product structural diversity, and molecular complexity.

Graphical abstract: Consecutive multicomponent reactions for the synthesis of complex molecules
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry.

Graphical abstract: Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in catalytic asymmetric intermolecular oxidation of alkynes

In recent years, gold-metal-catalyzed intermolecular alkyne oxidation by an N-oxide oxidant, which presumably involves a gold carbenoid intermediate, has attracted increasing attention because it circumvents the employment of hazardous and potentially explosive diazocarbonyl compounds as starting materials for carbene generation.

Graphical abstract: Recent advances in catalytic asymmetric intermolecular oxidation of alkynes
From the themed collection: Synthetic methodology in OBC
Review Article

Traceless point-to-axial chirality exchange in the atropselective synthesis of biaryls/heterobiaryls

A strategy for establishing a chiral axis from stereogenic centers via elimination or oxidative aromatization with a high level of chirality transfer was developed.

Graphical abstract: Traceless point-to-axial chirality exchange in the atropselective synthesis of biaryls/heterobiaryls
From the themed collection: Synthetic methodology in OBC
Review Article

Hantzsch esters: an emerging versatile class of reagents in photoredox catalyzed organic synthesis

This minireview highlights the recent advances in the chemistry of Hantzsch esters in photoredox catalyzed organic synthesis, with particular emphasis placed on reaction mechanisms.

Graphical abstract: Hantzsch esters: an emerging versatile class of reagents in photoredox catalyzed organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances and applications of p-toluenesulfonylmethyl isocyanide (TosMIC)

TosMIC, a unique and multifunctional synthetic reagent, reacts with a wide spectrum of synthons to deliver novel scaffolds.

Graphical abstract: Recent advances and applications of p-toluenesulfonylmethyl isocyanide (TosMIC)
From the themed collection: Synthetic methodology in OBC
Review Article

Late stage functionalization of heterocycles using hypervalent iodine(III) reagents

Iodine(III) reagents represent a powerful tool for the late-stage functionalization of a variety of heterocycles through a range of transformations.

Graphical abstract: Late stage functionalization of heterocycles using hypervalent iodine(iii) reagents
From the themed collection: Synthetic methodology in OBC
Review Article

Organoboron synthesis via ring opening coupling reactions

This review covers new trends towards the selective synthesis of organoboron compounds where boron reagents and cyclic substrates participate in the generation of carbanions, in the presence of stoichiometric amounts of main-group metals or catalytic amounts of transition metal complexes, via ring opening coupling transformations.

Graphical abstract: Organoboron synthesis via ring opening coupling reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the borylative transformation of carbonyl and carboxyl compounds

The recent advances in the borylative transformation of carbonyl and carboxyl compounds are summarized.

Graphical abstract: Recent advances in the borylative transformation of carbonyl and carboxyl compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the direct functionalization of quinoxalin-2(1H)-ones

The direct C3-functionalization of quinoxalin-2(1H)-ones via C–H bond activation has recently attracted considerable attention, due to their diverse biological activities and chemical properties.

Graphical abstract: Recent advances in the direct functionalization of quinoxalin-2(1H)-ones
From the themed collection: Synthetic methodology in OBC
Review Article

The Lossen rearrangement from free hydroxamic acids

During more than a century, the Lossen rearrangement was supposed to occur exclusively in the presence of stochiometric amount of activating reagents. Very recently, it was demonstrated that the Lossen rearrangement can take place directly from free hydroxamic acids offering a renewal of interest for this reaction.

Graphical abstract: The Lossen rearrangement from free hydroxamic acids
From the themed collection: Synthetic methodology in OBC
Review Article

Employment of α-nitroketones in organic synthesis

This review summarizes the recent developments of the reactions of α-nitroketones and the consequent formation of a variety of structural frameworks is discussed.

Graphical abstract: Employment of α-nitroketones in organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Chloroform as a CO surrogate: applications and recent developments

Transition-metal-catalyzed carbonylation reaction using chloroform as CO surrogate to synthesize carbonylated heterocyclic moieties.

Graphical abstract: Chloroform as a CO surrogate: applications and recent developments
From the themed collection: Synthetic methodology in OBC
Review Article

Synthetic strategies for fluorination of carbohydrates

Different synthetic strategies for accomplishing regio- and stereoselective fluorinations of carbohydrate scaffolds are discussed in light of the biological implications arising from such substitutions.

Graphical abstract: Synthetic strategies for fluorination of carbohydrates
From the themed collection: Chemical biology in OBC
Review Article

Photochemical C–H bond coupling for (hetero)aryl C(sp2)–C(sp3) bond construction

This review highlights the recent advances in photochemical (hetero)aryl C(sp2)–C(sp3) bond construction via C–H bond coupling such as (hetero)arylation of C(sp3)–H bonds and alkylation of (hetero)aryl C(sp2)–H bonds.

Graphical abstract: Photochemical C–H bond coupling for (hetero)aryl C(sp2)–C(sp3) bond construction
From the themed collection: Synthetic methodology in OBC
Review Article

Allylic azides: synthesis, reactivity, and the Winstein rearrangement

Allylic azides are useful synthetic intermediates, the Winstein rearrangement complicates usage, and mechanistic knowledge can enable selectivity.

Graphical abstract: Allylic azides: synthesis, reactivity, and the Winstein rearrangement
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions

In this review, recent applications of a stereoselective aza-Michael reaction for asymmetric synthesis of naturally occurring N-containing heterocyclic scaffolds and their usefulness to pharmacology are summarized.

Graphical abstract: Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic enantioselective iodolactonization reactions

The recent advances of catalytic enantioselective iodolactonizations of γ- or δ-substituted alkenoic carboxylic acids have been reviewed. The different catalysts and substrates are highlighted.

Graphical abstract: Catalytic enantioselective iodolactonization reactions
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent advances in metal-free aerobic C–H activation

An overview of recent reactions based on the metal-free, dioxygen-induced, C–H activation of various radical precursors.

Graphical abstract: Recent advances in metal-free aerobic C–H activation
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of C2-spiropseudoindoxyls

This review summarizes the recent development of novel approaches to construct structurally unique oxindoles featuring a spirocycle at the C2 position.

Graphical abstract: Recent advances in the synthesis of C2-spiropseudoindoxyls
From the themed collection: Synthetic methodology in OBC
Review Article

N-Alkyl amide synthesis via N-alkylation of amides with alcohols

The present review summarizes the recent development of N-alkylation of amides with alcohols according to the classification of catalysts.

Graphical abstract: N-Alkyl amide synthesis via N-alkylation of amides with alcohols
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Use of ArSO2SRf reagents: an efficient tool for the introduction of SRf moieties

This review discusses the use of several ArSO2SRf reagents as SRf sources, an emerging trend to access SRf-containing molecules.

Graphical abstract: Use of ArSO2SRf reagents: an efficient tool for the introduction of SRf moieties
From the themed collection: Synthetic methodology in OBC
Review Article

Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

Intermolecular alkene difunctionalizations for the direct synthesis of saturated heterocycles.

Graphical abstract: Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity

Diversity-oriented synthesis adds biological performance as a new diversity element.

Graphical abstract: Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis.

Graphical abstract: Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals
From the themed collection: Synthetic methodology in OBC
Review Article

Applications of N′-monofunctionalised TsDPEN derivatives in asymmetric catalysis

N′-Monoalkylated or N′-mono(thio)acylated(N-sulfonyl)-1,2-diphenylethylene-1,2-diamine (TsDPEN) derivatives are have found extensive applications in asymmetric catalysis of a wide range of synthetic applications.

Graphical abstract: Applications of N′-monofunctionalised TsDPEN derivatives in asymmetric catalysis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in transition metal-catalyzed C(sp2)–H nitration

This review updates advances of direct C(sp2)–H nitration for the synthesis of nitroaromatic compounds and the mechanisms during the past decade.

Graphical abstract: Recent advances in transition metal-catalyzed C(sp2)–H nitration
From the themed collection: Synthetic methodology in OBC
Review Article

SuperQuat chiral auxiliaries: design, synthesis, and utility

The design, synthesis and outline of some of the most common synthetic applications of the SuperQuat (4-substituted 5,5-dimethyloxazolidine-2-one) family of chiral auxiliaries, developed to address the shortcomings of the Evans (4-substituted oxazolidin-2-one) family of chiral auxiliaries, are presented.

Graphical abstract: SuperQuat chiral auxiliaries: design, synthesis, and utility
From the themed collection: Synthetic methodology in OBC
Review Article

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

This review article provides a summary of the detrifluoroacetylative in situ generation of fluorine-containing enolates and their related reactions.

Graphical abstract: Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in photochemical reactions of diazo compounds

Chemistry of diazo compounds is dominated by transition metal catalysis but recently, photoinitiated reactions of diazo compounds have attracted a lot of attention. This mini-review describes recent discoveries on the reactivity of diazo compounds under light irradiation.

Graphical abstract: Recent developments in photochemical reactions of diazo compounds
From the themed collection: Synthetic methodology in OBC
1000 items - Showing page 1 of 15

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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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