Themed collection Synthetic methodology in OBC

1000 items - Showing page 1 of 15
Review Article

Transition metal-catalyzed arylation of unstrained C–C single bonds

Carbon–carbon bond activation is one of the most challenging and important research areas in organic chemistry.

Graphical abstract: Transition metal-catalyzed arylation of unstrained C–C single bonds
From the themed collection: Synthetic methodology in OBC
Review Article

Ring closing metathesis for the construction of carbazole and indole-fused natural products

In this perspective, ring-closing metathesis (RCM) based approaches for the synthesis of carbazole derivatives and other indole-fused heteroaromatic systems have been described.

Graphical abstract: Ring closing metathesis for the construction of carbazole and indole-fused natural products
From the themed collection: Synthetic methodology in OBC
Review Article

Transition metal catalysed direct construction of 2-pyridone scaffolds through C–H bond functionalizations

A summary of literature on transition metal catalysed construction of 2-pyridone scaffolds using a wide range of coupling partners via C–H bond functionalizations has been described.

Graphical abstract: Transition metal catalysed direct construction of 2-pyridone scaffolds through C–H bond functionalizations
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Recent advances in palladium-catalyzed C(sp3)/C(sp2)-H bond functionalizations: Access to C-branched glycosides

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Phosphorylation of Arenes, Heteroarenes, Alkenes, Carbonyls and Imines by Dehydrogenative Cross-Coupling of P(O)-H and P(R)-H

From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in Cu-catalyzed transformations of internal alkynes to alkenes and heterocycles

Numerous metal-catalyzed reactions involving internal alkynes and aimed towards synthetically and pharmacologically important alkenes and heterocycles have appeared in the literature.

Graphical abstract: Recent advances in Cu-catalyzed transformations of internal alkynes to alkenes and heterocycles
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Recent development in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C=C-N donors

From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling

The free-radical-induced syntheses of indolizines were reviewed by type of catalyst.

Graphical abstract: Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

N-Triflylphosphoramides: highly acidic catalysts for asymmetric transformations

N-Triflylphosphoramides (NTPA), have become increasingly popular catalysts in the development of enantioselective transformations as they are stronger Brønsted acids than the corresponding phosphoric acids (PA).

Graphical abstract: N-Triflylphosphoramides: highly acidic catalysts for asymmetric transformations
From the themed collection: Synthetic methodology in OBC
Open Access Accepted Manuscript - Review Article

Current applications of kinetic resolution in the asymmetric synthesis of substituted pyrrolidines

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Catalytic Asymmetric Synthesis of α-Stereogenic Carboxylic Acids:Recent Advances

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Synthesis of 2H-Chromenes: Recent Advances and Perspectives

From the themed collection: Synthetic methodology in OBC
Review Article

β-Keto acids in asymmetric metal catalysis and organocatalysis

β-Keto acids: ideal ketone surrogates for diverse asymmetric nucleophilic addition reactions via a decarboxylative process.

Graphical abstract: β-Keto acids in asymmetric metal catalysis and organocatalysis
From the themed collection: Synthetic methodology in OBC
Review Article

C 1-Symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation to prepare chiral compounds

This review examines the potential of C1-symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation of alkenes to produce pharmaceutical intermediates, bioactive molecules, drug molecules, agrochemicals, and fragrances.

Graphical abstract: C 1-Symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation to prepare chiral compounds
From the themed collection: Synthetic methodology in OBC
Review Article

The construction of benzimidazo[2,1-a]isoquinolin-6(5H)-ones from N-methacryloyl-2-phenylbenzoimidazoles through radical strategies

We highlight significant progress in the synthesis of benzimidazo[2,1-a]isoquinolin-6(5H)-ones using C-, S-, P-, and Si-centered radicals, including the selection of the catalytic system, substrate scope, mechanistic understanding, and applications.

Graphical abstract: The construction of benzimidazo[2,1-a]isoquinolin-6(5H)-ones from N-methacryloyl-2-phenylbenzoimidazoles through radical strategies
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in decarbonylative annulation reactions

In recent years, decarbonylative annulation reactions have emerged as one of the most efficient routes to construct a variety of important carbocyclic and heterocyclic scaffolds.

Graphical abstract: Recent advances in decarbonylative annulation reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization

Development of straightforward protocols for the functionalization of unactivated cyclopropanes is still challenging, the realization of which could bestow the scientific community with a recurring building block for modern organic transformations.

Graphical abstract: Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization
From the themed collection: Synthetic methodology in OBC
Review Article

Oxidative cross-coupling of thiols for S–X (X = S, N, O, P, and C) bond formation: mechanistic aspects

This review describes the oxidative cross-couplings of thiols forming various organosulfur compounds, focusing on critical intermediates such as sulfenyl halides, thiyl radicals, sulfenium cations, disulfides, and organo-transition metal intermediates.

Graphical abstract: Oxidative cross-coupling of thiols for S–X (X = S, N, O, P, and C) bond formation: mechanistic aspects
From the themed collection: Synthetic methodology in OBC
Review Article

Application of combined cyanide sources in cyanation reactions

The cyanation reaction is a key transformation due to the wide-ranging applications of nitrile compounds in organic chemistry.

Graphical abstract: Application of combined cyanide sources in cyanation reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Direct radical functionalization methods to access substituted adamantanes and diamondoids

Substituted adamantanes are important and versatile products that can be derived from direct C–H to C–C transformations via radical intermediates. In this review, a wide range of direct functionalization methods are summarized with a focus on mechanism and scope.

Graphical abstract: Direct radical functionalization methods to access substituted adamantanes and diamondoids
From the themed collection: Synthetic methodology in OBC
Review Article

Recent strategies used in the synthesis of saturated four-membered heterocycles

Recent advances in the synthesis of O-, N-, and S-atom containing saturated 4-membered heterocycles are presented based on their preparative similarities. These strategic approaches highlight both progress made and remaining synthetic opportunities.

Graphical abstract: Recent strategies used in the synthesis of saturated four-membered heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation

Recent achievements in rhodium-catalyzed arylations through C(sp2)–H bond activation were summarized.

Graphical abstract: Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

C–H activation reactions of nitroarenes: current status and outlook

The current landscape of nitro group directed C–H activation reactions of (hetero)arenes is reviewed.

Graphical abstract: C–H activation reactions of nitroarenes: current status and outlook
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances and future challenges in the synthesis of 2,4,6-triarylpyridines

The present review is focused on recent advances (2015–present) in the synthesis of 2,4,6-triarylpyridines (also known as Kröhnke pyridines).

Graphical abstract: Recent advances and future challenges in the synthesis of 2,4,6-triarylpyridines
From the themed collection: Synthetic methodology in OBC
Review Article

The C–H functionalization of N-alkoxycarbamoyl indoles by transition metal catalysis

Indole and its congeners are ubiquitous nitrogen containing organic scaffolds found in a plethora of natural products. This review aims to highlight the transition-metal catalyzed C–H functionalization of N-alkoxycarbamoyl indoles.

Graphical abstract: The C–H functionalization of N-alkoxycarbamoyl indoles by transition metal catalysis
From the themed collection: Synthetic methodology in OBC
Review Article

Current developments in the synthesis of 4-chromanone-derived compounds

The chroman-4-one framework is a significant structural entity that belongs to the class of oxygen-containing heterocycles.

Graphical abstract: Current developments in the synthesis of 4-chromanone-derived compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

This short review highlights compelling case studies from the last five years showcasing how modern flow technology has impacted and advanced synthetic chemistry in academia and industry.

Graphical abstract: Forgotten and forbidden chemical reactions revitalised through continuous flow technology
From the themed collection: Synthetic methodology in OBC
Review Article

An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles

This review focuses on important cycloaddition reactions of 3-methyleneindolinones to afford 3,3′-spirocyclic oxindoles.

Graphical abstract: An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in catalytic cross-couplings with unsaturated carboxylates

This review summarises the recent advances in the field of transition metal-catalyzed C–O bond activation of readily accessible unsaturated carboxylates with organometallics until May 2021.

Graphical abstract: Recent developments in catalytic cross-couplings with unsaturated carboxylates
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of pyrrolo[1,2-a]indoles and their derivatives

This review focuses on recent developments in the synthesis of pyrrolo[1,2-a]indole derivatives. The mechanism, factors affecting the yield and selectivity of the product, and application to the synthesis of bioactive molecules are explained.

Graphical abstract: Recent advances in the synthesis of pyrrolo[1,2-a]indoles and their derivatives
From the themed collection: Synthetic methodology in OBC
Review Article

2-Thiazolines: an update on synthetic methods and catalysis

This review summarizes the recent developments in the synthesis and catalytic applications of 2-thiazoline ligands with literature coverage mainly extending from 2009 to 2021.

Graphical abstract: 2-Thiazolines: an update on synthetic methods and catalysis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress in the radical α-C(sp3)–H functionalization of ketones

We outline the recent progress in the development of methods that enable the radical α-C(sp3)–H functionalization of ketones, with an emphasis on radical initiation systems and possible mechanisms.

Graphical abstract: Recent progress in the radical α-C(sp3)–H functionalization of ketones
From the themed collection: Synthetic methodology in OBC
Review Article

CpxM(III)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes

In this review, we highlight the developments in chiral CpxM(III) complexes or achiral CpxM(III) complexes/chiral carboxylic acid-catalyzed enantioselective C–H functionalization reactions through migratory insertion of metal–carbenes/nitrenes.

Graphical abstract: CpxM(iii)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes
From the themed collection: Synthetic methodology in OBC
Review Article

Modern methods for the synthesis of perfluoroalkylated aromatics

This review summarizes the most recent organometallic, photochemical and electrochemical methods for the synthesis of perfluoroalkylated aromatic scaffolds, a family of compounds that is omnipresent in modern commercial and research applications.

Graphical abstract: Modern methods for the synthesis of perfluoroalkylated aromatics
From the themed collection: Synthetic methodology in OBC
Review Article

Unconventional approaches for the introduction of sulfur-based functional groups

Alternative solvents, ultrasound, electrochemistry and solvent-free methodologies to obtain sulfur-based compounds are herein reviewed. Special attention is paid to unconventional and/or sustainable processes.

Graphical abstract: Unconventional approaches for the introduction of sulfur-based functional groups
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Silicon compounds in carbon-11 radiochemistry: present use and future perspectives

The use of silicon-based reagents and precursors for carbon-11 labelling has shown wide applicability and robustness with short reaction times using mild conditions. In this review, recent advances and future perspectives are examined.

Graphical abstract: Silicon compounds in carbon-11 radiochemistry: present use and future perspectives
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Silicon compounds as stoichiometric coupling reagents for direct amidation

This review covers all the reported use of stoichiometric silicon reagents for direct amidation of carboxylic acids with amines, commencing with the first example in 1969 up until April 2021.

Graphical abstract: Silicon compounds as stoichiometric coupling reagents for direct amidation
From the themed collection: Synthetic methodology in OBC
Review Article

Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles

Palladium-catalysed isocyanide insertion reactions have witnessed great progress in recent years.

Graphical abstract: Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the carbon–phosphorus (C–P) bond formation from unsaturated compounds by s- and p-block metals

A detailed discussion on the catalytic addition of P–H bonds from various phosphine reagents to unsaturated bonds for the C–P bond formation promoted by various s- and p-block metal catalysts is reported.

Graphical abstract: Recent advances in the carbon–phosphorus (C–P) bond formation from unsaturated compounds by s- and p-block metals
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones

This review focuses on the transition metal-free oxidative dehydrogenative aromatization reactions of cyclohexanones, with an emphasis on the scope and limitations, as well as the mechanisms of these reactions.

Graphical abstract: Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones
From the themed collection: Synthetic methodology in OBC
Review Article

Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds

ortho-Alkynylarylcarbonyl derivatives, due to their unique chemical reactivity, have been employed in widely divergent synthesis for the creation of cyclic and heterocyclic small-molecule libraries.

Graphical abstract: Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules

This review summarizes the recent developments in the asymmetric intramolecular Heck reaction and carbometallation-initiated cascade transformations including Ni-catalyzed processes with literature coverage mainly extending from 2016 to 2021.

Graphical abstract: Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules
From the themed collection: Synthetic methodology in OBC
Review Article

Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles

In this review, we describe the important advances in cycloaddition methodologies involving cyclopropanes for the construction of seven-, eight- and nine-membered carbocycles, with a particular attention to the variety of the mechanisms involved.

Graphical abstract: Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress on electrochemical synthesis involving carboxylic acids

Recent progress on sustainable electrochemical synthesis involving carboxylic acids was reviewed.

Graphical abstract: Recent progress on electrochemical synthesis involving carboxylic acids
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in decarboxylative C(aryl)–X bond formation from (hetero)aryl carboxylic acids

This review highlights the recent developments in ipso-decarboxylative C–X (X = O/N/halo/S/Se/P/CN) bond formation using (hetero)aryl carboxylic acids, which are economical and environmentally benign starting materials.

Graphical abstract: Recent developments in decarboxylative C(aryl)–X bond formation from (hetero)aryl carboxylic acids
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Thioxanthone: a powerful photocatalyst for organic reactions

Thioxanthone is a powerful photocatalyst. In this review, its photophysical properties and its applications in photopolymerisation and in organic synthesis are highlighted.

Graphical abstract: Thioxanthone: a powerful photocatalyst for organic reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Antitumor activity of tridentate pincer and related metal complexes

Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.

Graphical abstract: Antitumor activity of tridentate pincer and related metal complexes
From the themed collection: Synthetic methodology in OBC
Review Article

Selected applications of Meldrum's acid – a tutorial

The overview describes synthetic routes towards substituted Meldrum's acids and its recent applications to inspire lab veterans and chemistry younglings.

Graphical abstract: Selected applications of Meldrum's acid – a tutorial
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress in the nitration of arenes and alkenes

This mini review summarizes the recent advances in the regiospecific nitrations of arenes and alkenes based on the structural features of substrates.

Graphical abstract: Recent progress in the nitration of arenes and alkenes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advancements in the development of molecular organic photocatalysts

A review on the recent advances of six classes of organic photocatalysts with respect to photophysical and redox properties.

Graphical abstract: Recent advancements in the development of molecular organic photocatalysts
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

This review highlights recent advancement in the synthesis of 3-hydroxyisoindolinones and their applications in stereoselective transformations.

Graphical abstract: Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones
From the themed collection: Synthetic methodology in OBC
Review Article

Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles

α-Activated cyclic isothiocyanates featuring pharmacophores were efficient percusors for the enantioselective construction of intriguing spirocycles.

Graphical abstract: Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies

This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.

Graphical abstract: Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies
From the themed collection: Synthetic methodology in OBC
Review Article

Light-induced borylation: developments and mechanistic insights

This perspective delineates light-induced borylation methodologies, which have been developed in the last 10 years. Mechanistic insights have been explored throughout the article for these UV- and visible-light-induced borylation reactions.

Graphical abstract: Light-induced borylation: developments and mechanistic insights
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates

This review article describes all the significant recent developments in catalytic asymmetric umpolung reactions of imines involving a 2-azaallyl anion intermediate.

Graphical abstract: Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates
From the themed collection: Synthetic methodology in OBC
Review Article

Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis

This review summarizes the recent advancements in transition-metal (TM) catalyzed enantioselective C–H activation via kinetic resolution approach.

Graphical abstract: Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Construction of bridged polycycles through dearomatization strategies

This review summarizes the-state-of-the-art advances of dearomatization strategies in the application of bridged ring formation.

Graphical abstract: Construction of bridged polycycles through dearomatization strategies
From the themed collection: Synthetic methodology in OBC
Review Article

The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes

This article covers ring expansions of vinylaziridines and vinyloxiranes developed over the past five years for accessing stereochemically enriched heterocycles.

Graphical abstract: The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes
From the themed collection: Synthetic methodology in OBC
Review Article

Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids

The 8-azabicyclo[3.2.1]octane core is the central motif of tropane alkaloids. This review compiles the methodologies employed to synthesize this scaffold in an enantioenriched form from achiral starting materials.

Graphical abstract: Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of pyrido[1,2-a]indoles

This review deals with the different accesses leading to the pyrido[1,2-a]indole nucleus in the last 20 years.

Graphical abstract: Recent advances in the synthesis of pyrido[1,2-a]indoles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle

Azetidines represent one of the most important four-membered heterocycles in organic synthesis. We provide an overview of the synthesis, reactivity and application of azetidines with a focus on the most recent advances, trends and future directions.

Graphical abstract: Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle
From the themed collection: Synthetic methodology in OBC
Review Article

Multicomponent reactions as a potent tool for the synthesis of benzodiazepines

The present review covers all synthetic methods based on multicomponent reactions for the preparation of benzodiazepines as the parent cores of many essential drugs.

Graphical abstract: Multicomponent reactions as a potent tool for the synthesis of benzodiazepines
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones

This review highlights recent developments relating to the preparation of β-keto sulfones and β-keto thiosulfones. And, also focused on widespread synthetic applications of β-keto sulfones for assembling many valuable carbo- and heterocycles.

Graphical abstract: Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones
From the themed collection: Synthetic methodology in OBC
Review Article

Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond

The recent progress in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions is described.

Graphical abstract: Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond
From the themed collection: Synthetic methodology in OBC
Review Article

Recent approaches towards one-carbon homologation–functionalization of aldehydes

This review describes the methods of homologation and functionalization of aldehydes by one carbon unit which are the most fundamental and attractive synthetic transformations in organic synthesis.

Graphical abstract: Recent approaches towards one-carbon homologation–functionalization of aldehydes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in aminative difunctionalization of alkenes

This review summarizes recent advances in transition metal-catalyzed or metal-free aminative difunctionalization of alkenes to construct nitrogen-containing compounds.

Graphical abstract: Recent advances in aminative difunctionalization of alkenes
From the themed collection: Synthetic methodology in OBC
Review Article

Pyrrole carboxamide introduction in the total synthesis of pyrrole–imidazole alkaloids

The pyrrole carboxamide is a characteristic structural feature found in the pyrrole–imidazole (oroidin) alkaloids, the various traditional and non-tradition methods for its introduction are reviewed herein.

Graphical abstract: Pyrrole carboxamide introduction in the total synthesis of pyrrole–imidazole alkaloids
From the themed collection: Synthetic methodology in OBC
Review Article

Electrohalogenation of organic compounds

In this review we target sp, sp2 and sp3 carbon fluorination, chlorination, bromination and iodination reactions using electrolysis as a redox medium. Mechanistic insights and substrate reactivity are also discussed.

Graphical abstract: Electrohalogenation of organic compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles

The present review provides a comprehensive and updated summary of the metal-free multicomponent synthesis of biologically privileged monocyclic six membered N-heterocycles covered in the literature since 2000.

Graphical abstract: Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update

α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformations including Michael additions, domino reactions and cycloadditions.

Graphical abstract: α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
From the themed collection: Catalysis & biocatalysis in OBC
1000 items - Showing page 1 of 15

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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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