Themed collection Synthetic methodology in OBC
Transition metal-catalyzed arylation of unstrained C–C single bonds
Carbon–carbon bond activation is one of the most challenging and important research areas in organic chemistry.
Ring closing metathesis for the construction of carbazole and indole-fused natural products
In this perspective, ring-closing metathesis (RCM) based approaches for the synthesis of carbazole derivatives and other indole-fused heteroaromatic systems have been described.
Transition metal catalysed direct construction of 2-pyridone scaffolds through C–H bond functionalizations
A summary of literature on transition metal catalysed construction of 2-pyridone scaffolds using a wide range of coupling partners via C–H bond functionalizations has been described.
Recent advances in palladium-catalyzed C(sp3)/C(sp2)-H bond functionalizations: Access to C-branched glycosides
Phosphorylation of Arenes, Heteroarenes, Alkenes, Carbonyls and Imines by Dehydrogenative Cross-Coupling of P(O)-H and P(R)-H
Recent advances in Cu-catalyzed transformations of internal alkynes to alkenes and heterocycles
Numerous metal-catalyzed reactions involving internal alkynes and aimed towards synthetically and pharmacologically important alkenes and heterocycles have appeared in the literature.
Recent development in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as C=C-N donors
Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling
The free-radical-induced syntheses of indolizines were reviewed by type of catalyst.
N-Triflylphosphoramides: highly acidic catalysts for asymmetric transformations
N-Triflylphosphoramides (NTPA), have become increasingly popular catalysts in the development of enantioselective transformations as they are stronger Brønsted acids than the corresponding phosphoric acids (PA).
Current applications of kinetic resolution in the asymmetric synthesis of substituted pyrrolidines
Catalytic Asymmetric Synthesis of α-Stereogenic Carboxylic Acids：Recent Advances
Synthesis of 2H-Chromenes: Recent Advances and Perspectives
β-Keto acids in asymmetric metal catalysis and organocatalysis
β-Keto acids: ideal ketone surrogates for diverse asymmetric nucleophilic addition reactions via a decarboxylative process.
C 1-Symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation to prepare chiral compounds
This review examines the potential of C1-symmetric diphosphorus ligands in metal-catalyzed asymmetric hydrogenation of alkenes to produce pharmaceutical intermediates, bioactive molecules, drug molecules, agrochemicals, and fragrances.
The construction of benzimidazo[2,1-a]isoquinolin-6(5H)-ones from N-methacryloyl-2-phenylbenzoimidazoles through radical strategies
We highlight significant progress in the synthesis of benzimidazo[2,1-a]isoquinolin-6(5H)-ones using C-, S-, P-, and Si-centered radicals, including the selection of the catalytic system, substrate scope, mechanistic understanding, and applications.
Recent advances in decarbonylative annulation reactions
In recent years, decarbonylative annulation reactions have emerged as one of the most efficient routes to construct a variety of important carbocyclic and heterocyclic scaffolds.
Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization
Development of straightforward protocols for the functionalization of unactivated cyclopropanes is still challenging, the realization of which could bestow the scientific community with a recurring building block for modern organic transformations.
Oxidative cross-coupling of thiols for S–X (X = S, N, O, P, and C) bond formation: mechanistic aspects
This review describes the oxidative cross-couplings of thiols forming various organosulfur compounds, focusing on critical intermediates such as sulfenyl halides, thiyl radicals, sulfenium cations, disulfides, and organo-transition metal intermediates.
Application of combined cyanide sources in cyanation reactions
The cyanation reaction is a key transformation due to the wide-ranging applications of nitrile compounds in organic chemistry.
Direct radical functionalization methods to access substituted adamantanes and diamondoids
Substituted adamantanes are important and versatile products that can be derived from direct C–H to C–C transformations via radical intermediates. In this review, a wide range of direct functionalization methods are summarized with a focus on mechanism and scope.
Recent strategies used in the synthesis of saturated four-membered heterocycles
Recent advances in the synthesis of O-, N-, and S-atom containing saturated 4-membered heterocycles are presented based on their preparative similarities. These strategic approaches highlight both progress made and remaining synthetic opportunities.
Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation
Recent achievements in rhodium-catalyzed arylations through C(sp2)–H bond activation were summarized.
C–H activation reactions of nitroarenes: current status and outlook
The current landscape of nitro group directed C–H activation reactions of (hetero)arenes is reviewed.
Recent advances and future challenges in the synthesis of 2,4,6-triarylpyridines
The present review is focused on recent advances (2015–present) in the synthesis of 2,4,6-triarylpyridines (also known as Kröhnke pyridines).
The C–H functionalization of N-alkoxycarbamoyl indoles by transition metal catalysis
Indole and its congeners are ubiquitous nitrogen containing organic scaffolds found in a plethora of natural products. This review aims to highlight the transition-metal catalyzed C–H functionalization of N-alkoxycarbamoyl indoles.
Current developments in the synthesis of 4-chromanone-derived compounds
The chroman-4-one framework is a significant structural entity that belongs to the class of oxygen-containing heterocycles.
Forgotten and forbidden chemical reactions revitalised through continuous flow technology
This short review highlights compelling case studies from the last five years showcasing how modern flow technology has impacted and advanced synthetic chemistry in academia and industry.
An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles
This review focuses on important cycloaddition reactions of 3-methyleneindolinones to afford 3,3′-spirocyclic oxindoles.
Recent developments in catalytic cross-couplings with unsaturated carboxylates
This review summarises the recent advances in the field of transition metal-catalyzed C–O bond activation of readily accessible unsaturated carboxylates with organometallics until May 2021.
Recent advances in the synthesis of pyrrolo[1,2-a]indoles and their derivatives
This review focuses on recent developments in the synthesis of pyrrolo[1,2-a]indole derivatives. The mechanism, factors affecting the yield and selectivity of the product, and application to the synthesis of bioactive molecules are explained.
2-Thiazolines: an update on synthetic methods and catalysis
This review summarizes the recent developments in the synthesis and catalytic applications of 2-thiazoline ligands with literature coverage mainly extending from 2009 to 2021.
Recent progress in the radical α-C(sp3)–H functionalization of ketones
We outline the recent progress in the development of methods that enable the radical α-C(sp3)–H functionalization of ketones, with an emphasis on radical initiation systems and possible mechanisms.
CpxM(III)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes
In this review, we highlight the developments in chiral CpxM(III) complexes or achiral CpxM(III) complexes/chiral carboxylic acid-catalyzed enantioselective C–H functionalization reactions through migratory insertion of metal–carbenes/nitrenes.
Modern methods for the synthesis of perfluoroalkylated aromatics
This review summarizes the most recent organometallic, photochemical and electrochemical methods for the synthesis of perfluoroalkylated aromatic scaffolds, a family of compounds that is omnipresent in modern commercial and research applications.
Unconventional approaches for the introduction of sulfur-based functional groups
Alternative solvents, ultrasound, electrochemistry and solvent-free methodologies to obtain sulfur-based compounds are herein reviewed. Special attention is paid to unconventional and/or sustainable processes.
Silicon compounds in carbon-11 radiochemistry: present use and future perspectives
The use of silicon-based reagents and precursors for carbon-11 labelling has shown wide applicability and robustness with short reaction times using mild conditions. In this review, recent advances and future perspectives are examined.
Silicon compounds as stoichiometric coupling reagents for direct amidation
This review covers all the reported use of stoichiometric silicon reagents for direct amidation of carboxylic acids with amines, commencing with the first example in 1969 up until April 2021.
Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles
Palladium-catalysed isocyanide insertion reactions have witnessed great progress in recent years.
Recent advances in the carbon–phosphorus (C–P) bond formation from unsaturated compounds by s- and p-block metals
A detailed discussion on the catalytic addition of P–H bonds from various phosphine reagents to unsaturated bonds for the C–P bond formation promoted by various s- and p-block metal catalysts is reported.
Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones
This review focuses on the transition metal-free oxidative dehydrogenative aromatization reactions of cyclohexanones, with an emphasis on the scope and limitations, as well as the mechanisms of these reactions.
Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds
ortho-Alkynylarylcarbonyl derivatives, due to their unique chemical reactivity, have been employed in widely divergent synthesis for the creation of cyclic and heterocyclic small-molecule libraries.
Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules
This review summarizes the recent developments in the asymmetric intramolecular Heck reaction and carbometallation-initiated cascade transformations including Ni-catalyzed processes with literature coverage mainly extending from 2016 to 2021.
Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles
In this review, we describe the important advances in cycloaddition methodologies involving cyclopropanes for the construction of seven-, eight- and nine-membered carbocycles, with a particular attention to the variety of the mechanisms involved.
Recent progress on electrochemical synthesis involving carboxylic acids
Recent progress on sustainable electrochemical synthesis involving carboxylic acids was reviewed.
Recent developments in decarboxylative C(aryl)–X bond formation from (hetero)aryl carboxylic acids
This review highlights the recent developments in ipso-decarboxylative C–X (X = O/N/halo/S/Se/P/CN) bond formation using (hetero)aryl carboxylic acids, which are economical and environmentally benign starting materials.
Thioxanthone: a powerful photocatalyst for organic reactions
Thioxanthone is a powerful photocatalyst. In this review, its photophysical properties and its applications in photopolymerisation and in organic synthesis are highlighted.
Antitumor activity of tridentate pincer and related metal complexes
Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.
Selected applications of Meldrum's acid – a tutorial
The overview describes synthetic routes towards substituted Meldrum's acids and its recent applications to inspire lab veterans and chemistry younglings.
Recent progress in the nitration of arenes and alkenes
This mini review summarizes the recent advances in the regiospecific nitrations of arenes and alkenes based on the structural features of substrates.
Recent advancements in the development of molecular organic photocatalysts
A review on the recent advances of six classes of organic photocatalysts with respect to photophysical and redox properties.
Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones
This review highlights recent advancement in the synthesis of 3-hydroxyisoindolinones and their applications in stereoselective transformations.
Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles
α-Activated cyclic isothiocyanates featuring pharmacophores were efficient percusors for the enantioselective construction of intriguing spirocycles.
Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies
This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.
Light-induced borylation: developments and mechanistic insights
This perspective delineates light-induced borylation methodologies, which have been developed in the last 10 years. Mechanistic insights have been explored throughout the article for these UV- and visible-light-induced borylation reactions.
Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates
This review article describes all the significant recent developments in catalytic asymmetric umpolung reactions of imines involving a 2-azaallyl anion intermediate.
Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis
This review summarizes the recent advancements in transition-metal (TM) catalyzed enantioselective C–H activation via kinetic resolution approach.
Construction of bridged polycycles through dearomatization strategies
This review summarizes the-state-of-the-art advances of dearomatization strategies in the application of bridged ring formation.
The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes
This article covers ring expansions of vinylaziridines and vinyloxiranes developed over the past five years for accessing stereochemically enriched heterocycles.
Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids
The 8-azabicyclo[3.2.1]octane core is the central motif of tropane alkaloids. This review compiles the methodologies employed to synthesize this scaffold in an enantioenriched form from achiral starting materials.
Recent advances in the synthesis of pyrido[1,2-a]indoles
This review deals with the different accesses leading to the pyrido[1,2-a]indole nucleus in the last 20 years.
Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle
Azetidines represent one of the most important four-membered heterocycles in organic synthesis. We provide an overview of the synthesis, reactivity and application of azetidines with a focus on the most recent advances, trends and future directions.
Multicomponent reactions as a potent tool for the synthesis of benzodiazepines
The present review covers all synthetic methods based on multicomponent reactions for the preparation of benzodiazepines as the parent cores of many essential drugs.
Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones
This review highlights recent developments relating to the preparation of β-keto sulfones and β-keto thiosulfones. And, also focused on widespread synthetic applications of β-keto sulfones for assembling many valuable carbo- and heterocycles.
Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond
The recent progress in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions is described.
Recent approaches towards one-carbon homologation–functionalization of aldehydes
This review describes the methods of homologation and functionalization of aldehydes by one carbon unit which are the most fundamental and attractive synthetic transformations in organic synthesis.
Recent advances in aminative difunctionalization of alkenes
This review summarizes recent advances in transition metal-catalyzed or metal-free aminative difunctionalization of alkenes to construct nitrogen-containing compounds.
Pyrrole carboxamide introduction in the total synthesis of pyrrole–imidazole alkaloids
The pyrrole carboxamide is a characteristic structural feature found in the pyrrole–imidazole (oroidin) alkaloids, the various traditional and non-tradition methods for its introduction are reviewed herein.
Electrohalogenation of organic compounds
In this review we target sp, sp2 and sp3 carbon fluorination, chlorination, bromination and iodination reactions using electrolysis as a redox medium. Mechanistic insights and substrate reactivity are also discussed.
Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles
The present review provides a comprehensive and updated summary of the metal-free multicomponent synthesis of biologically privileged monocyclic six membered N-heterocycles covered in the literature since 2000.
α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformations including Michael additions, domino reactions and cycloadditions.
About this collection
The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.