Themed collection Organic & Biomolecular Chemistry HOT article collection

103 items - Showing page 1 of 2
Review Article

Transition metal-free synthesis of alkyl pinacol boronates

This review systematically outlined the research in the area of transition metal free synthesis of alkyl pinacol boronates, which are versatile and important scaffolds to construct diverse organic compounds.

Graphical abstract: Transition metal-free synthesis of alkyl pinacol boronates
From the themed collection: Synthetic methodology in OBC
Review Article

Copper-catalysed radical reactions of alkenes, alkynes and cyclopropanes with N–F reagents

The mild generation of nitrogen-centred radicals from N–F reagents using copper-based catalysts has become a convenient synthetic tool.

Graphical abstract: Copper-catalysed radical reactions of alkenes, alkynes and cyclopropanes with N–F reagents
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Cobalt-catalyzed carbonylation of the C–H bond

Direct carbonylation of the C–H bond is a great tool for installing a carbonyl group in a wide variety of substrates.

Graphical abstract: Cobalt-catalyzed carbonylation of the C–H bond
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis strategies for non-symmetric, photochromic diarylethenes

This review surveys synthesis strategies for accessing non-symmetric diarylethene photochromes and highlights notable properties and applications of these compounds.

Graphical abstract: Synthesis strategies for non-symmetric, photochromic diarylethenes
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Synthetic approaches and applications of sulfonimidates

This review encompasses the developments in sulfonimidate chemistry, focusing on both syntheses and applications of these important organosulfur(VI) species.

Graphical abstract: Synthetic approaches and applications of sulfonimidates
From the themed collection: Synthetic methodology in OBC
Review Article

Rational design of small molecule fluorescent probes for biological applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

Graphical abstract: Rational design of small molecule fluorescent probes for biological applications
From the themed collection: Chemical Biology in OBC
Review Article

The curious yellow colouring matter of the Iceland poppy

This account provides an chronological overview of the fascinating history of the pigment responsible for the yellow colour of the Iceland poppy (Papaver nudicaule).

Graphical abstract: The curious yellow colouring matter of the Iceland poppy
From the themed collection: Chemical Biology in OBC
Review Article

TLR2 agonists and their structure–activity relationships

We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.

Graphical abstract: TLR2 agonists and their structure–activity relationships
From the themed collection: Chemical Biology in OBC
Review Article

Chemical methods for modification of proteins

The field of protein bioconjugation draws attention from stakeholders in chemistry, biology, and medicine. This review provides an overview of the present status, challenges, and opportunities for organic chemists.

Graphical abstract: Chemical methods for modification of proteins
From the themed collection: Chemical Biology in OBC
Review Article

Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms

Advances in the synthesis of multiphosphorylated peptides and peptide libraries: tools for studying the effects of phosphorylation patterns on protein function and regulation.

Graphical abstract: Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms
From the themed collection: Chemical Biology in OBC
Review Article

Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme

The review examines functional knowledge gathered over two decades of research on the 8-17 DNAzyme, focusing on three aspects: the structural requirements for catalysis, the role of metal ions and the participation of general acid-base catalysis.

Graphical abstract: Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
From the themed collection: Chemical Biology in OBC
Review Article

Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective

This review surveys known structures of staphylococcal polysaccharides and summarizes all synthetic efforts to obtain these sequences.

Graphical abstract: Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Recent trends in catalytic sp3 C–H functionalization of heterocycles

In this mini-review, we attempt to highlight gaps in existing techniques for sp3 C–H activation adjacent to heterocycles.

Graphical abstract: Recent trends in catalytic sp3 C–H functionalization of heterocycles
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Construction of an IMiD-based azide library as a kit for PROTAC research

As a promising protein degradation strategy, PROTAC technology is increasingly becoming a new star in cancer treatment.

Graphical abstract: Construction of an IMiD-based azide library as a kit for PROTAC research
From the themed collection: Chemical Biology in OBC
Communication

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Sulfoxides have been synthesised from various sulfide substrates under mild conditions exploiting CALB biocatalyst in the presence of urea hydrogen peroxide and AcOEt which acts with the dual role of solvent and reagent.

Graphical abstract: A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis

The synergy of an Ir-based photosensitizer with mild oxidizing ability and a thiol catalyst enables efficient allylic C–H functionalization of enol silyl ethers with imines under visible light irradiation.

Graphical abstract: Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis
From the themed collection: Synthetic methodology in OBC
Communication

A scalable continuous photochemical process for the generation of aminopropylsulfones

An efficient continuous photochemical process is presented that delivers a series of novel γ-aminopropylsulfones via a tetrabutylammonium decatungstate (TBADT) catalysed HAT-process.

Graphical abstract: A scalable continuous photochemical process for the generation of aminopropylsulfones
From the themed collection: Synthetic methodology in OBC
Communication

Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides

Ethyl thioglycosides could be selectively activated in the presence of phenyl thioglycosides carrying the same or even more armed protecting group pattern.

Graphical abstract: Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides
From the themed collection: Chemical Biology in OBC
Communication

Total synthesis of thioamycolamide A via a biomimetic route

A concise total synthesis of thioamycolamide A was accomplished as a key step of thio-Michael addition via a biomimetic route.

Graphical abstract: Total synthesis of thioamycolamide A via a biomimetic route
From the themed collection: Total synthesis in OBC
Communication

Chemo- and regioselective synthesis of polysubstituted 2-aminothiophenes by the cyclization of gem-dibromo or gem-dichloroalkenes with β-keto tertiary thioamides

A facile and practical method for the synthesis of 2,3,4-trisubstituted 2-aminothiophenes by the cyclization of gem-dibromoalkenes or gem-dichloroalkenes with β-keto tertiary thioamides has been developed.

Graphical abstract: Chemo- and regioselective synthesis of polysubstituted 2-aminothiophenes by the cyclization of gem-dibromo or gem-dichloroalkenes with β-keto tertiary thioamides
From the themed collection: Synthetic methodology in OBC
Communication

Highly stereocontrolled total synthesis of secodolastane diterpenoid isolinearol

The first total synthesis of the secodolastane diterpenoid isolinearol in both racemic and enantioenriched forms has been achieved with high stereoselectively.

Graphical abstract: Highly stereocontrolled total synthesis of secodolastane diterpenoid isolinearol
Communication

Selective construction of alkaloid scaffolds by alcohol-based direct and mild aerobic oxidative Pictet–Spengler reactions

Tetrahydro-β-carboline and β-carboline alkaloid scaffolds can be selectively obtained by direct aerobic oxidative Pictet–Spengler reactions of tryptamines with alcohols using TBN/TEMPO as the catalysts and oxygen as the oxidant under mild conditions.

Graphical abstract: Selective construction of alkaloid scaffolds by alcohol-based direct and mild aerobic oxidative Pictet–Spengler reactions
From the themed collection: Synthetic methodology in OBC
Communication

Rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans by hybrid use of Lewis/Brønsted acid catalysts

Expeditious synthesis of 3-indolyl-1-trifluoromethyl-isobenzofurans via [1,4]-hydride shift/cyclization/intermolecular nucleophilic addition reaction sequence.

Graphical abstract: Rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans by hybrid use of Lewis/Brønsted acid catalysts
From the themed collection: Synthetic methodology in OBC
Communication

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Aqueous Knoevenagel condensation of various aldehydes with malononitrile could efficiently proceed using hydroquinone and benzoquinone as mixed catalysts.

Graphical abstract: Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation
From the themed collection: Synthetic methodology in OBC
Communication

Boracene-based alkylborate enabled Ni/Ir hybrid catalysis

Boracene-based alkylborate enabled visible light-mediated Ni/Ir metallaphotoredox catalysis.

Graphical abstract: Boracene-based alkylborate enabled Ni/Ir hybrid catalysis
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Communication

Defluorination of 4-fluorothreonine by threonine deaminase

Threonine deaminase from E. coli catalyses defluorination on 4-fluorothreonine.

Graphical abstract: Defluorination of 4-fluorothreonine by threonine deaminase
From the themed collection: Chemical Biology in OBC
Communication

BINOL derivatives-catalysed enantioselective allylboration of isatins: application to the synthesis of (R)-chimonamidine

3-Allyl-3-hydroxyoxindoles are obtained with high ee in a metal-free catalytic process from isatins. This scaffold has been converted to the natural product chimonamidine.

Graphical abstract: BINOL derivatives-catalysed enantioselective allylboration of isatins: application to the synthesis of (R)-chimonamidine
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives.

Graphical abstract: Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity
From the themed collection: Synthetic methodology in OBC
Communication

Disulphide-mediated site-directed modification of proteins

Site-directed addition of a single thiols handle to proteins by means of temporary disulphide rebridging of solvent exposed disulphides is obtained with a new labelling reagent.

Graphical abstract: Disulphide-mediated site-directed modification of proteins
From the themed collection: Chemical Biology in OBC
Communication

Sesquiterpene synthases for bungoene, pentalenene and epi-isozizaene from Streptomyces bungoensis

A sesquiterpene synthase from Streptomyces bungoensis was characterised and produces the new compound bungoene.

Graphical abstract: Sesquiterpene synthases for bungoene, pentalenene and epi-isozizaene from Streptomyces bungoensis
From the themed collection: Chemical Biology in OBC
Communication

Site-selective modification of proteins using cucurbit[7]uril as supramolecular protection for N-terminal aromatic amino acids

Supramolecular protection of N-terminal aromatic amino acids through complexation with cucurbit[7]uril can enable site-selective protein modification of unfavored motifs.

Graphical abstract: Site-selective modification of proteins using cucurbit[7]uril as supramolecular protection for N-terminal aromatic amino acids
From the themed collection: Editor’s Collection
Communication

Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein–protein interactions

Homo-oligomers are difficult drug targets. Here, Differential Scanning Fluorimetry (DSF) is introduced as a method to identify inhibitors of these systems, by discriminating between oligomers and monomers based on their thermal stability.

Graphical abstract: Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein–protein interactions
From the themed collection: Chemical Biology in OBC
Open Access Communication

Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation

A genetically incorporated ThrK unnatural amino acid can undergo rapid periodate oxidation to reveal a reactive internal α-oxo aldehyde.

Graphical abstract: Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation
From the themed collection: Chemical Biology in OBC
Communication

Hierarchical self-assembly of an azobenzene dyad with inverted amide connection into toroidal and tubular nanostructures

Inversion of the amide connectivity of an azobenzene dyad, which self-assembles into chiral toroids and nanotubes, improves the thermal stability of the assemblies, however it negatively affects supramolecular chirality.

Graphical abstract: Hierarchical self-assembly of an azobenzene dyad with inverted amide connection into toroidal and tubular nanostructures
From the themed collection: Supramolecular chemistry in OBC
Communication

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8

N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions in the biosynthesis of trichostatin.

Graphical abstract: Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
From the themed collection: Chemical Biology in OBC
Communication

A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

Efficient approach for the facile construction of polyfunctionalized pyrazolone derivatives bearing two contiguous quaternary stereocenters in good yields with high regioselectivities and excellent diastereoselectivities.

Graphical abstract: A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Enantioselective synthesis and determination of the absolute configuration of the male sex pheromone of the parasitoid wasp Urolepis rufipes

The parasitoid wasp Urolepis rufipes uses terminally oxidized dihydrolinalool as a sex pheromone. The absolute configuration of the active enantiomer was established as 2S,6S by synthesis and its pheromonal activity was proven in a bioassay.

Graphical abstract: Enantioselective synthesis and determination of the absolute configuration of the male sex pheromone of the parasitoid wasp Urolepis rufipes
Communication

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides

A major current issue in medicinal chemistry is the design of small peptide analogues resistant to proteolysis and able to adopt preferential conformations, while preserving the selectivity and efficiency of natural peptides.

Graphical abstract: Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides
From the themed collection: Chemical Biology in OBC
Communication

Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.

Graphical abstract: Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates
From the themed collection: Chemical Biology in OBC
Communication

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

The practical synthesis of pseudo-enantiomeric carbohydrate-based NHC–Rh complexes bearing C1 or C3 sterically differentiated positions is reported. We show that steric bulk at either C1 or C3 leads to enantiotopic discrimination in the hydrosilylation of acetophenone.

Graphical abstract: Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination
From the themed collection: Chemical Biology in OBC
Communication

Non-biaryl atropisomerism at the C–B bond in sterically hindered aminoarylboranes

Sterically hindered aminoarylboranes with atropisomerism about the C–B bond were prepared and resolved by chiral stationary phase HPLC.

Graphical abstract: Non-biaryl atropisomerism at the C–B bond in sterically hindered aminoarylboranes
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Merging singlet-oxygen induced furan oxidations with organocatalysis: synthesis of enantiopure cyclopentanones and hydrindanes

A general, flexible and highly effective method for the regio-, diastereo- & enantioselective one-pot synthesis of important carbocycles, namely, enantiopure cyclopentanones and their hydrindane congeners is presented.

Graphical abstract: Merging singlet-oxygen induced furan oxidations with organocatalysis: synthesis of enantiopure cyclopentanones and hydrindanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

Genome mining and heterologous biosynthesis led to the discovery of a 12 membered macrolide from Macrophomina phaseolina.

Graphical abstract: Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina
From the themed collection: Chemical Biology in OBC
Open Access Communication

Organocatalytic carbon dioxide fixation to epoxides by perfluorinated 1,3,5-triols catalysts

A new type of perfluorinated triol catalysts of enhanced acidity was developed for the selective opening of epoxide to carbonates. This useful transformation using TBAI as co-catalyst is performed under only 1 atmosphere of CO2 at 30 to 80 °C.

Graphical abstract: Organocatalytic carbon dioxide fixation to epoxides by perfluorinated 1,3,5-triols catalysts
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines

The diastereoselective conjugate addition of chiral secondary lithium homoallylamides to α,β-unsaturated esters, providing tertiary amines bearing two chains integrating a stereogenic center adjacent to the nitrogen atom, is reported.

Graphical abstract: Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines
From the themed collection: Synthetic methodology in OBC
Communication

Regioselective catalytic asymmetric N-alkylation of isoxazol-5-ones with para-quinone methides

A highly regioselective and enantioselective N-alkylation of isoxazol-5-ones with para-quinone methides has been developed to obtain enantioenriched N-diarylmethane substituted isoxazolinones with high yields and enantioselectivities.

Graphical abstract: Regioselective catalytic asymmetric N-alkylation of isoxazol-5-ones with para-quinone methides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)

Deprotected iminosugar alkenes were subjected to thiol–ene coupling with deprotected sugar thiols to afford new imino-disaccharides. Two thiol–ene couplings converted these alkenes into iminosugar thiols and then multivalent iminosugars.

Graphical abstract: Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry

In this study we describe a novel platform for generating functionalised TIPS microparticles for “click” conjugation to various active compounds.

Graphical abstract: Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry
From the themed collection: Chemical Biology in OBC
Open Access Communication

Reagent controlled stereoselective synthesis of teichoic acid α-(1,2)-glucans

Additive controlled glycosylation reactions are used for the construction of α-(1,2)-glucosidic linkages, such as those featuring in E. faecalis lipoteichoic acid.

Graphical abstract: Reagent controlled stereoselective synthesis of teichoic acid α-(1,2)-glucans
From the themed collection: Synthetic methodology in OBC
Communication

Robust synthesis of NIR-emissive P-rhodamine fluorophores

A library of P-rhodamines was prepared via a new robust sequence that creates the core heterocycle by addition of diaryllithium reagents to esters. The first SAR study for P-rhodamines shows that they are NIR-emissive and highly bright fluorophores.

Graphical abstract: Robust synthesis of NIR-emissive P-rhodamine fluorophores
From the themed collection: Synthetic methodology in OBC
Communication

Cobalt-catalyzed regioselective hydrohydrazination of epoxides

A series of valuable 1,1-hydrazinoalcohols were conveniently synthesized by catalytic hydrohydrazination of epoxides with the NH group of hydrazines.

Graphical abstract: Cobalt-catalyzed regioselective hydrohydrazination of epoxides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

γ-C (sp3)–H bond functionalisation of α,β-unsaturated amides through an umpolung strategy

The nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides have been developed.

Graphical abstract: γ-C (sp3)–H bond functionalisation of α,β-unsaturated amides through an umpolung strategy
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Automated access to well-defined ionic oligosaccharides

Automated Glycan Assembly grants access to ionic oligosaccharides for structural studies.

Graphical abstract: Automated access to well-defined ionic oligosaccharides
From the themed collection: Chemical Biology in OBC
Communication

The strategic use of para-quinone methides to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides from unprotected carbohydrate amines

A practical route to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides via Sc(OTf)3-catalyzed 1,6-conjugate addition of unprotected amino sugars with p-QMs.

Graphical abstract: The strategic use of para-quinone methides to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides from unprotected carbohydrate amines
Open Access Communication

Enantioselective catalytic synthesis of α-aryl-α-SCF32,2-amino acids

Novel α-trifluoromethylthiolated-β2,2-amino acids were obtained in high enantiopurities under chiral phase-transfer catalysis.

Graphical abstract: Enantioselective catalytic synthesis of α-aryl-α-SCF3-β2,2-amino acids
From the themed collection: Synthetic methodology in OBC
Communication

Ag-Catalyzed minisci C–H difluoromethylarylation of N-heteroarenes

A mild silver-catalyzed decarboxylative C–H difluoromethylarylation of electron-deficient N-heteroarenes.

Graphical abstract: Ag-Catalyzed minisci C–H difluoromethylarylation of N-heteroarenes
From the themed collection: Synthetic methodology in OBC
Paper

Activation barriers in Class F G protein-coupled receptors revealed by umbrella sampling simulations

Molecular simulations reveal energetic barriers to Class F GPCR activation.

Graphical abstract: Activation barriers in Class F G protein-coupled receptors revealed by umbrella sampling simulations
From the themed collection: Chemical Biology in OBC
Paper

Kinase and GPCR polypharmacological approach for the identification of efficient anticancer medicines

Bifunctional molecules that inhibit casein kinase 1 delta and simultaneously antagonize muscarinic acetylcholine receptor M3 were identified.

Graphical abstract: Kinase and GPCR polypharmacological approach for the identification of efficient anticancer medicines
Paper

Using engineered 6-O-sulfotransferase to improve the synthesis of anticoagulant heparin

Heparan sulfate (HS) and heparin are sulfated polysaccharides exhibiting diverse physiological functions.

Graphical abstract: Using engineered 6-O-sulfotransferase to improve the synthesis of anticoagulant heparin
From the themed collection: Chemical Biology in OBC
Paper

Synthesis and antiproliferative effect of the proposed stereoisomer of the marine sponge metabolite halisphingosine A

The purported isomer of halisphingosine A was built up in 11 steps and 29% yield by catalytic Henry and hydrogenation reactions. Its 13C-NMR data differed from that of the natural isolate. It was antiproliferative in various tumour cells.

Graphical abstract: Synthesis and antiproliferative effect of the proposed stereoisomer of the marine sponge metabolite halisphingosine A
From the themed collection: Total synthesis in OBC
Paper

Facile synthesis of sulfotyrosine-containing α-conotoxins

A one-pot neopentyl deprotection and oxidative disulfide pairing strategy was developed for the facile synthesis of sulfotyrosine (sY)-containing α-conotoxins (Ctx).

Graphical abstract: Facile synthesis of sulfotyrosine-containing α-conotoxins
From the themed collection: Chemical Biology in OBC
Paper

Synthesis of 2-bromo- and 2-phenyl-neo-confused porphyrins

New examples of neo-confused porphyrins are reported. These retain global diatropic characteristics but are relatively unstable in solution.

Graphical abstract: Synthesis of 2-bromo- and 2-phenyl-neo-confused porphyrins
From the themed collection: Supramolecular chemistry in OBC
Paper

Metabolites of the anaerobic degradation of diethyl ether by denitrifying betaproteobacterium strain HxN1

The constitutions of five metabolites formed during anaerobic degradation of diethyl ether by the denitrifying bacterium Aromatoleum sp. HxN1 were identified by comparison with synthesized standards using GC-MS.

Graphical abstract: Metabolites of the anaerobic degradation of diethyl ether by denitrifying betaproteobacterium strain HxN1
From the themed collection: Chemical Biology in OBC
Open Access Paper

Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability

Binding of cations leads to inversion of conformational preference of cyclic octadepsipeptides and may be connected to incorporation in membranes.

Graphical abstract: Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability
Paper

Synthesis of N-acetylglucosamine and N-acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: unexpected affinity of N-acetylallosamine ligands towards Wheat Germ Agglutinin

Resorcinarene-based glycoclusters bearing β-S-GlcNAc and β-S-AllNAc residues were synthesized and ITC and molecular docking calculations provided evidence of their strong affinity towards WGA.

Graphical abstract: Synthesis of N-acetylglucosamine and N-acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: unexpected affinity of N-acetylallosamine ligands towards Wheat Germ Agglutinin
From the themed collection: Synthetic methodology in OBC
Paper

Mechanistic insights into Smiles rearrangement. Focus on π–π stacking interactions along the radical cascade

The synthesis of new arene and heteroarene scaffolds of therapeutic interest has generated a renewed interest in the domino radical cyclisation–Smiles.

Graphical abstract: Mechanistic insights into Smiles rearrangement. Focus on π–π stacking interactions along the radical cascade
Paper

Revisiting the role of acids and hydrogen bond acceptors in enamine formation

A systematic investigation into the effects of acids and hydrogen bond acceptors on the reaction rates and equilibria of enamine formation is reported.

Graphical abstract: Revisiting the role of acids and hydrogen bond acceptors in enamine formation
From the themed collection: Synthetic methodology in OBC
Paper

Absolute handedness control of oligoamide double helices by chiral oxazolylaniline induction

Aromatic oligoamide double helices bearing a chiral oxazolylaniline moiety were synthesized and their helix handedness was completely controlled (de > 99%).

Graphical abstract: Absolute handedness control of oligoamide double helices by chiral oxazolylaniline induction
From the themed collection: Supramolecular chemistry in OBC
Open Access Paper

Influence of the reducing-end anomeric configuration of the Man9 epitope on DC-SIGN recognition

The anomeric configuration of the reducing end of Man9 does not influence the binding to DC-SIGN.

Graphical abstract: Influence of the reducing-end anomeric configuration of the Man9 epitope on DC-SIGN recognition
From the themed collection: Chemical Biology in OBC
Paper

Novel synthetic strategy towards subphthalocyanine-functionalized acetylenic scaffolds via various dibromo-enynes

Axial alkynylation of boron subphthalocyanine with dibromo-substituted enynes and enediynes is presented and the convenient use of these compounds for subsequent metal-catalyzed coupling reactions.

Graphical abstract: Novel synthetic strategy towards subphthalocyanine-functionalized acetylenic scaffolds via various dibromo-enynes
From the themed collection: Synthetic methodology in OBC
103 items - Showing page 1 of 2

About this collection

This on-going collection features all the articles published in Organic & Biomolecular Chemistry in 2020 that were highlighted by the reviewers of these articles as being interesting or having particularly significant research.

Congratulations to all the authors whose articles are featured!

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