Appreciation of Iain Purchase and Cliff Elcombe
Introducing this themed issue dedicated to the memory of Iain Purchase and Cliff Elcombe.
The association between chemical-induced porphyria and hepatic cancer
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.
Role of xenobiotics in the induction and progression of fatty liver disease
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans.
The safety evaluation of food flavouring substances: the role of metabolic studies
The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data.
Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).
Chromatin dynamics underlying latent responses to xenobiotics
Xenobiotic-induced perturbations of somatic tissue or germline epigenomes may underlie delayed-onset and long-lasting adverse effects.
Goodbye to the bioassay
It is time to say goodbye to the standard two-year rodent bioassay.
Collaboration and competition: ethics in toxicology
Toxicology has frequently been a focus of scientific and societal concern. It's time to examine practices such as peer review, resourcing, transparency and data sharing to ensure the field stays current, relevant and ethical.
Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway
Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges.
Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action
The CAR-mediated MOA for liver tumorigenesis is of no carcinogenic risk for humans.
The failure of rodent carcinogenesis as a model for Man
Better understanding of carcinogenesis in Man makes clear that the detection of cancers in long-term rodent studies adds little to other predictive information, more reliably and reproducibly obtained.
Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary
Screening for carcinogens in general, and for the urinary bladder specifically, traditionally involves a two-year bioassay in rodents, the results of which often do not have direct relevance to humans with respect to mode of action (MOA) and/or dose response.
About this collection
This is a collection of papers consisting of invited contributions to honour the contributions made to toxicology by Professor Iain Purchase and Dr Cliff Elcombe. The British Toxicology Society (BTS) readily agreed with the guest editorial team that it would be appropriate to publish a special collection in their journal as a mark of respect and appreciation of the contribution of Iain Purchase and Cliff Elcombe made to the science of toxicology, primarily but not exclusively through their involvement with the Central Toxicology Laboratory (CTL). The contributors represent a range of scientific excellence, some having worked at CTL or had collaborated with scientists in CTL. Others are scientists whose success in solving toxicological problems represent the ambitions of Iain Purchase and Cliff Elcombe in their approach to addressing toxicological problems. Guest Edited by Brian Lake, Lewis Smith and Sam Cohen.