Application of proteomics in the elucidation of chemical-mediated allergic contact dermatitis
Allergic contact dermatitis (ACD) is a widespread hypersensitivity reaction of the skin. While technically still challenging in the context of ACD, proteomics provide a powerful and useful tool to study the underlying molecular mechanisms as well as for the identification of biomarkers.
Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.
Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator
A method of predicting drug-induced Torsade de Pointes risk based on the occurrence of simulated early after depolarisations.
Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract
Reduced impact of a tobacco product was observed on the smoking “field-of-injury” tissues.
About this collection
Systems toxicology, which forms a subdivision of systems biology and was pioneered by Leroy Hood, has many definitions, but as a framework for hypothesis generation and testing may represent an important new way of explaining, modelling and predicting the consequences of the exposure of organisms to toxins. Here we highlight work in this area of research that can cover a wide span of topics, from mathematical in silico models, more descriptive "omics"-based approaches (genomics, transcriptomics, proteomics, metabonomics, etc.), to developing a systems view of toxicity.