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Themed collection Bio-inspired and natural materials

22 items
Open Access Editorial

Naturally-derived and bioinspired materials

Guest editors Jennie B. Leach and Molly S. Shoichet introduce this Journal of Materials Chemistry B themed issue on Bio-inspired and Natural Materials.

Graphical abstract: Naturally-derived and bioinspired materials
From the themed collection: Bio-inspired and natural materials
Review Article

Strategies for skeletal muscle tissue engineering: seed vs. soil

The most commonly used tissue engineering approach includes the ex vivo combination of site-appropriate cell(s) and scaffold material(s) to create three-dimensional constructs for tissue replacement or reconstruction. Biologic scaffold materials facilitate endogenous cell recruitment.

Graphical abstract: Strategies for skeletal muscle tissue engineering: seed vs. soil
From the themed collection: Bio-inspired and natural materials
Review Article

Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses

Novel methods to endow cell-responsiveness into hydrogels are explored and successful work is summarized.

Graphical abstract: Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses
From the themed collection: Bio-inspired and natural materials
Review Article

Hydrogels that allow and facilitate bone repair, remodeling, and regeneration

Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success of the current “gold standard” treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate bone stock.

Graphical abstract: Hydrogels that allow and facilitate bone repair, remodeling, and regeneration
From the themed collection: Bio-inspired and natural materials
Review Article

Hyaluronic acid and neural stem cells: implications for biomaterial design

While in the past hyaluronic acid (HA) was considered a passive structural component, research over the past few decades has revealed its diverse and complex biological functions resulting in a major ideological shift. This review describes recent advances in biological interactions of HA with neural stem cells, with a focus on leveraging these interactions to develop advanced biomaterials that aid regeneration of the central nervous system.

Graphical abstract: Hyaluronic acid and neural stem cells: implications for biomaterial design
Review Article

Synthesis and design of biologically inspired biocompatible iron oxide nanoparticles for biomedical applications

Synthesis and design of biologically inspired biocompatible iron oxide nanoparticles.

Graphical abstract: Synthesis and design of biologically inspired biocompatible iron oxide nanoparticles for biomedical applications
From the themed collection: Bio-inspired and natural materials
Communication

Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment

Because current cell sheet-based blood vessels lack biomimetic structure and require excessively long culture times that may compromise smooth muscle cell phenotype, we modified a cell culture platform with thermoresponsive copolymers to allow intact cell sheet detachment after uniaxial conditioning.

Graphical abstract: Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment
From the themed collection: Bio-inspired and natural materials
Communication

Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Patterning of encapsulated MSCs for the spatio-temporal guidance of angiogenesis for modelling and design of therapeutic biomaterials.

Graphical abstract: Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis
Paper

Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation

Sustained and localized delivery of siRNA from photocrosslinked dextran hydrogels can enhance human mesenchymal stem cell osteogenesis.

Graphical abstract: Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation
From the themed collection: Bio-inspired and natural materials
Paper

Physically crosslinked polyvinyl alcohol and gelatin interpenetrating polymer network theta-gels for cartilage regeneration

Theta-gels are hydrogels that form during the solidification and phase separation of two dislike polymers, in which a low molecular weight polymer behaves as a porogen and is removed through dialysis.

Graphical abstract: Physically crosslinked polyvinyl alcohol and gelatin interpenetrating polymer network theta-gels for cartilage regeneration
From the themed collection: Bio-inspired and natural materials
Paper

Sustained small molecule delivery from injectable hyaluronic acid hydrogels through host–guest mediated retention

Shear-thinning hyaluronic acid hydrogels based on modifications of β-cyclodextrin and adamantane were developed for the tunable, sustained release of small molecules, through regulation of cyclodextrin content and affinity for cyclodextrin.

Graphical abstract: Sustained small molecule delivery from injectable hyaluronic acid hydrogels through host–guest mediated retention
From the themed collection: Bio-inspired and natural materials
Paper

Hydrolysis and sulfation pattern effects on release of bioactive bone morphogenetic protein-2 from heparin-based microparticles

Microparticles fabricated with more highly sulfated heparin species are able to release bioactive bone morphogenetic protein-2 (BMP-2), making these microparticles a promising method for growth factor delivery.

Graphical abstract: Hydrolysis and sulfation pattern effects on release of bioactive bone morphogenetic protein-2 from heparin-based microparticles
From the themed collection: Bio-inspired and natural materials
Paper

Systematic evaluation of natural scaffolds in cutaneous wound healing

In this report, we show the tissue healing capacity for solely conductive scaffolds composed of fibrin and/or hyaluronic acid and compared them to scaffolds that deliver a proangiogenic protein signal.

Graphical abstract: Systematic evaluation of natural scaffolds in cutaneous wound healing
From the themed collection: Bio-inspired and natural materials
Paper

Spontaneous helical structure formation in laminin nanofibers

Surface-initiated assembly is used to engineer laminin nanofibers that spontaneously adopt a helical conformation.

Graphical abstract: Spontaneous helical structure formation in laminin nanofibers
From the themed collection: Bio-inspired and natural materials
Open Access Paper

Tunable controlled release of bioactive SDF-1α via specific protein interactions within fibrin/nanoparticle composites

Control over burst release from SDF-1α-loaded PLGA nanoparticles when embedded in varying densities of fibrin matrices using specific protein/protein interactions.

Graphical abstract: Tunable controlled release of bioactive SDF-1α via specific protein interactions within fibrin/nanoparticle composites
From the themed collection: Bio-inspired and natural materials
Paper

Development and characterization of polyethylene glycol–carbon nanotube hydrogel composite

Polyethylene–glycol–carbon nanotube composite was developed where carbon nanotubes altered the hydrogel mechanical and physical properties and aided neuronal cell viability.

Graphical abstract: Development and characterization of polyethylene glycol–carbon nanotube hydrogel composite
From the themed collection: Bio-inspired and natural materials
Paper

Designer hydrogels for precision control of oxygen tension and mechanical properties

Controlled oxygen levels and mechanical properties in hydrogels provide cellular cues.

Graphical abstract: Designer hydrogels for precision control of oxygen tension and mechanical properties
From the themed collection: Bio-inspired and natural materials
Paper

In situ crosslinking of electrospun gelatin for improved fiber morphology retention and tunable degradation

In situ crosslinking provides a method to crosslink gelatin during electrospinning enabling tunable degradation rates and displaying improved fiber morphology retention after implantation.

Graphical abstract: In situ crosslinking of electrospun gelatin for improved fiber morphology retention and tunable degradation
From the themed collection: Bio-inspired and natural materials
Open Access Paper

Development of a glial cell-derived neurotrophic factor-releasing artificial dura for neural tissue engineering applications

Develop a scaffold consisting of aligned, drug releasing nanofiber to serve as a replacement for damaged dura mater.

Graphical abstract: Development of a glial cell-derived neurotrophic factor-releasing artificial dura for neural tissue engineering applications
From the themed collection: Bio-inspired and natural materials
Paper

Biomimetic microbeads containing a chondroitin sulfate/chitosan polyelectrolyte complex for cell-based cartilage therapy

Cell-encapsulating microbeads containing a biomimetic chondroitin sulfate–chitosan polyelectrolyte complex for cartilage tissue engineering.

Graphical abstract: Biomimetic microbeads containing a chondroitin sulfate/chitosan polyelectrolyte complex for cell-based cartilage therapy
From the themed collection: Bio-inspired and natural materials
Paper

Collagen-mimetic hydrogels promote human endothelial cell adhesion, migration and phenotypic maturation

This work evaluates the response of human aortic endothelial cells (HAECs) to thromboresistant collagen-mimetic hydrogel coatings.

Graphical abstract: Collagen-mimetic hydrogels promote human endothelial cell adhesion, migration and phenotypic maturation
From the themed collection: Bio-inspired and natural materials
Paper

Hydrogel-based engineering of beige adipose tissue

Brown and beige adipose tissues have a significant capacity for energy expenditure that may be exploited as a treatment for obesity and metabolic disease.

Graphical abstract: Hydrogel-based engineering of beige adipose tissue
From the themed collection: Bio-inspired and natural materials
22 items

About this collection

Bio-inspired and naturally-derived materials may derive their structure, crosslinking, fabrication or application from biological sources. Of particular interest are materials that are self-assembled, hierarchically structured, biologically active, dynamic, responsive or adaptable. Potential applications are diverse and include the medical, bioprocessing, environmental, energy, consumer or military fields. This themed issue aims to cover the most recent progress in the synthesis, processing and characterization of bio-inspired and natural materials, to highlight the new development in synthesis, engineering, and application of these materials.

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