Themed collection Wound healing materials

Proteomic profiling reveals dynamic protein expression and post-translational modifications regulating wound healing and tissue regeneration, controlling cell proliferation, stem cell activation, and signaling pathways.

This review summarizes recent advances in MN-mediated live bacterial delivery systems, focusing on their applications in biomedical field, representative bacteria, key challenges and future development prospects.

Smart natural polymer-based hydrogels integrate real-time wound monitoring with stimuli-responsive therapy, enabling adaptive regulation of the wound microenvironment for intelligent and personalized chronic wound care.

This review integrates structural classification with therapeutic functions of self-assembled hydrogels, offering a perspective that advances beyond existing surveys and underscores their potential as innovative strategies for effective wound repair.

A schematic illustrating the development of Cu-SANs, outlining the journey from their rational synthesis and enzyme-mimicking capabilities to their therapeutic applications in wound healing and tumor treatment.

This review summarizes advances in photothermal/photodynamic antimicrobial hydrogels, including design strategies, antibacterial mechanisms, and biomedical applications.

EV-integrated gelatin sponges preserved the EV bioactivity and enhanced the keratinocyte migration and angiogenesis in ex vivo and ex ovo models (the graphical abstract was created using https://Biorender.com).

C-/N-terminal capping and D-amino acid enantiomerization improves peptide’s protease resistance, physiological stability, antimicrobial and antibiofilm activity, thereby enabling sustained infection control in chronic wound microenvironments.

A photothermal RBP hydrogel enables NIR-triggered berberine release, synergistic antibacterial action against MRSA and P. aeruginosa and accelerates infected wound healing with good biocompatibility.

Synthesis and application of sprayable hydrogel dressings.

This work revealed lymphatic transport patterns of different Gd-based contrast agents across different size scale platforms.

An injectable, self-healing oxidized alginate–protein hydrogel incorporating in situ formed AgNP–GQD composites enabled complete healing of infected diabetic wounds in rats within 8 days.

A pH-responsive smart hydrogel dressing was developed for controlled antimicrobial therapy and accelerated wound healing.

Aggregation-driven BMP-2/hyaluronic acid hydrogel enables sustained drug release, enhanced biocompatibility, porous architecture, and accelerated wound healing through redox-mediated crosslinking mechanisms.

Infected diabetic wounds, particularly those complicated by multidrug-resistant bacteria, pose a significant clinical challenge due to the limited efficacy of conventional debridement and antibiotic therapies.

Overall scheme demonstrating the wound healing property of eggshell-derived nanoparticles.

An antibacterial artificial skin with gradient-pore architecture is developed for chronic wound care. This asymmetric design enables rapid, unidirectional exudate transport to prevent backflow while promoting accelerated hemostasis and wound healing.

An injectable self-healing polysaccharide hydrogel enables ADSC delivery, preserves stemness, promotes angiogenesis and regenerative collagen remodeling, and accelerates wound healing.

A chitosan (CS)-based hydrogel dressing enriched with gramicidin (GCN) and trehalose (TH) enhances antimicrobial activity and accelerates wound healing in an infected rat wound model.

We developed a functionally graded bilayer polyurethane sponge that sequentially provides hemostasis, synergistic antibacterial/anti-oxidant activity, and pro-angiogenic effects for full-cycle repair of infected wounds.

Designing antibiotic drug-impregnated Aloe vera and Sterculia gum polysaccharide-based network hydrogels by integrating a zwitterionic polymer via covalent and supra-molecular interactions for use in drug delivery and wound dressing applications.

An injectable self-healing F127-AG hydrogel with kaempferol enables rapid gelation, strong adhesion, and antioxidant-antibacterial activity, promoting oral ulcer healing through neovascularization, reduced inflammation, and immunomodulation.

Porous coacervate phosphate glasses fibres and powders loaded with gallium and clove oil for wound healing applications.

The CPTCu patch, tailored for tongue wound applications, provides dynamic wound protection while reducing scarring and enhancing vascular and muscular regeneration.

A dissolvable microneedle patch (MNP) system has been developed for localized co-delivery of levofloxacin and lidocaine. The dual-drug-loaded MNPs provide a minimally invasive, painless, and potentially therapeutic platform for diabetes wound care.

This bioengineered probiotic platform HW@EcN presents a clinically translatable approach for improving SDT efficacy and immune activation, paving the way for innovative cancer therapies.

A polycationic silk fibroin/nano-hydroxyapatite dressing promotes rapid angiogenesis via sustained Ca²⁺ release, significantly accelerating deep burn wound healing and structural regeneration.

This study developed platelet-rich fibrin (PRF)-loaded hyaluronic acid methacryloyl microneedles (PHMNs) for the treatment of pressure injury (PI), which demonstrated superior wound closure rates and enhanced tissue remodeling ability.

Photo-induced anti-bacterial activity of an organic–inorganic heterostructure empowers healing of infected wounds.

Chronic wounds are difficult to treat, often needing grafts. This study develops a super-absorbent microgel from decellularized human amniotic membrane, offering a promising regenerative solution for chronic wound healing and skin repair.

Hierarchically porous phosphate glass powders for wound healing. Significant wound healing promotion (up to 97%) was demonstrated using a human ex vivo wound model.