Layered double hydroxide nanostructures and nanocomposites for biomedical applications
Layered double hydroxide (LDH) nanostructures and related nanocomposites have attracted significant interest in biomedical applications including cancer therapy, bioimaging and antibacterial treatment.
Recent advances in gold nanoparticles for biomedical applications: from hybrid structures to multi-functionality
Hybrid gold nanoparticles for biomedical applications are reviewed in the context of a novel classification framework and illustrated by recent examples.
Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications
This review brings up to date the state of the art of strontium and zinc based regenerative therapies, both having a promoting effect on tissue formation and a role inhibiting resorption in musculoskeletal disorders.
Amorphous polyphosphate, a smart bioinspired nano-/bio-material for bone and cartilage regeneration: towards a new paradigm in tissue engineering
Physiological amorphous polyphosphate nano/micro-particles, injectable and implantable, attract and stimulate MSCs into implants for tissue regeneration.
Effects of bone substitute architecture and surface properties on cell response, angiogenesis, and structure of new bone
This paper presents an overview of the effect of porous biomaterial architecture on seeding efficiency, cell response, angiogenesis, and bone formation.
Contrast agents for cardiovascular magnetic resonance imaging: an overview
Contrast agents for Cardiovascular Magnetic Resonance (CMR) play a major role in research and clinical cardiology.
Surface modification strategies for combating catheter-related complications: recent advances and challenges
This review summarizes the progress made in addressing bacterial colonization and other surface-related complications arising from catheter use.
Ultra-programmable buckling-driven soft cellular mechanisms
We harnessed buckling which was once considered the epitome of design failure to develop mechanical metamaterials for soft robotic applications.
Seed-mediated synthesis of plasmonic gold nanoribbons using cancer cells for hyperthermia applications
MCF7 Cells biomineralize gold ions into long aspect-ratio nanoribbons in the presence of spherical nanoparticles as seeds with excellent photothermal properties.
Dual water-healable zwitterionic polymer coatings for anti-biofouling surfaces
Herein, we show for the first time drop-casting zwitterionic polymer colloidal particles onto different surfaces to obtain zwitterionic coatings with highly protein-repelling properties and dual self-healing capabilities.
Towards deployable meta-implants
The first step towards deployable meta-implants: design, manufacturing and proof of concept.
Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
Stability, biocompatibility and near-infrared photoluminescence of PbS nanocrystals capped with PEG-based ligands open up realistic prospects for non-invasive bioimaging applications.
Tuneable plasmonic gold dendrimer nanochains for sensitive disease detection
We report the development of a tuneable plasmonic nanochain immunoassay with increased sensitivity over traditional monodisperse nanoparticle lateral flow tests.
Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy
pH-Responsive drug nanocarriers were made via facile self-assembly, showing excellent stability in bio-media (50% PBS/FBS) and enhanced drug efficacy towards cancer cells.
Flexible, microstructured surfaces using chitin-derived biopolymers
A photocrosslinkable chitin derivative is used to create robust, transparent sheets, and high resolution microstructures via photolithography. The biopolymer can form flexible templates for spatially guiding cells, or in degradable bioelectronics.
A biomimetic hybrid material consisting of CaCO3 mesoporous microspheres and an alternating copolymer for reversed-phase HPLC
Inspired by egg shells, amphiphilic copolymer-modified monodisperse mesoporous CaCO3 microspheres were applied as a separation material.
Glutathione from recovered glucose as ingredient in antioxidant nanocapsules for triggered flavor delivery
Glucose recovered via enzymatic hydrolysis of rayon fibers was used for glutathione production by S. cerevisiae. Glutathione was used in combination with HSA and silk fibroin for ultrasound assisted nanocapsules production. Triggered release of flavor substances and antioxidant properties of the nanocapsules was demonstrated.
Monitoring the death of single BaF3 cells under plasmonic photothermal heating induced by ultrasmall gold nanorods
Morphological changes and trypan-blue staining are temporally tracked in single cells via optical microscopy after plasmonic photothermal heating.
Asymmetric multifunctional 3D cell microenvironments by capillary force assembly
The fabrication and characterization of advanced 3D cell culture microenvironments that enable systematic structure–property relationship studies are reported.
Influence of charged groups on the cross-linking efficiency and release of guest molecules from thiol–ene cross-linked poly(2-oxazoline) hydrogels
This study concerns hydrogels obtained from poly(oxazolines) bearing charged groups and their effect on the loading and release of guest molecules.
Tuning HIV drug release from a nanogel-based in situ forming implant by changing nanogel size
This paper reports an in situ forming implant based on responsive nanogels that gives tuneable long-acting drug release.
Reactive oxygen species mediated theranostics using a Fenton reaction activable lipo-polymersome
A succinic peroxide-filled Fenton reaction activable Pt/Fe3O4@SP-PLGA lipo-polymersome displays ROS mediated chemodynamic therapy (CDT).
Bioinspired reversible hydrogel adhesives for wet and underwater surfaces
A hydrogel-based wet adhesive with bioinspired microstructures can exhibit strong and reversible adhesion to wet and underwater surfaces.
Enzymatic synthesis of a thiolated chitosan-based wound dressing crosslinked with chicoric acid
This work describes the enzymatic synthesis of multifunctional hydrogels for chronic wound treatment using thiolated chitosan and the natural polyphenol chicoric acid.
Low-fouling, mixed-charge poly-L-lysine polymers with anionic oligopeptide side-chains
A mixed-charge polymer, with anionic oligopeptide moieties attached to a cationic poly-L-lysine backbone, provides antifouling surfaces for human plasma samples.
Barcoding chemical modifications into nucleic acids improves drug stability in vivo
The efficacy of nucleic acid therapies can be limited by unwanted degradation.
Sub-zero temperature mechanically stable low molecular weight hydrogels
We show here a low molecular weight hydrogelator based on a functionalised dipeptide which is stable down to temperatures of −12 °C despite being made from >99% water. With the addition of glycerol this can be lowered further to −40 °C. At these colder temperatures there is no effect on the mechanical properties of the gels.
Single cell analysis of proliferation and movement of cancer and normal-like cells on nanowire array substrates
Performing single cell analysis can reveal the existence of different cell populations on nanowire arrays.
Bioceramic microneedle arrays are able to deliver OVA to dendritic cells in human skin
Bioceramic arrays with high-aspect-ratio microneedles were able to penetrate human ex vivo skin and deliver their cargo to dendritic cells.
Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing
Novel reduction responsive oligo-β-aminoesters were successfully synthesized and condensed with siRNA through an inkjet method, thus showing promising biological response.
Non-invasive characterization of hybrid gelatin:poly-L-lactide electrospun scaffolds using second harmonic generation and multiphoton imaging
In this work we generated hybrid gelatin:poly-L-lactide electrospun scaffolds and implemented non-invasive methods to characterize them.
Rapid bioinspired mineralization using cell membrane nanofragments and alkaline milieu
Bone formation in vivo occurs in alkaline environment, which determines the optimal pKa of phosphatases, the optimal amount of calcium for mineral precipitation, and the spherical shape of initial minerals. Manipulation of environmental pH for in vitro synthesis of bone-like tissue, showed a markedly rapid mineralization with nanofragments and alkaline milieu.
Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering
The simplicity of making hydrogels with tunable mechanical properties from commercially available proteins is demonstrated for cardiac tissue engineering.
Biomimetic graphene for enhanced interaction with the external membrane of astrocytes
Phospholipids modified graphene oxide (GO–PL) shows enhanced compatibility with primary rat cortical astrocytes with respect to standard adhesion agents and non-functionalized GO.
Switchable presentation of cytokines on electroactive polypyrrole surfaces for hematopoietic stem and progenitor cells
Redox potential-dependent switching of immobilized interleukin-3 presentation towards hematopoietic progenitor cells using electroactive polypyrrole surfaces affects cell viability.
Combinatorial delivery of bioactive molecules by a nanoparticle-decorated and functionalized biodegradable scaffold
The combination of supportive biomaterials and bioactive factors to stimulate endogenous progenitor cells is of key interest for the treatment of conditions in which intrinsic bone healing capacities are compromised.
A hydroxamic acid–methacrylated collagen conjugate for the modulation of inflammation-related MMP upregulation
The selective covalent coupling of hydroxamic acid functions on to methacrylated type I collagen led to UV-cured networks with inherent MMP-modulating capability and enhanced proteolytic stability.
Nanoparticle-supported polymer brushes for temperature-regulated glycoprotein separation: investigation of structure–function relationship
Nanoparticle-supported polymer brushes enable temperature-regulated protein binding and release.
Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer
A thermoresponsive block copolymer has been developed with the capability to co-carry two drug molecules and to augment their cytotoxic properties via direct cell membrane interaction with cancer cells.
Turn-on fluorescence detection of protein by molecularly imprinted hydrogels based on supramolecular assembly of peptide multi-functional blocks
Supramolecular in-cavity target–peptide complex for self-reporting imprinted polymers.
Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line
Hierarchical formulation of hybrid nanoparticles that consist of aggregated gold nanoparticles impregnated into a gemcitabine–polymer conjugate matrix for photochemotherapy of pancreatic cancer.
Additives influence the phase behavior of calcium carbonate solution by a cooperative ion-association process
The role of biologically relevant additives on the phase behavior of calcium carbonate solution was studied by investigating their effects on the formation of amorphous calcium carbonate.
Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe3O4) as potential multifunctional theranostic nanodevices
Superparamagnetic nanocomposites with a well-defined mesoporous matrix and mesoporous surface available for the high loading of drugs or biological entities.
Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems
Novel organic–inorganic nanohybrids have been prepared, and are found to provide long-term extended drug release.
SU-8 based pyrolytic carbon for the electrochemical detection of dopamine
Here we investigated the electrochemical properties and dopamine (DA) detection capability of SU-8 photoresist based pyrolytic carbon (PyC) as well as its biocompatibility with neural cells.
Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer
The surface chemistry and charge of zinc oxide nanocrystals influence their behaviour in biological fluids. A novel lipid bilayer assembly is developed to shield ZnO nanocrystals improving their stability and cell internalization.
Antibody-modified hydroxyapatite surfaces for the efficient capture of bladder cancer cells in a patient's urine without recourse to any sample pre-treatment
In this study, we describe a sensitive protocol for the detection of bladder cancer cells in a patient's urine without pre-treatment of the urine sample using antibody-modified hydroxyapatite (HAp) micro/nanostructured surfaces converted from natural seashells under mild biomineralization conditions.
Detection of Posner's clusters during calcium phosphate nucleation: a molecular dynamics study
Molecular dynamics simulations of calcium and phosphate ions in water show that Posner-like clusters originate during the aggregation process.
Surface enhancement of a molecularly imprinted polymer film using sacrificial silica beads for increasing L-arabitol chemosensor sensitivity and detectability
Sacrificial silica beads, used for increasing the specific surface area of a molecularly imprinted polymer film, improve the performance of the chemosensor.
Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma
Using core–shell microparticles encapsulating p53/β-CD-g-CS NPs and nutlin-3a effectively suppressed p53–MDM2 interaction and restored p53 apoptotic activity in cancer cells.
Prevention of encrustation and blockage of urinary catheters by Proteus mirabilis via pH-triggered release of bacteriophage
The crystalline biofilms of Proteus mirabilis can seriously complicate the care of patients undergoing long-term indwelling urinary catheterisation.
Dendritic polyglycerol anions for the selective targeting of native and inflamed articular cartilage
Dye-conjugated polyanions show high affinities toward native and inflamed cartilage dependent on the anionic moiety and the condition of the tissue.
Gold–iron oxide dimers for magnetic hyperthermia: the key role of chloride ions in the synthesis to boost the heating efficiency
To produce Au–FexOy dimers with outstanding heating performances under clinical magnetic hyperthermia conditions, here we report two synthesis routes, a two-pot and a one-pot method.
Protein-repellent and antimicrobial nanoparticle coatings from hyaluronic acid and a lysine-derived biocompatible surfactant
A water based, green and one-step strategy to functionalize surfaces of silicone catheters, poly(dimethylsiloxane) (PDMS), with antifouling and antimicrobial nanoparticles (hyaluronic acid–surfactant mixture) to avoid uncontrolled protein adsorption and microbial attachment is reported.
On the subtle tuneability of cellulose hydrogels: implications for binding of biomolecules demonstrated for CBM 1
Choice of molecular probe for determining porosity, surface area, or binding in never-dried cellulose hydrogels is critical to discern differences in structure.
Growth behaviour of silica/carbonate nanocrystalline composites of calcite and aragonite
The precipitation of calcium carbonate into alkaline silica gel produces concomitant polymorphic precipitation of aragonite with biomorphic morphology and calcite crystalline dendrites.
Tuning the local solvent composition at a drug carrier surface: the effect of dimethyl sulfoxide/water mixture on the photofunctional properties of hypericin–β-lactoglobulin complexes
The introduction of a small amount of the organic cosolvent dimethyl sulfoxide leads to a remarkable improvement of the photophysical properties of the complex between hypericin and lactoglobulin.
A one-pot synthesis of water soluble highly fluorescent silica nanoparticles
We report a one-pot synthesis of water dispersible fluorescent silica nanoparticles (NPs) functionalized with terminal amine groups, starting from silicon tetrabromide (SiBr4) and aminopropyltriethoxy silane (APTES).
Biodegradable nitric oxide precursor-loaded micro- and nanoparticles for the treatment of Staphylococcus aureus biofilms
Bacteria in biofilms are more difficult to eradicate than planktonic bacteria and result in treatment challenges for many chronic infectious diseases.
Effective control of the intrinsic DNA morphology by photosensitive polyamines
Changes occurring in the intrinsic B-DNA morphology upon binding to molecular photoswitches.
Composite vector formulation for multiple siRNA delivery as a host targeting antiviral in a cell culture model of hepatitis C virus (HCV) infection
RNA interference-based gene therapies are promising tool to treat chronic viral infections. We design composite nanoparticle by the LbL technique to deliver sequentially siRNA against host targeting agents. They proved to be efficient in controlling HCV replication with up to 90% reduction over 10 days.
Exploiting the protein corona around gold nanorods for low-dose combined photothermal and photodynamic therapy
We load Ce6 onto NRs using its protein corona, deliver them to cells before performing laser irradiation for simultaneous PTT and PDT with greatly enhanced therapeutic efficacy.
About this collection
This collection contains recent Open Access articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this webpage as soon as possible after publication.