Themed collection Recent Open Access Articles
Electrospinning for healthcare: recent advancements
This perspective explores recent developments and innovations in the electrospinning technique and their potential applications in biomedicine.
The rise of bio-inspired polymer compartments responding to pathology-related signals
Self-organized nano- and microscale polymer compartments such as polymersomes, giant unilamellar vesicles (GUVs), polyion complex vesicles (PICsomes) and layer-by-layer (LbL) capsules have increasing potential in many sensing applications.
Biocompatibility and biodegradability of metal organic frameworks for biomedical applications
The biocompatibility and biodegradability of metal organic frameworks (MOFs) are discussed to highlight their best biomedical applications up-to-date.
Fabrication of nanoparticles for bone regeneration: new insight into applications of nanoemulsion technology
This review discusses nanoemulsion technology as a tool for fabrication of nanoparticles for bone regeneration applications including hydroxyapatite nanoparticles, polymer nanoparticles for drug/biomolecule delivery and bone-targeting nanoparticles.
Low-dimensional nanomaterials for antibacterial applications
In this review we discuss the development of nanomaterial based systems for antibacterial applications.
Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine
This review introduces the application of metal–organic frameworks in biological imaging, covering the incorporation of imaging functionality, the range of imaging techniques accessible, and their integration with other therapeutic capabilities.
Functional silk fibroin hydrogels: preparation, properties and applications
This article reviews the current status of the preparation, properties and application of functional silk protein hydrogels.
Advanced biomedical applications based on emerging 3D cell culturing platforms
We discuss the recent progress in the development of scaffold-free techniques for the fabrication of cell spheroids and their biomedical applications.
Promising nanomaterials in the fight against malaria
Nanomaterials can offer customized tools for prophylactic and therapeutic purposes that bring new solutions in different stages of malaria infection.
Multicomponent polysaccharide alginate-based bioinks
3D-Bioprinting has seen a rapid expansion in the last few years, with an increasing number of reported bioinks, amongst which, alginate is an ideal ingredient due to its biocompatibility and ease of gelation.
Advancements in the development on new liquid embolic agents for use in therapeutic embolisation
This review covers the current state-of-the-art in the development of liquid embolics for therapeutic embolisation.
Enzyme catalysis powered micro/nanomotors for biomedical applications
This review provides insights on enzyme powered motors using fuels present in biological environments for biomedical applications.
Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies
Selecting the appropriate nanoparticle, functionalization chemistry and sensing methodology can speed up the translation of liquid biopsies into the clinic.
Smart diagnostic nano-agents for cerebral ischemia
A summary of the latest developments on imaging techniques and smart nano-diagnostics used for ischemic stroke.
The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10
MUV-10 exhibits slow physiological degradation kinetics, good dispersibility, high biomolecular loading and excellent immune system biocompatibility.
Fluorescent nanodiamonds encapsulated by Cowpea Chlorotic Mottle Virus (CCMV) proteins for intracellular 3D-trajectory analysis
Fluorescent nanodiamonds are stabilized by a corona of virus capsid proteins. Intracellular diffusion studies were performed suggesting that virus-coated nanodiamonds could be attractive tools for conceptual understanding of cell-virus interactions.
Engineered protein cages for selective heparin encapsulation
Virus capsid proteins modified with a heparin binding peptide can selectively bind and encapsulate heparin inside a protein cage.
Specifiable biomimetic microsponges for timed release of crystal entrapped biomolecules useful in bone repair
Most marine biomaterials comprise of inorganic crystals with various tectonic structures that permit the inclusion, storage, release, and delivery of organic biomolecules. One analog with those functions is exploited for preclinical application.
Single-molecule DNA origami aptasensors for real-time biomarker detection
DNA nanostructures as platforms to monitor the inherent conformational changes of aptamers upon analyte binding, with single-molecule resolution and real-time capability.
Plasmonic photothermal microneedle arrays and single needles for minimally-invasive deep in-skin hyperthermia
We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm and 4.5 mm length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation.
Light-switchable anchors on magnetized biomorphic microcarriers
Combining silica-biomorphs, magnetite mesocrystals and covalently bound spiropyrans into light-switchable microcarriers.
Seed-mediated synthesis of plasmonic gold nanoribbons using cancer cells for hyperthermia applications
MCF7 Cells biomineralize gold ions into long aspect-ratio nanoribbons in the presence of spherical nanoparticles as seeds with excellent photothermal properties.
Dual water-healable zwitterionic polymer coatings for anti-biofouling surfaces
Herein, we show for the first time drop-casting zwitterionic polymer colloidal particles onto different surfaces to obtain zwitterionic coatings with highly protein-repelling properties and dual self-healing capabilities.
Towards deployable meta-implants
The first step towards deployable meta-implants: design, manufacturing and proof of concept.
Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
Stability, biocompatibility and near-infrared photoluminescence of PbS nanocrystals capped with PEG-based ligands open up realistic prospects for non-invasive bioimaging applications.
Tuneable plasmonic gold dendrimer nanochains for sensitive disease detection
We report the development of a tuneable plasmonic nanochain immunoassay with increased sensitivity over traditional monodisperse nanoparticle lateral flow tests.
Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy
pH-Responsive drug nanocarriers were made via facile self-assembly, showing excellent stability in bio-media (50% PBS/FBS) and enhanced drug efficacy towards cancer cells.
Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s
Novel bone-adhesive barrier membranes were successfully developed using a solvent-free approach by combining an occlusive polyester backing layer with a gelatin carrier impregnated with calcium-binding alendronate-functionalized poly(2-oxazoline)s.
Poly beta amino ester coated emulsions of NSAIDs for cartilage treatment
Delivering drugs directly into cartilage is still the major challenge in the management and treatment of osteoarthritis (OA) resulting from the aneural, avascular and alymphatic nature of an articular cartilage structure.
Assessing the impact of silicon nanowires on bacterial transformation and viability of Escherichia coli
In this study nanowires were engineered and we investigated the interface between the biomaterial and bacteria, looking in detail at membrane rupture and cell viability.
The mechanism underlying the functionalisation of cobalt nanoparticles by carboxylic acids: a first-principles computational study
Ab initio methods resolve mechanism behind carboxylic acid functionalisation of cobalt nanoparticles and identify the fate of dissociated hydrogen atoms.
Design of hybrid biocatalysts by controlled heteroaggregation of manganese oxide and sulfate latex particles to combat reactive oxygen species
Antioxidant nanocomposites of advanced functional and colloidal features were developed by controlled heteroaggregation of manganese oxide and sulfate latex particles.
Engineering of stealth (maghemite/PLGA)/chitosan (core/shell)/shell nanocomposites with potential applications for combined MRI and hyperthermia against cancer
Biocompatible and long-circulating (maghemite/poly(D,L-lactide-co-glycolide))/chitosan (core/shell)/shell nanoparticles with promising theranostic applications (biomedical imaging and hyperthermia) against cancer.
Thermal crystallization of amorphous calcium phosphate combined with citrate and fluoride doping: a novel route to produce hydroxyapatite bioceramics
The thermal crystallization of citrate-stabilized amorphous calcium phosphate leads to the formation of pure hydroxyapatite and represents an interesting route for producing ceramics for biomedical applications.
Development of a 3D printable and highly stretchable ternary organic–inorganic nanocomposite hydrogel
A novel 3D printable hybrid hydrogel is developed and characterized in detail in this study. After chemical curing of the 3D-printed constructs, the resulting hydrogel shows excellent mechanical strength with a tensile strain at break exceeding 550%.
Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release
We report the fabrication of a coaxial electrospun scaffold with a bioactive molecule in the core and a protein conjugated at the surface. To construct the scaffold, we chose polyethylene oxide for the core material and a polycaprolactone/Jeffamine blend for the shell.
L-Dopa release from mesoporous silica nanoparticles engineered through the concept of drug-structure-directing agents for Parkinson's disease
L-Dopa@MSNs based on the concept of drug-structure-directing agents were successfully prepared and proved to be programmed oral L-Dopa release nanosystem pH responsive for the treatment of Parkinson's disease.
Bi2O3 boosts brightness, biocompatibility and stability of Mn-doped Ba3(VO4)2 as NIR-II contrast agent
Fluorescent, ultrabright, stable and cytocompatible flame-made Mn5+-doped Ba3(VO4)2–Bi2O3 nanoparticles are most suitable for near-IR-II bioimaging within 1 cm deep lying tissues outperforming commercial organic fluorophores and quantum dots.
Bioinspired and eco-friendly high efficacy cinnamaldehyde antibacterial surfaces
Cinnamaldehyde essential oil containing surfaces display high levels of antibacterial activity.
“Sweet tooth”-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy
Motivated by the overexpression of GLUT1 in gastric cancer, a targeted SN38 prodrug delivery nanoplatform was constructed and exhibited potent antitumor efficiency, which brought a new insight to the design of nanomedicine against cancer.
Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico
In silico designed peptides showed high binding affinity towards activated human hepatic stellate cells, offering new strategies to target insulin-like growth factor 2 receptor in fibrotic liver and suggesting a potential for noninvasive diagnosis.
A pH/redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled intestinal release of magnesium ions
A pH/redox-dual responsive, nanoemulsion-embedded composite hydrogel was proposed to well retain magnesium ions in the highly acidic gastric environment, but efficiently release them in the neutral and reducing intestinal environment.
Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response
Fibronectin coating increases implant biocompatibility by enhancing surface endothelialization via integrin-mediated binding.
Self-assembling tetrameric peptides allow in situ 3D bioprinting under physiological conditions
Tetrameric peptide-based bioinks allow the printing of 3D cell-laden scaffolds under true physiological conditions avoiding harsh UV or chemical treatment.
Self-healing and mechanical performance of dynamic glycol chitosan hydrogel nanocomposites
Evaluation of Schiff base nanocomposite hydrogels properties using a benzaldehyde multifunctional amphiphilic polyacrylamide crosslinker in conjunction with glycol chitosan.
Design of biodegradable bi-compartmental microneedles for the stabilization and the controlled release of the labile molecule collagenase for skin healthcare
Polymeric microneedles (MNs) have emerged as a novel class of drug delivery system thanks to their ability in penetrating the skin with no pain, encapsulate active proteins and in particular, proposed bicompartimental MNs can tune protein release.
Intracellular delivery of therapeutic antisense oligonucleotides targeting mRNA coding mitochondrial proteins by cell-penetrating peptides
Development of a cell-penetrating peptide library to deliver biomolecules affecting mitochondria functionalities by targeting genes coding for mitochondrial proteins.
In vitro exploration of the synergistic effect of alternating magnetic field mediated thermo–chemotherapy with doxorubicin loaded dual pH- and thermo-responsive magnetic nanocomposite carriers
Nanoparticle induced hyperthermia has been considered as a promising approach for cancer treatment for decades.
Tailoring cellular microenvironments using scaffolds based on magnetically-responsive polymer brushes
A controlled cell detachment and transfer into a new place was triggered only by an external magnetic field.
Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinking
A novel methodology for the development of cell-laden silk hydrogels using a biocompatible photo-initiator.
Photonic hyperthermal and sonodynamic nanotherapy targeting oral squamous cell carcinoma
Photonic hyperthermal and sonodynamic nanotherapy targeting of oral squamous cell carcinoma by CRDAs.
Tuneable peptide cross-linked nanogels for enzyme-triggered protein delivery
A tuneable peptide-crosslinked, temperature-sensitive nanogel platform for protein delivery in response to MMP-7, which is overexpressed in many pathologies, is presented.
Superhydrophobic bowl-like SERS substrates patterned from CMOS sensors for extracellular vesicle characterization
Using a regular CMOS sensor as a template, we are able to fabricate a simple but highly effective superhydrophobic SERS substrate.
Effects of nanopores on the mechanical strength, osteoclastogenesis, and osteogenesis in honeycomb scaffolds
The nanopoers of honeycomb scaffolds affect mechanical strength, osteoclastogenesis, and osteogenesis. When the nanopore volume was 0.15 cm3 g−1, steady replacement of honeycomb scaffolds with new bone was achieved.
Development of an antibacterial nanocomposite hydrogel for human dental pulp engineering
Nanocomposite fibrin-based hydrogel with antibacterial and antibiofilm properties, safe for dental pulp mesenchymal stem cells.
Biocide mechanism of highly efficient and stable antimicrobial surfaces based on zinc oxide–reduced graphene oxide photocatalytic coatings
Highly efficient photoactive antimicrobial coatings were obtained using zinc oxide–reduced graphene oxide nanocomposites (ZnO–rGO).
Continuous production of uniform chitosan beads as hemostatic dressings by a facile flow injection method
In this work, we developed a facile flow injection method to fabricate chitosan beads of uniform size in a continuous manner and assessed their properties as hemostatic dressings.
Surfactant-free liquid-exfoliated copper hydroxide nanocuboids for non-enzymatic electrochemical glucose detection
Effect of hydrogen bonding parameter on concentration (left) and chronoamperometry of sequential addition of glucose (right).
Synthesis and in vivo evaluation of PEG-BP–BaYbF5 nanoparticles for computed tomography imaging and their toxicity
PEG(5)-BP–BaYbF5 nanoparticles provide superior CT contrast and circulation time compared to clinically-used iodinated molecules, but suffer from unexpected in vivo toxicity.
Growth of large-scale MoS2 nanosheets on double layered ZnCo2O4 for real-time in situ H2S monitoring in live cells
Real-time quantification of H2S production in live biological cells using a MoS2/ZnCo2O4–ZnCo2O4 modified carbon cloth electrode.
pH-Responsive nanocomposite fibres allowing MRI monitoring of drug release
pH-responsive nanofibres containing iron oxide nanoparticles (NPs) and a model drug demonstrate on-demand dissolution, triggering release of both drug and NPs and allowing magnetic resonance imaging-guided therapeutic delivery.
Anisotropic, porous hydrogels templated by lyotropic chromonic liquid crystals
Approaches to control the microstructure of hydrogels enable the control of cell–material interactions and the design of stimuli-responsive materials.
14N–1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
14N–1H HMQC experiments are powerful experiments to characterize amorphous drug–polymer formulations of paclitaxel yielding well-separated signals in the 14N dimension as well as information on the symmetry of 14N and 14N–1H interactions.
Mechanically adaptive implants fabricated with poly(2-hydroxyethyl methacrylate)-based negative photoresists
A negative photoresist approach towards physiologically responsive mechanically adaptive polymers that soften upon insertion into the body is reported. The framework relies on photoresists that can be processed into implants having complex shapes.
Liquid crystal elastomers as substrates for 3D, robust, implantable electronics
Liquid crystal elastomers are used as substrates for robust, implantable electronics that are planar processed then morph into 3D shapes.
Self-recovering dual cross-linked hydrogels based on bioorthogonal click chemistry and ionic interactions
The biocompatible, injectable and high water-swollen nature of dual cross-linked hydrogels makes them a popular candidate to imitate the extracellular matrix (ECM) for tissue engineering both in vitro and in vivo.
Hexametaphosphate as a potential therapy for the dissolution and prevention of kidney stones
Hexametaphosphate prevents aggregation and dissolves kidney stones an order of magnitude more effectively than the current therapy, citrate.
Size-controlled clustering of iron oxide nanoparticles within fluorescent nanogels using LCST-driven self-assembly
Size-controlled clustering of iron oxide nanoparticles (IONPs) within the fluorescent polymer nanogels was achieved using the lower critical solution temperature (LCST) driven self-assembly and cross-linking of grafted polymer on the IONPs.
Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage
Drug localisation is one of the main challenges in treating cartilage; poly-beta-amino-esters (PBAEs) drug conjugates are a possible solution; their efficacy depends on the polymer structure hence the full potential of this system is still unknown.
Stable anchoring of bacteria-based protein nanoparticles for surface enhanced cell guidance
The preparation of robust nano–micropatterns for prolonged cell culture studies using covalent anchoring between the surface and protein nanoparticles, which are produced in a human-safe bacterial platform.
About this collection
This collection contains recent Open Access articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this webpage as soon as possible after publication.