Themed collection Recent Open Access Articles
Engineering microbes to synthesize functionalized biopolymers
Engineering the metabolism of microbes has allowed simultaneous co-production of functional small molecules and biopolymers.
Fluidic enabled bioelectronic implants: opportunities and challenges
Fluidics are enabling new possibilities in bioelectronic medicine and research.
The importance of water content on the conductivity of biomaterials and bioelectronic devices
Water content derived from the environment is as an important a variable as temperature for affecting the conductivity and for understanding the charge transport mechanisms within conductive biomaterials as well as bioelectronic devices.
Molecularly imprinted materials for glycan recognition and processing
Molecularly imprinted materials are uniquely suited for glycan recognition. Biologically competitive binding and selective hydrolysis of glycans are achieved through innovation in imprinting techniques and postmodification of the imprinted sites.
RNA BioMolecular Electronics: towards new tools for biophysics and biomedicine
Nanoscience has enabled the electrical study of individual biomolecules. This perspective presents the nascent field of RNA BioMolecular Electronics, overviewing the main developments and exploring recent and future potential applications.
Organized mineralized cellulose nanostructures for biomedical applications
Cellulose is the most abundant biopolymer with outstanding mechanical robustness, biocompatibility, renewability and surface chemistry, which is an ideal biotemplate for biomineralizing hierarchical nanostructures for biomedical applications.
Surface modification of TiO2 nanoparticles with organic molecules and their biological applications
In recent years, titanium(IV) dioxide nanoparticles (TiO2NPs) have shown promising potential in various biological applications such as antimicrobials, drug delivery, photodynamic therapy, biosensors, and tissue engineering.
Hydrogels with electrically conductive nanomaterials for biomedical applications
Hydrogels with electrically conductive nanomaterials find numerous biomedical applications where conductivity is relevant, such as substrates for tissue engineering of electroactive cells, strain-sensitive sensors and platforms for drug delivery.
Getting drugs to the brain: advances and prospects of organic nanoparticle delivery systems for assisting drugs to cross the blood–brain barrier
Organic-nanoparticles (NPs) delivery systems for crossing the blood–brain barrier.
Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy
Strategies for reducing CRS in CAR-T cells capitalize on the specificity between CAR-T cells, cytokines, and their receptors, the role of macrophages in cytokine release, and genetic constructs to ablate CAR-T function reversibly and irreversibly.
Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids
Bio-applied molecularly imprinted polymers (MIPs) are biomimetic materials with tailor-made synthetic recognition sites, mimicking biological counterparts known for their sensitive and selective analyte detection.
Polysaccharide nanoparticles: from fabrication to applications
The present review highlights the developments in polysaccharide nanoparticles with a particular focus on applications in biomedicine, cosmetics and food.
A review on diatom biosilicification and their adaptive ability to uptake other metals into their frustules for potential application in bone repair
Diatoms are unicellular eukaryotic algae that have a distinctive siliceous cell wall (frustule) with unique architectures. These frustules are a naturally derived biomaterial, which can be chemically modified and may have potential in bone tissue engineering applications.
Biocompatibility and biodegradability of metal organic frameworks for biomedical applications
The biocompatibility and biodegradability of metal organic frameworks (MOFs) are discussed to highlight their best biomedical applications up-to-date.
Fabrication of nanoparticles for bone regeneration: new insight into applications of nanoemulsion technology
This review discusses nanoemulsion technology as a tool for fabrication of nanoparticles for bone regeneration applications including hydroxyapatite nanoparticles, polymer nanoparticles for drug/biomolecule delivery and bone-targeting nanoparticles.
Low-dimensional nanomaterials for antibacterial applications
In this review we discuss the development of nanomaterial based systems for antibacterial applications.
Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine
This review introduces the application of metal–organic frameworks in biological imaging, covering the incorporation of imaging functionality, the range of imaging techniques accessible, and their integration with other therapeutic capabilities.
Complementary charge-driven encapsulation of functional protein by engineered protein cages in cellulo
This study provides proof of charge complementarity-based inclusion complex formation between an engineered protein nanocage and an otherwise degradation-prone cargo protein in live bacterial cells.
Synergistic antibacterial action of lignin-squaraine hybrid photodynamic therapy: advancing towards effective treatment of antibiotic-resistant bacteria
SQR29 organophotosensitizer was encapsulated into poly(lignin/PEG/PPG urethane) to form a hydrogel (LSQR29), providing excellent antibacterial photodynamic therapy (aPDT) property to combat antibiotic-resistant pathogenic bacteria in wound infection.
Protein cohabitation: long-term immunoglobulin G storage at room temperature
We report a simple bioinspired strategy of protein cohabitation for long-term functional storage of therapeutic proteins at room temperature.
Assembly of chemically modified protein nanocages into 3D materials for the adsorption of uremic toxins
Protein-based adsorber materials with defined morphology for the removal of uremic toxins.
Nanoscale patterning of polymers on DNA origami
Structurally precise biohybrid nanomaterials were created by grafting various polymers to DNA with high conversions under ambient conditions. They are patterned onto DNA origami nanostructures to form customizable surface contours.
The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10
MUV-10 exhibits slow physiological degradation kinetics, good dispersibility, high biomolecular loading and excellent immune system biocompatibility.
Fluorescent nanodiamonds encapsulated by Cowpea Chlorotic Mottle Virus (CCMV) proteins for intracellular 3D-trajectory analysis
Fluorescent nanodiamonds are stabilized by a corona of virus capsid proteins. Intracellular diffusion studies were performed suggesting that virus-coated nanodiamonds could be attractive tools for conceptual understanding of cell-virus interactions.
White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination
AuNRs immobilized on rigid substrates are utilized as thermo-optical transducers under white light irradiation. The achieved temperature increase is suitable for producing photo-thermal disinfection of surgical tools contaminated with E. coli cells.
Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery
Free-standing (FS) membranes encompassing N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) and alginate (ALG) multilayers triggered a sustained release of FITC-BSA when incorporated as an intrinsic building block of the FS membranes.
3D printed and stimulus responsive drug delivery systems based on synthetic polyelectrolyte hydrogels manufactured via digital light processing
Combining the best of both worlds: the properties of synthetic hydrogels and the possibility of complex structures of 3D printing, obtaining an adjustable, flexible, and sustainable drug delivery system.
Novel α-mannose-functionalized poly(β-amino ester) nanoparticles as mRNA vaccines with increased antigen presenting cell selectivity in the spleen
Schematic representation of α-mannose-functionalized poly(β aminoester) nanoparticle administration to mice and their selective targeting to CD209-expressing antigen-presenting cells.
An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells
Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy.
Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms
A series of [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives have been synthesised as potential indicators of microbial nitroreductase activity.
Stability and potential degradation of the α′,β′-epoxyketone pharmacophore on ZnO nanocarriers: insights from reactive molecular dynamics and density functional theory calculations
Action and dynamics of an anti-cancer drug: how are they affected by an inorganic nanocarrier?
Spermine-starch nanoparticles with antisense vicR suppress Streptococcus mutans cariogenicity
We developed SSN nanovector for ASvicR delivery using natural starch spermine to protect ASvicR from nuclease degradation and achieve high transformation efficiency, inhibit EPS and cariogenicity of S. mutans, maintain oral flora homeostasis.
Amikacin@SiO2 core@shell nanocarriers to treat pulmonal bacterial infections
AMC@SiO2 core@shell nanocarriers (AMC: amikacin) with 200 nm AMC core, 20 nm silica shell, and unprecedented AMC load (80%) show high activity against Mycobacterium tuberculosis and Mycobacterium abscessus as pulmonal, often multiresistant bacteria.
One-step antibacterial modification of polypropylene non-woven fabrics via oxidation using photo-activated chlorine dioxide radicals
Antibacterial properties were imparted in polypropylene non-woven fabrics (PP NWFs) via a one-step modification using photo-activated ClO2˙. The modified PP NWFs showed 99.9% inhibition of bacterial growth against E. coli and S. aureus.
Functionalization of graphenic surfaces by oxygen plasma toward enhanced wettability and cell adhesion: experiments corroborated by molecular modelling
The water-graphenic interface were investigated experimentally (AFM, LDI-MS, and WCA) and theoretically (DFT modelling) providing insights for oxygen plasma functionalization towards enhanced wettability and cell adhesion.
Using host–guest interactions at the interface of quantum dots to load drug molecules for biocompatible, safe, and effective chemo-photodynamic therapy against cancer
Host–guest interactions were used to direct the interfacial self-assembly of quantum dots into a nanosystem for synergistic chemo-photodynamic therapy against cancer.
Multifunctional theranostic carbazole-based cyanine for real-time imaging of amyloid-β and therapeutic treatment of multiple pathologies in Alzheimer's disease
The multifunctional theranostic cyanine SLCOOH, capable of real-time imaging of Aβ contents in vivo and targeting multiple pathological pathways or mechanisms of neurodegeneration, was unambiguously demonstrated.
Development of a synthesis strategy for sulfamethoxazole derivatives and their coupling with hydrogel microparticles
For perspective biosensing applications, we demonstrate the synthesis of sulfamethoxazole derivatives and their site-directed coupling to microfluidic generated hydrogel microparticles.
Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation
Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.
Photomechanical response under physiological conditions of azobenzene-containing 4D-printed liquid crystal elastomer actuators
This work analyses the photomechanical work performance of 4D-printed liquid crystal elastomers under physiological conditions in PBS media.
Tuning the 1D–2D dimensionality upon ligand exchange in silver thiolate coordination polymers with photoemission switching
Thiol-ligand exchange to form either 1D luminescent or 2D non-emissive Ag(I)-based coordination polymers.
Controlling the structure of supramolecular fibre formation for benzothiazole based hydrogels with antimicrobial activity against methicillin resistant Staphylococcus aureus
Supramolecular self-associating amphiphiles form a variety of self-associated structures demonstrating antimicrobial activity, limited toxicity and number of structure activity relationships.
Dendritic polyglycerolsulfate-SS-poly(ester amide) micelles for the systemic delivery of docetaxel: pushing the limits of stability through the insertion of π–π interactions
Highly stable micelles are facilitated by π–π interactions in an amphiphilic block copolymer system consisting of dPGS-SS-POxPPh-Py, where each building block contributes a particular ability.
Amplification of oxidative stress with a hyperthermia-enhanced chemodynamic process and MTH1 inhibition for sequential tumor nanocatalytic therapy
We applied dendritic mesoporous silica NPs (DMSN NPs) as the deposition matrices to achieve a high dispersion of CeO2 NPs. Hyperthermia-enhanced CDT combined with DNA damage repair pathway inhibition has a powerful tumor inhibition efficiency.
Visible label-free detection of bacterial DNA using flocculation of sterically stabilised cationic latexes
This paper demonstrates a method for detecting the presence of amplified DNA from bacterial samples using a sterically-stabilised, cationic polymer latex and widely available equipment, providing an accessible alternative DNA detection technique.
Theranostic inorganic–organic hybrid nanoparticles with a cocktail of chemotherapeutic and cytostatic drugs
Theranostic inorganic–organic hybrid nanoparticles (IOH-NPs) with a cocktail of chemotherapeutic and cytostatic drugs and outstanding drug loading (71–82% of total nanoparticle mass) are evaluated with different cell lines and tumor spheroids.
Combined chemo-immuno-photothermal therapy based on ursolic acid/astragaloside IV-loaded hyaluronic acid-modified polydopamine nanomedicine inhibiting the growth and metastasis of non-small cell lung cancer
Combined chemo-immuno-photothermal therapy based on ursolic acid/astragaloside IV-loaded hyaluronic acid-modified polydopamine nanomedicine is a promising strategy for the treatment of non-small cell lung cancer (NSCLC) metastasis.
Gold nanoparticle-based two-photon fluorescent nanoprobe for monitoring intracellular nitric oxide levels
Highly-versatile two-photon fluorescent-nanoprobe for the detection of wide ranges of intracellular nitric oxide concentrations in macrophages, endothelial and cancer cells.
Ultrasmall superparamagnetic iron oxide nanoparticles for enhanced tumor penetration
This work suggests that, in the presence of a magnetic field, the size and magnetization of ultrasmall superparamagnetic Fe3O4 nanoparticles play dominant roles in tumor penetration.
Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy
A schematic representation of FeNP-induced ROS production and its involvement in ferroptosis.
Synthetic engineering of a new biocatalyst encapsulating [NiFe]-hydrogenases for enhanced hydrogen production
By incorporating [NiFe]-hydrogenases into a proteinaceous carboxysome shell, we generate a novel biocatalyst that has improved production of clean hydrogen, oxygen tolerance, and thermostability, highlighting its great potential in biotechnological applications.
Microcapsule functionalization enables rate-determining release from cellulose nonwovens for long-term performance
Microcapsule functionalization provides textile materials with controllable release rate-limiting properties. This enables sustained and predictable release of actives and extension of the functional lifetimes of these materials from hours to weeks.
Dual photoisomerization mechanism of azobenzene embedded in a lipid membrane
The photoisomerization of chromophores in biological environments is highly important for biomedical applications. While the trans-to-cis isomerization is slow and governed by a torsional mechanism, cis-to-trans is pedal-like on a sub-ps time scale.
Surface modified materials for active capture of enzymes
The insertion of bis(diarylcarbene)s onto a glass fiber (GF) membrane surface provided an active coating for the direct capture of protein – exemplified by the enzyme, cellulase – through a mild diazonium coupling process which does not require additional coupling agents.
Zn doped iron oxide nanoparticles with high magnetization and photothermal efficiency for cancer treatment
The substitution of Fe2+ ions by Zn2+ ions in the crystal lattice of ferrites increases both the nanoparticles magnetization, and their photothermal conversion efficiency.
Important roles of odontoblast membrane phospholipids in early dentin mineralization
Phospholipids co-localized with collagen were found at the early stages of dentin mineralization in mouse first molar. Plasma membrane phospholipids induced rapid mineralization of collagen.
Hybrid nano-architectures loaded with metal complexes for the co-chemotherapy of head and neck carcinomas
Developing strategies for the treatment of head and neck malignancies based on nano-structured co-chemotherapeutics is critical for the next cancer management.
Conjugation of gold nanoparticles with multidentate surfactants for enhanced stability and biological properties
Removal of polymer excess in NPs suspension causing colloidal instability. Multidentate polymer is a solution to avoid this critical phenomenon in the application of nanotechnology.
Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma
The cellular damage response induced by γ-rays, X-rays and proton beams suggest these type of radiations are promising therapeutic modalities against resistant glioblastoma tumours when combined to stable metallacarboranes as radiosensitizers and PBFR.
Development of a new 3D bioprinted antibiotic delivery system based on a cross-linked gelatin–alginate hydrogel
The work presents coherently the 3D bioprinted cross-linked drug-loaded gelatin–alginate hydrogel matrices and a detailed description of various properties important for a potential use as wound dressings.
Detachment of bovine corneal endothelial cell sheets by cooling-induced surface hydration of poly[(R)-3-hydroxybutyrate]-based thermoresponsive copolymer coating
A smart surface was prepared by non-covalently coating of a thermoresponsive copolymer via a simple drop-casting method. The smart surface was conducive to cell culture, from which intact cell sheets could be effectively detached by cooling.
3D bio-printing of photocrosslinked anatomically tooth-shaped scaffolds for alveolar ridge preservation after tooth extraction
3D printing interconnected porous scaffold with an in-organic-organic material for alveolar ridge preservation.
The amount of dextran in PLGA nanocarriers modulates protein corona and promotes cell membrane damage
Control over the amount of dextran added to the formulation of doxorubicin-loaded PLGA nanocarriers impacts their interaction with non-phagocytic cells due to the decrease of protein adsorption with the increase of dextran amount.
Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units
Nonionic hyperbranched polymers with phenolic terminal units were synthesized, which are non-leachable, non-cytotoxic, and show significant antibacterial effect.
Metal-phenolic networks as tuneable spore coat mimetics
Bacillus subtilis are probiotic microbes that are difficult to formulate when they are not in their spore form. Using self-assembling coatings, these cells were successfully protected during the freeze-drying process.
Raman and scanning probe microscopy for differentiating surface imprints of E. coli and B. cereus
Nanomechanical AFM and Raman-Microscopy data give evidence that surface imprinting of bacteria leads to chemical differences in cavities caused by different species. This experimentally corroborates a fundamental assumption of molecular imprinting.
Recyclable nanoparticles based on a boronic acid–diol complex for the real-time monitoring of imprinting, molecular recognition and copper ion detection
A simple, sensitive, and straightforward method is developed to study the process of molecular imprinting via real-time fluorescence measurements. The imprinted polymer can be used to remove ARS from water, and as a fluorescent probe to detect Cu2+.
Hollow protein microparticles formed through cross-linking by an Au3+ initiated redox reaction
We report the formation of hollow microparticles through the assembly of lipoproteins in CaCO3 templates and cross-linking by using Au3+ ions.
Thiolated cationic poly(aspartamides) with side group dependent gelation properties for the delivery of anionic polyelectrolytes
A new synthetic strategy of thiolated polyaspartamides accelerated their oxidation-induced gelation and anionic polyelectrolytes are released in a controlled manner.
Enzymatic elaboration of oxime-linked glycoconjugates in solution and on liposomes
Despite existing as a mixture of isomers, reducing sugar oximes can still be substrates for glycosyltransferases.
About this collection
This collection contains recent Open Access articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this webpage as soon as possible after publication.