The rise of bio-inspired polymer compartments responding to pathology-related signals
Self-organized nano- and microscale polymer compartments such as polymersomes, giant unilamellar vesicles (GUVs), polyion complex vesicles (PICsomes) and layer-by-layer (LbL) capsules have increasing potential in many sensing applications.
Enzyme catalysis powered micro/nanomotors for biomedical applications
This review provides insights on enzyme powered motors using fuels present in biological environments for biomedical applications.
Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies
Selecting the appropriate nanoparticle, functionalization chemistry and sensing methodology can speed up the translation of liquid biopsies into the clinic.
Smart diagnostic nano-agents for cerebral ischemia
A summary of the latest developments on imaging techniques and smart nano-diagnostics used for ischemic stroke.
Specifiable biomimetic microsponges for timed release of crystal entrapped biomolecules useful in bone repair
Most marine biomaterials comprise of inorganic crystals with various tectonic structures that permit the inclusion, storage, release, and delivery of organic biomolecules. One analog with those functions is exploited for preclinical application.
Single-molecule DNA origami aptasensors for real-time biomarker detection
DNA nanostructures as platforms to monitor the inherent conformational changes of aptamers upon analyte binding, with single-molecule resolution and real-time capability.
Plasmonic photothermal microneedle arrays and single needles for minimally-invasive deep in-skin hyperthermia
We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm and 4.5 mm length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation.
Light-switchable anchors on magnetized biomorphic microcarriers
Combining silica-biomorphs, magnetite mesocrystals and covalently bound spiropyrans into light-switchable microcarriers.
Seed-mediated synthesis of plasmonic gold nanoribbons using cancer cells for hyperthermia applications
MCF7 Cells biomineralize gold ions into long aspect-ratio nanoribbons in the presence of spherical nanoparticles as seeds with excellent photothermal properties.
Dual water-healable zwitterionic polymer coatings for anti-biofouling surfaces
Herein, we show for the first time drop-casting zwitterionic polymer colloidal particles onto different surfaces to obtain zwitterionic coatings with highly protein-repelling properties and dual self-healing capabilities.
Towards deployable meta-implants
The first step towards deployable meta-implants: design, manufacturing and proof of concept.
Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
Stability, biocompatibility and near-infrared photoluminescence of PbS nanocrystals capped with PEG-based ligands open up realistic prospects for non-invasive bioimaging applications.
Tuneable plasmonic gold dendrimer nanochains for sensitive disease detection
We report the development of a tuneable plasmonic nanochain immunoassay with increased sensitivity over traditional monodisperse nanoparticle lateral flow tests.
Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy
pH-Responsive drug nanocarriers were made via facile self-assembly, showing excellent stability in bio-media (50% PBS/FBS) and enhanced drug efficacy towards cancer cells.
Growth of large-scale MoS2 nanosheets on double layered ZnCo2O4 for real-time in situ H2S monitoring in live cells
Real-time quantification of H2S production in live biological cells using a MoS2/ZnCo2O4–ZnCo2O4 modified carbon cloth electrode.
pH-Responsive nanocomposite fibres allowing MRI monitoring of drug release
pH-responsive nanofibres containing iron oxide nanoparticles (NPs) and a model drug demonstrate on-demand dissolution, triggering release of both drug and NPs and allowing magnetic resonance imaging-guided therapeutic delivery.
Anisotropic, porous hydrogels templated by lyotropic chromonic liquid crystals
Approaches to control the microstructure of hydrogels enable the control of cell–material interactions and the design of stimuli-responsive materials.
14N–1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
14N–1H HMQC experiments are powerful experiments to characterize amorphous drug–polymer formulations of paclitaxel yielding well-separated signals in the 14N dimension as well as information on the symmetry of 14N and 14N–1H interactions.
Mechanically adaptive implants fabricated with poly(2-hydroxyethyl methacrylate)-based negative photoresists
A negative photoresist approach towards physiologically responsive mechanically adaptive polymers that soften upon insertion into the body is reported. The framework relies on photoresists that can be processed into implants having complex shapes.
Liquid crystal elastomers as substrates for 3D, robust, implantable electronics
Liquid crystal elastomers are used as substrates for robust, implantable electronics that are planar processed then morph into 3D shapes.
Self-recovering dual cross-linked hydrogels based on bioorthogonal click chemistry and ionic interactions
The biocompatible, injectable and high water-swollen nature of dual cross-linked hydrogels makes them a popular candidate to imitate the extracellular matrix (ECM) for tissue engineering both in vitro and in vivo.
Hexametaphosphate as a potential therapy for the dissolution and prevention of kidney stones
Hexametaphosphate prevents aggregation and dissolves kidney stones an order of magnitude more effectively than the current therapy, citrate.
Size-controlled clustering of iron oxide nanoparticles within fluorescent nanogels using LCST-driven self-assembly
Size-controlled clustering of iron oxide nanoparticles (IONPs) within the fluorescent polymer nanogels was achieved using the lower critical solution temperature (LCST) driven self-assembly and cross-linking of grafted polymer on the IONPs.
Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage
Drug localisation is one of the main challenges in treating cartilage; poly-beta-amino-esters (PBAEs) drug conjugates are a possible solution; their efficacy depends on the polymer structure hence the full potential of this system is still unknown.
Stable anchoring of bacteria-based protein nanoparticles for surface enhanced cell guidance
The preparation of robust nano–micropatterns for prolonged cell culture studies using covalent anchoring between the surface and protein nanoparticles, which are produced in a human-safe bacterial platform.
Enhanced photodynamic therapy and fluorescence imaging using gold nanorods for porphyrin delivery in a novel in vitro squamous cell carcinoma 3D model
In this paper, we show enhanced photodynamic therapy and fluorescence imaging using cationic porphyrin photosensitizer TMPyP loaded gold nanorods in 2D monolayer cultures and a novel in vitro head and neck squamous cell carcinoma 3D model.
Optimization of analytical assay performance of antibody-gated indicator-releasing mesoporous silica particles
An in-depth study of the chemical tuning modes of antibody-gated indicator delivery (gAID) systems revealed the importance of size matching, localisation of grafting and loading sequence for obtaining high-performance small-molecule sensor materials.
Polymer-encapsulation of iron oxide clusters using macroRAFT block copolymers as stabilizers: tuning of the particle morphology and surface functionalization
We report a versatile platform for the preparation of magnetic carriers stabilized by macroRAFT amphiphilic block copolymers, exhibiting encapsulated morphologies, high iron oxide content and tailored surface functionalizations.
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.
Enzyme-assisted in vivo polymerisation of conjugated oligomer based conductors
The conjugated oligomer ETE-S is enzymatically polymerized in vitro, in the presence of peroxidase and H2O2. This polymerization route occurs also in the plant cell wall where ETE-S polymerizes and forms conductors along the plant structure.
Designer DNA–silica/carbon nanotube nanocomposites for traceable and targeted drug delivery
A programmable drug delivery system can be synthesized in a highly modular fashion from DNA-functionalized carbon nanotubes and silica nanoparticles via enzymatic rolling circle amplification.
Self-defending additively manufactured bone implants bearing silver and copper nanoparticles
Exploiting the synergistic antibacterial behavior of Ag and Cu nanoparticles in self-defending implants.
Effect of boron incorporation on the bioactivity, structure, and mechanical properties of ordered mesoporous bioactive glasses
B2O3 doped (0.5–15 mol%) ordered mesoporous bioactive glasses were synthesized via sol–gel based evaporation-induced self-assembly using P123 as a structure directing agent and characterized by biokinetic, mechanical and structural investigations.
A low-cost paper-based platform for fast and reliable screening of cellular interactions with materials
Illustrating the versatility, processability and reliability of a paper-based screening platform for biological studies with cell-material interaction studies and drug testing.
Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
Herein, a versatile bilayer system, composed by a polypropylene (PP) mesh and a covalently bonded poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, is reported.
Dendrimeric calcium-sensitive MRI probes: the first low-field relaxometric study
In the present work the first investigation ever of calcium sensitive dendrimer relaxation mechanisms at low fields is reported.
Nanoporous hybrid core–shell nanoparticles for sequential release
Silica inside – organosilica outside, and nanoporous throughout: Drug molecules to be released sequentially from novel core–shell nanoparticles select their location (core/shell) autonomously.
“Tuning aggregative versus non-aggregative lectin binding with glycosylated nanoparticles by the nature of the polymer ligand”
Varying the nature of polymeric linkers modulates the aggregation response of glycosylated nanoparticles upon interaction with lectins.
Water-dispersed semiconductor nanoplatelets with high fluorescence brightness, chemical and colloidal stability
Water-dispersed quasi-two dimensional core/shell semiconductor nanoplatelets exhibit high fluorescence brightness, making them promising for various applications including bioimaging.
A label-free aptasensor FET based on Au nanoparticle decorated Co3O4 nanorods and a SWCNT layer for detection of cardiac troponin T protein
Acute myocardial infarction (AMI) is a serious health problem that must be identified in its early stages. Here, we report a FET device with combination of novel nanomaterials and SWCNTS for the detection of Troponin-T.
Preparation and characterization of a supramolecular hydrogel made of phospholipids and oleic acid with a high water content
Formation of a structured lipid hydrogel able to accommodate a high amount of water (95%) without needing gelling agents.
A combination of glioma in vivo imaging and in vivo drug delivery by metal–organic framework based composite nanoparticles
Metal–organic framework based composite nanoparticles (Mn-ZIF-8/5-Fu) was used for glioma treatment with high drug loading rate and pH responsive drug delivery capacity. Mn-ZIF-8/5-Fu demonstrated good magnetic resonance imaging capacity.
Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: copper and strontium
Porous composite scaffolds with decoupled ion release of copper and strontium were fabricated and characterized: a reproducible and cost-effective approach to obtain constructs with tailored release profiles and promising biological properties.
Flexible, microstructured surfaces using chitin-derived biopolymers
A photocrosslinkable chitin derivative is used to create robust, transparent sheets, and high resolution microstructures via photolithography. The biopolymer can form flexible templates for spatially guiding cells, or in degradable bioelectronics.
A biomimetic hybrid material consisting of CaCO3 mesoporous microspheres and an alternating copolymer for reversed-phase HPLC
Inspired by egg shells, amphiphilic copolymer-modified monodisperse mesoporous CaCO3 microspheres were applied as a separation material.
Glutathione from recovered glucose as ingredient in antioxidant nanocapsules for triggered flavor delivery
Glucose recovered via enzymatic hydrolysis of rayon fibers was used for glutathione production by S. cerevisiae. Glutathione was used in combination with HSA and silk fibroin for ultrasound assisted nanocapsules production. Triggered release of flavor substances and antioxidant properties of the nanocapsules was demonstrated.
Monitoring the death of single BaF3 cells under plasmonic photothermal heating induced by ultrasmall gold nanorods
Morphological changes and trypan-blue staining are temporally tracked in single cells via optical microscopy after plasmonic photothermal heating.
Asymmetric multifunctional 3D cell microenvironments by capillary force assembly
The fabrication and characterization of advanced 3D cell culture microenvironments that enable systematic structure–property relationship studies are reported.
Influence of charged groups on the cross-linking efficiency and release of guest molecules from thiol–ene cross-linked poly(2-oxazoline) hydrogels
This study concerns hydrogels obtained from poly(oxazolines) bearing charged groups and their effect on the loading and release of guest molecules.
Tuning HIV drug release from a nanogel-based in situ forming implant by changing nanogel size
This paper reports an in situ forming implant based on responsive nanogels that gives tuneable long-acting drug release.
Reactive oxygen species mediated theranostics using a Fenton reaction activable lipo-polymersome
A succinic peroxide-filled Fenton reaction activable Pt/Fe3O4@SP-PLGA lipo-polymersome displays ROS mediated chemodynamic therapy (CDT).
Bioinspired reversible hydrogel adhesives for wet and underwater surfaces
A hydrogel-based wet adhesive with bioinspired microstructures can exhibit strong and reversible adhesion to wet and underwater surfaces.
Enzymatic synthesis of a thiolated chitosan-based wound dressing crosslinked with chicoric acid
This work describes the enzymatic synthesis of multifunctional hydrogels for chronic wound treatment using thiolated chitosan and the natural polyphenol chicoric acid.
Low-fouling, mixed-charge poly-L-lysine polymers with anionic oligopeptide side-chains
A mixed-charge polymer, with anionic oligopeptide moieties attached to a cationic poly-L-lysine backbone, provides antifouling surfaces for human plasma samples.
Barcoding chemical modifications into nucleic acids improves drug stability in vivo
The efficacy of nucleic acid therapies can be limited by unwanted degradation.
Sub-zero temperature mechanically stable low molecular weight hydrogels
We show here a low molecular weight hydrogelator based on a functionalised dipeptide which is stable down to temperatures of −12 °C despite being made from >99% water. With the addition of glycerol this can be lowered further to −40 °C. At these colder temperatures there is no effect on the mechanical properties of the gels.
Single cell analysis of proliferation and movement of cancer and normal-like cells on nanowire array substrates
Performing single cell analysis can reveal the existence of different cell populations on nanowire arrays.
Bioceramic microneedle arrays are able to deliver OVA to dendritic cells in human skin
Bioceramic arrays with high-aspect-ratio microneedles were able to penetrate human ex vivo skin and deliver their cargo to dendritic cells.
Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing
Novel reduction responsive oligo-β-aminoesters were successfully synthesized and condensed with siRNA through an inkjet method, thus showing promising biological response.
Non-invasive characterization of hybrid gelatin:poly-L-lactide electrospun scaffolds using second harmonic generation and multiphoton imaging
In this work we generated hybrid gelatin:poly-L-lactide electrospun scaffolds and implemented non-invasive methods to characterize them.
Rapid bioinspired mineralization using cell membrane nanofragments and alkaline milieu
Bone formation in vivo occurs in alkaline environment, which determines the optimal pKa of phosphatases, the optimal amount of calcium for mineral precipitation, and the spherical shape of initial minerals. Manipulation of environmental pH for in vitro synthesis of bone-like tissue, showed a markedly rapid mineralization with nanofragments and alkaline milieu.
Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering
The simplicity of making hydrogels with tunable mechanical properties from commercially available proteins is demonstrated for cardiac tissue engineering.
Biomimetic graphene for enhanced interaction with the external membrane of astrocytes
Phospholipids modified graphene oxide (GO–PL) shows enhanced compatibility with primary rat cortical astrocytes with respect to standard adhesion agents and non-functionalized GO.
Switchable presentation of cytokines on electroactive polypyrrole surfaces for hematopoietic stem and progenitor cells
Redox potential-dependent switching of immobilized interleukin-3 presentation towards hematopoietic progenitor cells using electroactive polypyrrole surfaces affects cell viability.
Combinatorial delivery of bioactive molecules by a nanoparticle-decorated and functionalized biodegradable scaffold
The combination of supportive biomaterials and bioactive factors to stimulate endogenous progenitor cells is of key interest for the treatment of conditions in which intrinsic bone healing capacities are compromised.
A hydroxamic acid–methacrylated collagen conjugate for the modulation of inflammation-related MMP upregulation
The selective covalent coupling of hydroxamic acid functions on to methacrylated type I collagen led to UV-cured networks with inherent MMP-modulating capability and enhanced proteolytic stability.
Nanoparticle-supported polymer brushes for temperature-regulated glycoprotein separation: investigation of structure–function relationship
Nanoparticle-supported polymer brushes enable temperature-regulated protein binding and release.
Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer
A thermoresponsive block copolymer has been developed with the capability to co-carry two drug molecules and to augment their cytotoxic properties via direct cell membrane interaction with cancer cells.
Turn-on fluorescence detection of protein by molecularly imprinted hydrogels based on supramolecular assembly of peptide multi-functional blocks
Supramolecular in-cavity target–peptide complex for self-reporting imprinted polymers.
Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line
Hierarchical formulation of hybrid nanoparticles that consist of aggregated gold nanoparticles impregnated into a gemcitabine–polymer conjugate matrix for photochemotherapy of pancreatic cancer.
About this collection
This collection contains recent Open Access articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this webpage as soon as possible after publication.