Activatable molecular agents for cancer theranostics
Activatable molecualr agents that intergrate diagnosis and treatment modalities have attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome.
Two-dimensional UV spectroscopy: a new insight into the structure and dynamics of biomolecules
Two-dimensional ultraviolet spectroscopy has the potential to deliver rich structural and dynamical information on biomolecules such as DNA and proteins.
Fluorescent probes for organelle-targeted bioactive species imaging
The dynamic fluctuations of bioactive species in living cells are associated with numerous physiological and pathological phenomena. The emergence of organelle-targeted fluorescent probes has significantly facilitated our understanding on the biological functions of these species. This review describes the design, applications, challenges and potential directions of organelle-targeted bioactive species probes.
Self-assembled amphiphilic fluorescent probe: detecting pH-fluctuations within cancer cells and tumour tissues
A self-assembled amphiphilic fluorescent probe allows pH-fluctuations within cancer cells and tumour tissues to be readily detected.
Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications
Pinkment, a resorufin based ONOO− selective and sensitive ‘plug and play’ fluorescence-based platform for in vitro and in vivo use, enables facile functionalisation for various imaging and theranostic applications.
A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin
Real-time imaging of intracellular glutathione in response to cisplatin by a ratiometric fluorescent probe reveals that the different trends in intracellular GSH levels is crucial in distinguishing cisplatin-resistant from cisplatin-sensitive cells.
Core remodeling leads to long wavelength fluoro-coumarins
Fluoro-Coumarins are a novel class of far-red and near-infrared solvent sensitive dyes of exceptionally low molecular weight.
A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice
A near-infrared emitting fluorogenic dimer with environment-sensitive folding and exceptional brightness enables background-free and target-specific imaging of the naturally expressed oxytocin GPCR in living mice.
TinyPols: a family of water-soluble binitroxides tailored for dynamic nuclear polarization enhanced NMR spectroscopy at 18.8 and 21.1 T
TinyPol binitroxides provide significantly higher DNP enhancement factors for solid-state NMR spectroscopy at high magnetic fields than today's reference radical AMPUPol.
Mechanisms of IR amplification in radical cation polarons
Break down of the Born–Oppenheimer approximation is caused by mixing of electronic and vibrational transitions in the radical cations of some conjugated polymers, resulting in unusually intense vibrational bands known as infrared active vibrations (IRAVs).
Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
Trp(redBODIPY) is the first red-emitting Trp-based amino acid for the preparation of fluorogenic peptides with retention of target binding affinity.
Persistent organic room temperature phosphorescence: what is the role of molecular dimers?
The first purely organic room temperature phosphorescence (RTP) luminogen, with singlet excimer emission and thermally activated delayed fluorescence (TADF) effect, was successfully developed.
An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging
An aggregation-induced emission (AIE) dye-powered afterglow luminogen has been designed for in vivo tumor imaging. The underlying afterglow mechanism can be described as a closed-loop of “photon–1O2–SP intermediates–photon”.
AIE-active non-conjugated poly(N-vinylcaprolactam) as a fluorescent thermometer for intracellular temperature imaging
Unprecedented photoluminescence, AIE and heat-induced emission characteristics of non-conjugated thermoresponsive PNVCL were unveiled for the very first time which eventually empowered PNVCL to act as an intracellular thermometer.
Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+
Two endoplasmic reticulum (ER) targeting probes were developed to image mobile Zn2+ to help understand Zn2+ related biological processes in the ER.
A “Double-Locked” and enzyme-activated molecular probe for accurate bioimaging and hepatopathy differentiation
A “double-locked” and enzyme-activated molecular fluorescent probe for accurate bioimaging and hepatopathy differentiation.
Resolving the structure of the E1 state of Mo nitrogenase through Mo and Fe K-edge EXAFS and QM/MM calculations
The FeMoco cluster of Mo nitrogenase undergoes minor distortions upon reduction to E1, supporting iron-based reduction and belt sulfide protonation.
A conceptual framework for the development of iridium(III) complex-based electrogenerated chemiluminescence labels
A new strategy to create iridium(III)-based ECL labels reveals limitations of conventional approaches.
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples
Highly selective fluorescent activity-based probe for the visualization of cathepsin B in cancer cells.
Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
Theranostic nanoprobes (SYL NPs) prepared from a newly designed NIR-II fluorophore and FDA approved DSPE-mPEG5000 were well tolerated and exhibited multifunctional potential in diagnosis (photoacoustic & fluorescence imaging) and phototherapy in animal models.
Reactive oxygen species-triggered off-on fluorescence donor for imaging hydrogen sulfide delivery in living cells
A reactive oxygen species-triggered off-on fluorescence H2S donor is develop for the real-time imaging of H2S delivery and the cytoprotection against the hazardous oxidative environment.
A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging
A molecular design strategy is established to access diverse enzyme-activated probes that are excitable and emit in the NIR (I and II) region with favorable Stokes shifts, enabling targeted cancer imaging by real-time monitoring enzyme activities.
Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe
Probe C7 for the first time presents different modes of fluorescence signals to both nanomolar and micromolar concentrations of HOCl.
An enzyme-free molecular catalytic device: dynamically self-assembled DNA dendrimers for in situ imaging of microRNAs in live cells
Branched catalytic hairpin assembly is proposed for dynamic self-assembly of DNA dendrimers for signal amplification and in situ imaging of microRNAs in live cells with high sensitivity and selectivity.
Thiahelicene-based inherently chiral films for enantioselective electroanalysis
Enantiopure inherently chiral films with helicoidal stereogenicity of outstanding enantiodiscrimination potentialities for chiral redox probes and as spin filters.
Collision cross section compendium to annotate and predict multi-omic compound identities
The Unified Compendium is an online interactive tool that utilizes ion mobility collision cross sections to annotate biochemical molecules.
An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells
We describe an enzyme-regulated liberation strategy to in situ generate AIEgen nanoaggregates for on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.
Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery
A super-contrast NIR-II fluorophore IR-BEMC6P with enhanced quantum yield is developed and the excretion mechanism is identified.
A cell membrane-anchored fluorescent probe for monitoring carbon monoxide release from living cells
A novel cell membrane-anchored probe (ANRP) was constructed to monitor CO release from living cells for the first time.
Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission versus anti-aggregation-caused quenching
This article presents the first work to fundamentally study the effect of steric hindrance in Pdot systems.
About this collection
This specially curated collection pulls together some of the most popular articles from 2019 and 2020 in the field of analytical chemistry. The collection presents some outstanding contributions to the field, ranging from fluorescent probes for bioactive imaging to dynamic nuclear polarisation enhanced NMR spectroscopy, and as with all Chemical Science articles – they are all completely free to access and read. We hope you enjoy browsing through this collection.
Most popular 2019-2020 inorganic, main group and crystal engineering chemistry articles
Most popular 2019-2020 materials and energy chemistry articles
Most popular 2019-2020 physical and theoretical chemistry articles
Most popular 2019-2020 organic chemistry articles
Most popular 2019-2020 catalysis articles
Most popular 2019-2020 supramolecular chemistry articles
Most popular 2019-2020 chemical biology articles
Most popular 2019-2020 review articles