Themed collection 2026 Organic Chemistry Frontiers HOT Articles

A review covering early studies to the latest development in carbon isotope exchange and transfer reactions involving CO₂.

In this perspective, we summarize recent advances in visible-light-driven defluorinative functionalization of α-trifluoromethyl arylalkenes, highlighting the strategies for gem-difluoroalkene synthesis via photoinduced SET and radical–polar crossover.

A review of recent research progress in the synthesis of α-trifluoromethyl amines through the asymmetric reduction of trifluoromethylated imines and nucleophilic addition to trifluoromethylated imines.

The oxidation reactions employed in selected total syntheses from 2020 to 2025 are surveyed to reflect their current status, guide planning in total syntheses, and prompt organic chemists to develop more efficient oxidation reactions and reagents.

This review highlights recent advances in transition-metal-catalyzed hydroalkynylation of internal alkynes, outlining emerging strategies and future prospects.

Atropisomeric architectures with a chiral axis are prevalent in biologically active molecules and natural products, and they are widely put to use in privileged catalysts and chiral ligands.

This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.

Aryl thianthrenium salts, accessed through highly selective arene thianthrenation, offer a versatile platform for generating aryl radicals under mild conditions, enabling streamlined C–D, C–C, and C–heteroatom bond formation among diverse substrates.

A dumbbell-shaped amphiphile assembles into a spherical polyaromatic micelle in water. Binding of organic and metal–organic dyes by the micelle yields host–guest composites with very high stability against organic solvent addition (up to 75% v/v).

An efficient method for the remote asymmetric C–H allenylation of carbazoles with propargylic alcohols via 1,8-conjugate addition has been developed.

Inspired by theoretical studies of the Corey–Winter-olefination, the Corey–Hopkins reagent has been found to be a very effective means to desulfurize isothiocyanates to isocyanides featuring excellent functional group tolerance.

In this study, we report a direct acylation method for saccharides, achieved through the combination of copper and N-heterocyclic carbene (NHC) catalysis.

A synthetic method for the preparation of functionalized 3-amino-carbazoles through Sc(OTf)₃-catalyzed C2-selective allylation/defluorination and DBN-mediated defluorinative annulation under catalyst-free conditions has been developed.

A convenient (3 + 2) cycloaddition of di-tert-butyl azodicarboxylate with terminal alkynes has been developed. This protocol, which employs a readily available copper catalyst, provides direct access to unprecedented N-aminooxazol-2-ones.

A catalyst-free, visible-light-induced annulation of 2H-azirines and hydrazonyl chlorides via EDA activation affords 1,3,5-triazines or imidazoles. The 2H-azirine substitution pattern controls reactivity, giving a practical route to N-heterocycles.

New aryl imidazoisoindoles were synthesized and identified as 10π photochromic systems. Catalytic amounts of acid significantly accelerate the ring-opening reaction, exhibiting nonlinear acid responsiveness.

Outer-sphere reductive elimination as the enantio-determining step in Ir^III/Ni^II metallaphotoredox-catalyzed α-(hetero)aryl amination has been theoretically disclosed.

Pd-catalyzed enantioselective intermolecular hydroamination of acyclic 1,3-dienes can proceed with aniline nucleophiles, featuring enantiodivergence via modulation of non-chiral acid additives.

A scandium catalyzed regio- and enantioselective 1,2-homopropargylic addition of β,γ-unsaturated α-ketoesters was demonstrated, affording enantioenriched tertiary homopropargylic allylic alcohols in good yields with excellent enantioselectivities.

We report a palladium(II)-catalyzed (3 + 3) allylic annulation between 2-(1-alkynyl)-2-alken-1-ones and 2- or 3-substituted (Z)-4-hydroxy-but-2-en-1-yl acetates.

A Pd-catalyzed late-stage C–H olefination of [n]naphthalenophanes has been developed.

We demonstrate an Au-catalysed synthesis of B-spiroBODIPYs with a 1,3-dioxinone moiety. The B-spiroBODIPY exhibits solvent-dependent fluorescence arising from hydrogen-bonding interactions, which offers a platform for stimulus-responsive probes.

Cross-electrophile stannylation of alkyl electrophiles with chlorostannanes was enabled by phenanthroline-ligated Cr(II) catalysis, offering a mild, step-economical route to α-functionalized alkyltin reagents in one step.

We report the first synthesis of phosphorothiosulfonates as competent radical –S–P(O)(OR)₂ precursors. Under mild photoredox conditions, these reagents enable metal-, oxidant-free phosphorothiolation/cyclization of diverse alkenes and alkynes.

Chemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobalt-catalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes.

Here we report a nickel/photo co-catalyzed direct radical Si–H arylation of hydrosilanes with aryl halides.