Themed collection 2026 Organic Chemistry Frontiers Review-type Articles

Over the past decade, acyl boronates have emerged as versatile precursors in organic synthesis, facilitating the construction of diverse and important classes of compounds, including boronate-substituted and boron-containing heterocycles.

A review covering early studies to the latest development in carbon isotope exchange and transfer reactions involving CO₂.

In this perspective, we summarize recent advances in visible-light-driven defluorinative functionalization of α-trifluoromethyl arylalkenes, highlighting the strategies for gem-difluoroalkene synthesis via photoinduced SET and radical–polar crossover.

A review of recent research progress in the synthesis of α-trifluoromethyl amines through the asymmetric reduction of trifluoromethylated imines and nucleophilic addition to trifluoromethylated imines.

The oxidation reactions employed in selected total syntheses from 2020 to 2025 are surveyed to reflect their current status, guide planning in total syntheses, and prompt organic chemists to develop more efficient oxidation reactions and reagents.

Fluorinated steroid chemistry evolved from a niche field into a central discipline linking organic synthesis, medicinal chemistry, and chemical biology. Advances in mechanisms, reagents, and selectivity will expand tools for drug discovery.

This review summarizes advances in earth-abundant transition-metal-catalyzed asymmetric oxidative sp³–sp³ cross-couplings, focusing on reaction development, mechanistic insights, synthetic applications, key challenges, and future perspectives.

This review highlights recent advances in transition-metal-catalyzed hydroalkynylation of internal alkynes, outlining emerging strategies and future prospects.

Atropisomeric architectures with a chiral axis are prevalent in biologically active molecules and natural products, and they are widely put to use in privileged catalysts and chiral ligands.

This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.

Recent advances in the synthesis of boryl-substituted cyclobutanes are summarized, highlighting strain-release, boronate complex reactivity, 1,2-migration, and catalytic strategies for stereocontrolled access to sp³-rich building blocks.

Aryl thianthrenium salts, accessed through highly selective arene thianthrenation, offer a versatile platform for generating aryl radicals under mild conditions, enabling streamlined C–D, C–C, and C–heteroatom bond formation among diverse substrates.

We summarize recent advances in nitro(hetero)arenes-enabled CADA, with a detailed discussion of diverse types of reactions, involving asymmetric cycloaddition, asymmetric Michael addition, and asymmetric interrupted Barton-Zard reaction.