Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development
The key learnings of the utilization of sulfoximines, sulfondiimines and sulfonimidamides in drug discovery at Bayer AG are shared.
Progress in the synthesis of perylene bisimide dyes
Rapid progress in the synthesis of perylene bisimide dyes gave an old scaffold new life.
Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme
The first example of a hydroxylammonium derivative that causes a specific covalent modification of the active-site lysine residue of an aldolase enzyme, which is a promising target for anti-bacterial drug discovery, is reported.
Trioxotriangulene with carbazole: a donor–acceptor molecule showing strong near-infrared absorption exceeding 1000 nm
A donor–acceptor type trioxotriangulene neutral radical derivative having three carbazolyl groups as electron-donors was newly synthesized, and exhibited a strong near-infrared photo absorption over 1000 nm.
Visible light-mediated photo-oxygenation of arylcyclohexenes
The photo-oxygenation of versatile arylcycloalkenes proceeds through zwitterionic intermediates and provides access to new allyl hydroperoxides and endoperoxides.
Direct methylation and carbonylation of in situ generated arynes via HDDA-Wittig coupling
A high-efficiency HDDA-Wittig coupling strategy for synthesis of fully functionalized benzenes is reported. Direct methylation and carbonylation of aryne intermediates reacted with phosphorus ylides to form the carbonylated 2,3-dihydro-1H-indenes.
Oxidative selenofunctionalization of allenes: convenient access to 2-(phenylselanyl)-but-2-enals and 4-oxo-3-(phenylselanyl)pent-2-enoates
The controlled preparation of two types of α-seleno-α,β-unsaturated carbonyls, namely, α-selenoenals and α-selenoenones, have been accomplished.
Radical addition of ketones and cyanide to olefins via acid catalyzed formation of intermediate alkenyl peroxides
γ-Cyanoketones are formed by double radical addition from olefins, ketones and sulfonyl cyanides via reactive alkenyl peroxide intermediates.
About this collection
This collection contains recent Open Access articles published from Organic Chemistry Frontiers . New articles will be added to this webpage as soon as possible after publication.