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Themed collection Vitamin D update

11 items
Editorial

Introduction to the themed issue ‘Vitamin D update’

The editors introduce the collection of papers updating several issues of vitamin D and health.

Graphical abstract: Introduction to the themed issue ‘Vitamin D update’
From the themed collection: Vitamin D update
Perspective

Protective actions of vitamin D in UVB induced skin cancer

Vitamin D is made in the skin under the same wavelength of light (UVB) that induces skin cancer. Evidence that vitamin D production may counter the carcinogenic effects of UVB in the skin is reviewed.

Graphical abstract: Protective actions of vitamin D in UVB induced skin cancer
From the themed collection: Vitamin D update
Perspective

Vitamin D content of food and its contribution to vitamin D status: a brief overview and Australian focus

There are only a few natural foods that contain nutritionally significant quantities of vitamin D.

Graphical abstract: Vitamin D content of food and its contribution to vitamin D status: a brief overview and Australian focus
From the themed collection: Vitamin D update
Perspective

Vitamin D and drug-metabolising enzymes

Clinical pharmacologists at Karolinska Institutet describe that seasonal changes in sunlight and vitamin D have an impact on the enzymes that are responsible for detoxification reactions, and that this contributes to variable exposure to therapeutic drugs.

Graphical abstract: Vitamin D and drug-metabolising enzymes
From the themed collection: Vitamin D update
Perspective

The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation

Here we discuss the converging and diverging immunoregulatory pathways of ultraviolet radiation and vitamin D, and potential in vivo approaches to determine if vitamin D mediates the immunosuppressive effects of UVR.

Graphical abstract: The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation
From the themed collection: Vitamin D update
Paper

Influence of high levels of cloud cover on vitamin D effective and erythemal solar UV irradiances

The solar irradiances for the initiation of vitamin D synthesis (UVD3) have been measured concurrently with the amount of cloud cover to investigate the influence of high cloud cover fraction.

Graphical abstract: Influence of high levels of cloud cover on vitamin D effective and erythemal solar UV irradiances
From the themed collection: Vitamin D update
Paper

The effects of a mid-winter 8-week course of sub-sunburn sunbed exposures on tanning, vitamin D status and colds

A mid-winter 8-week sub-erythemal tanning course raised vitamin D levels to high summer levels, as did an 8-week course of vitamin D supplementation @ 1000 IU per day. But neither lowered the incidence of colds significantly.

Graphical abstract: The effects of a mid-winter 8-week course of sub-sunburn sunbed exposures on tanning, vitamin D status and colds
From the themed collection: Vitamin D update
Paper

1α,25 Dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin

Photoprotection by 1,25(OH)2D3 against UV-induced cyclobutane pyrimidine dimers, 8-oxo-7,8-dihydro-2′-deoxyguanosine and abasic sites in skin is demonstrated by comet assay with site specific DNA repair enzymes and by immunohistochemistry. Possible mechanisms for these protective effects are discussed.

Graphical abstract: 1α,25 Dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin
From the themed collection: Vitamin D update
Paper

Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening

We found that patients with polymorphic light eruption have low serum 25-hydroxyvitamin-D3 levels. 311 nm UVB phototherapy increased those levels. This boosting of vitamin D levels may be important in ameliorating polymorphic light eruption.

Graphical abstract: Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening
From the themed collection: Vitamin D update
Paper

Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid

Here we show that a low-calcaemic vitamin D analogue, QW, is photoprotective in vitro and in vivo. Like the active vitamin D hormone, 1,25-dihydroxyvitamin D3, QW protects against ultraviolet radiation-induced cell loss, DNA damage and immunosuppression.

Graphical abstract: Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid
From the themed collection: Vitamin D update
Paper

Increase in serum 25-hydroxyvitamin-D3 in humans after solar exposure under natural conditions compared to artificial UVB exposure of hands and face

Solar-UVR exposure of hands and face did not increase 25(OH)D significantly and was less effective in increasing 25(OH)D compared to artificial UVB by a factor of at least 8.

Graphical abstract: Increase in serum 25-hydroxyvitamin-D3 in humans after solar exposure under natural conditions compared to artificial UVB exposure of hands and face
From the themed collection: Vitamin D update
11 items

About this collection

This collection of articles provides an update on several issues surrounding the potential for increased vitamin D status to provide better health.  Guest Edited by Vivienne Reeve (University of Sydney, Australia).

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