Review Article
Intratumoral microbiota: a new perspective in cancer initiation, development, and therapy
This review summarizes how intratumoral microbiota influence tumor development and explores their potential as targets for drug delivery and immunotherapy enhancement.
Review Article
Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics
Proteins and nucleic acid therapeutics are delivered into cells via endosomal uptake/direct cytosolic entry. Endocytic pathways require endosomal escape, while direct fusion bypasses endosomes, enabling efficient delivery.
Review Article
AI-driven innovations in pharmaceuticals: optimizing drug discovery and industry operations
The current review provides insights into how AI can be applied in drug discovery, industrial pharmaceutical manufacture, and at all stages of clinical trials and regulatory processes.
Review Article
The rise of mRNA therapeutic vaccines
The development of mRNA therapeutic vaccine products is reviewed.
Communication
Reversibility of FUS-aided blood–tumor barrier opening for the delivery of therapeutics
In a dual-GBM mouse model, FUS was applied to selectively open the blood–tumor barrier in one tumor to assess 18F-avelumab and 18F-FDS penetration over 1–72 h, addressing whether FUS-induced barrier disruption is reversible.
Communication
Standard purification methods are not sufficient to remove micellular lipophilic dye from polymer nanoparticle solution
Polymeric nanoparticle synthesis using lipophilic dye for tracking produces dye-only micelles which go undetected during characterization and cause false-positive signals. Density gradient centrifugation separates these micelles from nanoparticles. Created with BioRender.com.
Paper
Personalized medicine: a quality by design approach to printable tablet production
On-demand personalized medicine printing enabled customizable dose and tailored taper regimen tablet production with atline verification and inline quality assurance for patient safety.
Paper
Biocompatible ionic liquid-based nanoparticles for effective skin penetration and intracellular uptake of antisense oligonucleotides
A novel formulation (IL-NP) for the transdermal delivery of nucleic acid medicines was developed using biocompatible ionic liquid (IL).
Paper
A molecular simulation-based deep neural network model for deciphering the adsorption of 5-Fluorouracil in COFs
Molecular simulations and machine learning models on a database of 1242 experimentally synthesized COFs help understand their potential as drug carriers by studying adsorption abilities and predicting loading capacity of anticancer drug 5-FU.
Paper
Exploiting nano-in-micro-technologies to couple PLGA-hydroxyl-FK866 nanoparticles to a hydrogel network for local drug release
Alginate-based hydrogels loaded with hydroxyl-FK866-PLGA nanoparticles.
Paper
Polysaccharide-capped silver nanoparticles impregnated cream for the efficient management of wound healing
Fabrication of a cost-effective, eco-friendly and antimicrobial cream for skin care using polysaccharide-capped silver nanoparticles showcasing a sustainable approach to developing a value-added product with promising biomedical applications.
Paper
Polybasic nanogels for intracellular co-delivery of paclitaxel and carboplatin: a novel approach to ovarian cancer therapy
Paclitaxel and carboplatin-loaded polybasic nanogels are internalized by cancer cells via endocytosis, undergo cationic swelling and endosomal escape, and ultimately induce apoptosis.
Paper
Drug-loaded 3D-printed magnetically guided pills for biomedical applications
A 3D-printed magnetically driven drug loaded magnetic pill for simultaneous heat generation and drug release within AC magnetic fields for the treatment of stomach cancer.
About this collection
This themed collection features articles published in RSC Pharmaceutics marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.