Review Article
A new strategy for the extrahepatic delivery of lipid-based nanomedicines: a protein corona-mediated selective targeting system based on an ionizable cationic lipid library
Applying a molecularly diverse lipid library in the formulation of LNPs recruits endogenous proteins to generate a customized protein corona that directs LNPs to various extrahepatic organs, eliminating the need for external targeting ligands.
Review Article
Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics
Proteins and nucleic acid therapeutics are delivered into cells via endosomal uptake/direct cytosolic entry. Endocytic pathways require endosomal escape, while direct fusion bypasses endosomes, enabling efficient delivery.
Communication
trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity
Click-triggered reactivation of caged cytokine constructs at the tumour site via a Diels–Alder–pyridazine-elimination cascade restores signalling and immune activation. This approach reduces systemic toxicity of immunocytokine therapies.
Paper
Effect of shape on cellular internalization and anti-cancer efficacy of hydroxyapatite nanoparticles in an osteosarcoma cell line
The effect of hydroxyapatite nanoparticle shape (spherical, rod, or needle) on anticancer efficacy in an osteosarcoma cell line.
About this collection
This collection across RSC Chemical Biology and RSC Pharmaceutics is Guest Edited by Prof. Dr Alexander Kros (Leiden University, The Netherlands, ORCID 0000-0002-3983-3048), Prof. Vincent Rotello (University of Massachusetts, United States, ORCID 0000-0002-5184-5439) and Prof. Georgina Such (University of Melbourne, Australia, ORCID 0000-0002-2868-5799). It explores how both biological and synthetic tools can be leveraged to understand the impact of material structure on the migration of specific cellular barriers, aiming to enhance the delivery efficiency of macromolecules and delivery systems such as liposomes, lipid nanoparticles, and polymeric carriers.