Themed collection 2021 Organic & Biomolecular Chemistry HOT article collection

62 items
Review Article

Light-induced borylation: developments and mechanistic insights

This perspective delineates light-induced borylation methodologies, which have been developed in the last 10 years. Mechanistic insights have been explored throughout the article for these UV- and visible-light-induced borylation reactions.

Graphical abstract: Light-induced borylation: developments and mechanistic insights
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Chemical probes targeting the kinase CK2: a journey outside the catalytic box

An up-to-date and comprehensive review on chemical probes targeting the important kinase CK2.

Graphical abstract: Chemical probes targeting the kinase CK2: a journey outside the catalytic box
From the themed collection: Chemical Biology in OBC
Review Article

Phosphorus containing porous organic polymers: synthetic techniques and applications in organic synthesis and catalysis

This review features the recent advancement made in phosphorus-containing POPs, highlighting different synthetic techniques for their preparation and application in organic synthesis.

Graphical abstract: Phosphorus containing porous organic polymers: synthetic techniques and applications in organic synthesis and catalysis
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Review Article

Approaches for peptide and protein cyclisation

Polypeptide cyclisation can enhance thermal stability, proteolytic resistance and membrane permeability. Cyclisation can be achieved by methods including chemical, enzyme and protein tag approaches. Each has strengths and limitations.

Graphical abstract: Approaches for peptide and protein cyclisation
From the themed collection: Chemical Biology in OBC
Review Article

Modelling biocompatible ionic liquids based on organic acids and amino acids: challenges for computational models and future perspectives

From isolated molecules to the bulk phase: building models of biocompatible ionic liquids.

Graphical abstract: Modelling biocompatible ionic liquids based on organic acids and amino acids: challenges for computational models and future perspectives
Review Article

Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle

Azetidines represent one of the most important four-membered heterocycles in organic synthesis. We provide an overview of the synthesis, reactivity and application of azetidines with a focus on the most recent advances, trends and future directions.

Graphical abstract: Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update

α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformations including Michael additions, domino reactions and cycloadditions.

Graphical abstract: α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Aromatic Cope rearrangements

This review summarizes the ∼40 papers dating back to 1956 on the aromatic Cope rearrangement, and highlights the need for further studies, development, and applications of this transformation in synthesis.

Graphical abstract: Aromatic Cope rearrangements
From the themed collection: Synthetic methodology in OBC
Review Article

The role of intermolecular forces in ionic reactions: the solvent effect, ion-pairing, aggregates and structured environment

A general view of the medium effects on ionic reactions involves the solvent effect, ion pairing, formation of aggregates and structured environment.

Graphical abstract: The role of intermolecular forces in ionic reactions: the solvent effect, ion-pairing, aggregates and structured environment
Review Article

Recent advances in single-benzene-based fluorophores: physicochemical properties and applications

The recently reported physicochemical properties and applications of single-benzene-based fluorophores (SBBFs) are summarized.

Graphical abstract: Recent advances in single-benzene-based fluorophores: physicochemical properties and applications
From the themed collection: Editor’s Collection
Open Access Review Article

Recent advances in the synthesis of α-amino ketones

This review on α-amino ketone synthesis collates and evaluates developments made in this area over the past decade, with an extended discussion on functional group compatibility, resultant product substitution patterns, and medicinal applications.

Graphical abstract: Recent advances in the synthesis of α-amino ketones
From the themed collection: Synthetic methodology in OBC
Review Article

Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes

Olefin 1,2-difunctionalization is a popular synthetic strategy for synthesis of vicinal amino alcohols and their derivatives. This comprehensive review covers methods developed beyond the pioneering osmium-catalyzed Sharpless amino hydroxylation.

Graphical abstract: Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes
From the themed collection: Synthetic methodology in OBC
Review Article

Reframing primary alkyl amines as aliphatic building blocks

This review covers recent and historical aliphatic deaminative functionalization reactions to encourage the use of primary amines as aliphatic building blocks.

Graphical abstract: Reframing primary alkyl amines as aliphatic building blocks
From the themed collection: Synthetic methodology in OBC
Review Article

Integrating abiotic chemical catalysis and enzymatic catalysis in living cells

We review hybrid systems of abiotic catalysis and enzymatic catalysis, which function in living cells. This research direction will stimulate multidisciplinary fields, including complex molecule synthesis, energy production, and life science.

Graphical abstract: Integrating abiotic chemical catalysis and enzymatic catalysis in living cells
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Asymmetric bis(oxazoline)–Ni(II) catalyzed α-hydroxylation of cyclic β-keto esters under visible light

Driven by light, a highly enantioselective α-hydroxylation of β-keto esters catalyzed by bis(oxazoline)–Ni(acac)2 complexes under an O2 atmosphere has been developed.

Graphical abstract: Asymmetric bis(oxazoline)–Ni(ii) catalyzed α-hydroxylation of cyclic β-keto esters under visible light
From the themed collection: Synthetic methodology in OBC
Communication

Water binding stabilizes stacked conformations of ferrocene containing sheet-like aromatic oligoamides

The encapsulation of discrete water molecules in flexible sheet-like aromatic oligoamide foldamers, as evidenced by structural and spectroscopic studies, stabilizes their structure.

Graphical abstract: Water binding stabilizes stacked conformations of ferrocene containing sheet-like aromatic oligoamides
From the themed collection: Supramolecular chemistry in OBC
Communication

Plasma induced acceleration and selectivity in strain-promoted azide–alkyne cycloadditions

We report the unexpected acceleration of strain-promoted azide–alkyne cycloaddition in human plasma compared to classical solvent systems. Besides fast kinetics, human plasma also allows for discrimination between two azides in competition reaction.

Graphical abstract: Plasma induced acceleration and selectivity in strain-promoted azide–alkyne cycloadditions
From the themed collection: Chemical Biology in OBC
Communication

Cu(I)-Catalyzed asymmetric exo-selective synthesis of substituted pyrrolidines via a 1,3-dipolar cycloaddition reaction

An efficient chiral metal complex catalysed asymmetric 1,3-dipolar cycloaddition reaction was developed to synthesize highly functionalised exo-pyrrolidines.

Graphical abstract: Cu(i)-Catalyzed asymmetric exo-selective synthesis of substituted pyrrolidines via a 1,3-dipolar cycloaddition reaction
From the themed collection: Synthetic methodology in OBC
Communication

One-pot multi-step cascade protocols toward β-indolyl sulfoximidoyl amides via intermolecular trapping of an α-indolylpalladium complex by CO

Various β-indolyl sulfoximidoyl amides were efficiently prepared from ortho-iodoanilines, propargyl bromides, 1 atm of CO, and NH-sulfoximines, through a palladium-catalyzed indole annulation/carbonyl insertion/C–N bond formation cascade.

Graphical abstract: One-pot multi-step cascade protocols toward β-indolyl sulfoximidoyl amides via intermolecular trapping of an α-indolylpalladium complex by CO
From the themed collection: Synthetic methodology in OBC
Communication

The copper-catalyzed selective monoalkylation of active methylene compounds with alkylsilyl peroxides

A novel method for a mild copper-catalyzed selective monoalkylation of active methylene compounds with various alkylsilyl peroxides has been developed.

Graphical abstract: The copper-catalyzed selective monoalkylation of active methylene compounds with alkylsilyl peroxides
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free access to 3-allyl-2-alkoxychromanones via phosphine-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols

A phosphine-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols is established for the metal-free synthesis of 3-allyl-2-alkoxychromanones with high diastereoselectivity.

Graphical abstract: Metal-free access to 3-allyl-2-alkoxychromanones via phosphine-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols
From the themed collection: Synthetic methodology in OBC
Communication

Direct and straightforward transfer of C1 functionalized synthons to phosphorous electrophiles for accessing gem-P-containing methanes

A modular strategy for preparing α-functionalized phosphorous-containing methyl-units.

Graphical abstract: Direct and straightforward transfer of C1 functionalized synthons to phosphorous electrophiles for accessing gem-P-containing methanes
Communication

Continuous flow as an enabling technology: a fast and versatile entry to functionalized glyoxal derivatives

Continuous Flow methods to access glyoxal derivatives, which serve as valuable precursors for heterocyclic chemistry.

Graphical abstract: Continuous flow as an enabling technology: a fast and versatile entry to functionalized glyoxal derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Cyanoalkylation/alkynylation of allylic alcohol through intramolecular radical 1,2-alkynyl migration

A di-tert-butyl peroxide (DTBP)-promoted difunctionalization of α-aryl α-alkynyl allylic alcohols with alkyl nitriles was developed, affording a series of α-alkynyl γ-cyano functionalized ketones in moderate yields.

Graphical abstract: Cyanoalkylation/alkynylation of allylic alcohol through intramolecular radical 1,2-alkynyl migration
From the themed collection: Synthetic methodology in OBC
Communication

Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes

Assessment of the eosin Y initiated protein–protein thiol–ene reaction in a metal-free, oxygen-tolerant, visible-light mediated system.

Graphical abstract: Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes
From the themed collection: Chemical Biology in OBC
Communication

Stereocontrolled syntheses of (−)- and (+)-γ-diisoeugenol along with optically active eight stereoisomers of 7,8′-epoxy-8,7′-neolignan

It was shown that reduction of the tertiary benzylic hydroxy group of 3-furanol followed by the intramolecular Friedel–Crafts reaction gave exclusively indane structure along with 7,8′-epoxy-8,7′-neolignan structure.

Graphical abstract: Stereocontrolled syntheses of (−)- and (+)-γ-diisoeugenol along with optically active eight stereoisomers of 7,8′-epoxy-8,7′-neolignan
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed one-pot amine-alkylation of quinones with amines and alkanes

Copper-catalyzed three-component amine-alkylation of quinones with amines and alkanes.

Graphical abstract: Copper-catalyzed one-pot amine-alkylation of quinones with amines and alkanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Development and application of a high throughput assay system for the detection of Rieske dioxygenase activity

A new periodate-based reactive assay system enables the rapid evaluation of the cis-dihydroxylation activity of Rieske dioxygenase enzymes.

Graphical abstract: Development and application of a high throughput assay system for the detection of Rieske dioxygenase activity
From the themed collection: Chemical Biology in OBC
Paper

Total synthesis of cynaropicrin

The first total synthesis of the sesquiterpene lactone cynaropicrin, isolated from artichoke, was achieved starting from (S)-α-pinene. The synthesis involved a stereoselective Favorskii rearrangement and a diastereoselective Barbier reaction.

Graphical abstract: Total synthesis of cynaropicrin
From the themed collection: Total synthesis in OBC
Paper

An air-stable, Zn2+-based catalyst for hydrosilylation of alkenes and alkynes

An air-stable, Zn2+-based catalyst for catalytic hydrosilylation reactions of alkenes and alkynes.

Graphical abstract: An air-stable, Zn2+-based catalyst for hydrosilylation of alkenes and alkynes
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Formation of amidino-borate derivatives by a multi-component reaction

Amidino-borate derivatives are formed in a five-component reaction between an olefin, three arylisocyanide equivalents and the dimethyl sulfide adduct of the bulky borane (Fmes)BH2.

Graphical abstract: Formation of amidino-borate derivatives by a multi-component reaction
From the themed collection: p-Block Lewis Acids in Organic Synthesis
Open Access Paper

Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues

Chondroitin sulfate E mimetics displaying CH2OH groups instead of carboxylates retain the 3D structure and binding properties of natural sequences.

Graphical abstract: Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues
From the themed collection: Chemical Biology in OBC
Paper

Switchable regioselective hydroalkylation of 2-arylindoles with maleimides

A condition-based switchable regioselective hydroalkylation of 2-arylindoles with maleimides has been developed.

Graphical abstract: Switchable regioselective hydroalkylation of 2-arylindoles with maleimides
From the themed collection: Synthetic methodology in OBC
Open Access Paper

Direct monitoring of biocatalytic deacetylation of amino acid substrates by 1H NMR reveals fine details of substrate specificity

A convenient NMR assay was used to monitor hydrolysis of a range of N-acyl-amino acids by an acylase biocatalyst.

Graphical abstract: Direct monitoring of biocatalytic deacetylation of amino acid substrates by 1H NMR reveals fine details of substrate specificity
Paper

The effect of deoxyfluorination and O-acylation on the cytotoxicity of N-acetyl-D-gluco- and D-galactosamine hemiacetals

Multiple deoxyfluorination of GlcNAc/GalNAc hemiacetals generated cytotoxic compounds.

Graphical abstract: The effect of deoxyfluorination and O-acylation on the cytotoxicity of N-acetyl-d-gluco- and d-galactosamine hemiacetals
From the themed collection: Chemical Biology in OBC
Open Access Paper

Studies on a catalytic version of the Matteson asymmetric homologation reaction

Both Li and Yb complexes of a bis(oxazoline) ligand can induce asymmetry but the nature of Yb(OTf)3 is significant for its performance.

Graphical abstract: Studies on a catalytic version of the Matteson asymmetric homologation reaction
From the themed collection: Synthetic methodology in OBC
Paper

Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry

An Ag(I)-catalyzed synthesis of 2-amino-4-methylenethiazolines from isothiocyanate and propargylamine was developed, and its implication in bioconjugation was examined.

Graphical abstract: Ag(i)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry
From the themed collection: Catalysis & biocatalysis in OBC
Paper

HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of α-substituted homoallylamines at ambient temperature

A synthesis of α-substituted homoallylamine derivatives is presented, involving the in situ generation of aldimines from readily available aldehydes and 1,1-diphenylhomoallylamines, followed by a 2-aza-Cope rearrangement in HFIP at room temperature.

Graphical abstract: HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of α-substituted homoallylamines at ambient temperature
From the themed collection: Synthetic methodology in OBC
Paper

Mechanistic studies of Cp*Ir(III)/Cp*Rh(III)-catalyzed branch-selective allylic C–H amidation: why is Cp*Ir(III) superior to Cp*Rh(III)?

DFT mechanistic investigations uncovered the origins of the reactivity and regioselectivity of Cp*Ir(III)/Cp*Rh(III)-catalyzed allylic C–H amidation reactions.

Graphical abstract: Mechanistic studies of Cp*Ir(iii)/Cp*Rh(iii)-catalyzed branch-selective allylic C–H amidation: why is Cp*Ir(iii) superior to Cp*Rh(iii)?
Paper

Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates

Electrochemical sulfonylation/cyclization of 2-alkynylthioanisoles with sodium sulfinates was developed under catalyst-, external oxidant- and metal-free conditions.

Graphical abstract: Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates
From the themed collection: Synthetic methodology in OBC
Open Access Paper

Horeau amplification in the sequential acylative kinetic resolution of (±)-1,2-diols and (±)-1,3-diols in flow

The sequential kinetic resolution of (±)-1,2-syn and (±)-1,3-anti-diols in flow, using the polystyrene supported isothiourea, HyperBTM, gives highly enantioenriched products using the principles of Horeau amplification.

Graphical abstract: Horeau amplification in the sequential acylative kinetic resolution of (±)-1,2-diols and (±)-1,3-diols in flow
Paper

Palladium-catalyzed aerobic oxyarylthiolation of alkynone O-methyloximes with arylhydrazines and elemental sulfur

A novel and practical palladium-catalyzed aerobic oxyarylthiolation of alkynone O-methyloximes for the assembly of 4-sulfenylisoxazole derivatives is accomplished.

Graphical abstract: Palladium-catalyzed aerobic oxyarylthiolation of alkynone O-methyloximes with arylhydrazines and elemental sulfur
From the themed collection: Synthetic methodology in OBC
Paper

Pairing multicomponent stators with aromatic rotators for new emissive molecular rotors

Highly fluorescent molecular rotors sensitive to polarity changes were obtained through an Ugi–Sonogashira sequence.

Graphical abstract: Pairing multicomponent stators with aromatic rotators for new emissive molecular rotors
From the themed collection: Synthetic methodology in OBC
Paper

Oxidative alkylation/alkynylation of terminal alkenes via alkylaldehyde decarbonylation and 1,2-alkynyl migration

Alkenes and alkylaldehydes offer a general access to the challenging quaternary carbon-containing but-3-yn-1-ones through decarbonylation and 1,2-alkynyl migration.

Graphical abstract: Oxidative alkylation/alkynylation of terminal alkenes via alkylaldehyde decarbonylation and 1,2-alkynyl migration
From the themed collection: Synthetic methodology in OBC
Paper

Concise catalytic asymmetric synthesis of (R)-4-amino Uhle's ketone

An efficient asymmetric synthesis of (R)-4-amino Uhle's ketone, a framework shared by most ergot alkaloids, was completed in five steps.

Graphical abstract: Concise catalytic asymmetric synthesis of (R)-4-amino Uhle's ketone
From the themed collection: Synthetic methodology in OBC
Paper

N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones

Ethynyl benziodoxolone enabled the chemoselective N-functionalization of O-alkyl hydroxamic acids derived from amino acids and pharmaceuticals. The synthesized cis-vinyl benziodoxolone was derivatized to hydroxamic acid-derived enamides.

Graphical abstract: N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones
From the themed collection: Synthetic methodology in OBC
Paper

Photocatalyst-free visible-light-promoted quinazolinone synthesis at room temperature utilizing aldehydes generated in situ via C[double bond, length as m-dash]C bond cleavage

This is the first report on a facile tandem route for synthesizing quinazolinones at room temperature from various aminobenzamides and in situ-generated aldehydes.

Graphical abstract: Photocatalyst-free visible-light-promoted quinazolinone synthesis at room temperature utilizing aldehydes generated in situ via C [[double bond, length as m-dash]] C bond cleavage
From the themed collection: Catalysis & biocatalysis in OBC
Paper

The mass spectrometric fragmentation mechanisms of catenulane and isocatenulane diterpenes

The EI-MS fragmentation mechanisms of three diterpenes from Catenulispora acidiphila and two semisynthetic derivatives were studied in extensive 13C-labelling experiments.

Graphical abstract: The mass spectrometric fragmentation mechanisms of catenulane and isocatenulane diterpenes
Paper

Nickel-catalyzed coupling of R2P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols

α-Alkylation of methyldiarylphosphine oxides and dialkyl methylphosphonates with (hetero)arylmethyl alcohols was performed under nickel catalysis.

Graphical abstract: Nickel-catalyzed coupling of R2P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols
From the themed collection: Synthetic methodology in OBC
Paper

Construction of fully substituted carbon centers containing a heteroatom and a CF3 group via in situ generated p-quinone methides

Facile and practical construction of heteroatom as well as CF3-containing fully substituted carbon centers was realized by 1,6-conjugate additions of a variety of heteronucleophiles to in situ generated δ-CF3-δ-substituted p-quinone methides.

Graphical abstract: Construction of fully substituted carbon centers containing a heteroatom and a CF3 group via in situ generated p-quinone methides
From the themed collection: Synthetic methodology in OBC
Paper

Semisynthesis and biological evaluation of a focused library of unguinol derivatives as next-generation antibiotics

Semisynthetic unguinol derivatives showed potent activity against a panel of methicillin-resistant Staphylococcus aureus strains and are promising candidates for further development.

Graphical abstract: Semisynthesis and biological evaluation of a focused library of unguinol derivatives as next-generation antibiotics
From the themed collection: Chemical Biology in OBC
Paper

Ligand-free Suzuki–Miyaura cross-coupling with low Pd content: rapid development by a fluorescence-based high-throughput screening method

Highly efficient ligand-free Suzuki–Miyaura cross-coupling in aqueous solvent at room temperature was developed using metal oxides with low Pd content via a fluorescence-based high-throughput screening method.

Graphical abstract: Ligand-free Suzuki–Miyaura cross-coupling with low Pd content: rapid development by a fluorescence-based high-throughput screening method
From the themed collection: Catalysis & biocatalysis in OBC
Paper

A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates

A cyclic tetrapeptide paired with six commercially available indicators provides a chemosensing array able to classify biological phosphate derivatives.

Graphical abstract: A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates
Paper

A matrix targeted fluorescent probe to monitor mitochondrial dynamics

A far-red turn-on fluorescent probe (Mito-TG) with excellent biocompatibility, photostability, chemical stability targets mitochondrial matrix. The insensitivity of probe under different pH and ROS enabled tracking of mitophagy and Aβ induced mitochondrial dynamics.

Graphical abstract: A matrix targeted fluorescent probe to monitor mitochondrial dynamics
From the themed collection: Chemical Biology in OBC
Paper

Bifunctional metal–organic frameworks for the hydrogenation of nitrophenol using methanol as the hydrogen source

This work reports the reduction of 4-nitrophenol to 4-aminophenol using UiO-66(Zr) as a bifunctional photocatalyst and hydrogenation catalyst using methanol as the hydrogen source.

Graphical abstract: Bifunctional metal–organic frameworks for the hydrogenation of nitrophenol using methanol as the hydrogen source
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Paper

Kinetic and structure–activity studies of the triazolium ion-catalysed benzoin condensation

An initial rate evaluation of the triazolium-catalysed benzoin condensation permitted a Hammett structure–activity analysis providing insight into the rate-limiting step.

Graphical abstract: Kinetic and structure–activity studies of the triazolium ion-catalysed benzoin condensation
Paper

Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones

Synthesis of dynamic combinatorial libraries of acylhydrazones in the presence of a G-quadruplex DNA template, followed by pull-down with streptavidin-coated magnetic beads, allows the identification of putative G-quadruplex binders.

Graphical abstract: Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones
From the themed collection: Chemical Biology in OBC
Paper

Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: improved catalyst design and the role of in situ racemisation

A N-heterocyclic carbene catalyst incorporating a bulky yet electron-deficient N-aryl substituent promotes chemoselective and enantioselective intermolecular crossed benzoin condensations.

Graphical abstract: Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: improved catalyst design and the role of in situ racemisation
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Paper

One pot synthesis of thio-glycosides via aziridine opening reactions

thio-Glycosides with a pseudo-disaccharide structure are synthesized via aziridine opening reactions starting from glycosyl thioacetates with a one-pot protocol, which affords glycomimetics equipped for easy and stable conjugation to aglycones.

Graphical abstract: One pot synthesis of thio-glycosides via aziridine opening reactions
From the themed collection: Chemical Biology in OBC
Paper

Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii

Two rare seco-polycyclic polyprenylated acylphloroglucinols (1 and 2) were isolated from Hypericum sampsonii. Compounds 1 and 2 showed moderate multidrug resistance (MDR) reversal activity to resistant cancer cells, HepG2/ADR and MCF-7/ADR.

Graphical abstract: Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii
From the themed collection: Chemical Biology in OBC
Paper

Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation

Functionalized peptides which consist of myostatin-binding peptide and on/off-switchable catalyst efficiently inhibit myostatin by selective photooxygenation, leading to a therapeutic strategy for muscular atrophic disorders.

Graphical abstract: Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation
From the themed collection: Chemical Biology in OBC
Paper

DNAzymes for amine and peptide lysine acylation

In vitro selection identifies DNAzymes that acylate amino groups, including Lys in tethered peptides, and in some cases by transfer of a small glutaryl group.

Graphical abstract: DNAzymes for amine and peptide lysine acylation
From the themed collection: Chemical Biology in OBC
62 items

About this collection

This on-going collection features all the articles published in Organic & Biomolecular Chemistry in 2021 that were highlighted by the reviewers of these articles as being interesting or having particularly significant research.

Congratulations to all the authors whose articles are featured!


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