Development of a new microwave-assisted cleavable backbone
amide linker ( BAL): a comparative study
A thorough comparative study to demonstrate the properties of a new microwave labile backbone amide linker is presented.
The development and evaluation of a conducting matrix for the electrochemical
regeneration of the immobilised co-factor NAD(H) under continuous flow
Employing a novel conducting controlled pore glass-poly(pyrrole) material for the co-immobilisation of HLADH and NAD(H), we were able to fabricate a reagent-less flow reactor capable of the continuous biosynthesis of chiral compounds under an applied voltage.
Microwave-assisted Maillard reactions for the preparation of advanced glycation end products (AGEs)
A MW-assisted Maillard reaction in DMF showed to be a straightforward method for the preparation of pentosidine and other AGE derivatives paving the road to a plethora of challenging scientific applications.
The application of stop-flow microwave technology to scaling-out SNAr reactions using a soluble organic base
Substituted diaryl ethers have been prepared by SNAr reaction in combination with a soluble organic base, with productivities of >0.5 kg per day using an automated stop-flow microwave reactor.
Continuous flow processing from microreactors to mesoscale: the Bohlmann–Rahtz cyclodehydration reaction
Combining microwave dielectric heating and flow processing provides a reliable and robust means to transfer operations from discovery to mesoscale production, exemplified by the Bohlmann–Rahtz cyclodehydration reaction.
The application of flow microreactors to the preparation of a family of casein
kinase I inhibitors
In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes
Versatile microwave-induced reactions for the multiple functionalization of
Doubly functionalized CNTs, obtained via microwave activation, can serve as multipurpose, versatile synthons.
monoterpenes in near-critical water and supercritical alcohols assisted by microwave irradiation
The behaviour of α- and β-pinene in near-critical water and supercritical alcohols generated under closed-vessel conditions using a microwave was investigated, revealing significant differences in product distribution and reactivity.
etching: generation of highly reactive magnesium for application in Grignard reagent formation
Microwave-induced electrical discharges influence the surface and, therefore, the reactivity in Grignard reagent formation of magnesium turnings.
The continuous flow synthesis of
butane-2,3-diacetal protected building blocks using microreactors
The continuous flow syntheses of a family of butane-2,3-diacetal protected building blocks has been achieved using microreactors in concert with solid supported reagents and scavengers.
Generation and reaction of
cyano-substituted aryllithium compounds using microreactors
An effective method for the generation and reaction of aryllithium compounds bearing a cyano group has been developed using microflow systems.
On the importance of simultaneous infrared/fiber-optic temperature monitoring in the microwave-assisted synthesis of ionic liquids
Infrared sensors give erroneous temperature readings and can not be used for microwave chemistry involving ionic liquids.
About this collection
Organic & Biomolecular Chemistry's web theme issue on Enabling Technologies for Organic Synthesis is now published. The articles and an introduction from Guest Editor C. Oliver Kappe can be viewed below.
Introduction to the web theme issue by C. Oliver Kappe
Welcome to the 2010 web theme issue "Enabling Technologies for Organic Synthesis"