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Themed collection Synthetic methodology in OBC

1000 items - Showing page 1 of 15
Review Article

Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules

This review summarizes the recent developments in the asymmetric intramolecular Heck reaction and carbometallation-initiated cascade transformations including Ni-catalyzed processes with literature coverage mainly extending from 2016 to 2021.

Graphical abstract: Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules
From the themed collection: Synthetic methodology in OBC
Review Article

Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles

In this review, we describe the important advances in cycloaddition methodologies involving cyclopropanes for the construction of seven-, eight- and nine-membered carbocycles, with a particular attention to the variety of the mechanisms involved.

Graphical abstract: Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress in the nitration of arenes and alkenes

This mini review summarizes the recent advances in the regiospecific nitrations of arenes and alkenes based on the structural features of substrates.

Graphical abstract: Recent progress in the nitration of arenes and alkenes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advancements in the development of molecular organic photocatalysts

A review on the recent advances of six classes of organic photocatalysts with respect to photophysical and redox properties.

Graphical abstract: Recent advancements in the development of molecular organic photocatalysts
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress on electrochemical synthesis involving carboxylic acids

Recent progress on sustainable electrochemical synthesis involving carboxylic acids was reviewed.

Graphical abstract: Recent progress on electrochemical synthesis involving carboxylic acids
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds

From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in decarboxylative C(aryl)–X bond formation from (hetero)aryl carboxylic acids

This review highlights the recent developments in ipso-decarboxylative C–X (X = O/N/halo/S/Se/P/CN) bond formation using (hetero)aryl carboxylic acids, which are economical and environmentally benign starting materials.

Graphical abstract: Recent developments in decarboxylative C(aryl)–X bond formation from (hetero)aryl carboxylic acids
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

This review highlights recent advancement in the synthesis of 3-hydroxyisoindolinones and their applications in stereoselective transformations.

Graphical abstract: Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones
From the themed collection: Synthetic methodology in OBC
Review Article

Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles

α-Activated cyclic isothiocyanates featuring pharmacophores were efficient percusors for the enantioselective construction of intriguing spirocycles.

Graphical abstract: Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Antitumor activity of tridentate pincer and related metal complexes

Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.

Graphical abstract: Antitumor activity of tridentate pincer and related metal complexes
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Thioxanthone: a powerful photocatalyst for organic reactions

Thioxanthone is a powerful photocatalyst. In this review, its photophysical properties and its applications in photopolymerisation and in organic synthesis are highlighted.

Graphical abstract: Thioxanthone: a powerful photocatalyst for organic reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies

This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.

Graphical abstract: Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies
From the themed collection: Synthetic methodology in OBC
Review Article

Light-induced borylation: developments and mechanistic insights

This perspective delineates light-induced borylation methodologies, which have been developed in the last 10 years. Mechanistic insights have been explored throughout the article for these UV- and visible-light-induced borylation reactions.

Graphical abstract: Light-induced borylation: developments and mechanistic insights
From the themed collection: Synthetic methodology in OBC
Review Article

Selected applications of Meldrum's acid – a tutorial

The overview describes synthetic routes towards substituted Meldrum's acids and its recent applications to inspire lab veterans and chemistry younglings.

Graphical abstract: Selected applications of Meldrum's acid – a tutorial
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates

This review article describes all the significant recent developments in catalytic asymmetric umpolung reactions of imines involving a 2-azaallyl anion intermediate.

Graphical abstract: Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates
From the themed collection: Synthetic methodology in OBC
Review Article

Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis

This review summarizes the recent advancements in transition-metal (TM) catalyzed enantioselective C–H activation via kinetic resolution approach.

Graphical abstract: Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Construction of bridged polycycles through dearomatization strategies

This review summarizes the-state-of-the-art advances of dearomatization strategies in the application of bridged ring formation.

Graphical abstract: Construction of bridged polycycles through dearomatization strategies
From the themed collection: Synthetic methodology in OBC
Review Article

The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes

This article covers ring expansions of vinylaziridines and vinyloxiranes developed over the past five years for accessing stereochemically enriched heterocycles.

Graphical abstract: The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes
From the themed collection: Synthetic methodology in OBC
Review Article

Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids

The 8-azabicyclo[3.2.1]octane core is the central motif of tropane alkaloids. This review compiles the methodologies employed to synthesize this scaffold in an enantioenriched form from achiral starting materials.

Graphical abstract: Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of pyrido[1,2-a]indoles

This review deals with the different accesses leading to the pyrido[1,2-a]indole nucleus in the last 20 years.

Graphical abstract: Recent advances in the synthesis of pyrido[1,2-a]indoles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle

Azetidines represent one of the most important four-membered heterocycles in organic synthesis. We provide an overview of the synthesis, reactivity and application of azetidines with a focus on the most recent advances, trends and future directions.

Graphical abstract: Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle
From the themed collection: Synthetic methodology in OBC
Review Article

Multicomponent reactions as a potent tool for the synthesis of benzodiazepines

The present review covers all synthetic methods based on multicomponent reactions for the preparation of benzodiazepines as the parent cores of many essential drugs.

Graphical abstract: Multicomponent reactions as a potent tool for the synthesis of benzodiazepines
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones

This review highlights recent developments relating to the preparation of β-keto sulfones and β-keto thiosulfones. And, also focused on widespread synthetic applications of β-keto sulfones for assembling many valuable carbo- and heterocycles.

Graphical abstract: Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones
From the themed collection: Synthetic methodology in OBC
Review Article

Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond

The recent progress in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions is described.

Graphical abstract: Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond
From the themed collection: Synthetic methodology in OBC
Review Article

Recent approaches towards one-carbon homologation–functionalization of aldehydes

This review describes the methods of homologation and functionalization of aldehydes by one carbon unit which are the most fundamental and attractive synthetic transformations in organic synthesis.

Graphical abstract: Recent approaches towards one-carbon homologation–functionalization of aldehydes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in aminative difunctionalization of alkenes

This review summarizes recent advances in transition metal-catalyzed or metal-free aminative difunctionalization of alkenes to construct nitrogen-containing compounds.

Graphical abstract: Recent advances in aminative difunctionalization of alkenes
From the themed collection: Synthetic methodology in OBC
Review Article

Pyrrole carboxamide introduction in the total synthesis of pyrrole–imidazole alkaloids

The pyrrole carboxamide is a characteristic structural feature found in the pyrrole–imidazole (oroidin) alkaloids, the various traditional and non-tradition methods for its introduction are reviewed herein.

Graphical abstract: Pyrrole carboxamide introduction in the total synthesis of pyrrole–imidazole alkaloids
From the themed collection: Synthetic methodology in OBC
Review Article

Electrohalogenation of organic compounds

In this review we target sp, sp2 and sp3 carbon fluorination, chlorination, bromination and iodination reactions using electrolysis as a redox medium. Mechanistic insights and substrate reactivity are also discussed.

Graphical abstract: Electrohalogenation of organic compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles

The present review provides a comprehensive and updated summary of the metal-free multicomponent synthesis of biologically privileged monocyclic six membered N-heterocycles covered in the literature since 2000.

Graphical abstract: Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update

α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformations including Michael additions, domino reactions and cycloadditions.

Graphical abstract: α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Aromatic Cope rearrangements

This review summarizes the ∼40 papers dating back to 1956 on the aromatic Cope rearrangement, and highlights the need for further studies, development, and applications of this transformation in synthesis.

Graphical abstract: Aromatic Cope rearrangements
From the themed collection: Synthetic methodology in OBC
Review Article

Visible-light-induced silylation: an update

This review summarizes the recent findings and developments in the emerging area of photocatalytic silylation with literature coverage mainly extending from 2014 to February 2021.

Graphical abstract: Visible-light-induced silylation: an update
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in reactions using diacyl peroxides as sources of O- and C-functional groups

This review summarizes recent advances in reactions utilizing diacyl peroxides as O- and C-sources, with examples illustrating how the reactivity of diacyl peroxides in organic reactions can be controlled.

Graphical abstract: Recent advances in reactions using diacyl peroxides as sources of O- and C-functional groups
From the themed collection: Synthetic methodology in OBC
Review Article

Conjugated ynones in catalytic enantioselective reactions

This review summarizes the recent literature examples of catalytic asymmetric reactions of conjugated ynones and classified these reaction types, alongside their mechanistic insights whenever possible.

Graphical abstract: Conjugated ynones in catalytic enantioselective reactions
From the themed collection: Synthetic methodology in OBC
Review Article

NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds

An unique combination of MI-TBHP (M = Na, K, NH4) oxidation system has ameliorated the metal-free access to construct various chemical bonds and appeared as an impeccable synthetic manoeuvre for the construction of complex molecular frameworks.

Graphical abstract: NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds
From the themed collection: Synthetic methodology in OBC
Review Article

Recent approaches to the synthesis of tetrahydrocarbazoles

The tetrahydrocarbazole (THC) motif is ubiquitous in natural products and biologically active compounds.

Graphical abstract: Recent approaches to the synthesis of tetrahydrocarbazoles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the Rh-catalyzed cascade arene C–H bond activation/annulation toward diverse heterocyclic compounds

A review highlighting the advances in Cp*Rh(III) catalysed cascade arene C–H activation/annulation including application, scope, limitations and mechanism of these transformations.

Graphical abstract: Recent advances in the Rh-catalyzed cascade arene C–H bond activation/annulation toward diverse heterocyclic compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Metal-catalyzed C–S bond formation using sulfur surrogates

This review presents the metal-catalyzed C–S bond-formation reaction to access organosulfur compounds using various sulfur surrogates with an extended discussion on the reaction mechanism, regioselectivity of product and pharmaceutical application.

Graphical abstract: Metal-catalyzed C–S bond formation using sulfur surrogates
From the themed collection: Synthetic methodology in OBC
Review Article

Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future

Construction of C–C bonds in the absence of a catalyst and an additive by means of various name reactions including C–H functionalizations, coupling reactions and UV-visible-light-driven reactions is discussed here.

Graphical abstract: Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future
From the themed collection: Synthetic methodology in OBC
Review Article

Modern approaches towards the synthesis of geminal difluoroalkyl groups

This review will cover the importance of and most recent approaches toward geminal difluoroalkyl groups using transition metal-mediated, photochemical, organocatalytic, and other methods.

Graphical abstract: Modern approaches towards the synthesis of geminal difluoroalkyl groups
From the themed collection: Synthetic methodology in OBC
Review Article

Syntheses and medicinal chemistry of azepinoindolones: a look back to leap forward

This review emphasizes the synthetic aspects, derivatization methods of azepinoindolones and the application of this nucleus in the whole range of medicinal chemistry.

Graphical abstract: Syntheses and medicinal chemistry of azepinoindolones: a look back to leap forward
From the themed collection: Synthetic methodology in OBC
Review Article

Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons

This review provides a collective and informative discussion on the potential applications of Kobayashi's aryne precursor as a versatile building block for the synthesis of polycyclic aromatic hydrocarbons.

Graphical abstract: Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent advances in the synthesis of α-amino ketones

This review on α-amino ketone synthesis collates and evaluates developments made in this area over the past decade, with an extended discussion on functional group compatibility, resultant product substitution patterns, and medicinal applications.

Graphical abstract: Recent advances in the synthesis of α-amino ketones
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles

This review highlights the advances in the direct C(sp2)–H functionalization of cyclic aldimines, aldohydrazones, and aldonitrones since 2008.

Graphical abstract: C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes

Olefin 1,2-difunctionalization is a popular synthetic strategy for synthesis of vicinal amino alcohols and their derivatives. This comprehensive review covers methods developed beyond the pioneering osmium-catalyzed Sharpless amino hydroxylation.

Graphical abstract: Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes
From the themed collection: Synthetic methodology in OBC
Review Article

Reframing primary alkyl amines as aliphatic building blocks

This review covers recent and historical aliphatic deaminative functionalization reactions to encourage the use of primary amines as aliphatic building blocks.

Graphical abstract: Reframing primary alkyl amines as aliphatic building blocks
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances and prospects in the metal-free synthesis of quinolines

Metal-free synthesis of quinolines has recently gained attention, and this review focuses on the recent advances in the metal-free synthesis of quinolines.

Graphical abstract: Recent advances and prospects in the metal-free synthesis of quinolines
From the themed collection: Synthetic methodology in OBC
Review Article

The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles

The present review emphasizes the scope of and recent developments in the microwave-assisted synthesis of various non-(benzo)fused single-nitrogen-containing heterocycles and related applications in the past decade.

Graphical abstract: The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of organophosphorus compounds via Kobayashi's aryne precursor: a review

This review systematically summarizes the progress in aryne chemistry for the synthesis of organophosphorus compounds via aryne insertion into the C–P, P–N, P–P, P–O, P[double bond, length as m-dash]P, P[double bond, length as m-dash]N and P[double bond, length as m-dash]S bonds.

Graphical abstract: Recent advances in the synthesis of organophosphorus compounds via Kobayashi's aryne precursor: a review
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of fluorinated compounds via an aryne intermediate

In this review, the usefulness of aryne intermediates for the synthesis of various fluorinated organic compounds during the last decade has been demonstrated.

Graphical abstract: Recent advances in the synthesis of fluorinated compounds via an aryne intermediate
From the themed collection: Synthetic methodology in OBC
Review Article

An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry

Use of sulfinate derivatives as versatile coupling partners in organic chemistry.

Graphical abstract: An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry
From the themed collection: Synthetic methodology in OBC
Review Article

Transition metal-free synthesis of alkyl pinacol boronates

This review systematically outlined the research in the area of transition metal free synthesis of alkyl pinacol boronates, which are versatile and important scaffolds to construct diverse organic compounds.

Graphical abstract: Transition metal-free synthesis of alkyl pinacol boronates
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes

In this article, some representative reactions of 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes have been discussed and reviewed based on the types of substrates.

Graphical abstract: Recent advances in 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes
From the themed collection: Synthetic methodology in OBC
Review Article

The C–H functionalization of organic cations: an interesting and fresh journey

This review summarizes the substantial progress that has been made relating to the C–H functionalization of organic cations, and it covers transition-metal-enabled C–H alkylation, arylation, and photo-induced C–H functionalization.

Graphical abstract: The C–H functionalization of organic cations: an interesting and fresh journey
From the themed collection: Synthetic methodology in OBC
Review Article

Metal-free C–S coupling of thiols and disulfides

A literature overview on C–S coupling reactions using thiols or disulfides as sulfur surrogates under metal-free conditions is presented. Reagents for the transformations include polyvalent iodines, peroxides, tert-butyl nitrite (TBN), DDQ, and aerial oxygen, among others.

Graphical abstract: Metal-free C–S coupling of thiols and disulfides
From the themed collection: Synthetic methodology in OBC
Review Article

Sulfoxonium ylides: simple compounds with chameleonic reactivity

Sulfoxonium ylides, manageable compounds with an appealing safety profile, adapt to reaction partners like chameleons to their environment, resulting in a variety of useful, and sometimes surprising and unique, reactions.

Graphical abstract: Sulfoxonium ylides: simple compounds with chameleonic reactivity
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic enantioselective synthesis using carbon dioxide as a C1 synthon

This review summarizes the advances in catalytic enantioselective reactions using CO2 as a C1 synthon, introduces strategies and discusses advantages and limitations, highlights the application, and outlines the synthetic opportunities.

Graphical abstract: Catalytic enantioselective synthesis using carbon dioxide as a C1 synthon
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Syntheses and reactivity of spiro-epoxy/aziridine oxindole cores: developments in the past decade

This review highlights various reactions to afford spiro-epoxy/aziridine oxindoles and their potential synthetic transformations.

Graphical abstract: Syntheses and reactivity of spiro-epoxy/aziridine oxindole cores: developments in the past decade
From the themed collection: Synthetic methodology in OBC
Review Article

Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures

Multi-divergent transformations of cyclohexadienone derivatives for the synthesis of stereoenriched and complex architectures.

Graphical abstract: Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures
From the themed collection: Synthetic methodology in OBC
Review Article

Potassium tert-butoxide mediated C–C, C–N, C–O and C–S bond forming reactions

Potassium tertiary butoxide (KOtBu) mediated constructions of C–C, C–O, C–N, and C–S bonds are reviewed with special emphasis on their synthetic applications.

Graphical abstract: Potassium tert-butoxide mediated C–C, C–N, C–O and C–S bond forming reactions
From the themed collection: Synthetic methodology in OBC
Review Article

Photochemical methods in metathesis reactions

In this first review about photometathesis, we have gathered the relevant literature to give the reader an in-depth understanding of these fascinating reactions and to inspire future research.

Graphical abstract: Photochemical methods in metathesis reactions
From the themed collection: Synthetic methodology in OBC
Review Article

2-Activated 1,3-enynes in enantioselective synthesis

2-Activated 1,3-enyne has emerged as a versatile synthetic precursor for the construction of valuable enantioenriched molecules.

Graphical abstract: 2-Activated 1,3-enynes in enantioselective synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Trifunctionalization of alkenes and alkynes

In this review, the development of trifunctionalization methods for alkenes and alkynes, including arynes and allenes, over the last decade is disclosed.

Graphical abstract: Trifunctionalization of alkenes and alkynes
From the themed collection: Synthetic methodology in OBC
Review Article

Aldehydes: magnificent acyl equivalents for direct acylation

This review sheds light on the use of aldehydes in the selective acylation of arene, heteroarene and alkyl (sp3, sp2 and sp) C–H bonds by proficient utilization of the C–H activation strategy.

Graphical abstract: Aldehydes: magnificent acyl equivalents for direct acylation
From the themed collection: Synthetic methodology in OBC
Review Article

Ammonia borane as a reducing agent in organic synthesis

Ammonia borane is gaining increasing attention as a sustainable and atom-economical winning reagent for the reduction of several substrates.

Graphical abstract: Ammonia borane as a reducing agent in organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Organic synthesis of fixed CO2 using nitrogen as a nucleophilic center

With nitrogen as the nucleophilic center, CO2 is fixed by using metal catalysis, non-metal catalysis, photocatalysis and electrocatalysis.

Graphical abstract: Organic synthesis of fixed CO2 using nitrogen as a nucleophilic center
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in cobalt-catalyzed allylic functionalization

Recent advances in cobalt-catalyzed allylic functionalization including allylic substitution, nucleophilic allylation, and Heck-type allylic functionalization are highlighted.

Graphical abstract: Recent advances in cobalt-catalyzed allylic functionalization
From the themed collection: Synthetic methodology in OBC
Review Article

C-Alkylation of alkali metal carbanions with olefins

C-Alkylations of alkali metal carbanions with olefins, first reported five decades ago, is undergoing a resurgence in organic synthesis. A historical perspective, contemporary applications and developing mechanistic understanding are presented.

Graphical abstract: C-Alkylation of alkali metal carbanions with olefins
From the themed collection: Synthetic methodology in OBC
Review Article

Cobalt-catalyzed carbonylation of the C–H bond

Direct carbonylation of the C–H bond is a great tool for installing a carbonyl group in a wide variety of substrates.

Graphical abstract: Cobalt-catalyzed carbonylation of the C–H bond
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis

Five-membered ring cyclic sulfamidate imines (5H-1,2,3-oxathiazole 2,2-dioxides) have received increasing attention as useful precursors for the synthesis of many valuable heterocycles. This review highlights recent developments in this area.

Graphical abstract: Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis
From the themed collection: Synthetic methodology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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