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Themed collection Synthetic methodology in OBC

577 items - Showing page 1 of 9
Review Article

Recent advances in metal-free aerobic C–H activation

An overview of recent reactions based on the metal-free, dioxygen-induced, C–H activation of various radical precursors.

Graphical abstract: Recent advances in metal-free aerobic C–H activation
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of C2-spiropseudoindoxyls

This review summarizes the recent development of novel approaches to construct structurally unique oxindoles featuring a spirocycle at the C2 position.

Graphical abstract: Recent advances in the synthesis of C2-spiropseudoindoxyls
From the themed collection: Synthetic methodology in OBC
Review Article

Use of ArSO2SRf reagents: an efficient tool for the introduction of SRf moieties

This review discusses the use of several ArSO2SRf reagents as SRf sources, an emerging trend to access SRf-containing molecules.

Graphical abstract: Use of ArSO2SRf reagents: an efficient tool for the introduction of SRf moieties
From the themed collection: Synthetic methodology in OBC
Review Article

Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

Intermolecular alkene difunctionalizations for the direct synthesis of saturated heterocycles.

Graphical abstract: Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity

Diversity-oriented synthesis adds biological performance as a new diversity element.

Graphical abstract: Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis.

Graphical abstract: Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals
From the themed collection: Synthetic methodology in OBC
Review Article

Applications of N′-monofunctionalised TsDPEN derivatives in asymmetric catalysis

N′-Monoalkylated or N′-mono(thio)acylated(N-sulfonyl)-1,2-diphenylethylene-1,2-diamine (TsDPEN) derivatives are have found extensive applications in asymmetric catalysis of a wide range of synthetic applications.

Graphical abstract: Applications of N′-monofunctionalised TsDPEN derivatives in asymmetric catalysis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in transition metal-catalyzed C(sp2)–H nitration

This review updates advances of direct C(sp2)–H nitration for the synthesis of nitroaromatic compounds and the mechanisms during the past decade.

Graphical abstract: Recent advances in transition metal-catalyzed C(sp2)–H nitration
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

SuperQuat chiral auxiliaries: design, synthesis, and utility

The design, synthesis and outline of some of the most common synthetic applications of the SuperQuat (4-substituted 5,5-dimethyloxazolidine-2-one) family of chiral auxiliaries, developed to address the shortcomings of the Evans (4-substituted oxazolidin-2-one) family of chiral auxiliaries, are presented.

Graphical abstract: SuperQuat chiral auxiliaries: design, synthesis, and utility
From the themed collection: Synthetic methodology in OBC
Review Article

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

This review article provides a summary of the detrifluoroacetylative in situ generation of fluorine-containing enolates and their related reactions.

Graphical abstract: Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates
From the themed collection: Synthetic methodology in OBC
Review Article

N-Alkyl amide synthesis via N-alkylation of amides with alcohols

The present review summarizes the recent development of N-alkylation of amides with alcohols according to the classification of catalysts.

Graphical abstract: N-Alkyl amide synthesis via N-alkylation of amides with alcohols
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in photochemical reactions of diazo compounds

Chemistry of diazo compounds is dominated by transition metal catalysis but recently, photoinitiated reactions of diazo compounds have attracted a lot of attention. This mini-review describes recent discoveries on the reactivity of diazo compounds under light irradiation.

Graphical abstract: Recent developments in photochemical reactions of diazo compounds
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles

In this review, cascade reaction based synthesis strategies delivering biologically intriguing indole polycycles are presented.

Graphical abstract: Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles
From the themed collection: Synthetic methodology in OBC
Review Article

Non-toxic cyanide sources and cyanating agents

This review focuses on alternative cyanide sources and cyanating agents which are less hazardous than HCN or its salts.

Graphical abstract: Non-toxic cyanide sources and cyanating agents
From the themed collection: Synthetic methodology in OBC
Review Article

Recent methods for the synthesis of α-acyloxy ketones

The present review provides a broad description of the methods reported for the synthesis of α-acyloxy ketones and some of their derivatives.

Graphical abstract: Recent methods for the synthesis of α-acyloxy ketones
From the themed collection: Synthetic methodology in OBC
Review Article

Synthetic manipulations of polyunsaturated fatty acids as a convenient strategy for the synthesis of bioactive compounds

The utilization of commercial polyunsaturated fatty acids in semi-syntheses of polyunsaturated natural products and derivatives has been reviewed.

Graphical abstract: Synthetic manipulations of polyunsaturated fatty acids as a convenient strategy for the synthesis of bioactive compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Multicomponent reactions: a sustainable tool to 1,2- and 1,3-azoles

The present review outlines the recent advancements and pioneering efforts on the synthesis of 1,2/1,3-azoles employing a multicomponent strategy.

Graphical abstract: Multicomponent reactions: a sustainable tool to 1,2- and 1,3-azoles
From the themed collection: Synthetic methodology in OBC
Review Article

Donor- and acceptor-enynals/enynones

Three kinds of transformations based on benzo-fused donor- and acceptor-enynals/enynones, including reactions with alkenes, alkynes, and H2O, were discussed.

Graphical abstract: Donor- and acceptor-enynals/enynones
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Cascade reactions involving a catalytic carbene/alkyne metathesis (CAM) process through a vinyl carbene intermediate provide an efficient and step-economic approach for the construction of polycyclic frameworks with structural diversity.

Graphical abstract: Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic dehydrogenative aromatization of cyclohexanones and cyclohexenones

Prompted by the scant attention paid by published literature reviews to the comprehensive catalytic dehydrogenative aromatization of cyclohexa(e)nones, this review describes recent methods developed to-date involving transition-metal-catalyzed oxidative aromatization and metal-free strategies for the transformation of cyclohexa(e)nones to substituted phenols.

Graphical abstract: Catalytic dehydrogenative aromatization of cyclohexanones and cyclohexenones
From the themed collection: Synthetic methodology in OBC
Review Article

Decarbonylative cross-coupling of amides

We present recent advances and key developments in the field of decarbonylative cross-coupling reactions of amides by a formal double N–C/C–C bond activation as well as discuss future challenges and potential applications for this exciting field.

Graphical abstract: Decarbonylative cross-coupling of amides
From the themed collection: Synthetic methodology in OBC
Review Article

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

This Review article provides a summary and critical metrics-based analysis of recently developed catalytic Mitsunobu reactions.

Graphical abstract: The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Recent progress in the synthesis of phosphorus-containing indole derivatives

Phosphorus-containing indole derivatives represent a special class of phosphorus-containing nitrogen heterocycles. This review summarizes the recent progress in the synthesis of such compounds, briefly discusses the reaction mechanisms and challenges, and outlines the synthetic opportunities still open.

Graphical abstract: Recent progress in the synthesis of phosphorus-containing indole derivatives
From the themed collection: Synthetic methodology in OBC
Review Article

Cyclic imines – preparation and application in synthesis

Cyclic imines, available from various nitrogen-containing reactants, serve as versatile synthetic intermediates for biologically active compounds.

Graphical abstract: Cyclic imines – preparation and application in synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of cyclopropanes

Cyclopropanes have gained much attention by virtue of their interesting structure and unique reactivity. This review discusses the recent advances in the synthesis of cyclopropanes, and some of the related applications will be discussed.

Graphical abstract: Recent advances in the synthesis of cyclopropanes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments and applications of cyanamides in electrophilic cyanation

This review summarizes the recent developments and applications of readily accessible cyanamides in the electrophilic cyanation of various nucleophiles.

Graphical abstract: Recent developments and applications of cyanamides in electrophilic cyanation
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in functionalization of acyclic α-keto amides

This review describes the synthetic utility of α-keto amides to synthesize various important molecules via mono, dual and triple functionalization reactions.

Graphical abstract: Recent developments in functionalization of acyclic α-keto amides
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in β-lactam synthesis

During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis.

Graphical abstract: Recent advances in β-lactam synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

Recent synthetic applications and methodological advancements of the Pd(II)-catalyzed C2 functionalisation of indoles are highlighted and discussed in this review.

Graphical abstract: C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the annulation of Morita–Baylis–Hillman adducts

In this review, we summarize some of the most recent advances in the construction of cyclic compounds from the annulation of Morita–Baylis–Hillman (MBH) adducts, which have demonstrated their importance by possessing diverse functional groups.

Graphical abstract: Recent advances in the annulation of Morita–Baylis–Hillman adducts
From the themed collection: Synthetic methodology in OBC
Review Article

Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant

This review is focused on recent developments in the use of small organic molecules as photocatalysts.

Graphical abstract: Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant
From the themed collection: Synthetic methodology in OBC
Review Article

Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation

This review describes recent developments in the use of catalytic transient directing groups, through imine linkages, which in combination with transition metal catalysts provide streamlined C–H functionalisation processes.

Graphical abstract: Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation
From the themed collection: Synthetic methodology in OBC
Review Article

Copper nitrate: a privileged reagent for organic synthesis

This review demonstrates the state-of-the-art applications of copper nitrate as a nitration reagent, oxidant, catalyst, promoter and precursor of nitrile oxides.

Graphical abstract: Copper nitrate: a privileged reagent for organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of polyheterocycles via multicomponent reactions

Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields.

Graphical abstract: Synthesis of polyheterocycles via multicomponent reactions
From the themed collection: Synthetic methodology in OBC
Review Article

C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process

This review is focused on the recent advances in the C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process. Diverse substituted hydrazones including N-heterocycles are afforded under mild conditions with excellent selectivities. In general, an aminyl radical as the key intermediate is involved during the reaction process.

Graphical abstract: C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process
From the themed collection: Synthetic methodology in OBC
Review Article

Nitrilium ions – synthesis and applications

Access to both stable and transient nitrilium ions and the use of these synthons in the organic synthesis of imines and a large spectrum of heterocycles and transition metal complexes are succinctly summarized.

Graphical abstract: Nitrilium ions – synthesis and applications
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Thiosquaramide-catalysed Asymmetric Double Michael Addition of 2-(3H)-Furanone to Nitroolefines

From the themed collection: Synthetic methodology in OBC
Communication

tert-Butyl nitrite-mediated radical cyclization of tetrazole amines and alkynes toward tetrazolo[1,5-a]quinolines

A general and efficient radical cyclization of 1H-tetrazol-5-amines and alkynes toward tetrazolo[1,5-a]quinolines is established for the first time.

Graphical abstract: tert-Butyl nitrite-mediated radical cyclization of tetrazole amines and alkynes toward tetrazolo[1,5-a]quinolines
From the themed collection: Synthetic methodology in OBC
Communication

α,β-Unsaturated butenolides in an organocatalytic doubly annulative cascade for the preparation of 3,4-dihydrocoumarins

An organocatalytic doubly annulative cascade utilizing α,β-unsaturated butenolides and imines (derived from salicyl aldehydes and α-amino-γ-lactones) as starting materials is described.

Graphical abstract: α,β-Unsaturated butenolides in an organocatalytic doubly annulative cascade for the preparation of 3,4-dihydrocoumarins
From the themed collection: Synthetic methodology in OBC
Communication

Indium- and zinc-catalyzed enantioselective amide propargylation of aldehydes with stannylated allenyl amides

A highly enantioselective allylation of aldehydes with newly prepared stannyl allenyl amides has been achieved using catalytic amounts of InCl3, ZnCl2 and a BINOL derivative.

Graphical abstract: Indium- and zinc-catalyzed enantioselective amide propargylation of aldehydes with stannylated allenyl amides
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

A convenient and operationally simple protocol for the synthesis of quinazolin-4(1H)-one derivatives has been developed via amination and annulation of amidines and benzamides.

Graphical abstract: Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of α-arylthioacetones using TEMPO as the C3 synthon via a reaction cascade of sequential oxidation, skeletal rearrangement and C–S bond formation

Here, we present an unprecedented pathway to α-arythioacetones from commercially available thiols and universally employed TEMPO and its analogues.

Graphical abstract: Synthesis of α-arylthioacetones using TEMPO as the C3 synthon via a reaction cascade of sequential oxidation, skeletal rearrangement and C–S bond formation
From the themed collection: Synthetic methodology in OBC
Communication

Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling.

Graphical abstract: Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Photoinduced decarboxylative azidation of cyclic amino acids

The direct decarboxylative azidation of cyclic α-amino acids has been achieved via visible light-mediated organo-photoredox catalysis.

Graphical abstract: Photoinduced decarboxylative azidation of cyclic amino acids
From the themed collection: Synthetic methodology in OBC
Communication

Formal [4 + 2] benzannulation of 2-alkenyl indoles with aldehydes: a route to structurally diverse carbazoles and bis-carbazoles

Construction of structurally diverse carbazoles and bis-carbazoles by protecting-group-free formal [4 + 2]-benzannulation of 2-alkenyl indoles and aldehydes is demonstrated.

Graphical abstract: Formal [4 + 2] benzannulation of 2-alkenyl indoles with aldehydes: a route to structurally diverse carbazoles and bis-carbazoles
From the themed collection: Synthetic methodology in OBC
Communication

Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling

An alternative protocol for the B-alkyl Suzuki–Miyaura reaction to produce cyclic α,β-disubstituted enones is reported.

Graphical abstract: Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling
From the themed collection: Synthetic methodology in OBC
Communication

An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters.

Graphical abstract: An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis
From the themed collection: Synthetic methodology in OBC
Communication

Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

Direct arylation and heteroarylation of unprotected tetrahydroisoquinolines were achieved under conditions free of metals, oxidants and solvents.

Graphical abstract: Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction
From the themed collection: Synthetic methodology in OBC
Communication

Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides

An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using N-aromatic zwitterions, aldehydes, and amino acids.

Graphical abstract: Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of fluoroalkylated alkynes via visible-light photocatalysis

Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis.

Graphical abstract: Synthesis of fluoroalkylated alkynes via visible-light photocatalysis
From the themed collection: Synthetic methodology in OBC
Communication

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. Various chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities.

Graphical abstract: Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines
From the themed collection: Synthetic methodology in OBC
Communication

Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues

A one-pot oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters at room temperature is reported.

Graphical abstract: Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Robust Buchwald–Hartwig amination enabled by ball-milling

An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system.

Graphical abstract: Robust Buchwald–Hartwig amination enabled by ball-milling
From the themed collection: Synthetic methodology in OBC
Communication

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

The first regioselective MBH-type α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved using diarylcarbinols with an excellent E/Z selectivity under mild reaction conditions.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Efficient two-step synthesis of structurally diverse indolo[2,3-b]quinoline derivatives

A general and efficient synthesis of tetracyclic indolo[2,3-b]quinoline motifs with diverse functional groups is achieved through a simple but conceptually different annulation strategy in excellent yields.

Graphical abstract: Efficient two-step synthesis of structurally diverse indolo[2,3-b]quinoline derivatives
From the themed collection: Synthetic methodology in OBC
Communication

An atom efficient synthesis of tamoxifen

A highly selective and atom efficient synthesis of triarylethylenes.

Graphical abstract: An atom efficient synthesis of tamoxifen
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection

Photochemical benzylic bromination in flow using BrCCl3, which is compatible with electron-rich aromatics, allowing in situ p-methoxybenzyl bromide formation and PMB-protection.

Graphical abstract: Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection
From the themed collection: Synthetic methodology in OBC
Communication

Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S–H/N–H

The synthesis of sulfenamides via the oxidant- and metal-free electrochemical dehydrogenative coupling reaction of thiols and amines.

Graphical abstract: Scalable electrochemical oxidant-and metal-free dehydrogenative coupling of S–H/N–H
From the themed collection: Synthetic methodology in OBC
Communication

Silver-mediated oxidative C–C bond sulfonylation/arylation of methylenecyclopropanes with sodium sulfinates: facile access to 3-sulfonyl-1,2-dihydronaphthalenes

The novel AgNO3-mediated sulfonylation/arylation of a C–C σ-bond in MCPs with sodium sulfinates to synthesize 3-sulfonylated 1,2-dihydronaphthalenes is reported.

Graphical abstract: Silver-mediated oxidative C–C bond sulfonylation/arylation of methylenecyclopropanes with sodium sulfinates: facile access to 3-sulfonyl-1,2-dihydronaphthalenes
From the themed collection: Synthetic methodology in OBC
Communication

Oxidative C(sp3)–H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines

An oxidative [4 + 1] annulation for triazolo[4,3-a]pyridine–quinoline linked diheterocycle synthesis via functionalization of the sp3 C–H bonds of 2-methyl-azaheteroarenes has been developed.

Graphical abstract: Oxidative C(sp3)–H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines
From the themed collection: Synthetic methodology in OBC
Communication

Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane

An enantioselective synthesis of the non-proteinogenic amino acid (R)-2-cubylglycine and the first examples of cubane C–H insertion are reported.

Graphical abstract: Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane
From the themed collection: Synthetic methodology in OBC
Communication

Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents

We report an efficient and highly diastereoselective protocol for the rapid construction of 3-nitro substituted 4-chromanones by an intramolecular Michael-type cyclization of α-nitro aryl ketones bearing unsaturated ester units.

Graphical abstract: Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents
From the themed collection: Synthetic methodology in OBC
Communication

Facile amidinations of 2-aminophenylboronic acid promoted by boronate ester formation

Amidine synthesis by amine addition to nitriles normally requires high temperatures or harsh catalysts.

Graphical abstract: Facile amidinations of 2-aminophenylboronic acid promoted by boronate ester formation
From the themed collection: Synthetic methodology in OBC
Communication

Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

A convenient base-promoted cascade benzannulation reaction of allenic ketones with indole derivatives has been established.

Graphical abstract: Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles
From the themed collection: Synthetic methodology in OBC
Communication

Silver or cerium-promoted free radical cascade difunctionalization of o-vinylanilides with sodium aryl- or alkylsulfinates

An efficient cascade oxysulfonylation of o-vinylanilides with sodium aryl- or alkylsulfinates was developed for the synthesis of sulfonated benzoxazines.

Graphical abstract: Silver or cerium-promoted free radical cascade difunctionalization of o-vinylanilides with sodium aryl- or alkylsulfinates
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of 1,3-disubstituted cyclohexenes from dienylethers via sequential hydrozirconation/deoxygenative cyclisation

The preparation of 1,3-disubstituted cyclohexenes from 3-methoxyhexa-1,5-dienes involving a sequential hydrozirconation/TMSOTf-mediated activation is described.

Graphical abstract: Synthesis of 1,3-disubstituted cyclohexenes from dienylethers via sequential hydrozirconation/deoxygenative cyclisation
From the themed collection: Synthetic methodology in OBC
Communication

The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor

A fast and green Michael addition based protocol in a continuous flow microreactor was developed, an innovation which may open up the use of enzymatic microreactors in imidazole analogue biotransformations.

Graphical abstract: The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor
From the themed collection: Synthetic methodology in OBC
Communication

Visible-light-promoted oxidation/condensation of benzyl alcohols with dialkylacetamides to cinnamides

An oxidative cross-coupling reaction of benzyl alcohols with dialkylacetamides was developed to construct cinnamides under visible-light-enabled photocatalytic conditions.

Graphical abstract: Visible-light-promoted oxidation/condensation of benzyl alcohols with dialkylacetamides to cinnamides
From the themed collection: Synthetic methodology in OBC
Communication

I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources.

Graphical abstract: I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles
From the themed collection: Synthetic methodology in OBC
Communication

Cross 1,3-dipolar cycloadditions of C,N-cyclic azomethine imines with an N-benzyl azomethine ylide: facile access to fused tricyclic 1,2,4-hexahydrotriazines

A cross 1,3-dipolar cycloaddition of two different ylides between C,N-cyclic azomethine imines with an in situ generated non-stabilized azomethine ylide from an N-benzyl precursor is reported.

Graphical abstract: Cross 1,3-dipolar cycloadditions of C,N-cyclic azomethine imines with an N-benzyl azomethine ylide: facile access to fused tricyclic 1,2,4-hexahydrotriazines
From the themed collection: Synthetic methodology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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