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Themed collection Synthetic methodology in OBC

382 items - Showing page 1 of 6
Review Article

Decarbonylative cross-coupling of amides

We present recent advances and key developments in the field of decarbonylative cross-coupling reactions of amides by a formal double N–C/C–C bond activation as well as discuss future challenges and potential applications for this exciting field.

Graphical abstract: Decarbonylative cross-coupling of amides
From the themed collection: Synthetic methodology in OBC
Review Article

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

This Review article provides a summary and critical metrics-based analysis of recently developed catalytic Mitsunobu reactions.

Graphical abstract: The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments and applications of cyanamides in electrophilic cyanation

This review summarizes the recent developments and applications of readily accessible cyanamides in the electrophilic cyanation of various nucleophiles.

Graphical abstract: Recent developments and applications of cyanamides in electrophilic cyanation
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in functionalization of acyclic α-keto amides

This review describes the synthetic utility of α-keto amides to synthesize various important molecules via mono, dual and triple functionalization reactions.

Graphical abstract: Recent developments in functionalization of acyclic α-keto amides
From the themed collection: Synthetic methodology in OBC
Review Article

Non-toxic cyanide sources and cyanating agents

This review focuses on alternative cyanide sources and cyanating agents which are less hazardous than HCN or its salts.

Graphical abstract: Non-toxic cyanide sources and cyanating agents
From the themed collection: Synthetic methodology in OBC
Review Article

Recent progress in the synthesis of phosphorus-containing indole derivatives

Phosphorus-containing indole derivatives represent a special class of phosphorus-containing nitrogen heterocycles. This review summarizes the recent progress in the synthesis of such compounds, briefly discusses the reaction mechanisms and challenges, and outlines the synthetic opportunities still open.

Graphical abstract: Recent progress in the synthesis of phosphorus-containing indole derivatives
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in β-lactam synthesis

During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis.

Graphical abstract: Recent advances in β-lactam synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Cyclic imines – preparation and application in synthesis

Cyclic imines, available from various nitrogen-containing reactants, serve as versatile synthetic intermediates for biologically active compounds.

Graphical abstract: Cyclic imines – preparation and application in synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of cyclopropanes

Cyclopropanes have gained much attention by virtue of their interesting structure and unique reactivity. This review discusses the recent advances in the synthesis of cyclopropanes, and some of the related applications will be discussed.

Graphical abstract: Recent advances in the synthesis of cyclopropanes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis.

Graphical abstract: Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals
From the themed collection: New Talent
Review Article

C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

Recent synthetic applications and methodological advancements of the Pd(II)-catalyzed C2 functionalisation of indoles are highlighted and discussed in this review.

Graphical abstract: C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the annulation of Morita–Baylis–Hillman adducts

In this review, we summarize some of the most recent advances in the construction of cyclic compounds from the annulation of Morita–Baylis–Hillman (MBH) adducts, which have demonstrated their importance by possessing diverse functional groups.

Graphical abstract: Recent advances in the annulation of Morita–Baylis–Hillman adducts
From the themed collection: Synthetic methodology in OBC
Review Article

Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant

This review is focused on recent developments in the use of small organic molecules as photocatalysts.

Graphical abstract: Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant
From the themed collection: Synthetic methodology in OBC
Review Article

Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation

This review describes recent developments in the use of catalytic transient directing groups, through imine linkages, which in combination with transition metal catalysts provide streamlined C–H functionalisation processes.

Graphical abstract: Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation
From the themed collection: Synthetic methodology in OBC
Review Article

Copper nitrate: a privileged reagent for organic synthesis

This review demonstrates the state-of-the-art applications of copper nitrate as a nitration reagent, oxidant, catalyst, promoter and precursor of nitrile oxides.

Graphical abstract: Copper nitrate: a privileged reagent for organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of polyheterocycles via multicomponent reactions

Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields.

Graphical abstract: Synthesis of polyheterocycles via multicomponent reactions
From the themed collection: Synthetic methodology in OBC
Review Article

C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process

This review is focused on the recent advances in the C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process. Diverse substituted hydrazones including N-heterocycles are afforded under mild conditions with excellent selectivities. In general, an aminyl radical as the key intermediate is involved during the reaction process.

Graphical abstract: C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process
From the themed collection: Synthetic methodology in OBC
Review Article

Nitrilium ions – synthesis and applications

Access to both stable and transient nitrilium ions and the use of these synthons in the organic synthesis of imines and a large spectrum of heterocycles and transition metal complexes are succinctly summarized.

Graphical abstract: Nitrilium ions – synthesis and applications
From the themed collection: Synthetic methodology in OBC
Communication

Iron(III)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines

A Fe-catalyzed highly regioselective α,β-difunctionalization of vinylarenes with diphenylphosphine oxides and anilines is disclosed, in which α,β-aminophosphinoylation is efficiently and conveniently constructed with good functional compatibility and a broad substrate scope.

Graphical abstract: Iron(iii)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines
From the themed collection: Catalysis & biocatalysis in OBC
Accepted Manuscript - Communication

KHMDS Mediated Synthesis of 9-Arylfluorenes from Dibenzothiophene dioxides and Arylacetonitriles by Tandem SNAr-Decyanation-Based Arylation

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Copper-catalyzed synthesis of 2-acylbenzo[b]thiophenes from 3-(2-iodophenyl)-1-arylpropan-1-ones and potassium sulfide under aerobic conditions

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Efficient Assembly of Hydantoins via a [3+2] Annulation Involving Azaoxyallyl Cations

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Regioselective [3+2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Metal-free KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins using Bunte salts

From the themed collection: Synthetic methodology in OBC
Communication

Atom-economic synthesis of cyclobuta[a]naphthalen-4-ols via a base-promoted [2 + 2] cycloaddition/1,6-nucleophilic addition cascade

An atom-economic [2 + 2] cycloaddition cascade of yne-allenones with C-nucleophiles has been established, enabling the direct generation of functionalized cyclobuta[a]naphthalen-4-ols with generally good yields.

Graphical abstract: Atom-economic synthesis of cyclobuta[a]naphthalen-4-ols via a base-promoted [2 + 2] cycloaddition/1,6-nucleophilic addition cascade
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free visible-light synthesis of quaternary α-perfluoroalkyl aldehydes via an enamine intermediate

Visible-light induced perfluoroalkylation of the α-position of aldehydes via enamines.

Graphical abstract: Metal-free visible-light synthesis of quaternary α-perfluoroalkyl aldehydes via an enamine intermediate
From the themed collection: Synthetic methodology in OBC
Communication

Dimethylamine adducts of allylic triorganoboranes as effective reagents for Petasis-type homoallylation of primary amines with formaldehyde

A mild method of Petasis-type homoallylation of NH3 and amines with CH2O aq. and Me2NH adducts of allylic triorganoboranes has elaborated.

Graphical abstract: Dimethylamine adducts of allylic triorganoboranes as effective reagents for Petasis-type homoallylation of primary amines with formaldehyde
From the themed collection: Synthetic methodology in OBC
Communication

Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization

An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically important spirocyclic tetrahydroquinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization.

Graphical abstract: Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization
From the themed collection: Synthetic methodology in OBC
Communication

Facile synthesis of triphenylenes and triphenylene/phenanthrene fused heteroaromatics

Facile synthesis of triphenylene fused imidazoles, quinoxaline and phenanthro[9,10-d]-fused pyrazines via CAN-mediated oxidative cyclodehydrogenation.

Graphical abstract: Facile synthesis of triphenylenes and triphenylene/phenanthrene fused heteroaromatics
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

A cascade synthesis of S-allyl benzoylcarbamothioates via Mumm-type rearrangement

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Four-component acyloxy-trifluoromethylation of arylalkenes mediated by photoredox catalyst

From the themed collection: Synthetic methodology in OBC
Communication

C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor

C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and other pharmaceutically-relevant scaffolds in excellent mass balance.

Graphical abstract: C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor
From the themed collection: Synthetic methodology in OBC
Communication

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed.

Graphical abstract: Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

New Friedel-Crafts strategy of preparing 3-acylindoles

From the themed collection: Synthetic methodology in OBC
Communication

Biomimetic synthesis of the bisindole framework present in sciodole, an alkaloid from Tricholoma sciodes

The unique bisindole bond present in the alkaloid sciodole can be forged by amination of an azafulvene, validating a biosynthetic hypothesis.

Graphical abstract: Biomimetic synthesis of the bisindole framework present in sciodole, an alkaloid from Tricholoma sciodes
From the themed collection: Synthetic methodology in OBC
Communication

Rhodium(III)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation

An efficient procedure for 6H-benzo[c]chromenes via a new Rh(III)-catalyzed domino annulation is described.

Graphical abstract: Rhodium(iii)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation
From the themed collection: Synthetic methodology in OBC
Communication

Metal- and base-free synthesis of functionalized α,α-difluoroimines via electrophilic fluorination of N-substituted enamines

A metal- and base-free synthesis of functionalized α,α-difluoroimines is presented. The reaction features mild condition, high E/Z control and broad functional group tolerance. The utility of the products was demonstrated through valuable synthetic transformations.

Graphical abstract: Metal- and base-free synthesis of functionalized α,α-difluoroimines via electrophilic fluorination of N-substituted enamines
From the themed collection: Synthetic methodology in OBC
Communication

Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation

An efficient synthesis of 2,5-disubstituted tetrazoles was developed via three-component hemiaminal silylation of 5-substituted tetrazoles, aldehydes, and silyl triflates.

Graphical abstract: Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation
From the themed collection: Synthetic methodology in OBC
Communication

Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

A novel and efficient fast synthesis of 3-amino isocoumarins in good to excellent yields is reported.

Graphical abstract: Rapid synthesis of 3-amino isocoumarin derivatives from ynamides
From the themed collection: Synthetic methodology in OBC
Communication

An efficient synthesis of triazolium ion based NHC precursors using diaryliodonium salts and their photophysical properties

Triazolium salts were prepared by copper-catalyzed N-arylation of fused triazoles using diaryliodonium salts. These salts could behave as versatile NHC catalysts and fluorescent probes.

Graphical abstract: An efficient synthesis of triazolium ion based NHC precursors using diaryliodonium salts and their photophysical properties
From the themed collection: Synthetic methodology in OBC
Communication

Cp*Co(III)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Cp*Co(III)-catalysed selective alkylation of directed C–H bonds of arenes and heteroarenes has been accomplished employing donor–acceptor carbenes, derived from α-diazocarbonyl compounds.

Graphical abstract: Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

Substituted 2-aminophenyl benzothiazoles have been constructed from thiourea via copper-catalyzed desulfurization/nucleophilic substitution followed by domino intra- and intermolecular C–N cross-coupling reactions under moderate reaction conditions.

Graphical abstract: Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach
From the themed collection: Synthetic methodology in OBC
Communication

Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

Synthesis of S-thiocarbamates by employing simple and readily available precursors under mild reaction conditions with good to excellent yields.

Graphical abstract: Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates
From the themed collection: Synthetic methodology in OBC
Communication

Thio-Michael addition of thioamides and allenes for the selective construction of polysubstituted 2-arylthiophenes via TBAI/H2O2 promoted tandem oxidative annulation and 1,2-sulfur migration

TBAI/H2O2 promoted tandem thio-Michael addition/oxidative annulation and the 1,2-sulfur migration transformation protocol to construct polysubstituted 2-arylthiophenes.

Graphical abstract: Thio-Michael addition of thioamides and allenes for the selective construction of polysubstituted 2-arylthiophenes via TBAI/H2O2 promoted tandem oxidative annulation and 1,2-sulfur migration
From the themed collection: Synthetic methodology in OBC
Communication

Preparation of homoallylic amines via a three-component coupling process

A three-component synthesis of homoallylic amines is described.

Graphical abstract: Preparation of homoallylic amines via a three-component coupling process
From the themed collection: Synthetic methodology in OBC
Communication

Phosphine-mediated partial reduction of alkynes to form both (E)- and (Z)-alkenes

A mild, tunable method to form both (E)- and (Z)-alkenes from alkynes is reported using PPh3 as a reductant.

Graphical abstract: Phosphine-mediated partial reduction of alkynes to form both (E)- and (Z)-alkenes
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed C–N bond formation with imidazo[1,2-a]pyridines

An efficient Cu-catalyzed C–N bond formation with imidazo[1,2-a]pyridines on the C-3 position via a radical pathway is reported.

Graphical abstract: Copper-catalyzed C–N bond formation with imidazo[1,2-a]pyridines
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of functionalized 2,5-dihydropyrrole derivatives via a convenient [3 + 2] annulation of azomethine ylides with allenoates

A convenient [3 + 2] annulation of azomethine ylides with allenoates to synthesize highly functionalized 2,5-dihydropyrrole derivatives was developed.

Graphical abstract: Synthesis of functionalized 2,5-dihydropyrrole derivatives via a convenient [3 + 2] annulation of azomethine ylides with allenoates
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure

A general method for the synthesis of chiral pentacyclic spirooxindoles containing a tetrahydropyrano[2,3-b]indole scaffold through a one-pot stepwise sequence is reported.

Graphical abstract: Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure
From the themed collection: Synthetic methodology in OBC
Communication

Robust Buchwald–Hartwig amination enabled by ball-milling

An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system.

Graphical abstract: Robust Buchwald–Hartwig amination enabled by ball-milling
From the themed collection: New Talent
Communication

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

The first regioselective MBH-type α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved using diarylcarbinols with an excellent E/Z selectivity under mild reaction conditions.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

A nickel catalyzed C–H bond functionalization reaction has been used for the first time to study an intramolecular site-selective C–S bond formation of arenes.

Graphical abstract: Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Thermally-induced intramolecular [2 + 2] cycloaddition of acrylamide-tethered alkylidenecyclopropanes

Thermally-induced intramolecular [2 + 2] cycloadditions of acrylamide-tethered alkylidenecyclopropanes to generate a series of novel cyclobutane-containing spiro[2.3]hexanes were disclosed.

Graphical abstract: Thermally-induced intramolecular [2 + 2] cycloaddition of acrylamide-tethered alkylidenecyclopropanes
From the themed collection: Synthetic methodology in OBC
Communication

Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

A redox-neutral, transition-metal-free and photocatalytic protocol is developed for the synthesis of functionalized phenols from para-quinone methides.

Graphical abstract: Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis
From the themed collection: Synthetic methodology in OBC
Communication

Copper(I)-catalysed stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes with bis(pinacolato)diboron

The first example of the selective debromoborylation of gem-dibromoalkenes.

Graphical abstract: Copper(i)-catalysed stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes with bis(pinacolato)diboron
From the themed collection: Synthetic methodology in OBC
Communication

Silver-catalyzed intermolecular amination of fluoroarenes

A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed.

Graphical abstract: Silver-catalyzed intermolecular amination of fluoroarenes
From the themed collection: Synthetic methodology in OBC
Communication

Phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts

In this communication, an interesting phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts has been reported.

Graphical abstract: Phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts
From the themed collection: Synthetic methodology in OBC
Communication

2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes

2-Picoline efficiently catalyzes the formation of α,β-enones from acetylenedicarboxylates and aldehydes in the presence of alkenes, thereby leading to pyrans with complete regioselectivities. This method is represented as a first example of catalytic and metal-free [2 + 2 + 2] cycloaddition of three different components.

Graphical abstract: 2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides.

Graphical abstract: Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines

The di- and trichloromethylation of N-allyl anilines with CH2Cl2, CHCl3 and CCl4 was developed, leading to di- and trichloromethylated indolines.

Graphical abstract: Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines
From the themed collection: Synthetic methodology in OBC
Communication

E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes

An efficient and highly E-selective protocol for the synthesis of vinyl sulfones is described.

Graphical abstract: E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination

An efficient procedure for imidazo[1,5-a]pyridine formation via dual oxidative Csp3–H amination using elemental sulfur is described.

Graphical abstract: Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination
From the themed collection: Synthetic methodology in OBC
Communication

Two catalytic protocols for Achmatowicz rearrangement using cyclic diacyl peroxides as oxidants

The development of two new catalytic protocols for Achmatowicz rearrangement using cyclic diacyl peroxides as terminal oxidants.

Graphical abstract: Two catalytic protocols for Achmatowicz rearrangement using cyclic diacyl peroxides as oxidants
From the themed collection: Synthetic methodology in OBC
Communication

Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

A transition-metal-free, operationally simple and atom-economic protocol that converts isocyanoacetates and aurones to 2,3,4-trisubstituted pyrroles catalyzed by NaOH was presented.

Graphical abstract: Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues
From the themed collection: Synthetic methodology in OBC
Communication

The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(III) reagents

Aradical acylarylation of N-arylacrylamides with aliphatic aldehydes using a combination of hypervalent iodine(III) reagents and UV light is reported.

Graphical abstract: The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(iii) reagents
From the themed collection: Synthetic methodology in OBC
Communication

Pd-Catalyzed cascade cyclization of o-alkynylanilines via C–H/C–N bond cleavage leading to dibenzo[a,c]carbazoles

A new and efficient Pd-catalyzed cascade cyclization of biaryl-tethered o-alkynylanilines for the formation of dibenzo[a,c]carbazole derivatives has been reported.

Graphical abstract: Pd-Catalyzed cascade cyclization of o-alkynylanilines via C–H/C–N bond cleavage leading to dibenzo[a,c]carbazoles
From the themed collection: Synthetic methodology in OBC
Communication

TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Highly selective and catalyst-free tandem multi-functionalization of terminal alkynes was developed with 2-oxindoles and benzo-furan-2(3H)-one using TEMPO both as a radical promoter and a trapping reagent.

Graphical abstract: TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one
From the themed collection: Synthetic methodology in OBC
Communication

Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO3)3·9H2O

Al(NO3)3·9H2O as a nitro source for the synthesis of 3-nitrofurans from homopropargylic alcohols through Fe-catalyzed tandem cyclization is described.

Graphical abstract: Fe-Catalyzed tandem cyclization for the synthesis of 3-nitrofurans from homopropargylic alcohols and Al(NO3)3·9H2O
From the themed collection: Synthetic methodology in OBC
Communication

Phosphine-catalysed α-umpolung addition of nucleophiles to δ-acetoxy allenoates: stereoselective synthesis of 2,4-dienoates

The first example of phosphine-catalyzed α-umpolung addition of nucleophiles to allenoates is described, which features the use of δ-acetoxy allenoate to generate a 3-phosphonium-2,4-dienoate intermediate, thus facilitating the α-umpolung addition of nucleophiles.

Graphical abstract: Phosphine-catalysed α-umpolung addition of nucleophiles to δ-acetoxy allenoates: stereoselective synthesis of 2,4-dienoates
From the themed collection: Synthetic methodology in OBC
Communication

Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

Graphical abstract: Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles
From the themed collection: Synthetic methodology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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