Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules
This review summarizes the recent developments in the asymmetric intramolecular Heck reaction and carbometallation-initiated cascade transformations including Ni-catalyzed processes with literature coverage mainly extending from 2016 to 2021.
Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles
In this review, we describe the important advances in cycloaddition methodologies involving cyclopropanes for the construction of seven-, eight- and nine-membered carbocycles, with a particular attention to the variety of the mechanisms involved.
Recent progress in the nitration of arenes and alkenes
This mini review summarizes the recent advances in the regiospecific nitrations of arenes and alkenes based on the structural features of substrates.
Recent advancements in the development of molecular organic photocatalysts
A review on the recent advances of six classes of organic photocatalysts with respect to photophysical and redox properties.
Recent progress on electrochemical synthesis involving carboxylic acids
Recent progress on sustainable electrochemical synthesis involving carboxylic acids was reviewed.
Utilization of ortho-alkynylarylcarbonyl derivatives for creating structurally diverse chemical compounds
Recent developments in decarboxylative C(aryl)–X bond formation from (hetero)aryl carboxylic acids
This review highlights the recent developments in ipso-decarboxylative C–X (X = O/N/halo/S/Se/P/CN) bond formation using (hetero)aryl carboxylic acids, which are economical and environmentally benign starting materials.
Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones
This review highlights recent advancement in the synthesis of 3-hydroxyisoindolinones and their applications in stereoselective transformations.
Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles
α-Activated cyclic isothiocyanates featuring pharmacophores were efficient percusors for the enantioselective construction of intriguing spirocycles.
Antitumor activity of tridentate pincer and related metal complexes
Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.
Thioxanthone: a powerful photocatalyst for organic reactions
Thioxanthone is a powerful photocatalyst. In this review, its photophysical properties and its applications in photopolymerisation and in organic synthesis are highlighted.
Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies
This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.
Light-induced borylation: developments and mechanistic insights
This perspective delineates light-induced borylation methodologies, which have been developed in the last 10 years. Mechanistic insights have been explored throughout the article for these UV- and visible-light-induced borylation reactions.
Selected applications of Meldrum's acid – a tutorial
The overview describes synthetic routes towards substituted Meldrum's acids and its recent applications to inspire lab veterans and chemistry younglings.
Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates
This review article describes all the significant recent developments in catalytic asymmetric umpolung reactions of imines involving a 2-azaallyl anion intermediate.
Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis
This review summarizes the recent advancements in transition-metal (TM) catalyzed enantioselective C–H activation via kinetic resolution approach.
Construction of bridged polycycles through dearomatization strategies
This review summarizes the-state-of-the-art advances of dearomatization strategies in the application of bridged ring formation.
The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes
This article covers ring expansions of vinylaziridines and vinyloxiranes developed over the past five years for accessing stereochemically enriched heterocycles.
Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids
The 8-azabicyclo[3.2.1]octane core is the central motif of tropane alkaloids. This review compiles the methodologies employed to synthesize this scaffold in an enantioenriched form from achiral starting materials.
Recent advances in the synthesis of pyrido[1,2-a]indoles
This review deals with the different accesses leading to the pyrido[1,2-a]indole nucleus in the last 20 years.
Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle
Azetidines represent one of the most important four-membered heterocycles in organic synthesis. We provide an overview of the synthesis, reactivity and application of azetidines with a focus on the most recent advances, trends and future directions.
Multicomponent reactions as a potent tool for the synthesis of benzodiazepines
The present review covers all synthetic methods based on multicomponent reactions for the preparation of benzodiazepines as the parent cores of many essential drugs.
Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones
This review highlights recent developments relating to the preparation of β-keto sulfones and β-keto thiosulfones. And, also focused on widespread synthetic applications of β-keto sulfones for assembling many valuable carbo- and heterocycles.
Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond
The recent progress in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions is described.
Recent approaches towards one-carbon homologation–functionalization of aldehydes
This review describes the methods of homologation and functionalization of aldehydes by one carbon unit which are the most fundamental and attractive synthetic transformations in organic synthesis.
Recent advances in aminative difunctionalization of alkenes
This review summarizes recent advances in transition metal-catalyzed or metal-free aminative difunctionalization of alkenes to construct nitrogen-containing compounds.
Pyrrole carboxamide introduction in the total synthesis of pyrrole–imidazole alkaloids
The pyrrole carboxamide is a characteristic structural feature found in the pyrrole–imidazole (oroidin) alkaloids, the various traditional and non-tradition methods for its introduction are reviewed herein.
Electrohalogenation of organic compounds
In this review we target sp, sp2 and sp3 carbon fluorination, chlorination, bromination and iodination reactions using electrolysis as a redox medium. Mechanistic insights and substrate reactivity are also discussed.
Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles
The present review provides a comprehensive and updated summary of the metal-free multicomponent synthesis of biologically privileged monocyclic six membered N-heterocycles covered in the literature since 2000.
α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update
α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformations including Michael additions, domino reactions and cycloadditions.
Aromatic Cope rearrangements
This review summarizes the ∼40 papers dating back to 1956 on the aromatic Cope rearrangement, and highlights the need for further studies, development, and applications of this transformation in synthesis.
Visible-light-induced silylation: an update
This review summarizes the recent findings and developments in the emerging area of photocatalytic silylation with literature coverage mainly extending from 2014 to February 2021.
Recent advances in reactions using diacyl peroxides as sources of O- and C-functional groups
This review summarizes recent advances in reactions utilizing diacyl peroxides as O- and C-sources, with examples illustrating how the reactivity of diacyl peroxides in organic reactions can be controlled.
Conjugated ynones in catalytic enantioselective reactions
This review summarizes the recent literature examples of catalytic asymmetric reactions of conjugated ynones and classified these reaction types, alongside their mechanistic insights whenever possible.
NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds
An unique combination of MI-TBHP (M = Na, K, NH4) oxidation system has ameliorated the metal-free access to construct various chemical bonds and appeared as an impeccable synthetic manoeuvre for the construction of complex molecular frameworks.
Recent approaches to the synthesis of tetrahydrocarbazoles
The tetrahydrocarbazole (THC) motif is ubiquitous in natural products and biologically active compounds.
Recent advances in the Rh-catalyzed cascade arene C–H bond activation/annulation toward diverse heterocyclic compounds
A review highlighting the advances in Cp*Rh(III) catalysed cascade arene C–H activation/annulation including application, scope, limitations and mechanism of these transformations.
Metal-catalyzed C–S bond formation using sulfur surrogates
This review presents the metal-catalyzed C–S bond-formation reaction to access organosulfur compounds using various sulfur surrogates with an extended discussion on the reaction mechanism, regioselectivity of product and pharmaceutical application.
Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future
Construction of C–C bonds in the absence of a catalyst and an additive by means of various name reactions including C–H functionalizations, coupling reactions and UV-visible-light-driven reactions is discussed here.
Modern approaches towards the synthesis of geminal difluoroalkyl groups
This review will cover the importance of and most recent approaches toward geminal difluoroalkyl groups using transition metal-mediated, photochemical, organocatalytic, and other methods.
Syntheses and medicinal chemistry of azepinoindolones: a look back to leap forward
This review emphasizes the synthetic aspects, derivatization methods of azepinoindolones and the application of this nucleus in the whole range of medicinal chemistry.
Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons
This review provides a collective and informative discussion on the potential applications of Kobayashi's aryne precursor as a versatile building block for the synthesis of polycyclic aromatic hydrocarbons.
Recent advances in the synthesis of α-amino ketones
This review on α-amino ketone synthesis collates and evaluates developments made in this area over the past decade, with an extended discussion on functional group compatibility, resultant product substitution patterns, and medicinal applications.
C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles
This review highlights the advances in the direct C(sp2)–H functionalization of cyclic aldimines, aldohydrazones, and aldonitrones since 2008.
Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes
Olefin 1,2-difunctionalization is a popular synthetic strategy for synthesis of vicinal amino alcohols and their derivatives. This comprehensive review covers methods developed beyond the pioneering osmium-catalyzed Sharpless amino hydroxylation.
Reframing primary alkyl amines as aliphatic building blocks
This review covers recent and historical aliphatic deaminative functionalization reactions to encourage the use of primary amines as aliphatic building blocks.
Recent advances and prospects in the metal-free synthesis of quinolines
Metal-free synthesis of quinolines has recently gained attention, and this review focuses on the recent advances in the metal-free synthesis of quinolines.
The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles
The present review emphasizes the scope of and recent developments in the microwave-assisted synthesis of various non-(benzo)fused single-nitrogen-containing heterocycles and related applications in the past decade.
Recent advances in the synthesis of organophosphorus compounds via Kobayashi's aryne precursor: a review
This review systematically summarizes the progress in aryne chemistry for the synthesis of organophosphorus compounds via aryne insertion into the C–P, P–N, P–P, P–O, PP, PN and PS bonds.
Recent advances in the synthesis of fluorinated compounds via an aryne intermediate
In this review, the usefulness of aryne intermediates for the synthesis of various fluorinated organic compounds during the last decade has been demonstrated.
An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry
Use of sulfinate derivatives as versatile coupling partners in organic chemistry.
Transition metal-free synthesis of alkyl pinacol boronates
This review systematically outlined the research in the area of transition metal free synthesis of alkyl pinacol boronates, which are versatile and important scaffolds to construct diverse organic compounds.
Recent advances in 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes
In this article, some representative reactions of 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes have been discussed and reviewed based on the types of substrates.
The C–H functionalization of organic cations: an interesting and fresh journey
This review summarizes the substantial progress that has been made relating to the C–H functionalization of organic cations, and it covers transition-metal-enabled C–H alkylation, arylation, and photo-induced C–H functionalization.
Metal-free C–S coupling of thiols and disulfides
A literature overview on C–S coupling reactions using thiols or disulfides as sulfur surrogates under metal-free conditions is presented. Reagents for the transformations include polyvalent iodines, peroxides, tert-butyl nitrite (TBN), DDQ, and aerial oxygen, among others.
Sulfoxonium ylides: simple compounds with chameleonic reactivity
Sulfoxonium ylides, manageable compounds with an appealing safety profile, adapt to reaction partners like chameleons to their environment, resulting in a variety of useful, and sometimes surprising and unique, reactions.
Catalytic enantioselective synthesis using carbon dioxide as a C1 synthon
This review summarizes the advances in catalytic enantioselective reactions using CO2 as a C1 synthon, introduces strategies and discusses advantages and limitations, highlights the application, and outlines the synthetic opportunities.
Syntheses and reactivity of spiro-epoxy/aziridine oxindole cores: developments in the past decade
This review highlights various reactions to afford spiro-epoxy/aziridine oxindoles and their potential synthetic transformations.
Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures
Multi-divergent transformations of cyclohexadienone derivatives for the synthesis of stereoenriched and complex architectures.
Potassium tert-butoxide mediated C–C, C–N, C–O and C–S bond forming reactions
Potassium tertiary butoxide (KOtBu) mediated constructions of C–C, C–O, C–N, and C–S bonds are reviewed with special emphasis on their synthetic applications.
Photochemical methods in metathesis reactions
In this first review about photometathesis, we have gathered the relevant literature to give the reader an in-depth understanding of these fascinating reactions and to inspire future research.
2-Activated 1,3-enynes in enantioselective synthesis
2-Activated 1,3-enyne has emerged as a versatile synthetic precursor for the construction of valuable enantioenriched molecules.
Trifunctionalization of alkenes and alkynes
In this review, the development of trifunctionalization methods for alkenes and alkynes, including arynes and allenes, over the last decade is disclosed.
Aldehydes: magnificent acyl equivalents for direct acylation
This review sheds light on the use of aldehydes in the selective acylation of arene, heteroarene and alkyl (sp3, sp2 and sp) C–H bonds by proficient utilization of the C–H activation strategy.
Ammonia borane as a reducing agent in organic synthesis
Ammonia borane is gaining increasing attention as a sustainable and atom-economical winning reagent for the reduction of several substrates.
Organic synthesis of fixed CO2 using nitrogen as a nucleophilic center
With nitrogen as the nucleophilic center, CO2 is fixed by using metal catalysis, non-metal catalysis, photocatalysis and electrocatalysis.
Recent advances in cobalt-catalyzed allylic functionalization
Recent advances in cobalt-catalyzed allylic functionalization including allylic substitution, nucleophilic allylation, and Heck-type allylic functionalization are highlighted.
C-Alkylation of alkali metal carbanions with olefins
C-Alkylations of alkali metal carbanions with olefins, first reported five decades ago, is undergoing a resurgence in organic synthesis. A historical perspective, contemporary applications and developing mechanistic understanding are presented.
Cobalt-catalyzed carbonylation of the C–H bond
Direct carbonylation of the C–H bond is a great tool for installing a carbonyl group in a wide variety of substrates.
Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis
Five-membered ring cyclic sulfamidate imines (5H-1,2,3-oxathiazole 2,2-dioxides) have received increasing attention as useful precursors for the synthesis of many valuable heterocycles. This review highlights recent developments in this area.
About this collection
The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.