Electrochemical asymmetric synthesis of biologically active substances
This review discusses the literature published in the last ten years on electrochemically driven oxidation and reduction reactions utilized in the asymmetric synthesis of biologically active substances.
Organic synthesis of fixed CO2 using nitrogen as a nucleophilic center
With nitrogen as the nucleophilic center, CO2 is fixed by using metal catalysis, non-metal catalysis, photocatalysis and electrocatalysis.
Exploring the behavior of the NFSI reagent as a nitrogen source
Applications of the N-fluorobenzenesulfonimide (NFSI) reagent in organic synthesis.
Recent progress of 1,1-difunctionalization of olefins
Olefins are a very important class of compounds and broadly used in the construction of various synthetic building blocks and practical industrial production.
Stereocontrolled Transformations of Cyclohexadienone Derivatives to Access Stereochemically-Rich and Natural Products-Inspired Architectures
Tandem Prins cyclizations for the construction of oxygen containing heterocycles
This review focuses on tandem Prins cyclizations for the construction of oxygen containing heterocycles.
Recent advances in cobalt-catalyzed allylic functionalization
Recent advances in cobalt-catalyzed allylic functionalization including allylic substitution, nucleophilic allylation, and Heck-type allylic functionalization are highlighted.
Cobalt-catalyzed carbonylation of the C–H bond
Direct carbonylation of the C–H bond is a great tool for installing a carbonyl group in a wide variety of substrates.
Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis
Five-membered ring cyclic sulfamidate imines (5H-1,2,3-oxathiazole 2,2-dioxides) have received increasing attention as useful precursors for the synthesis of many valuable heterocycles. This review highlights recent developments in this area.
Transient imine directing groups for the C–H functionalisation of aldehydes, ketones and amines: an update 2018–2020
This review describes recent advances in C–H functionalisation using transient directing groups. Advances in directing group design, new bond forming methodologies, regio- and stereoselective processes, and new mechanistic insights are discussed.
Synthesis strategies for non-symmetric, photochromic diarylethenes
This review surveys synthesis strategies for accessing non-symmetric diarylethene photochromes and highlights notable properties and applications of these compounds.
C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles
2-Activated 1,3-Enynes in Enantioselective Synthesis
An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry
Trifunctionalization of Alkenes and Alkynes
Aldehydes: magnificent acyl equivalents for direct acylation
Potassium tert- Butoxide Mediated C-C, C-N, C-O and C-S Bond Forming Reactions
Ammonia borane as a reducing agent in organic synthesis
Synthetic approaches and applications of sulfonimidates
This review encompasses the developments in sulfonimidate chemistry, focusing on both syntheses and applications of these important organosulfur(VI) species.
Recent advances in alkaline earth metal-enabled syntheses of heterocyclic compounds
This review summarizes recent progress in alkaline earth metal enabled syntheses of heterocyclic compounds.
Catalytic C3 aza-alkylation of indoles
The aza-alkylation reaction at position 3 of the indole scaffold allows the introduction of a differently substituted aminomethyl group, with the formation of a stereogenic centre. Critical summary of 2000–2019 meaningful papers.
Transition-metal-catalyzed C–H functionalization of pyrazoles
This review describes recent advances in transition-metal-catalyzed C–H functionalization reactions of pyrazoles to form new C–C and C–heteroatom bonds on the pyrazole ring.
C-Alkylation of alkali metal carbanions with olefins
C-Alkylations of alkali metal carbanions with olefins, first reported five decades ago, is undergoing a resurgence in organic synthesis. A historical perspective, contemporary applications and developing mechanistic understanding are presented.
Gold-catalyzed enantioselective functionalization of indoles
This review documents the potential of enantioselective gold catalysis for the functionalization of indoles.
Recent advances in the catalytic asymmetric reactions of thiazolone derivatives
This review highlights the recent advances in catalytic asymmetric reactions of thiazolone derivatives, including Michael additions, Mannich reactions as well as various cascade reactions.
Recent advances in PIII-assisted deoxygenative reactions under photochemical or electrochemical conditions
Recent progress in PIII-assisted direct deoxygenative reactions under photochemical or electrochemical conditions is reviewed.
The renaissance of strained 1-azabicyclo[1.1.0]butanes as useful reagents for the synthesis of functionalized azetidines
Since their discovery in the late 1960s, 1-azabicyclo[1.1.0]butanes have demonstrated to be interesting precursors of azetidines, because of the peculiar reactivity of the C3–N bond that allows double functionalization in the 1,3 positions.
Recent applications of thiourea-based organocatalysts in asymmetric multicomponent reactions (AMCRs)
This review describes the recent applications of thiourea-based organocatalysts in asymmetric multicomponent reactions.
Stereoselective synthesis of 2,6-disubstituted piperidine alkaloids
The synthetic methods to build the 2,6-disubstituted piperidine structural motif were described focusing on stereochemical control of two substituents at C2 and C6 with specific examples of natural products.
Halogen-mediated electrochemical organic synthesis
Halogen anion is oxidized to molecular halogens, halogen cations or halogen radicals at the anode, which combines with substrates to provide different products.
Synthesis of indoles from alkynes and a nitrogen source under metal-free conditions
This review deals with the methodologies published in the last ten years, which used metal-free conditions to prepare indoles starting from alkynes and nitrogen compounds.
Recent advances in the oxime-participating synthesis of isoxazolines
This review is devoted to highlighting the main achievements in the development of methodologies for the synthesis of isoxazolines.
Recent advances in the catalytic synthesis of 3-aminooxindoles: an update
3-Substituted-3-aminooxindoles are versatile scaffolds and these motifs constitute the core structure of number of natural products and biologically active compounds.
Synthesis and practical applications of 2-(2-nitroalkyl)pyrroles
Two main approaches can be designed for the synthesis of 2-(2-nitroalkyl)pyrroles using nitroalkenes or nitroalkanes in the reaction with pyrrole derivatives. The obtained nitroalkyl pyrroles can be converted into various bioactive compounds.
Remote C–C bond formation via visible light photoredox-catalyzed intramolecular hydrogen atom transfer
Visible light photoredox catalysis combined with intramolecular hydrogen atom transfer (HAT) can serve as a unique tool for achieving remote C–C bond formation. Recent advances in photoredox-catalyzed remote C–C bond formation are summarized.
C–H functionalization of quinazolinones by transition metal catalysis
Quinazolinone and its derivatives are an important class of heterocyclic scaffolds in pharmaceuticals and natural products. This review provides the recent research advances in the transition metal catalyzed selective C–H bond functionalization of quinazolinone.
Aromatic [b]-fused BODIPY dyes as promising near-infrared dyes
This review describes aromatic [b]-fused BODIPY dyes with the focus on design and synthesis, the relationships between their photophysical/spectroscopic properties and molecular structures, and potential uses in bioassays and optoelectronic devices.
Recent progress of transition metal-catalysed regioselective C–H transformations based on noncovalent interactions
Recent advances in the transition metal-catalysed regioselective C–H transformations controlled by noncovalent interactions between substrates and reagents or ligands are summarised.
Recent advances in the synthesis of imidazoles
The review highlights the recent advances (2018-present) in the regiocontrolled synthesis of substituted imidazoles.
Palladium-catalysed decarboxylative annulations of vinylethylene carbonates leading to diverse functionalised heterocycles
This review provides an overview of the palladium-catalysed diverse cyclisations of VECs over the past five years, which could offer powerful synthetic tools to access various functionalised heterocycles.
Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives
β2-Amino acids: recent advances in the synthesis of β2-amino acids and their derivatives from various stereoselective transformations of β-nitroacrylates are summarized.
Catalytic enantioselective decarboxylative nucleophilic addition reactions using chiral organocatalysts
Catalytic decarboxylative reactions are attractive as biomimetic and environmentally friendly reaction processes. This review summarizes recent results for organocatalytic enantioselective decarboxylative reactions from October 2013 to December 2019.
Visible light promoted C–H functionalization of imidazoheterocycles
The present review summarizes the visible light mediated direct C–H functionalizations of pharmacologically active imidazo[1,2-a]pyridines and other related heterocycles.
Synthetic and mechanistic aspects of sulfonyl migrations
Sulfonyl migrations, frequently described as ‘unusual’ or ‘unexpected’, from the last 20 years, including 1,2-, 1,3-, 1,4-, 1,5-, 1,6- and 1,7-sulfonyl shifts, through either radical or polar processes, either inter- or intramolecularly are reviewed.
Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy
In this review, the progress of tandem transformation of nitro, nitrile and azide functionalities is summarised to develop new C–C and C–N bonds as well as multi-component reactions using alcohols.
Macrocyclization via C–H functionalization: a new paradigm in macrocycle synthesis
The emergence and applications of the C–H activation logic as a new paradigm in macrocyclization reactions are captured in this review.
Synthesis of α-functionalized ketones by visible-light promoted oxygenation of alkenes
This article gives a short review on the visible-light promoted synthesis of α-functionalized ketones from alkenes.
Sequential conjugation methods based on triazole formation and related reactions using azides
This review highlights recent transformations involving selective triazole formation, allowing efficient preparation of unsymmetric bis- and tris(triazole)s using diverse platform molecules.
Recent advances in the direct β-C(sp2)–H functionalization of enamides
Recent advances in the direct β-C(sp2)–H functionalization of enamides, mainly including arylation, alkenylation, alkynylation, alkylation, acylation, sulfonylation, phosphorylation, and others, are reported.
Chemical transformations of quaternary ammonium salts via C–N bond cleavage
The reaction of quaternary ammonium salts via C–N bond cleavage to construct C–C, C–H and C–heteroatom bonds is summarized.
Catalytic strategies towards 1,3-polyol synthesis by enantioselective cascades creating multiple alcohol functions
This review highlights the different enantioselective catalyst-controlled cascades creating multiple alcohol functions and ensuring through subsequent simple derivatization, the rapid preparation of extended 1,3-polyols.
The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines
Intramolecular endo-aza-Michael additions are categorised in various ways.
Recent trends in catalytic sp3 C–H functionalization of heterocycles
In this mini-review, we attempt to highlight gaps in existing techniques for sp3 C–H activation adjacent to heterocycles.
Recent developments in the chemistry of allenyl sulfones
Allenyl sulfones are versatile building blocks for the construction of various acyclic, carbocyclic and heterocyclic motifs. Recent developments in the preparation and synthetic applications of allenyl sulfones are summarised.
Recent progress in transition-metal-catalyzed hydrocyanation of nonpolar alkenes and alkynes
Hydrocyanation is a powerful method for the preparation of nitriles which are versatile building blocks for the synthesis of amines, acids and amides.
The reticent tautomer: exploiting the interesting multisite and multitype reactivity of 4-pyrrolin-2-ones
Multisite and multitype reactivities of the highly versatile and valuable synthetic building block 4-pyrrolin-2-one are covered in this review.
Developments in the construction of cyclopropanols
This review introduces and discusses the advances in the construction of cyclopropanols; improved synthetic methods are included, as well as the highly stereoselective production of cyclopropanols.
Recent advances in cobalt-catalysed C–H functionalizations
Ready availability, low cost and low toxicity of cobalt salts have redirected the attention of researchers away from noble metals, such as Pd, Rh, and Ir, towards Co in the field of C–H functionalisation.
Imidates: an emerging synthon for N-heterocycles
This review highlights the recent application of imidates as building blocks for the synthesis of saturated and un-saturated N-heterocycles via C–N annulation reactions under acid/base/metal-catalyzed/radical-mediated reaction conditions.
Catalytic enantioselective cross dehydrogenative coupling of sp3 C–H of heterocycles
The recent developments in the asymmetric functionalization of heterocycles via the catalytic enantioselective cross dehydrogenative coupling reactions of heterocyclic sp3 C–H bonds are highlighted in this review.
Recent trends and applications of the Cadiot–Chodkiewicz reaction
The Cadiot–Chodkiewicz reaction offers an elegant strategy for the formation of 1,3-diynes via Cu-catalyzed cross-coupling of alkynyl halides with terminal alkynes in the presence of an amine.
Application of copper(I) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules
This review summarises the synthesis of bioactive molecules through the use of Cu(I) salt and fluoride promoted Stille coupling reactions.
Catalytic allylic functionalization via π-allyl palladium chemistry
This review highlights the palladium-catalyzed allylic C–H functionalizations via π-allyl palladium reported from early 2014 to present date.
Advances in asymmetric visible-light photocatalysis, 2015–2019
Asymmetric visible-light photocatalysis has recently drawn considerable attention of the scientific community owing to its unique activation modes and significance for the enantioselective green synthesis.
α-Halogenoacetamides: versatile and efficient tools for the synthesis of complex aza-heterocycles
This review presents the use of α-alkyl- and α-alkoxy-halogenoacetamides as powerful partners for domino and 1,3-dipolar cycloaddition reactions resulting in a ring closure.
Modifications of amino acids using arenediazonium salts
Aryl transfer reactions from arenediazonium salts have started to make their impact in chemical biology with initial forays in the arena of arylative modifications and bio-conjugations of amino acids, peptides and proteins.
Hypervalent iodine reactions utilized in carbon–carbon bond formations
This review covers recent developments of hypervalent iodine chemistry in dearomatizations, radicals, hypervalent iodine-guided electrophilic substitution, arylations, photoredox, and more.
Consecutive multicomponent reactions for the synthesis of complex molecules
Consecutive multicomponent reactions (MCRs) combine two or more MCRs to achieve high synthetic efficiency, product structural diversity, and molecular complexity.
Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products
Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry.
Recent advances in catalytic asymmetric intermolecular oxidation of alkynes
In recent years, gold-metal-catalyzed intermolecular alkyne oxidation by an N-oxide oxidant, which presumably involves a gold carbenoid intermediate, has attracted increasing attention because it circumvents the employment of hazardous and potentially explosive diazocarbonyl compounds as starting materials for carbene generation.
About this collection
The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.