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Themed collection Synthetic methodology in OBC

681 items - Showing page 1 of 10
Open Access Accepted Manuscript - Paper

One-pot ortho-amination of aryl C-H bonds using consecutive iron and copper catalysis: late-stage structural diversification of 3,4-dihydroquinolin-2-ones

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Oxidative Sulfonamidomethylation of Imidazopyridines Utilizing Methanol as the Main C1 Source

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

An efficient light on-off one-pot method for the synthesis of 3-styryl coumarins from aryl alkynoates

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Catalyst-Free Regioselective Hydroxyfluorination and Aminofluorination of α, β-Unsaturated Ketones

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Organic photoredox catalysis enabled cross-coupling of arenediazonium and sulfinate salts: synthesis of (un)symmetrical diaryl/alkyl aryl sulfones

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Catalyst-Free and Selective Trifluoromethylative Cyclizations of Acryloanilides Using PhICF3Cl

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Review Article

Synthetic Strategies for Fluorination of Carbohydrates

From the themed collection: Chemical biology in OBC
Accepted Manuscript - Communication

N-Heterocyclic carbene-catalyzed diastereoselective synthesis of sulfenylated indanes via sulfa-Michael-Michael (aldol) cascade reaction

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Synthesis of pyrazolylvinyl ketones from furan derivatives

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Silver-mediated three-component cycloaddition reaction for direct synthesis of 1-N-vinyl-substituted 1,2,3-triazoles

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Palladium catalyzed chemo- and siteselective C-H acetoxylation and hydroxylation of oxobenzoxazine derivatives

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Synthesis of Multisubstituted Arylsulfones via One-Pot, Three-Component [3+3] Benzannulation Reaction

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Copper-Catalyzed Oxidative Amination of Methanol to Access Quinazolines

From the themed collection: Synthetic methodology in OBC
Paper

Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

Catalytic alkylation reactions of weakly acidic carbonyl and related pronucleophiles such as amides, esters, and sulfonamides with substituted alkenes have been reported.

Graphical abstract: Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles
From the themed collection: Synthetic methodology in OBC
Communication

E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes

An efficient and highly E-selective protocol for the synthesis of vinyl sulfones is described.

Graphical abstract: E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes
From the themed collection: Synthetic methodology in OBC
Communication

Mild and regioselective azol-halogenation of alkenes

An economical, practical, and environmentally benign azol-halogenation protocol of alkenes was developed, which provides a general approach to construct a series of structurally diverse β-halogenated amine derivatives.

Graphical abstract: Mild and regioselective azol-halogenation of alkenes
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis of α-amino ketones through aminations of umpoled enolates

An efficient synthesis of α-amino ketones is developed using the umpolung strategy.

Graphical abstract: Synthesis of α-amino ketones through aminations of umpoled enolates
From the themed collection: Synthetic methodology in OBC
Communication

Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid

Herein we present a new strategy for the dehydrogenative–decarboxylative coupling of indoles with glyoxylic acid.

Graphical abstract: Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid
From the themed collection: Synthetic methodology in OBC
Communication

2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes

2-Picoline efficiently catalyzes the formation of α,β-enones from acetylenedicarboxylates and aldehydes in the presence of alkenes, thereby leading to pyrans with complete regioselectivities. This method is represented as a first example of catalytic and metal-free [2 + 2 + 2] cycloaddition of three different components.

Graphical abstract: 2-Picoline catalyst-triggered [2 + 2 + 2] cycloaddition-type reaction of acetylenedicarboxylates, aldehydes and alkenes
From the themed collection: Synthetic methodology in OBC
Communication

New Friedel–Crafts strategy for preparing 3-acylindoles

A new Friedel–Crafts acylation generates diverse high-biological value 3-acylindoles, and forms a new C–C bond under transition-metal-free conditions.

Graphical abstract: New Friedel–Crafts strategy for preparing 3-acylindoles
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Biomimetic synthesis of the bisindole framework present in sciodole, an alkaloid from Tricholoma sciodes

The unique bisindole bond present in the alkaloid sciodole can be forged by amination of an azafulvene, validating a biosynthetic hypothesis.

Graphical abstract: Biomimetic synthesis of the bisindole framework present in sciodole, an alkaloid from Tricholoma sciodes
From the themed collection: Synthetic methodology in OBC
Paper

Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

A palladium catalysed ring-opening [3 + 2]-annulation of novel spirovinylcyclopropanes with α,β-unsaturated nitroalkenes has been presented.

Graphical abstract: Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles
From the themed collection: Synthetic methodology in OBC
Communication

Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

An elemental sulfur-based metal- and base-free system enables oxidative imidazo[1,2-a]pyridine annulations.

Graphical abstract: Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Metal- and base-free synthesis of functionalized α,α-difluoroimines via electrophilic fluorination of N-substituted enamines

A metal- and base-free synthesis of functionalized α,α-difluoroimines is presented. The reaction features mild condition, high E/Z control and broad functional group tolerance. The utility of the products was demonstrated through valuable synthetic transformations.

Graphical abstract: Metal- and base-free synthesis of functionalized α,α-difluoroimines via electrophilic fluorination of N-substituted enamines
From the themed collection: Synthetic methodology in OBC
Communication

Cyclopropanation of alkenes with metallocarbenes generated from monocarbonyl iodonium ylides

Wittig-type reactivity between iodosoarenes and phosphoranes leads to monocarbonyl iodonium ylides, which readily serve as metallocarbene precursors.

Graphical abstract: Cyclopropanation of alkenes with metallocarbenes generated from monocarbonyl iodonium ylides
From the themed collection: Carbenes in Organic Synthesis
Communication

Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination

An efficient procedure for imidazo[1,5-a]pyridine formation via dual oxidative Csp3–H amination using elemental sulfur is described.

Graphical abstract: Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination
From the themed collection: Synthetic methodology in OBC
Communication

Silver or cerium-promoted free radical cascade difunctionalization of o-vinylanilides with sodium aryl- or alkylsulfinates

An efficient cascade oxysulfonylation of o-vinylanilides with sodium aryl- or alkylsulfinates was developed for the synthesis of sulfonated benzoxazines.

Graphical abstract: Silver or cerium-promoted free radical cascade difunctionalization of o-vinylanilides with sodium aryl- or alkylsulfinates
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Robust Buchwald–Hartwig amination enabled by ball-milling

An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system.

Graphical abstract: Robust Buchwald–Hartwig amination enabled by ball-milling
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of 1,3-disubstituted cyclohexenes from dienylethers via sequential hydrozirconation/deoxygenative cyclisation

The preparation of 1,3-disubstituted cyclohexenes from 3-methoxyhexa-1,5-dienes involving a sequential hydrozirconation/TMSOTf-mediated activation is described.

Graphical abstract: Synthesis of 1,3-disubstituted cyclohexenes from dienylethers via sequential hydrozirconation/deoxygenative cyclisation
From the themed collection: Synthetic methodology in OBC
Communication

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Graphical abstract: Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones

Asymmetric nucleophilic phenylation of N-alkoxyenamine with triphenylaluminium is achieved for the formation of enantioenriched α-phenyl ketones through a one-pot process.

Graphical abstract: Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones
From the themed collection: Synthetic methodology in OBC
Communication

Copper(I)-catalysed stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes with bis(pinacolato)diboron

The first example of the selective debromoborylation of gem-dibromoalkenes.

Graphical abstract: Copper(i)-catalysed stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes with bis(pinacolato)diboron
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives using simple α-keto amides and alkynes as substrates.

Graphical abstract: Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
From the themed collection: Synthetic methodology in OBC
Communication

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. Various chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities.

Graphical abstract: Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines
From the themed collection: Synthetic methodology in OBC
Communication

The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 + 2] cycloaddition

An organocatalytic method for the asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds has been developed.

Graphical abstract: The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 + 2] cycloaddition
From the themed collection: Synthetic methodology in OBC
Communication

BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization

An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization using BINOL-derived bifunctional sulfide catalysts.

Graphical abstract: BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization
From the themed collection: Synthetic methodology in OBC
Communication

Cross 1,3-dipolar cycloadditions of C,N-cyclic azomethine imines with an N-benzyl azomethine ylide: facile access to fused tricyclic 1,2,4-hexahydrotriazines

A cross 1,3-dipolar cycloaddition of two different ylides between C,N-cyclic azomethine imines with an in situ generated non-stabilized azomethine ylide from an N-benzyl precursor is reported.

Graphical abstract: Cross 1,3-dipolar cycloadditions of C,N-cyclic azomethine imines with an N-benzyl azomethine ylide: facile access to fused tricyclic 1,2,4-hexahydrotriazines
From the themed collection: Synthetic methodology in OBC
Communication

Palladium-catalyzed synthesis of quinolin-2(1H)-ones: the unexpected reactivity of azodicarboxylate

A Pd(II)-catalyzed synthesis of quinolin-2(1H)-ones from quinoline N-oxides with azodicarboxylates as the activating agent has been developed.

Graphical abstract: Palladium-catalyzed synthesis of quinolin-2(1H)-ones: the unexpected reactivity of azodicarboxylate
From the themed collection: Synthetic methodology in OBC
Communication

An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons

A series of trifluoromethyl dihydroquinazolinones were obtained in excellent results via an asymmetric Mannich reaction of pyrazoleamides and cyclic trifluoromethyl ketimines.

Graphical abstract: An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons
From the themed collection: Synthetic methodology in OBC
Communication

Pd-Catalyzed cascade cyclization of o-alkynylanilines via C–H/C–N bond cleavage leading to dibenzo[a,c]carbazoles

A new and efficient Pd-catalyzed cascade cyclization of biaryl-tethered o-alkynylanilines for the formation of dibenzo[a,c]carbazole derivatives has been reported.

Graphical abstract: Pd-Catalyzed cascade cyclization of o-alkynylanilines via C–H/C–N bond cleavage leading to dibenzo[a,c]carbazoles
From the themed collection: Synthetic methodology in OBC
Communication

A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

The syntheses of 2-aryl indenones via gold(I)-catalyzed cyclization/aerobic oxidation was reported. The mechanism was probed by heavy atom labelling and control experiments. A formal total synthesis of isoprekinamycin was achieved.

Graphical abstract: A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes
From the themed collection: Synthetic methodology in OBC
Communication

Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways

A Cu/B2pin2 system promoted cyclization for the synthesis of 1-difluoroalkylated isoquinolines with vinyl isocyanides and bromodifluoroacetic derivatives in moderate to good yields was reported.

Graphical abstract: Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways
From the themed collection: Synthetic methodology in OBC
Communication

Catalyst-free 1 : 2 annulation of quinolines with trifluoroacetylacetylenes: an access to functionalized oxazinoquinolines

Catalyst-free reaction of quinolines with two molecules of aryltrifluoroacetylacetylenes afforded 3-arylethynyl-3-trifluoromethyl-1,3-oxazinoquinolines in up to 92% yields.

Graphical abstract: Catalyst-free 1 [ ] : [ ] 2 annulation of quinolines with trifluoroacetylacetylenes: an access to functionalized oxazinoquinolines
From the themed collection: Synthetic methodology in OBC
Communication

A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides

An efficient method for cyano-substituted amides via a tandem decyanation/cyanation reaction of α-iminonitriles.

Graphical abstract: A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of α-keto imides through copper-catalyzed oxidation of N-sulfonyl ynamides

A novel copper-catalyzed N-oxide oxidation of N-sulfonyl ynamides has been developed, allowing the facile synthesis of various α-keto imides in generally moderate to good yields.

Graphical abstract: Synthesis of α-keto imides through copper-catalyzed oxidation of N-sulfonyl ynamides
From the themed collection: Synthetic methodology in OBC
Communication

Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature

A wide range of glycals underwent C-arylation with aryldiazonium tetrafluoroborates and provided synthetically useful 2,3-deoxy 3-keto α-aryl-C-glycosides in good to excellent yields.

Graphical abstract: Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature
From the themed collection: Synthetic methodology in OBC
Communication

Cyclopropane–alkene metathesis by gold(I)-catalyzed decarbenation of persistent cyclopropanes

Benzo-fused norcaradienes derived from naphthalene and phenanthrene undergo gold(I)-catalyzed cyclopropane–alkene metathesis via decarbenation.

Graphical abstract: Cyclopropane–alkene metathesis by gold(i)-catalyzed decarbenation of persistent cyclopropanes
From the themed collection: Synthetic methodology in OBC
Communication

Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migration

An effective dehydrochlorination of bis(phenylsulfonyl)alkane to prepare alkene building blocks is developed.

Graphical abstract: Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migration
From the themed collection: Synthetic methodology in OBC
Communication

Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling.

Graphical abstract: Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives
From the themed collection: Synthetic methodology in OBC
Paper

Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy

Synthesis of quinolines via transfer hydrogenative coupling with high step- and atom efficiency, mild conditions and operational simplicity.

Graphical abstract: Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from commercially available nitroarenes and sulfonyl chlorides, moderate to excellent yields of the corresponding N-arylsulfonamides can be obtained. In particular, Fe dust was the sole reductant in the transformation and it can be easily performed on a large scale.

Graphical abstract: Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium
From the themed collection: Synthetic methodology in OBC
Communication

Thiosquaramide-catalysed asymmetric double Michael addition of 2-(3H)-furanones to nitroolefines

2,2,4-Trisubstituted butenolides bearing a quaternary stereogenic center were smoothly constructed with excellent stereoselectivities under mild conditions.

Graphical abstract: Thiosquaramide-catalysed asymmetric double Michael addition of 2-(3H)-furanones to nitroolefines
From the themed collection: Synthetic methodology in OBC
Communication

Iron(III)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines

A Fe-catalyzed highly regioselective α,β-difunctionalization of vinylarenes with diphenylphosphine oxides and anilines is disclosed, in which α,β-aminophosphinoylation is efficiently and conveniently constructed with good functional compatibility and a broad substrate scope.

Graphical abstract: Iron(iii)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts

In this communication, an interesting phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts has been reported.

Graphical abstract: Phosphite-catalyzed alkoxycarbonylation of aryl diazonium salts
From the themed collection: Synthetic methodology in OBC
Communication

Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy

A metal-free and efficient synthesis of highly substituted diaryl sulfones via a base-mediated [3 + 3] benzannulation strategy.

Graphical abstract: Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy
From the themed collection: Synthetic methodology in OBC
Communication

Phosphine-mediated partial reduction of alkynes to form both (E)- and (Z)-alkenes

A mild, tunable method to form both (E)- and (Z)-alkenes from alkynes is reported using PPh3 as a reductant.

Graphical abstract: Phosphine-mediated partial reduction of alkynes to form both (E)- and (Z)-alkenes
From the themed collection: Synthetic methodology in OBC
Communication

Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones

Pd-Catalysed C–H aziridination of 3,3,5,5-tetrasubsituted piperazin-2-ones catalysed by succinic acid. The mechanistic role of the acid is investigated through kinetics experiments.

Graphical abstract: Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones
From the themed collection: Synthetic methodology in OBC
Paper

Oxidation of α-trifluoromethyl and non-fluorinated alcohols via the merger of oxoammonium cations and photoredox catalysis

The merger of oxoammonium cation mediated oxidation with visible-light photoredox catalysis is demonstrated in the oxidation of α-trifluoromethyl and non-fluorinated alcohols.

Graphical abstract: Oxidation of α-trifluoromethyl and non-fluorinated alcohols via the merger of oxoammonium cations and photoredox catalysis
From the themed collection: Synthetic methodology in OBC
Paper

Gold-catalysed regioselective cascade cycloisomerisation reactions of aza-enediynes for the synthesis of substituted benzoisoquinoline derivatives

A facile, regioselective, gold-catalysed cascade cycloisomerisation of easily assembled aza-enediynes to afford dihydrobenzo[f]isoquinoline derivatives is reported.

Graphical abstract: Gold-catalysed regioselective cascade cycloisomerisation reactions of aza-enediynes for the synthesis of substituted benzoisoquinoline derivatives
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines

The di- and trichloromethylation of N-allyl anilines with CH2Cl2, CHCl3 and CCl4 was developed, leading to di- and trichloromethylated indolines.

Graphical abstract: Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines
From the themed collection: Synthetic methodology in OBC
Communication

The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(III) reagents

Aradical acylarylation of N-arylacrylamides with aliphatic aldehydes using a combination of hypervalent iodine(III) reagents and UV light is reported.

Graphical abstract: The radical acylarylation of N-arylacrylamides with aliphatic aldehydes using the photolysis of hypervalent iodine(iii) reagents
From the themed collection: Synthetic methodology in OBC
Paper

Organocatalytic asymmetric Michael addition between 3-subsituted oxindoles and enals catalyzed by camphor sulfonyl hydrazine

3,3-Disubstituted oxindoles containing vicinal stereogenic carbon centers have been synthesized through organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs).

Graphical abstract: Organocatalytic asymmetric Michael addition between 3-subsituted oxindoles and enals catalyzed by camphor sulfonyl hydrazine
From the themed collection: Synthetic methodology in OBC
Paper

KIO3-catalyzed cross dehydrogenative coupling reaction: sulfenylation of phenol and arylamine derivatives in water at room temperature

A metal-free direct sulfenylation of phenol and arylamine derivatives with various heterocyclic thiols and thiones using a cross dehydrogenative coupling protocol in water at room temperature has been developed.

Graphical abstract: KIO3-catalyzed cross dehydrogenative coupling reaction: sulfenylation of phenol and arylamine derivatives in water at room temperature
From the themed collection: Synthetic methodology in OBC
Paper

TsOH·H2O-mediated N-amidation of quinoline N-oxides: facile and regioselective synthesis of N-(quinolin-2-yl)amides

An operationally simple method with 100% atom economy was developed for the synthesis of various N-(quinolin-2-yl)amides via the TsOH·H2O-mediated N-amidation of quinoline N-oxides using inexpensive and commercially available nitriles as the amidation reagents.

Graphical abstract: TsOH·H2O-mediated N-amidation of quinoline N-oxides: facile and regioselective synthesis of N-(quinolin-2-yl)amides
From the themed collection: Synthetic methodology in OBC
Communication

Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides.

Graphical abstract: Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides
From the themed collection: Synthetic methodology in OBC
Communication

Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation

An efficient synthesis of 2,5-disubstituted tetrazoles was developed via three-component hemiaminal silylation of 5-substituted tetrazoles, aldehydes, and silyl triflates.

Graphical abstract: Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation
From the themed collection: Synthetic methodology in OBC
Communication

Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids

Asymmetric hydrogenations of imines were realized by using readily available chiral alkene-derived Lewis acids to give up to 89% ee.

Graphical abstract: Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids
From the themed collection: Synthetic methodology in OBC
Communication

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

The first regioselective MBH-type α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved using diarylcarbinols with an excellent E/Z selectivity under mild reaction conditions.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Organo-selenium mediated regio- and stereoselective iodoselenylation of alkynes in an aqueous medium: simple access to (E)-β-iodoalkenyl selenides

A method for the simple, efficient, and atom economical iodoselenylation of simple alkynes under mild conditions using molecular iodine (I2) and 1,2-diselanes as starting materials was developed.

Graphical abstract: Organo-selenium mediated regio- and stereoselective iodoselenylation of alkynes in an aqueous medium: simple access to (E)-β-iodoalkenyl selenides
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis, structural characterisation, and synthetic application of stable seleniranium ions

Stable seleniranium ions were prepared, their solid state structures determined and their application as highly efficient selenenylating agents was demonstrated.

Graphical abstract: Synthesis, structural characterisation, and synthetic application of stable seleniranium ions
From the themed collection: Synthetic methodology in OBC
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