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Themed collection Synthetic methodology in OBC

473 items - Showing page 1 of 7
Accepted Manuscript - Review Article

Recent developments in photochemical reactions of diazo compounds

From the themed collection: Carbenes in Organic Synthesis
Review Article

Recent methods for the synthesis of α-acyloxy ketones

The present review provides a broad description of the methods reported for the synthesis of α-acyloxy ketones and some of their derivatives.

Graphical abstract: Recent methods for the synthesis of α-acyloxy ketones
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles

In this review, cascade reaction based synthesis strategies delivering biologically intriguing indole polycycles are presented.

Graphical abstract: Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles
From the themed collection: Synthetic methodology in OBC
Review Article

Multicomponent reactions: a sustainable tool to 1,2- and 1,3-azoles

The present review outlines the recent advancements and pioneering efforts on the synthesis of 1,2/1,3-azoles employing a multicomponent strategy.

Graphical abstract: Multicomponent reactions: a sustainable tool to 1,2- and 1,3-azoles
From the themed collection: Synthetic methodology in OBC
Review Article

Synthetic manipulations of polyunsaturated fatty acids as a convenient strategy for the synthesis of bioactive compounds

The utilization of commercial polyunsaturated fatty acids in semi-syntheses of polyunsaturated natural products and derivatives has been reviewed.

Graphical abstract: Synthetic manipulations of polyunsaturated fatty acids as a convenient strategy for the synthesis of bioactive compounds
From the themed collection: Synthetic methodology in OBC
Review Article

Donor- and acceptor-enynals/enynones

Three kinds of transformations based on benzo-fused donor- and acceptor-enynals/enynones, including reactions with alkenes, alkynes, and H2O, were discussed.

Graphical abstract: Donor- and acceptor-enynals/enynones
From the themed collection: Synthetic methodology in OBC
Review Article

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Cascade reactions involving a catalytic carbene/alkyne metathesis (CAM) process through a vinyl carbene intermediate provide an efficient and step-economic approach for the construction of polycyclic frameworks with structural diversity.

Graphical abstract: Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization
From the themed collection: Carbenes in Organic Synthesis
Review Article

Catalytic dehydrogenative aromatization of cyclohexanones and cyclohexenones

Prompted by the scant attention paid by published literature reviews to the comprehensive catalytic dehydrogenative aromatization of cyclohexa(e)nones, this review describes recent methods developed to-date involving transition-metal-catalyzed oxidative aromatization and metal-free strategies for the transformation of cyclohexa(e)nones to substituted phenols.

Graphical abstract: Catalytic dehydrogenative aromatization of cyclohexanones and cyclohexenones
From the themed collection: Synthetic methodology in OBC
Review Article

Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

Intermolecular alkene difunctionalizations for the direct synthesis of saturated heterocycles.

Graphical abstract: Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

Decarbonylative cross-coupling of amides

We present recent advances and key developments in the field of decarbonylative cross-coupling reactions of amides by a formal double N–C/C–C bond activation as well as discuss future challenges and potential applications for this exciting field.

Graphical abstract: Decarbonylative cross-coupling of amides
From the themed collection: Synthetic methodology in OBC
Review Article

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

This Review article provides a summary and critical metrics-based analysis of recently developed catalytic Mitsunobu reactions.

Graphical abstract: The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Recent progress in the synthesis of phosphorus-containing indole derivatives

Phosphorus-containing indole derivatives represent a special class of phosphorus-containing nitrogen heterocycles. This review summarizes the recent progress in the synthesis of such compounds, briefly discusses the reaction mechanisms and challenges, and outlines the synthetic opportunities still open.

Graphical abstract: Recent progress in the synthesis of phosphorus-containing indole derivatives
From the themed collection: Synthetic methodology in OBC
Review Article

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity

Diversity-oriented synthesis adds biological performance as a new diversity element.

Graphical abstract: Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
Review Article

Cyclic imines – preparation and application in synthesis

Cyclic imines, available from various nitrogen-containing reactants, serve as versatile synthetic intermediates for biologically active compounds.

Graphical abstract: Cyclic imines – preparation and application in synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the synthesis of cyclopropanes

Cyclopropanes have gained much attention by virtue of their interesting structure and unique reactivity. This review discusses the recent advances in the synthesis of cyclopropanes, and some of the related applications will be discussed.

Graphical abstract: Recent advances in the synthesis of cyclopropanes
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments and applications of cyanamides in electrophilic cyanation

This review summarizes the recent developments and applications of readily accessible cyanamides in the electrophilic cyanation of various nucleophiles.

Graphical abstract: Recent developments and applications of cyanamides in electrophilic cyanation
From the themed collection: Synthetic methodology in OBC
Review Article

Recent developments in functionalization of acyclic α-keto amides

This review describes the synthetic utility of α-keto amides to synthesize various important molecules via mono, dual and triple functionalization reactions.

Graphical abstract: Recent developments in functionalization of acyclic α-keto amides
From the themed collection: Synthetic methodology in OBC
Review Article

Non-toxic cyanide sources and cyanating agents

This review focuses on alternative cyanide sources and cyanating agents which are less hazardous than HCN or its salts.

Graphical abstract: Non-toxic cyanide sources and cyanating agents
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in β-lactam synthesis

During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis.

Graphical abstract: Recent advances in β-lactam synthesis
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis.

Graphical abstract: Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals
From the themed collection: Synthetic methodology in OBC
Review Article

C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

Recent synthetic applications and methodological advancements of the Pd(II)-catalyzed C2 functionalisation of indoles are highlighted and discussed in this review.

Graphical abstract: C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments
From the themed collection: Synthetic methodology in OBC
Review Article

Recent advances in the annulation of Morita–Baylis–Hillman adducts

In this review, we summarize some of the most recent advances in the construction of cyclic compounds from the annulation of Morita–Baylis–Hillman (MBH) adducts, which have demonstrated their importance by possessing diverse functional groups.

Graphical abstract: Recent advances in the annulation of Morita–Baylis–Hillman adducts
From the themed collection: Synthetic methodology in OBC
Review Article

Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant

This review is focused on recent developments in the use of small organic molecules as photocatalysts.

Graphical abstract: Photoorganocatalysis, small organic molecules and light in the service of organic synthesis: the awakening of a sleeping giant
From the themed collection: Synthetic methodology in OBC
Review Article

Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation

This review describes recent developments in the use of catalytic transient directing groups, through imine linkages, which in combination with transition metal catalysts provide streamlined C–H functionalisation processes.

Graphical abstract: Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation
Review Article

Copper nitrate: a privileged reagent for organic synthesis

This review demonstrates the state-of-the-art applications of copper nitrate as a nitration reagent, oxidant, catalyst, promoter and precursor of nitrile oxides.

Graphical abstract: Copper nitrate: a privileged reagent for organic synthesis
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of polyheterocycles via multicomponent reactions

Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields.

Graphical abstract: Synthesis of polyheterocycles via multicomponent reactions
From the themed collection: Synthetic methodology in OBC
Review Article

C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process

This review is focused on the recent advances in the C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process. Diverse substituted hydrazones including N-heterocycles are afforded under mild conditions with excellent selectivities. In general, an aminyl radical as the key intermediate is involved during the reaction process.

Graphical abstract: C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process
From the themed collection: Synthetic methodology in OBC
Review Article

Nitrilium ions – synthesis and applications

Access to both stable and transient nitrilium ions and the use of these synthons in the organic synthesis of imines and a large spectrum of heterocycles and transition metal complexes are succinctly summarized.

Graphical abstract: Nitrilium ions – synthesis and applications
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Cross 1,3-dipolar cycloadditions of C,N-cyclic azomethine imines with N-benzyl azomethine ylide: facile access to fused tricyclic 1,2,4-hexahydrotriazines

From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Communication

Ruthenium-Catalyzed Synthesis of Indole Derivatives From N-Aryl-2-aminopyridines and alpha-Carbonyl Sulfoxonium Ylides

From the themed collection: Synthetic methodology in OBC
Communication

Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

Direct arylation and heteroarylation of unprotected tetrahydroisoquinolines were achieved under conditions free of metals, oxidants and solvents.

Graphical abstract: Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction
From the themed collection: Synthetic methodology in OBC
Communication

A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

The syntheses of 2-aryl indenones via gold(I)-catalyzed cyclization/aerobic oxidation was reported. The mechanism was probed by heavy atom labelling and control experiments. A formal total synthesis of isoprekinamycin was achieved.

Graphical abstract: A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes
From the themed collection: Synthetic methodology in OBC
Communication

A new synthetic route to 5,6,11,12-tetraarylethynyltetracenes

A new synthetic route to 5,6,11,12-tetrakis(arylethynyl)tetracenes, π-extended rubrenes, was developed via [4 + 2] cycloadditions of dialkynylisobenzofuran and 1,4-naphthoquinone.

Graphical abstract: A new synthetic route to 5,6,11,12-tetraarylethynyltetracenes
From the themed collection: Synthetic methodology in OBC
Communication

Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling

An alternative protocol for the B-alkyl Suzuki–Miyaura reaction to produce cyclic α,β-disubstituted enones is reported.

Graphical abstract: Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling
From the themed collection: New Talent
Communication

Organocatalytic asymmetric synthesis of highly substituted pyrrolidines bearing a stereogenic quaternary centre at the 3-position

An organocatalytic asymmetric cascade reaction has been developed between N-tosyl aminomethyl enones and trans-α-cyano-α,β-unsaturated ketones for the synthesis of highly substituted pyrrolidines having a stereogenic quaternary centre at the 3-position.

Graphical abstract: Organocatalytic asymmetric synthesis of highly substituted pyrrolidines bearing a stereogenic quaternary centre at the 3-position
From the themed collection: Synthetic methodology in OBC
Communication

Practical regio- and stereoselective azidation and amination of terminal alkenes

A metal-free synthesis of allylic azides and allylic amines was achieved under mild reaction conditions, which represents a milder alternative for azidation and amination reactions.

Graphical abstract: Practical regio- and stereoselective azidation and amination of terminal alkenes
From the themed collection: Synthetic methodology in OBC
Communication

An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters.

Graphical abstract: An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis
From the themed collection: New Talent
Communication

Aza-tricycles containing a perfluoroalkyl group: synthesis, structure and fluorescence

Perfluoroalkyl-containing aza-tricycles have been prepared in one synthetic operation via an ambient light-promoted three-component reaction of β-oxo esters, perfluoroalkyl iodide and DBU.

Graphical abstract: Aza-tricycles containing a perfluoroalkyl group: synthesis, structure and fluorescence
From the themed collection: Synthetic methodology in OBC
Communication

Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones

Asymmetric nucleophilic phenylation of N-alkoxyenamine with triphenylaluminium is achieved for the formation of enantioenriched α-phenyl ketones through a one-pot process.

Graphical abstract: Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones
From the themed collection: Synthetic methodology in OBC
Communication

One-step synthesis of N,N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction

A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent.

Graphical abstract: One-step synthesis of N,N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
From the themed collection: Synthetic methodology in OBC
Communication

Inverse-electron-demand Diels–Alder reactions of α,β-unsaturated hydrazones with 3-methoxycarbonyl α-pyrones

Inverse-electron-demand Diels–Alder reactions of 3-electron-withdrawing group substituted α-pyrones with α,β-unsaturated hydrazones as electron-rich counterparts are catalyzed by Eu(hfc)3 to afford bicyclic lactone cycloadducts.

Graphical abstract: Inverse-electron-demand Diels–Alder reactions of α,β-unsaturated hydrazones with 3-methoxycarbonyl α-pyrones
From the themed collection: Synthetic methodology in OBC
Communication

A removable functional group strategy for regiodivergent Wittig rearrangement products

Controlling anionic pericyclic [2,3] Wittig and bis-radical [1,2] Wittig reactions for unprecedented regiodivergency via a single removable functional group.

Graphical abstract: A removable functional group strategy for regiodivergent Wittig rearrangement products
From the themed collection: Synthetic methodology in OBC
Communication

Electrochemical cobalt-catalyzed C–H or N–H oxidation: a facile route to synthesis of substituted oxindoles

Two comparable protocols for the electrochemical cobalt-catalyzed C–H/N–H oxidation have been exploited for the synthesis of oxindoles via radical pathways.

Graphical abstract: Electrochemical cobalt-catalyzed C–H or N–H oxidation: a facile route to synthesis of substituted oxindoles
From the themed collection: Synthetic methodology in OBC
Communication

Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides

An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using N-aromatic zwitterions, aldehydes, and amino acids.

Graphical abstract: Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides
From the themed collection: Synthetic methodology in OBC
Communication

Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids

Asymmetric hydrogenations of imines were realized by using readily available chiral alkene-derived Lewis acids to give up to 89% ee.

Graphical abstract: Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of fluoroalkylated alkynes via visible-light photocatalysis

Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis.

Graphical abstract: Synthesis of fluoroalkylated alkynes via visible-light photocatalysis
From the themed collection: Synthetic methodology in OBC
Communication

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. Various chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities.

Graphical abstract: Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines
From the themed collection: Synthetic methodology in OBC
Communication

Cyclopropanation of alkenes with metallocarbenes generated from monocarbonyl iodonium ylides

Wittig-type reactivity between iodosoarenes and phosphoranes leads to monocarbonyl iodonium ylides, which readily serve as metallocarbene precursors.

Graphical abstract: Cyclopropanation of alkenes with metallocarbenes generated from monocarbonyl iodonium ylides
From the themed collection: Carbenes in Organic Synthesis
Communication

A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides

An efficient method for cyano-substituted amides via a tandem decyanation/cyanation reaction of α-iminonitriles.

Graphical abstract: A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides
From the themed collection: Synthetic methodology in OBC
Communication

Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel

A green and efficient electrocatalytic reductive amination of electron-deficient aldehydes/ketones for the preparation of racemic clopidogrel.

Graphical abstract: Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel
From the themed collection: Synthetic methodology in OBC
Communication

Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

1,1-Dimethyl-2,2,2-trifluoroethyl substituted oxindoles were prepared by a novel transition metal-free decarboxylative fluoroalkylation of activated alkenes and C–H functionalization cascade process.

Graphical abstract: Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)
From the themed collection: Synthetic methodology in OBC
Communication

Catalyst-free 1 : 2 annulation of quinolines with trifluoroacetylacetylenes: an access to functionalized oxazinoquinolines

Catalyst-free reaction of quinolines with two molecules of aryltrifluoroacetylacetylenes afforded 3-arylethynyl-3-trifluoromethyl-1,3-oxazinoquinolines in up to 92% yields.

Graphical abstract: Catalyst-free 1 [ ] : [ ] 2 annulation of quinolines with trifluoroacetylacetylenes: an access to functionalized oxazinoquinolines
From the themed collection: Synthetic methodology in OBC
Communication

Copper-catalyzed synthesis of 2-acylbenzo[b]thiophenes from 3-(2-iodophenyl)-1-arylpropan-1-ones and potassium sulfide under aerobic conditions

A method was developed for the synthesis of 2-acylbenzo[b]thiophenes via a copper-catalyzed sulfuration of 3-(2-iodophenyl)-1-arylpropan-1-ones with K2S.

Graphical abstract: Copper-catalyzed synthesis of 2-acylbenzo[b]thiophenes from 3-(2-iodophenyl)-1-arylpropan-1-ones and potassium sulfide under aerobic conditions
From the themed collection: Synthetic methodology in OBC
Communication

Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

Access to hydantoin cores via a [3 + 2] annulation of α-halohydroxamates and isocyanates involving aza-oxyallyl cations.

Graphical abstract: Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates
From the themed collection: Synthetic methodology in OBC
Communication

Transition-metal-free KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins using Bunte salts

An efficient and eco-friendly protocol for the KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins with Bunte salts was established under metal-free conditions.

Graphical abstract: Transition-metal-free KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins using Bunte salts
From the themed collection: Synthetic methodology in OBC
Communication

Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues

A one-pot oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters at room temperature is reported.

Graphical abstract: Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues
From the themed collection: Synthetic methodology in OBC
Communication

Multi-component synthesis of 3-substituted indoles and their cyclisation to α-carbolines via I2-promoted intramolecular C2 oxidative amination/aromatisation at room temperature

The synthesis of α-carbolines through intramolecular C2 amination/aromatization of the indole ring under mild conditions is reported.

Graphical abstract: Multi-component synthesis of 3-substituted indoles and their cyclisation to α-carbolines via I2-promoted intramolecular C2 oxidative amination/aromatisation at room temperature
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives using simple α-keto amides and alkynes as substrates.

Graphical abstract: Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
From the themed collection: Synthetic methodology in OBC
Communication

Iron(III)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines

A Fe-catalyzed highly regioselective α,β-difunctionalization of vinylarenes with diphenylphosphine oxides and anilines is disclosed, in which α,β-aminophosphinoylation is efficiently and conveniently constructed with good functional compatibility and a broad substrate scope.

Graphical abstract: Iron(iii)-catalyzed radical α,β-aminophosphinoylation of styrenes with diphenylphosphine oxides and anilines
From the themed collection: Catalysis & biocatalysis in OBC
Communication

KHMDS mediated synthesis of 9-arylfluorenes from dibenzothiophene dioxides and arylacetonitriles by tandem SNAr-decyanation-based arylation

A straightforward KHMDS mediated synthetic route to 9-arylfluorenes from readily available starting materials has been developed.

Graphical abstract: KHMDS mediated synthesis of 9-arylfluorenes from dibenzothiophene dioxides and arylacetonitriles by tandem SNAr-decyanation-based arylation
From the themed collection: Synthetic methodology in OBC
Communication

Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

The facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and 1,3-dicarbonyl compounds has been developed. Hydrazonyl chlorides reacted with N-phenyl-3-oxobutanamides smoothly to afford a series of polysubstituted pyrazoles in 67–98% yields via the [3 + 2]-cycloaddition.

Graphical abstract: Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles
From the themed collection: Synthetic methodology in OBC
Communication

A cascade synthesis of S-allyl benzoylcarbamothioates via Mumm-type rearrangement

A cascade synthesis of S-allyl benzoylcarbamothioates has been achieved from Morita Baylis Hillman alcohols and aroyl isothiocyanates via Mumm-type rearrangement.

Graphical abstract: A cascade synthesis of S-allyl benzoylcarbamothioates via Mumm-type rearrangement
From the themed collection: Synthetic methodology in OBC
Communication

New Friedel–Crafts strategy for preparing 3-acylindoles

A new Friedel–Crafts acylation generates diverse high-biological value 3-acylindoles, and forms a new C–C bond under transition-metal-free conditions.

Graphical abstract: New Friedel–Crafts strategy for preparing 3-acylindoles
From the themed collection: Synthetic methodology in OBC
Communication

C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor

C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and other pharmaceutically-relevant scaffolds in excellent mass balance.

Graphical abstract: C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor
From the themed collection: Synthetic methodology in OBC
Communication

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed.

Graphical abstract: Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride
From the themed collection: Synthetic methodology in OBC
Communication

Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

A novel and efficient fast synthesis of 3-amino isocoumarins in good to excellent yields is reported.

Graphical abstract: Rapid synthesis of 3-amino isocoumarin derivatives from ynamides
From the themed collection: Synthetic methodology in OBC
Communication

An efficient synthesis of triazolium ion based NHC precursors using diaryliodonium salts and their photophysical properties

Triazolium salts were prepared by copper-catalyzed N-arylation of fused triazoles using diaryliodonium salts. These salts could behave as versatile NHC catalysts and fluorescent probes.

Graphical abstract: An efficient synthesis of triazolium ion based NHC precursors using diaryliodonium salts and their photophysical properties
From the themed collection: Synthetic methodology in OBC
Communication

Cp*Co(III)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Cp*Co(III)-catalysed selective alkylation of directed C–H bonds of arenes and heteroarenes has been accomplished employing donor–acceptor carbenes, derived from α-diazocarbonyl compounds.

Graphical abstract: Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds
From the themed collection: Carbenes in Organic Synthesis
Communication

Four-component acyloxy-trifluoromethylation of arylalkenes mediated by a photoredox catalyst

A four-component intermolecular trifluoromethylation–acyloxylation of arylalkenes induced by visible light has been developed in the presence of the photoredox catalyst Ru(bpy)3(PF6)2 under mild reaction conditions.

Graphical abstract: Four-component acyloxy-trifluoromethylation of arylalkenes mediated by a photoredox catalyst
From the themed collection: Synthetic methodology in OBC
Communication

Atom-economic synthesis of cyclobuta[a]naphthalen-4-ols via a base-promoted [2 + 2] cycloaddition/1,6-nucleophilic addition cascade

An atom-economic [2 + 2] cycloaddition cascade of yne-allenones with C-nucleophiles has been established, enabling the direct generation of functionalized cyclobuta[a]naphthalen-4-ols with generally good yields.

Graphical abstract: Atom-economic synthesis of cyclobuta[a]naphthalen-4-ols via a base-promoted [2 + 2] cycloaddition/1,6-nucleophilic addition cascade
From the themed collection: Synthetic methodology in OBC
473 items - Showing page 1 of 7

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The latest articles published in Organic and Biomolecular Chemistry related to synthetic methodology.

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