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Themed collection Organic & Biomolecular Chemistry HOT article collection

119 items - Showing page 1 of 2
Review Article

Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes

Olefin 1,2-difunctionalization is a popular synthetic strategy for synthesis of vicinal amino alcohols and their derivatives. This comprehensive review covers methods developed beyond the pioneering osmium-catalyzed Sharpless amino hydroxylation.

Graphical abstract: Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes
From the themed collection: Synthetic methodology in OBC
Review Article

Reframing primary alkyl amines as aliphatic building blocks

This review covers recent and historical aliphatic deaminative functionalization reactions to encourage the use of primary amines as aliphatic building blocks.

Graphical abstract: Reframing primary alkyl amines as aliphatic building blocks
From the themed collection: Synthetic methodology in OBC
Review Article

Integrating abiotic chemical catalysis and enzymatic catalysis in living cells

We review hybrid systems of abiotic catalysis and enzymatic catalysis, which function in living cells. This research direction will stimulate multidisciplinary fields, including complex molecule synthesis, energy production, and life science.

Graphical abstract: Integrating abiotic chemical catalysis and enzymatic catalysis in living cells
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Review Article

Recent advances in the synthesis of α-amino ketones

This review on α-amino ketone synthesis collates and evaluates developments made in this area over the past decade, with an extended discussion on functional group compatibility, resultant product substitution patterns, and medicinal applications.

Graphical abstract: Recent advances in the synthesis of α-amino ketones
From the themed collection: Synthetic methodology in OBC
Review Article

Transition metal-free synthesis of alkyl pinacol boronates

This review systematically outlined the research in the area of transition metal free synthesis of alkyl pinacol boronates, which are versatile and important scaffolds to construct diverse organic compounds.

Graphical abstract: Transition metal-free synthesis of alkyl pinacol boronates
From the themed collection: Synthetic methodology in OBC
Review Article

Copper-catalysed radical reactions of alkenes, alkynes and cyclopropanes with N–F reagents

The mild generation of nitrogen-centred radicals from N–F reagents using copper-based catalysts has become a convenient synthetic tool.

Graphical abstract: Copper-catalysed radical reactions of alkenes, alkynes and cyclopropanes with N–F reagents
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Cobalt-catalyzed carbonylation of the C–H bond

Direct carbonylation of the C–H bond is a great tool for installing a carbonyl group in a wide variety of substrates.

Graphical abstract: Cobalt-catalyzed carbonylation of the C–H bond
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Synthesis strategies for non-symmetric, photochromic diarylethenes

This review surveys synthesis strategies for accessing non-symmetric diarylethene photochromes and highlights notable properties and applications of these compounds.

Graphical abstract: Synthesis strategies for non-symmetric, photochromic diarylethenes
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Synthetic approaches and applications of sulfonimidates

This review encompasses the developments in sulfonimidate chemistry, focusing on both syntheses and applications of these important organosulfur(VI) species.

Graphical abstract: Synthetic approaches and applications of sulfonimidates
From the themed collection: Synthetic methodology in OBC
Review Article

Rational design of small molecule fluorescent probes for biological applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

Graphical abstract: Rational design of small molecule fluorescent probes for biological applications
Review Article

The curious yellow colouring matter of the Iceland poppy

This account provides an chronological overview of the fascinating history of the pigment responsible for the yellow colour of the Iceland poppy (Papaver nudicaule).

Graphical abstract: The curious yellow colouring matter of the Iceland poppy
Review Article

TLR2 agonists and their structure–activity relationships

We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.

Graphical abstract: TLR2 agonists and their structure–activity relationships
Review Article

Chemical methods for modification of proteins

The field of protein bioconjugation draws attention from stakeholders in chemistry, biology, and medicine. This review provides an overview of the present status, challenges, and opportunities for organic chemists.

Graphical abstract: Chemical methods for modification of proteins
Review Article

Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms

Advances in the synthesis of multiphosphorylated peptides and peptide libraries: tools for studying the effects of phosphorylation patterns on protein function and regulation.

Graphical abstract: Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms
Review Article

Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme

The review examines functional knowledge gathered over two decades of research on the 8-17 DNAzyme, focusing on three aspects: the structural requirements for catalysis, the role of metal ions and the participation of general acid-base catalysis.

Graphical abstract: Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
Review Article

Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective

This review surveys known structures of staphylococcal polysaccharides and summarizes all synthetic efforts to obtain these sequences.

Graphical abstract: Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective
Open Access Review Article

Recent trends in catalytic sp3 C–H functionalization of heterocycles

In this mini-review, we attempt to highlight gaps in existing techniques for sp3 C–H activation adjacent to heterocycles.

Graphical abstract: Recent trends in catalytic sp3 C–H functionalization of heterocycles
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Construction of an IMiD-based azide library as a kit for PROTAC research

As a promising protein degradation strategy, PROTAC technology is increasingly becoming a new star in cancer treatment.

Graphical abstract: Construction of an IMiD-based azide library as a kit for PROTAC research
Communication

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Sulfoxides have been synthesised from various sulfide substrates under mild conditions exploiting CALB biocatalyst in the presence of urea hydrogen peroxide and AcOEt which acts with the dual role of solvent and reagent.

Graphical abstract: A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis

The synergy of an Ir-based photosensitizer with mild oxidizing ability and a thiol catalyst enables efficient allylic C–H functionalization of enol silyl ethers with imines under visible light irradiation.

Graphical abstract: Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis
From the themed collection: Synthetic methodology in OBC
Communication

A scalable continuous photochemical process for the generation of aminopropylsulfones

An efficient continuous photochemical process is presented that delivers a series of novel γ-aminopropylsulfones via a tetrabutylammonium decatungstate (TBADT) catalysed HAT-process.

Graphical abstract: A scalable continuous photochemical process for the generation of aminopropylsulfones
From the themed collection: Synthetic methodology in OBC
Communication

Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides

Ethyl thioglycosides could be selectively activated in the presence of phenyl thioglycosides carrying the same or even more armed protecting group pattern.

Graphical abstract: Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides
Communication

Total synthesis of thioamycolamide A via a biomimetic route

A concise total synthesis of thioamycolamide A was accomplished as a key step of thio-Michael addition via a biomimetic route.

Graphical abstract: Total synthesis of thioamycolamide A via a biomimetic route
Communication

Chemo- and regioselective synthesis of polysubstituted 2-aminothiophenes by the cyclization of gem-dibromo or gem-dichloroalkenes with β-keto tertiary thioamides

A facile and practical method for the synthesis of 2,3,4-trisubstituted 2-aminothiophenes by the cyclization of gem-dibromoalkenes or gem-dichloroalkenes with β-keto tertiary thioamides has been developed.

Graphical abstract: Chemo- and regioselective synthesis of polysubstituted 2-aminothiophenes by the cyclization of gem-dibromo or gem-dichloroalkenes with β-keto tertiary thioamides
From the themed collection: Synthetic methodology in OBC
Communication

Highly stereocontrolled total synthesis of secodolastane diterpenoid isolinearol

The first total synthesis of the secodolastane diterpenoid isolinearol in both racemic and enantioenriched forms has been achieved with high stereoselectively.

Graphical abstract: Highly stereocontrolled total synthesis of secodolastane diterpenoid isolinearol
Communication

Selective construction of alkaloid scaffolds by alcohol-based direct and mild aerobic oxidative Pictet–Spengler reactions

Tetrahydro-β-carboline and β-carboline alkaloid scaffolds can be selectively obtained by direct aerobic oxidative Pictet–Spengler reactions of tryptamines with alcohols using TBN/TEMPO as the catalysts and oxygen as the oxidant under mild conditions.

Graphical abstract: Selective construction of alkaloid scaffolds by alcohol-based direct and mild aerobic oxidative Pictet–Spengler reactions
From the themed collection: Synthetic methodology in OBC
Communication

Rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans by hybrid use of Lewis/Brønsted acid catalysts

Expeditious synthesis of 3-indolyl-1-trifluoromethyl-isobenzofurans via [1,4]-hydride shift/cyclization/intermolecular nucleophilic addition reaction sequence.

Graphical abstract: Rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans by hybrid use of Lewis/Brønsted acid catalysts
From the themed collection: Synthetic methodology in OBC
Communication

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Aqueous Knoevenagel condensation of various aldehydes with malononitrile could efficiently proceed using hydroquinone and benzoquinone as mixed catalysts.

Graphical abstract: Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation
From the themed collection: Synthetic methodology in OBC
Communication

Boracene-based alkylborate enabled Ni/Ir hybrid catalysis

Boracene-based alkylborate enabled visible light-mediated Ni/Ir metallaphotoredox catalysis.

Graphical abstract: Boracene-based alkylborate enabled Ni/Ir hybrid catalysis
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Communication

Defluorination of 4-fluorothreonine by threonine deaminase

Threonine deaminase from E. coli catalyses defluorination on 4-fluorothreonine.

Graphical abstract: Defluorination of 4-fluorothreonine by threonine deaminase
Communication

BINOL derivatives-catalysed enantioselective allylboration of isatins: application to the synthesis of (R)-chimonamidine

3-Allyl-3-hydroxyoxindoles are obtained with high ee in a metal-free catalytic process from isatins. This scaffold has been converted to the natural product chimonamidine.

Graphical abstract: BINOL derivatives-catalysed enantioselective allylboration of isatins: application to the synthesis of (R)-chimonamidine
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives.

Graphical abstract: Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity
From the themed collection: Synthetic methodology in OBC
Communication

Disulphide-mediated site-directed modification of proteins

Site-directed addition of a single thiols handle to proteins by means of temporary disulphide rebridging of solvent exposed disulphides is obtained with a new labelling reagent.

Graphical abstract: Disulphide-mediated site-directed modification of proteins
Communication

Sesquiterpene synthases for bungoene, pentalenene and epi-isozizaene from Streptomyces bungoensis

A sesquiterpene synthase from Streptomyces bungoensis was characterised and produces the new compound bungoene.

Graphical abstract: Sesquiterpene synthases for bungoene, pentalenene and epi-isozizaene from Streptomyces bungoensis
Communication

Site-selective modification of proteins using cucurbit[7]uril as supramolecular protection for N-terminal aromatic amino acids

Supramolecular protection of N-terminal aromatic amino acids through complexation with cucurbit[7]uril can enable site-selective protein modification of unfavored motifs.

Graphical abstract: Site-selective modification of proteins using cucurbit[7]uril as supramolecular protection for N-terminal aromatic amino acids
Communication

Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein–protein interactions

Homo-oligomers are difficult drug targets. Here, Differential Scanning Fluorimetry (DSF) is introduced as a method to identify inhibitors of these systems, by discriminating between oligomers and monomers based on their thermal stability.

Graphical abstract: Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein–protein interactions
Open Access Communication

Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation

A genetically incorporated ThrK unnatural amino acid can undergo rapid periodate oxidation to reveal a reactive internal α-oxo aldehyde.

Graphical abstract: Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation
Communication

Hierarchical self-assembly of an azobenzene dyad with inverted amide connection into toroidal and tubular nanostructures

Inversion of the amide connectivity of an azobenzene dyad, which self-assembles into chiral toroids and nanotubes, improves the thermal stability of the assemblies, however it negatively affects supramolecular chirality.

Graphical abstract: Hierarchical self-assembly of an azobenzene dyad with inverted amide connection into toroidal and tubular nanostructures
Communication

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8

N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions in the biosynthesis of trichostatin.

Graphical abstract: Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
Communication

A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

Efficient approach for the facile construction of polyfunctionalized pyrazolone derivatives bearing two contiguous quaternary stereocenters in good yields with high regioselectivities and excellent diastereoselectivities.

Graphical abstract: A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Enantioselective synthesis and determination of the absolute configuration of the male sex pheromone of the parasitoid wasp Urolepis rufipes

The parasitoid wasp Urolepis rufipes uses terminally oxidized dihydrolinalool as a sex pheromone. The absolute configuration of the active enantiomer was established as 2S,6S by synthesis and its pheromonal activity was proven in a bioassay.

Graphical abstract: Enantioselective synthesis and determination of the absolute configuration of the male sex pheromone of the parasitoid wasp Urolepis rufipes
Communication

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides

A major current issue in medicinal chemistry is the design of small peptide analogues resistant to proteolysis and able to adopt preferential conformations, while preserving the selectivity and efficiency of natural peptides.

Graphical abstract: Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides
Communication

Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.

Graphical abstract: Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates
Communication

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

The practical synthesis of pseudo-enantiomeric carbohydrate-based NHC–Rh complexes bearing C1 or C3 sterically differentiated positions is reported. We show that steric bulk at either C1 or C3 leads to enantiotopic discrimination in the hydrosilylation of acetophenone.

Graphical abstract: Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination
Communication

Non-biaryl atropisomerism at the C–B bond in sterically hindered aminoarylboranes

Sterically hindered aminoarylboranes with atropisomerism about the C–B bond were prepared and resolved by chiral stationary phase HPLC.

Graphical abstract: Non-biaryl atropisomerism at the C–B bond in sterically hindered aminoarylboranes
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Merging singlet-oxygen induced furan oxidations with organocatalysis: synthesis of enantiopure cyclopentanones and hydrindanes

A general, flexible and highly effective method for the regio-, diastereo- & enantioselective one-pot synthesis of important carbocycles, namely, enantiopure cyclopentanones and their hydrindane congeners is presented.

Graphical abstract: Merging singlet-oxygen induced furan oxidations with organocatalysis: synthesis of enantiopure cyclopentanones and hydrindanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

Genome mining and heterologous biosynthesis led to the discovery of a 12 membered macrolide from Macrophomina phaseolina.

Graphical abstract: Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina
Open Access Communication

Organocatalytic carbon dioxide fixation to epoxides by perfluorinated 1,3,5-triols catalysts

A new type of perfluorinated triol catalysts of enhanced acidity was developed for the selective opening of epoxide to carbonates. This useful transformation using TBAI as co-catalyst is performed under only 1 atmosphere of CO2 at 30 to 80 °C.

Graphical abstract: Organocatalytic carbon dioxide fixation to epoxides by perfluorinated 1,3,5-triols catalysts
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines

The diastereoselective conjugate addition of chiral secondary lithium homoallylamides to α,β-unsaturated esters, providing tertiary amines bearing two chains integrating a stereogenic center adjacent to the nitrogen atom, is reported.

Graphical abstract: Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines
From the themed collection: Synthetic methodology in OBC
Communication

Regioselective catalytic asymmetric N-alkylation of isoxazol-5-ones with para-quinone methides

A highly regioselective and enantioselective N-alkylation of isoxazol-5-ones with para-quinone methides has been developed to obtain enantioenriched N-diarylmethane substituted isoxazolinones with high yields and enantioselectivities.

Graphical abstract: Regioselective catalytic asymmetric N-alkylation of isoxazol-5-ones with para-quinone methides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)

Deprotected iminosugar alkenes were subjected to thiol–ene coupling with deprotected sugar thiols to afford new imino-disaccharides. Two thiol–ene couplings converted these alkenes into iminosugar thiols and then multivalent iminosugars.

Graphical abstract: Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry

In this study we describe a novel platform for generating functionalised TIPS microparticles for “click” conjugation to various active compounds.

Graphical abstract: Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry
Open Access Communication

Reagent controlled stereoselective synthesis of teichoic acid α-(1,2)-glucans

Additive controlled glycosylation reactions are used for the construction of α-(1,2)-glucosidic linkages, such as those featuring in E. faecalis lipoteichoic acid.

Graphical abstract: Reagent controlled stereoselective synthesis of teichoic acid α-(1,2)-glucans
From the themed collection: Synthetic methodology in OBC
Communication

Robust synthesis of NIR-emissive P-rhodamine fluorophores

A library of P-rhodamines was prepared via a new robust sequence that creates the core heterocycle by addition of diaryllithium reagents to esters. The first SAR study for P-rhodamines shows that they are NIR-emissive and highly bright fluorophores.

Graphical abstract: Robust synthesis of NIR-emissive P-rhodamine fluorophores
From the themed collection: Synthetic methodology in OBC
Communication

Cobalt-catalyzed regioselective hydrohydrazination of epoxides

A series of valuable 1,1-hydrazinoalcohols were conveniently synthesized by catalytic hydrohydrazination of epoxides with the NH group of hydrazines.

Graphical abstract: Cobalt-catalyzed regioselective hydrohydrazination of epoxides
From the themed collection: Catalysis & biocatalysis in OBC
Communication

γ-C (sp3)–H bond functionalisation of α,β-unsaturated amides through an umpolung strategy

The nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides have been developed.

Graphical abstract: γ-C (sp3)–H bond functionalisation of α,β-unsaturated amides through an umpolung strategy
From the themed collection: Synthetic methodology in OBC
Open Access Communication

Automated access to well-defined ionic oligosaccharides

Automated Glycan Assembly grants access to ionic oligosaccharides for structural studies.

Graphical abstract: Automated access to well-defined ionic oligosaccharides
Communication

The strategic use of para-quinone methides to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides from unprotected carbohydrate amines

A practical route to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides via Sc(OTf)3-catalyzed 1,6-conjugate addition of unprotected amino sugars with p-QMs.

Graphical abstract: The strategic use of para-quinone methides to access synthetically challenging and chemoselective α,α′-diarylmethyl N-glycosides from unprotected carbohydrate amines
Open Access Communication

Enantioselective catalytic synthesis of α-aryl-α-SCF32,2-amino acids

Novel α-trifluoromethylthiolated-β2,2-amino acids were obtained in high enantiopurities under chiral phase-transfer catalysis.

Graphical abstract: Enantioselective catalytic synthesis of α-aryl-α-SCF3-β2,2-amino acids
From the themed collection: Synthetic methodology in OBC
Communication

Ag-Catalyzed minisci C–H difluoromethylarylation of N-heteroarenes

A mild silver-catalyzed decarboxylative C–H difluoromethylarylation of electron-deficient N-heteroarenes.

Graphical abstract: Ag-Catalyzed minisci C–H difluoromethylarylation of N-heteroarenes
From the themed collection: Synthetic methodology in OBC
Open Access Paper

Kinetic and structure–activity studies of the triazolium ion-catalysed benzoin condensation

An initial rate evaluation of the triazolium-catalysed benzoin condensation permitted a Hammett structure–activity analysis providing insight into the rate-limiting step.

Graphical abstract: Kinetic and structure–activity studies of the triazolium ion-catalysed benzoin condensation
Paper

Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones

Synthesis of dynamic combinatorial libraries of acylhydrazones in the presence of a G-quadruplex DNA template, followed by pull-down with streptavidin-coated magnetic beads, allows the identification of putative G-quadruplex binders.

Graphical abstract: Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones
From the themed collection: Chemical biology in OBC
Paper

Ligand-free Suzuki–Miyaura cross-coupling with low Pd content: rapid development by a fluorescence-based high-throughput screening method

Highly efficient ligand-free Suzuki–Miyaura cross-coupling in aqueous solvent at room temperature was developed using metal oxides with low Pd content via a fluorescence-based high-throughput screening method.

Graphical abstract: Ligand-free Suzuki–Miyaura cross-coupling with low Pd content: rapid development by a fluorescence-based high-throughput screening method
From the themed collection: Catalysis & biocatalysis in OBC
Paper

A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates

A cyclic tetrapeptide paired with six commercially available indicators provides a chemosensing array able to classify biological phosphate derivatives.

Graphical abstract: A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates
From the themed collection: Supramolecular chemistry in OBC
Paper

A matrix targeted fluorescent probe to monitor mitochondrial dynamics

A far-red turn-on fluorescent probe (Mito-TG) with excellent biocompatibility, photostability, chemical stability targets mitochondrial matrix. The insensitivity of probe under different pH and ROS enabled tracking of mitophagy and Aβ induced mitochondrial dynamics.

Graphical abstract: A matrix targeted fluorescent probe to monitor mitochondrial dynamics
From the themed collection: Chemical biology in OBC
Paper

Photocatalyst-free visible-light-promoted quinazolinone synthesis at room temperature utilizing aldehydes generated in situ via C[double bond, length as m-dash]C bond cleavage

This is the first report on a facile tandem route for synthesizing quinazolinones at room temperature from various aminobenzamides and in situ-generated aldehydes.

Graphical abstract: Photocatalyst-free visible-light-promoted quinazolinone synthesis at room temperature utilizing aldehydes generated in situ via C [[double bond, length as m-dash]] C bond cleavage
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: improved catalyst design and the role of in situ racemisation

A N-heterocyclic carbene catalyst incorporating a bulky yet electron-deficient N-aryl substituent promotes chemoselective and enantioselective intermolecular crossed benzoin condensations.

Graphical abstract: Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: improved catalyst design and the role of in situ racemisation
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Paper

One pot synthesis of thio-glycosides via aziridine opening reactions

thio-Glycosides with a pseudo-disaccharide structure are synthesized via aziridine opening reactions starting from glycosyl thioacetates with a one-pot protocol, which affords glycomimetics equipped for easy and stable conjugation to aglycones.

Graphical abstract: One pot synthesis of thio-glycosides via aziridine opening reactions
Paper

Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii

Two rare seco-polycyclic polyprenylated acylphloroglucinols (1 and 2) were isolated from Hypericum sampsonii. Compounds 1 and 2 showed moderate multidrug resistance (MDR) reversal activity to resistant cancer cells, HepG2/ADR and MCF-7/ADR.

Graphical abstract: Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii
Paper

Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation

Functionalized peptides which consist of myostatin-binding peptide and on/off-switchable catalyst efficiently inhibit myostatin by selective photooxygenation, leading to a therapeutic strategy for muscular atrophic disorders.

Graphical abstract: Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation
119 items - Showing page 1 of 2

About this collection

This on-going collection features all the articles published in Organic & Biomolecular Chemistry in 2020 that were highlighted by the reviewers of these articles as being interesting or having particularly significant research.

Congratulations to all the authors whose articles are featured!

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