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Themed collection Organic & Biomolecular Chemistry HOT article collection

65 items
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
Review Article

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity

Diversity-oriented synthesis adds biological performance as a new diversity element.

Graphical abstract: Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
Review Article

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

This Review article provides a summary and critical metrics-based analysis of recently developed catalytic Mitsunobu reactions.

Graphical abstract: The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Non-toxic cyanide sources and cyanating agents

This review focuses on alternative cyanide sources and cyanating agents which are less hazardous than HCN or its salts.

Graphical abstract: Non-toxic cyanide sources and cyanating agents
Review Article

Progress in the synthesis of fluorinated phosphatidylcholines for biological applications

Fluorinated phospholipids have attracted a lot of interest over the past 40 years. While mono- and polyfluorinated analogs are mostly designed to be used as 19F NMR probes, highly fluorinated phospholipids are mainly developed as drug delivery devices and oxygen carriers. This review describes their synthetic pathways, their properties and potential applications.

Graphical abstract: Progress in the synthesis of fluorinated phosphatidylcholines for biological applications
Review Article

Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation

This review describes recent developments in the use of catalytic transient directing groups, through imine linkages, which in combination with transition metal catalysts provide streamlined C–H functionalisation processes.

Graphical abstract: Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation
Review Article

Review of synthetic approaches toward maoecrystal V

Synthetic approaches toward the complex natural product diterpenoid maoecrystal V are reviewed, including successful total syntheses, published synthetic efforts, and efforts compiled from dissertations.

Graphical abstract: Review of synthetic approaches toward maoecrystal V
Review Article

Chiral proton-transfer shuttle catalysts for carbene insertion reactions

The development of chiral proton-transfer shuttles provides a totally new enantiocontrol strategy for transition metal-catalyzed asymmetric carbene insertion reactions.

Graphical abstract: Chiral proton-transfer shuttle catalysts for carbene insertion reactions
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

The Piancatelli reaction and its variants: recent applications to high added-value chemicals and biomass valorization

The conversion of furfuryl alcohols by the Piancatelli reaction (and its C- and N-variants) provided highly functionalized cyclopentenones (intermolecular) and spirocycles (intramolecular).

Graphical abstract: The Piancatelli reaction and its variants: recent applications to high added-value chemicals and biomass valorization
Review Article

Catalytic asymmetric enamine protonation reaction

Recent advances in catalytic enantioselective enamine protonation for the synthesis of optically active carbonyl compounds are summarized in this review.

Graphical abstract: Catalytic asymmetric enamine protonation reaction
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates

Access to hydantoin cores via a [3 + 2] annulation of α-halohydroxamates and isocyanates involving aza-oxyallyl cations.

Graphical abstract: Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates
Communication

Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

The facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and 1,3-dicarbonyl compounds has been developed. Hydrazonyl chlorides reacted with N-phenyl-3-oxobutanamides smoothly to afford a series of polysubstituted pyrazoles in 67–98% yields via the [3 + 2]-cycloaddition.

Graphical abstract: Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles
Communication

Fluorogenic “photoclick” labelling of DNA using a Cy3 dye

Two 2′-deoxyuridines as new building blocks for automated DNA synthesis carry a small aryltetrazole as a “photoclickable” group at their 5-positions.

Graphical abstract: Fluorogenic “photoclick” labelling of DNA using a Cy3 dye
Open Access Communication

A pendant peptide endows a sunscreen with water-resistance

A small-molecule UV-filter with a pendant collagen mimetic peptide anneals to a collagen-laden surface and protects against UV radiation.

Graphical abstract: A pendant peptide endows a sunscreen with water-resistance
Communication

Preparation of homoallylic amines via a three-component coupling process

A three-component synthesis of homoallylic amines is described.

Graphical abstract: Preparation of homoallylic amines via a three-component coupling process
Communication

Two-step activity-based protein profiling of diacylglycerol lipase

Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release.

Graphical abstract: Two-step activity-based protein profiling of diacylglycerol lipase
Communication

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product.

Graphical abstract: Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans
Communication

Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates

An electrochemical Hofmann rearrangement is reported, which provides general and practical access to bioactive carbamates.

Graphical abstract: Electrochemical Hofmann rearrangement mediated by NaBr: practical access to bioactive carbamates
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Chiral NHC-catalyzed 1,3-dipolar [3 + 2] cycloaddition of azomethine imines with α-chloroaldehydes for the synthesis of bicyclic pyrazolidinones

An NHC-catalyzed [3 + 2] cycloaddition reaction of azomethine imines and α-chloroaldehydes was developed for the synthesis of chiral bicyclic pyrazolidinone derivatives.

Graphical abstract: Chiral NHC-catalyzed 1,3-dipolar [3 + 2] cycloaddition of azomethine imines with α-chloroaldehydes for the synthesis of bicyclic pyrazolidinones
Communication

Tuning the fluorescence of tetraphenylethylene in dilute solutions via modulating multiple-hydrogen-bonding interactions between a Hamilton receptor and cyanuric acid

A hydrogen bonded luminescent supramolecular network from HTPE and CTPE can be further tuned.

Graphical abstract: Tuning the fluorescence of tetraphenylethylene in dilute solutions via modulating multiple-hydrogen-bonding interactions between a Hamilton receptor and cyanuric acid
Communication

Synthesis of the [7-5-5] tricyclic core of Daphniphyllum alkaloids

The [7-5-5] tricyclic core of the Daphniphyllum alkaloids was constructed, featuring a Claisen-Ireland rearrangement to install the two contiguous stereogenic centers, E1cB elimination to form the tetrasubstituted C–C double bond, and a 2,3-Wittig rearrangement to construct the quaternary carbon.

Graphical abstract: Synthesis of the [7-5-5] tricyclic core of Daphniphyllum alkaloids
Communication

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

A new bilirubin degradation end product was isolated and characterized.

Graphical abstract: In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product
Communication

A concise total synthesis of cochlearoid B

A T-type calcium channel inhibiting natural product cochlearoid B was synthesized in 7 linear steps.

Graphical abstract: A concise total synthesis of cochlearoid B
Open Access Communication

Total synthesis of incargranine A

Synthetic studies into the origins of the alkaloid incargranine A have resulted in the development of a four-step (longest linear sequence) total synthesis.

Graphical abstract: Total synthesis of incargranine A
Open Access Communication

Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes

These simple bis-ureas are found to be powerful anionophores in synthetic vesicles, and also in a live cell assay employing yellow fluorescent protein.

Graphical abstract: Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes
Paper

Dirhodium(II)/P(t-Bu)3 catalyzed tandem reaction of α,β-unsaturated aldehydes with arylboronic acids

Axially alkylphosphane ligated Rh2(OAc)4 catalyzes the tandem reaction of α,β-unsaturated aldehydes with arylboronic acids to produce ketone derivatives in high yields.

Graphical abstract: Dirhodium(ii)/P(t-Bu)3 catalyzed tandem reaction of α,β-unsaturated aldehydes with arylboronic acids
From the themed collection: Catalysis & biocatalysis in OBC
Paper

A novel peptide conformation: the γ-bend ribbon

Conformational analysis of oligopeptides based on the repeating –(S)-(αMe)Aze-(S)-Ala– dyad allowed the characterization of a 3D-structure featuring multiple, non-consecutive γ-bends.

Graphical abstract: A novel peptide conformation: the γ-bend ribbon
Paper

Sulfur polymer composites as controlled-release fertilisers

A controlled-release fertiliser was prepared by the inverse vulcanisation of canola oil in the presence of nitrogen, phosphorous and potassium nutrients.

Graphical abstract: Sulfur polymer composites as controlled-release fertilisers
Paper

Synthesis of highly rigid phosphine–oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation

Rigid phosphine–oxazoline ligands with a spirocarbon stereogenic center were developed, which exhibited excellent catalytic performance for Pd-catalyzed allylic alkylation reactions.

Graphical abstract: Synthesis of highly rigid phosphine–oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Paper

Stereoselective synthesis of 1,3-disubstituted dihydroisoquinolines viaL-phenylalanine-derived dihydroisoquinoline N-oxides

Addition of Grignard reagents and alkenes to readily available (S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2-oxide allow the highly stereoselective synthesis of a range of 1,3-disubstituted tetrahydroisoquinolines.

Graphical abstract: Stereoselective synthesis of 1,3-disubstituted dihydroisoquinolines vial-phenylalanine-derived dihydroisoquinoline N-oxides
Paper

Synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes

A novel and efficient method for the synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes with the assistance of NaOtBu was developed.

Graphical abstract: Synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes
Paper

Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas

Two unprecedented hexacyclic dimeric diterpenoids from Jatropha curcas and 2 showed significant NO inhibitory activity with IC50 values of 5.65 μM.

Graphical abstract: Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas
Paper

Toward the total synthesis of patellazole B: synthesis of an advanced C1–C25 fragment corresponding to the macrocyclic skeleton

A modular and highly convergent approach enables the assembly of an advanced intermediate towards the total synthesis of patellazole B – a promising anticancer agent.

Graphical abstract: Toward the total synthesis of patellazole B: synthesis of an advanced C1–C25 fragment corresponding to the macrocyclic skeleton
Paper

tert-Butyl nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature

A conversion of o-phenylenediamines into benzotriazoles is reported with tert-butyl nitrite at room temperature. The optimized condition is also well suited for the transformation of sulfonyl and acyl hydrazines into corresponding azides.

Graphical abstract: tert-Butyl nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature
Paper

First catalyst-free CO2 trapping of N-acyliminium ions under ambient conditions: sustainable multicomponent synthesis of thia- and oxazolidinyl carbamates

A sustainable multicomponent approach through catalyst-free utilization of carbon dioxide under ambient conditions for the preparation of carbamates is reported.

Graphical abstract: First catalyst-free CO2 trapping of N-acyliminium ions under ambient conditions: sustainable multicomponent synthesis of thia- and oxazolidinyl carbamates
Paper

Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens.

Graphical abstract: Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus
Open Access Paper

Azodicarboxylate-free esterification with triphenylphosphine mediated by flavin and visible light: method development and stereoselectivity control

Photoredox catalysis: A new way to induce triphenylphosphine to be able to mediate nucleophilic substitution reactions of alcohols and acids.

Graphical abstract: Azodicarboxylate-free esterification with triphenylphosphine mediated by flavin and visible light: method development and stereoselectivity control
Paper

Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis

The site-directed mutagenesis of FgaPT2 switches a regular C4-prenylation to a reverse C3-prenylation of tryptophan-containing cyclic dipeptides.

Graphical abstract: Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis
From the themed collection: Catalysis & biocatalysis in OBC
Open Access Paper

Stereoselective synthesis of 2,6-trans-4-oxopiperidines using an acid-mediated 6-endo-trig cyclisation

An acid-mediated 6-endo-trig cyclisation has been developed for the synthesis of trans-6-alkyl-2-methyl-4-oxopiperidines and used for the stereoselective preparation of quinolizidine alkaloid, (+)-myrtine and the piperidine alkaloid, (−)-solenopsin A.

Graphical abstract: Stereoselective synthesis of 2,6-trans-4-oxopiperidines using an acid-mediated 6-endo-trig cyclisation
Paper

Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules

Efficient route for the stereoselective synthesis of common C1–C19 segment of strevertenes A and G has been developed.

Graphical abstract: Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules
Paper

Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles

Efficient syntheses of 4-epi-galiellalactone and the corresponding activity-based probe enabled chemoproteomic studies to reveal the biological targets.

Graphical abstract: Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles
Open Access Paper

Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer

We present a highly-specific, rapidly activatable dual-FRET-smartprobe for the independent optical detection of metalloproteinases and thrombin in lung cancer tissue.

Graphical abstract: Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer
Paper

Why do A·T and G·C self-sort? Hückel aromaticity as a driving force for electronic complementarity in base pairing

Computations reveal that the potential for aromaticity gain and loss in nucleobases play key roles in modulating base pairing strengths.

Graphical abstract: Why do A·T and G·C self-sort? Hückel aromaticity as a driving force for electronic complementarity in base pairing
Paper

Tracking down protein–protein interactions via a FRET-system using site-specific thiol-labeling

A novel Cys-specific bioorthogonalized linker was synthesized and applied in combination with bioorthogonally applicable fluorescent markers to track down protein–protein (p38-MK2) interactions by FRET.

Graphical abstract: Tracking down protein–protein interactions via a FRET-system using site-specific thiol-labeling
Paper

Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins

FR900452 was demonstrated to be biosynthesized by the gene cluster of maremycin G and diversified by SnoaL-like protein MarP.

Graphical abstract: Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins
Paper

Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches

cis-2-Aminocyclohexanecarboxylic acid replacements at the edges of β-sandwiches reduce β-sheet propensities just enough to prevent aggregation but still maintain a compact structure.

Graphical abstract: Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches
Open Access Paper

Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives

Downsizing of antibodies: molecular construction of chemo-synthetic antibodies of infliximab by scaffolding of three CDR loops yields synthetic antibodies binding hTNFα.

Graphical abstract: Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives
Paper

An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings

A mild and operationally simple methodology is reported for the synthesis of cyclobutane rings imbedded within a C2-symmetric tricyclic framework.

Graphical abstract: An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings
Paper

Synthesis of substituted piperidines by enantioselective desymmetrizing intramolecular aza-Michael reactions

An organocatalytic enantioselective intramolecular aza-Michael reaction has been described for the first time in a desymmetrization process employing substrates different from cyclohexadienones.

Graphical abstract: Synthesis of substituted piperidines by enantioselective desymmetrizing intramolecular aza-Michael reactions
Paper

Diastereo- and enantioselective Mannich/cyclization cascade reaction of isocyanoacetates with cyclic sulfamide ketimines by cinchona alkaloid squaramide/AgOAc cooperative catalysis

This reaction provides facile access to a variety of optically active imidazoline-fused sulfahydantoin derivatives in excellent yields and good to excellent stereoselectivities.

Graphical abstract: Diastereo- and enantioselective Mannich/cyclization cascade reaction of isocyanoacetates with cyclic sulfamide ketimines by cinchona alkaloid squaramide/AgOAc cooperative catalysis
Paper

Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum

Hypermonins A and B, two novel 6-norpolycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from the leaves and twigs of Hypericum monogynum.

Graphical abstract: Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum
Paper

Dynamic kinetic resolution of biaryl atropisomers by chiral dialkylaminopyridine catalysts

Dynamic kinetic resolutions of atropisomers using chiral DMAPs with fluxional chirality.

Graphical abstract: Dynamic kinetic resolution of biaryl atropisomers by chiral dialkylaminopyridine catalysts
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Expanding antibiotic chemical space around the nidulin pharmacophore

Reinvestigating antibiotic scaffolds that were identified during the Golden Age of antibiotic discovery, but have long since been “forgotten”, has proven to be an effective strategy for delivering next-generation antibiotics capable of combatting multidrug-resistant superbugs.

Graphical abstract: Expanding antibiotic chemical space around the nidulin pharmacophore
Paper

Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation

A 10-step synthesis of the antimalarial lead, 13C18-enriched plasmodione, and of seven putative metabolites is described.

Graphical abstract: Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation
Paper

Synthetic polyprenol-pyrophosphate linked oligosaccharides are efficient substrates for mycobacterial galactan biosynthetic enzymes

Synthetic glycosyl polyprenol phosphates are substrates for enzymes required for cell wall assembly in mycobacteria, including the organism that causes tuberculosis.

Graphical abstract: Synthetic polyprenol-pyrophosphate linked oligosaccharides are efficient substrates for mycobacterial galactan biosynthetic enzymes
Paper

High efficiency two-photon uncaging coupled by the correction of spontaneous hydrolysis

DNI-Glu proved to be several times more efficient, than MNI-Glu and other analogues.

Graphical abstract: High efficiency two-photon uncaging coupled by the correction of spontaneous hydrolysis
Paper

Asymmetric synthesis of trans-4,5-disubstituted γ-butyrolactones involving a key allylboration step. First access to (−)-nicotlactone B and (−)-galbacin

A new approach based on one-pot sequential transformations with application for the first total synthesis of (−)-nicotlactone B and (−)-galbacin.

Graphical abstract: Asymmetric synthesis of trans-4,5-disubstituted γ-butyrolactones involving a key allylboration step. First access to (−)-nicotlactone B and (−)-galbacin
Paper

An efficient synthesis of 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones via an Ullmann reaction catalyzed by CuI

16H-Dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones were obtained from the available reactants 2-amino-N-(2-hydroxyphenyl)benzamide and 2-bromobenzaldehyde via an Ullmann reaction catalyzed by CuI.

Graphical abstract: An efficient synthesis of 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones via an Ullmann reaction catalyzed by CuI
Paper

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner.

Graphical abstract: Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner
Paper

Supramolecular chiroptical switching of helical-sense preferences through the two-way intramolecular transmission of a single chiral source

Complexation-induced reversal of helical-sense preferences is demonstrated with a simple molecule with a pair of exciton-coupled chromophores.

Graphical abstract: Supramolecular chiroptical switching of helical-sense preferences through the two-way intramolecular transmission of a single chiral source
Paper

EZ isomerization in Suzuki cross-couplings of haloenones: ligand effects and evidence for a separate catalytic cycle

We present evidence for a palladocyclic enolate-like pathway for isomerization of enones occurring during Suzuki cross-coupling reactions.

Graphical abstract: E–Z isomerization in Suzuki cross-couplings of haloenones: ligand effects and evidence for a separate catalytic cycle
Paper

Nickel-catalyzed cross-coupling of β-carbonyl alkenyl pivalates with arylzinc chlorides

The reaction of β-carbonyl alkenyl pivalates with arylzinc reagents was carried out via nickel-catalyzed C–O bond cleavage, forming 3-aryl-substituted α,β-unsaturated carbonyl compounds in moderate to excellent yields.

Graphical abstract: Nickel-catalyzed cross-coupling of β-carbonyl alkenyl pivalates with arylzinc chlorides
Paper

A semi-rigid isoindoline-derived nitroxide spin label for RNA

The new semi-rigid spin label ImUm showed limited motion in RNA duplexes and accurate distances between two spin labels in RNA duplexes were obtained by pulsed EPR spectroscopy.

Graphical abstract: A semi-rigid isoindoline-derived nitroxide spin label for RNA
Paper

Formal total synthesis of salvianolic acid N

Salvianolic acid N was synthesized starting from 3,4-dimethoxybenzaldehyde in 11 steps and with an overall yield of 11%. The key reaction steps were the Wittig reaction for Z-stereoselectivity, the copper catalyzed intramolecular cyclization for seven membered ring skeleton, and the deprotected allylic group with Pd catalysis.

Graphical abstract: Formal total synthesis of salvianolic acid N
Paper

Kinetic basis for the activation of human cyclooxygenase-2 rather than cyclooxygenase-1 by nitric oxide

Kinetic basis for the activation of human cyclooxygenase-2 by nitric oxide.

Graphical abstract: Kinetic basis for the activation of human cyclooxygenase-2 rather than cyclooxygenase-1 by nitric oxide
65 items

About this collection

This on-going collection features all the articles published in Organic & Biomolecular Chemistry in 2018 that were highlighted by the reviewers of these articles as being interesting or having particularly significant research.

Congratulations to all the authors whose articles are featured!

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