Jump to main content
Jump to site search

Themed collection Fungal Natural Products

18 items
Editorial

Editorial: Fungal natural products themed issue

From the themed collection: Fungal Natural Products
Viewpoint

Aflatoxin and deconstruction of type I, iterative polyketide synthase function

In this viewpoint highlights are drawn from a deep analysis of the multifaceted problem of aflatoxin biosynthesis, one of the most highly rearranged polyketide natural products known.

Graphical abstract: Aflatoxin and deconstruction of type I, iterative polyketide synthase function
From the themed collection: Fungal Natural Products
Viewpoint

Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint

This viewpoint on biosynthesis of reduced polyketides in fungi traces evolution of the research area over more than 4 decades.

Graphical abstract: Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint
From the themed collection: Fungal Natural Products
Viewpoint

Fungal polyketide biosynthesis – a personal perspective

A personal summary of 40 years research in fungal polyketide biosynthesis is presented and developments in the field in the authors and other laboratories over that period are highlighted.

Graphical abstract: Fungal polyketide biosynthesis – a personal perspective
From the themed collection: Celebrating our 2018 prize and award winners
Highlight

Fungal type III polyketide synthases

This article covers the recent literature on fungal type III polyketide synthases (PKSs).

Graphical abstract: Fungal type III polyketide synthases
From the themed collection: Fungal Natural Products
Highlight

Biosynthesis of the ergot alkaloids

An update on new developments in the field of ergot alkaloid biosynthesis since 2011 is highlighted.

Graphical abstract: Biosynthesis of the ergot alkaloids
From the themed collection: Celebrating our 2019 Prize and Award winners
Highlight

Discovering the secondary metabolite potential encoded within entomopathogenic fungi

This highlight discusses the secondary metabolite potential of the insect pathogens Metarhizium and Beauveria, including a bioinformatics analysis of secondary metabolite genes for which no products are yet identified. (Top picture is a mole cricket infected with Beauveria bassiana and the bottom picture is a wasp infected with Beauveria bassiana.)

Graphical abstract: Discovering the secondary metabolite potential encoded within entomopathogenic fungi
From the themed collection: Fungal Natural Products
Highlight

Spatial and temporal control of fungal natural product synthesis

This highlight summarizes some major breakthroughs in understanding the genes and regulation of fungal natural product synthesis and introduces the current state of knowledge on the spatial and temporal control of their biosynthetic machineries.

Graphical abstract: Spatial and temporal control of fungal natural product synthesis
From the themed collection: Fungal Natural Products
Highlight

Reconstructing fungal natural product biosynthetic pathways

Molecular biology plays a vital role in contemporary natural product research. Responding to developments in whole genome sequencing, heterologous expression systems are being refined to accommodate whole fungal biosynthetic pathways.

Graphical abstract: Reconstructing fungal natural product biosynthetic pathways
From the themed collection: Fungal Natural Products
Open Access Highlight

Fungal siderophore metabolism with a focus on Aspergillus fumigatus

This Highlight provides an overview of fungal siderophore metabolism and its role in physiology, cellular differentiation, interaction with other organisms, as well as potential clinical applications.

Graphical abstract: Fungal siderophore metabolism with a focus on Aspergillus fumigatus
From the themed collection: Fungal Natural Products
Review Article

Biosynthesis of fungal indole alkaloids

This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids.

Graphical abstract: Biosynthesis of fungal indole alkaloids
From the themed collection: Fungal Natural Products
Review Article

Traversing the fungal terpenome

Fungi are prolific producers of a vast array of structurally diverse terpenoid natural products. Classes of terpenoids identified from Ascomycota and Basidiomycota include the sesquiterpenoids, the diterpenoids and the triterpenoids. This review will provide an overview of their known diversity and biosynthesis with a special emphasis on genomic resources available for pathway discovery.

Graphical abstract: Traversing the fungal terpenome
From the themed collection: Fungal Natural Products
Review Article

New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics

Non-ribosomal peptide synthetases (NRPSs) are a primary modality for fungal peptidic natural product assembly and are responsible for some of the best known, most useful, and most destructive fungal metabolites.

Graphical abstract: New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics
From the themed collection: Fungal Natural Products
Review Article

Fungal natural products in research and development

This review focuses on new fungal natural products published from 2009 to 2013 highlighting the originality of the structures and their biological potential. Additionally progress in the use or the biological activity of known compounds or new derivatives is emphasized.

Graphical abstract: Fungal natural products in research and development
From the themed collection: Fungal Natural Products
Open Access Review Article

Oxidative rearrangements during fungal biosynthesis

Oxidative rearrangements are key reactions during the biosyntheses of many secondary metabolites in fungi.

Graphical abstract: Oxidative rearrangements during fungal biosynthesis
From the themed collection: Fungal Natural Products
Review Article

Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

Nearly twenty distinct families of epidithiodioxopiperazine alkaloids have been isolated and characterized since the seminal discovery of gliotoxin in 1936. Herein, we discuss the occurrence, synthesis and biogenesis of these unusual fungal natural products.

Graphical abstract: Epidithiodioxopiperazines. occurrence, synthesis and biogenesis
From the themed collection: Fungal Natural Products
Review Article

Fungal metabolites with anticancer activity

The review discusses the reported sources, structures and biochemical studies aimed at the exploitation of the anticancer potential associated with fungal secondary metabolites.

Graphical abstract: Fungal metabolites with anticancer activity
From the themed collection: Fungal Natural Products
Review Article

Methods of discovery and techniques to study endophytic fungi producing fuel-related hydrocarbons

Some endophytic fungi are capable of making a plethora of hydrocarbons having fuel potential. One of the major fuel-like products, among others, is cineole as produced by Nodulisporium spp. Methods for measuring hydrocarbon production by microorganisms are summarized as well as information on the products, genomes, and potential importance of these organisms as fuel producers.

Graphical abstract: Methods of discovery and techniques to study endophytic fungi producing fuel-related hydrocarbons
From the themed collection: Fungal Natural Products
18 items

About this collection

Natural Product Reports is delighted to present a themed collection dedicated to Fungal Natural Products. Guest-edited by Professors Sheryl Tsai (UC Irvine) and Greg Challis (University of Warwick), the collection features contributions from leaders in the field and highlights the emerging impact of fungal biology on natural product chemistry.

This collection is also dedicated to three colleagues who have made seminal contribution to the fungal natural product research: Prof. Thomas Simpson, Craig Townsend, and John Vederas. The recent advancement in fungal biology related to natural product biosynthesis, enzymology and biochemistry has bridged a key knowledge gap, especially in elucidating how fungi creates such a huge diverse array of natural products.

We hope you enjoy this selection!

Spotlight

Advertisements