Themed collection Botanical Natural Products in Drug Discovery

8 items
Open Access Viewpoint

From plant to cancer drug: lessons learned from the discovery of taxol

This Viewpoint describes events during the 1960s and 1970s that led to the discovery of taxol, which remains one of the most effective treatments for breast and ovarian cancer. We highlight lessons relevant to natural products drug discovery today.

Graphical abstract: From plant to cancer drug: lessons learned from the discovery of taxol
From the themed collection: Botanical Natural Products in Drug Discovery
Open Access Review Article

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

This review covers the role of the nematode Caenorhabditis elegans as a whole organism model to study natural products for healthy aging. Literature between 2012 and 2023 was comprehensively analysed and is presented in a concise way.

Graphical abstract: The role of Caenorhabditis elegans in the discovery of natural products for healthy aging
From the themed collection: Botanical Natural Products in Drug Discovery
Review Article

Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022

Plants produce a wide array of secondary metabolites capable of inhibiting pathways crucial for microbial survival and pathogenicity.

Graphical abstract: Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022
From the themed collection: Botanical Natural Products in Drug Discovery
Review Article

Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer

This review highlights botanical natural products with activity against ovarian cancer and key drug development considerations for their advancement.

Graphical abstract: Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer
From the themed collection: Botanical Natural Products in Drug Discovery
Review Article

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

This review summarizes plant metabolites targeting crucial enzymes involved in glucose homeostasis useful for antidiabetic drug development.

Graphical abstract: Natural products from plants targeting key enzymes for the future development of antidiabetic agents
From the themed collection: Celebrating Latin American Chemistry
Review Article

Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study

The present review summarizes recent accomplishments made as part of a multidisciplinary, multi-institutional anticancer drug discovery project, wherein higher plant samples were collected primarily from tropical rainforests in Southeast Asia.

Graphical abstract: Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study
From the themed collection: Botanical Natural Products in Drug Discovery
Review Article

Plant glycosyltransferases for expanding bioactive glycoside diversity

This article highlights previous and prospective uses for plant glycosyltransferases in generating and diversifying bioactive glycosides, with implications in drug discovery applications.

Graphical abstract: Plant glycosyltransferases for expanding bioactive glycoside diversity
From the themed collection: Botanical Natural Products in Drug Discovery
Review Article

Artemisinin as a therapeutic vs. its more complex Artemisia source material

Many small molecule drugs are first discovered in nature, commonly the result of long ethnopharmacological use by people, and then characterized and purified from their biological sources.

Graphical abstract: Artemisinin as a therapeutic vs. its more complex Artemisia source material
From the themed collection: Botanical Natural Products in Drug Discovery
8 items

About this collection

This themed issue, guest edited by Nadja Cech, Nicholas Oberlies and Cassandra Quave, aims to highlight the impact botanical natural products have had in drug discovery along with their potential for the future.

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