Review Article
Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions
This review provides an overview of recent advances in mass spectrometric methods for phosphoinositide analysis, with a focus on the separation of regioisomers and acyl chain profiling.
MALDI mass spectrometry imaging in plant and food lipidomics: advances, challenges, and future perspectives
MALDI MSI enables high-resolution spatial lipid analysis in plants and food. This review covers current methods, challenges, and emerging technologies shaping the future of plant and food lipidomics research.
Review Article
Advancing colorectal cancer research through lipidomics
Lipidomic profiling of CRC plasma and tissue reveals alterations in lipid species, including from phospholipids, sphingolipids, and glycerolipids.
Research Article
Lipidomics reveals cell specific changes during pluripotent differentiation to neural and mesodermal lineages
Lipidomic analyses of induced pluripotent stem cells at critical stages of differentiation toward neural or mesodermal fates illustrate unique species and class-based fluctuations.
Research Article
Unmasking the lipid landscape: carbamazepine induces alterations in Leydig cell lipidome
Leydig cells rely on lipids and fatty acids (FA) for essential functions like maintaining structural integrity, energy metabolism, and steroid hormone synthesis, including testosterone production.
About this collection
Lipidomics has advanced into a key discipline for understanding the molecular landscape of living systems. Rather than focusing solely on cataloguing lipid species, the field investigates how lipid structures, interactions, and metabolic pathways shape biological function. With progress in high-resolution instrumentation, data-driven analysis, and bioinformatic tools, researchers can now investigate lipid behaviour at scales that were not previously achievable, revealing new layers of cellular organization and metabolic organization. Lipidomics is a rapidly expanding scientific frontier, translating molecular insights into practical benefits that advance healthcare, strengthen One Health initiatives, and promote sustainability.
This themed issue, guest edited by Anthony Don (University of Sydney), Baoru Yang (University of Turku), Hyungwon Choi (National University Singapore) and Rosário Domingues (University of Aveiro), aims to present the most recent advances in lipidomics, from analytical advances to innovative solutions addressing societal challenges, from across diseases, health and food.