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Themed collection Engineering immunity with quantitative tools

8 items
Editorial

Engineering immunity with quantitative tools

Guest Editors Chris Jewell and Jeff Gray introduce this themed collection of papers showcasing the latest research that leverages quantitative tools and technologies to decipher and control immune function.

Graphical abstract: Engineering immunity with quantitative tools
From the themed collection: Engineering immunity with quantitative tools
Review Article

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires

The adaptive immune system is a natural diagnostic sensor and therapeutic.

Graphical abstract: Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires
From the themed collection: Engineering immunity with quantitative tools
Review Article

Functional genomics in cancer immunotherapy: computational approaches for biomarker and drug discovery

A hitchhiker's guide to biomarker discovery in immune checkpoint blockade.

Graphical abstract: Functional genomics in cancer immunotherapy: computational approaches for biomarker and drug discovery
From the themed collection: Engineering immunity with quantitative tools
Review Article

Antibody–antigen complex modelling in the era of immunoglobulin repertoire sequencing

This review describes a pipeline to find antigen binders in large immunoglobulin gene sequencing datasets via high-throughput antibody–antigen complex modelling.

Graphical abstract: Antibody–antigen complex modelling in the era of immunoglobulin repertoire sequencing
From the themed collection: Engineering immunity with quantitative tools
Open Access Paper

Functional clustering of B cell receptors using sequence and structural features

We describe a method for clustering BCRs based on sequence and predicted structural features in order to identify groups with similar antigen and epitope binding specificity.

Graphical abstract: Functional clustering of B cell receptors using sequence and structural features
From the themed collection: Engineering immunity with quantitative tools
Open Access Paper

Repertoire Builder: high-throughput structural modeling of B and T cell receptors

Repertoire Builder (https://sysimm.org/rep_builder/) is a method for generating atomic-resolution, three-dimensional models of B cell receptors (BCRs) or T cell receptors (TCRs) from their amino acid sequences.

Graphical abstract: Repertoire Builder: high-throughput structural modeling of B and T cell receptors
From the themed collection: Engineering immunity with quantitative tools
Open Access Paper

Learning-accelerated discovery of immune-tumour interactions

An integrated computational framework utilizing PhysiCell and EMEWS for design-space identification and feature optimization of tumour immunotherapy.

Graphical abstract: Learning-accelerated discovery of immune-tumour interactions
From the themed collection: Engineering immunity with quantitative tools
Paper

Role of antibody heavy and light chain interface residues in affinity maturation of binding to HIV envelope glycoprotein

Optimization of the heavy chain/light chain interface could serve as an important tool for maximizing antibody/antigen binding affinity without altering antigen contact residues.

Graphical abstract: Role of antibody heavy and light chain interface residues in affinity maturation of binding to HIV envelope glycoprotein
From the themed collection: Engineering immunity with quantitative tools
8 items

About this collection

From MSDE

Guest Editors: Professor Christopher M. Jewell (University of Maryland, College Park) and Professor Jeffrey J. Gray (Johns Hopkins University)

 This collection of papers highlights research on computational, simulation, and modelling tools to study fundamental immunological phenomena, to design precision immunological interactions, or to test vaccines and immunotherapies.

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