Contributors to ‘New Talent: Europe’
MedChemComm profiles the contributors to the ‘New Talent: Europe’ themed issue.
Bioorthogonal metabolic labelling with acyl-CoA reporters: targeting protein acylation
Bioorthogonal labels in protein acylation: advantages and disadvantages of metaBO(W)lic tagging with acyl-CoA(RROWS).
Methods of protein surface PEGylation under structure preservation for the emulsion-based formation of stable nanoparticles
We evaluated different methods for a high surface PEGylation of lysozyme. The resulting lipophilic enzymes can be used for the formation of stable nanoparticles.
Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes.
Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action
A series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines.
Injectable peptide hydrogels for controlled-release of opioids
Peptide-based hydrogels as a drug carrier system for the subcutaneous administration of morphine.
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase
Improving the physico-chemical profile of a MTDL series.
Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor
A novel PSD-95 PDZ2 peptidomimetic has been discovered by designing azide and alkyne amino acid analogues and click chemistry.
Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors
Burkholderia cenocepacia is an opportunistic Gram-negative pathogen and especially hazardous for cystic fibrosis patients.
Targeting the protein backbone with aryl halides: systematic comparison of halogen bonding and π⋯π interactions using N-methylacetamide
Systematic plane scans reveal a seamless transition from σ-hole interactions with the carbonyl oxygen to interactions with the amide π-electrons at increasing distances.
Fragment pharmacophore-based in silico screening: a powerful approach for efficient lead discovery
A fragmentation–recombination process coupled with fragment-based pharmacophore in silico screening: a tailor-made approach for the discovery of new cosmetics.
Drug trapping in hERG K+ channels: (not) a matter of drug size?
The hERG cavity can trap very bulky compounds, without perturbing normal gate closure.
eCF309: a potent, selective and cell-permeable mTOR inhibitor
Kinase inhibitors capable of blocking the phosphorylation of protein substrates with high selectivity are essential to probe and elucidate the etiological role of such molecules and their signalling pathways.
Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus
Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl uracil nucleosides with bulky aryl groups, appeared to have considerable activity against tick-borne encephalitis virus (TBEV) in cell culture.
A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes
Herein we report the development of a new versatile chemical tool for the rapid identification of LRRK2-targeting probes as potential anti-Parkinson's agents.
A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action
Kinetic evaluation of HDAC inhibitors containing different zinc-binding chemotypes demonstrates that trifluoromethyl ketone-containing compounds can inhibit individual HDAC isozymes via differential mechanisms.
Tetrahydro-pyrimido-indoles as selective LIMK inhibitors: synthesis, selectivity profiling and structure–activity studies
Extensive structure–activity studies on three different modification sites resulted in a series of LIM kinase inhibitors, containing a novel tricyclic hinge-binding motif based on the pyrrolopyrimidine scaffold.
Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi
Dehydroabietic acid derivatives have potent antiprotozoal activity and selectivity against L. donovani and T. cruzi.
Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation
The influence of P1-variation on DPP8/9 inhibitor selectivity is investigated.
Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAA receptors
Within the continuous quest for the discovery of pharmacologically interesting compounds, the development of new and superior drug screening assays is desired.
Novel indole–flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus
Structure-based design and synthesis of novel indole–flutimide derivatives with antiviral activity.
Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library
The combination of flow chemistry and computational tools has been successfully applied to prepare a focused library of tricyclic tetrahydroquinolines endowed with drug-like properties.
Spirooxadiazoline oxindoles with promising in vitro antitumor activities
This paper reports the synthesis and biological evaluation of thirty one spirooxadiazoline oxindoles as potential anticancer agents.
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors
A virtual library of 50 000 000 compounds synthesizable via the van Leusen MCR was created, screened and filtered to afford a series of disubstituted imidazoles with improved properties compared to 4-phenylimidazole.
About this collection
This themed issue, guest edited by Professors Gerhard Ecker, Koen Augustyns and Uli Stilz, showcases some of the top research from emerging investigators from Europe. This issue covers medicinal chemistry research in its broadest sense, and showcases the strength of research being carried out by tomorrow's leaders in the field
Articles in this themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.