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Themed collection New Talent: Asia-Pacific

17 items
Cover

Front cover

Graphical abstract: Front cover
From the themed collection: New Talent: Asia-Pacific
Cover

Inside front cover

Graphical abstract: Inside front cover
From the themed collection: New Talent: Asia-Pacific
Profile

Contributors to ‘New Talent: Asia-Pacific’

MedChemComm profiles the contributors to the ‘New Talent: Asia-Pacific’ themed issue.

Graphical abstract: Contributors to ‘New Talent: Asia-Pacific’
From the themed collection: New Talent: Asia-Pacific
Review Article

Recent advances in molecular imaging probes for β-amyloid plaques

We review recent advances in our development of molecular imaging probes for PET, SPECT, and optical imaging for in vivo detection of β-amyloid plaques in the brain.

Graphical abstract: Recent advances in molecular imaging probes for β-amyloid plaques
From the themed collection: Neurodegenerative diseases
Open Access Concise Article

Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin

An improved method of recombinant human lactoferrin (hLF) expression in rich culture medium is demonstrated using macroporous microencapsulation.

Graphical abstract: Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin
From the themed collection: New Talent: Asia-Pacific
Concise Article

Application of QM/MM and QM methods to investigate histone deacetylase 8

Computational chemistry plays an important supporting role in the early stages of drug discovery research.

Graphical abstract: Application of QM/MM and QM methods to investigate histone deacetylase 8
From the themed collection: New Talent: Asia-Pacific
Open Access Concise Article

Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists

A potent neurokinin-3 receptor (NK3R) selective agonist with resistance to proteolytic digestion was developed.

Graphical abstract: Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists
From the themed collection: New Talent: Asia-Pacific
Concise Article

Photoswitching properties of hairpin ODNs with azobenzene derivatives at the loop position

Photoisomerization of an azobenzene moiety modulates the thermodynamic stability of hairpin ODNs by interfering with stacking interation between azobenzene and neighbouring base pair and dihedral angle of the neighbouring base pair.

Graphical abstract: Photoswitching properties of hairpin ODNs with azobenzene derivatives at the loop position
From the themed collection: New Talent: Asia-Pacific
Concise Article

Naturally occurring FANCF–Hes1 complex inhibitors from Wrightia religiosa

The first naturally occurring inhibitors of FANCF–Hes1 complex were isolated by a newly constructed protein-based high-throughput screening assay.

Graphical abstract: Naturally occurring FANCF–Hes1 complex inhibitors from Wrightia religiosa
From the themed collection: New Talent: Asia-Pacific
Concise Article

Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9

Novel 5-fluoro-pyrimidine derivatives have been designed, synthesized and evaluated as potential CDK inhibitors as well as antitumor and anti-HIV agents.

Graphical abstract: Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9
From the themed collection: New Talent: Asia-Pacific
Concise Article

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

An N-methylation strategy has been applied to transition state mimetics that are potent inhibitors of plasmepsin V to improve their physical characteristics and their ability to reduce the viability of Plasmodium parasites in culture.

Graphical abstract: The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V
From the themed collection: New Talent: Asia-Pacific
Concise Article

Exclusive formation of imino[4 + 4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators

We synthetically demonstrate that eight-membered heterocycles are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition.

Graphical abstract: Exclusive formation of imino[4 + 4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators
From the themed collection: New Talent: Asia-Pacific
Concise Article

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

The synthesis of a compound library based on a high throughput screening hit led to the discovery of several potent anti-trypanosomal agents.

Graphical abstract: Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents
Concise Article

Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes

Since fungal natural products biosynthesized by polyketide synthases frequently exhibit useful biological activities, identifying and understanding the mechanism of biosynthetic steps taken by PKSs are of great interest.

Graphical abstract: Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes
From the themed collection: New Talent: Asia-Pacific
Concise Article

Synthesis and biological evaluation of a series of aryl triazoles as firefly luciferase inhibitors

A series of novel aryl triazoles was synthesized as firefly luciferase inhibitors in vitro and in vivo. More interestingly, these compounds are mixed noncompetitive for luciferin and noncompetitive for ATP.

Graphical abstract: Synthesis and biological evaluation of a series of aryl triazoles as firefly luciferase inhibitors
From the themed collection: New Talent: Asia-Pacific
Concise Article

Discovery of novel sphingosine kinase 1 inhibitors via structure-based hierarchical virtual screening

Hierarchical structure-based virtual screening against the sphingosine kinase 1(SphK1) binding pocket was performed. 25 compounds were selected for biological evaluation. Compound 25 exhibited comparable SphK1 and SphK2 inhibitory activities and anti-proliferative effects on U937 cells to the positive control N,N-dimethylsphingosine (DMS) 1. Further molecule dynamic (MD) simulations revealed the binding mode between SphK1 and 25.

Graphical abstract: Discovery of novel sphingosine kinase 1 inhibitors via structure-based hierarchical virtual screening
From the themed collection: New Talent: Asia-Pacific
Concise Article

Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1

A hybridization of NCL1 and compound 5 led to the identification of a potent lysine-specific demethylase 1 inhibitor 5.

Graphical abstract: Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1
From the themed collection: New Talent: Asia-Pacific
17 items

About this collection

This themed issue, guest edited by Dr Ming-Qiang Zhang and Professor Motonari Uesugi, showcases some of the top research from emerging investigators from the Asia-Pacific region. This issue covers medicinal chemistry research in its broadest sense, and showcases the strength of research being carried out by tomorrow's leaders in the field

Articles in this themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.

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