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Themed collection Antibiotic resistance

24 items
Cover

Front cover

Graphical abstract: Front cover
From the themed collection: Antibiotic resistance
Cover

Inside front cover

Graphical abstract: Inside front cover
From the themed collection: Antibiotic resistance
Editorial

Antibiotic Resistance themed issue

Welcome to the Antibiotic Resistance themed issue of MedChemComm.

Graphical abstract: Antibiotic Resistance themed issue
From the themed collection: Antibiotic resistance
Review Article

Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides

Membrane anionic lipids as attractive targets in the design of amphiphilic antibacterial drugs active against resistant bacteria: molecular foundations and examples.

Graphical abstract: Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides
From the themed collection: Antibiotic resistance
Review Article

Drug-target networks in aminoglycoside resistance: hierarchy of priority in structural drug design

Drug-target network analysis for advancing next-generation aminoglycoside therapies that combat antibiotic resistant infections.

Graphical abstract: Drug-target networks in aminoglycoside resistance: hierarchy of priority in structural drug design
From the themed collection: Antibiotic resistance
Review Article

A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

The information about synthesis, resistance, and toxicity of aminoglycosides in all patents from 2011–2015 is presented in details.

Graphical abstract: A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides
From the themed collection: Antibiotic resistance
Review Article

Mechanisms of resistance to membrane-disrupting antibiotics in Gram-positive and Gram-negative bacteria

A diverse repertoire of mechanisms has evolved to confer resistance to bacterial membrane disrupting antimicrobial cationic amphiphiles.

Graphical abstract: Mechanisms of resistance to membrane-disrupting antibiotics in Gram-positive and Gram-negative bacteria
From the themed collection: Antibiotic resistance
Review Article

Targeting the trehalose utilization pathways of Mycobacterium tuberculosis

Tuberculosis (TB) is an epidemic disease and the growing burden of multidrug-resistant (MDR) TB world wide underlines the need to discover new drugs to treat the disease.

Graphical abstract: Targeting the trehalose utilization pathways of Mycobacterium tuberculosis
From the themed collection: Antibiotic resistance
Review Article

Endless resistance. Endless antibiotics?

The practice of medicine was profoundly transformed by the introduction of the antibiotics (compounds isolated from Nature) and the antibacterials (compounds prepared by synthesis) for the control of bacterial infection.

Graphical abstract: Endless resistance. Endless antibiotics?
From the themed collection: Antibiotic resistance
Review Article

Molecular basis for resistance against phosphonate antibiotics and herbicides

Research studies in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098.

Graphical abstract: Molecular basis for resistance against phosphonate antibiotics and herbicides
From the themed collection: Antibiotic resistance
Review Article

Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives

The newest information (2010-present) on the four main mechanisms of resistance to the broad-spectrum aminoglycoside antibiotics is presented in details.

Graphical abstract: Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives
From the themed collection: Antibiotic resistance
Concise Article

Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis

RFQ-EXAFS studies were used to probe the metal centers in metallo-β-lactamase L1 during catalysis.

Graphical abstract: Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis
From the themed collection: Antibiotic resistance
Concise Article

6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine

ANT(6) has a narrow tolerance to chemical variations in the aminoglycoside/nucleotide, making it very useful in the design of non-inactivable derivatives.

Graphical abstract: 6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine
From the themed collection: Antibiotic resistance
Concise Article

In vitro and in vivo activity of ML302F: a thioenolate inhibitor of VIM-subfamily metallo β-lactamases

The thioenol ML302F, recently identified as an inhibitor of class B metallo-β-lactamases (MBLs), restores antibiotic susceptibility to meropenem resistant strains in cells and the Galleria mellonella invertebrate model.

Graphical abstract: In vitro and in vivo activity of ML302F: a thioenolate inhibitor of VIM-subfamily metallo β-lactamases
From the themed collection: Antibiotic resistance
Concise Article

Identification of an inhibitor of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] by glide molecular docking

The aminoglycoside 6′-N-acetyltransferase type Ib, AAC(6′)-Ib, confers resistance to clinically relevant aminoglycosides and is the most widely distributed enzyme among AAC(6′)-I-producing Gram-negative pathogens.

Graphical abstract: Identification of an inhibitor of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] by glide molecular docking
From the themed collection: Antibiotic resistance
Concise Article

Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes

Systematically blending structural features from obsolete aminoglycosides gleaned from X-ray co-crystal models rendered a promising antibiotic inert to enzymatic modification.

Graphical abstract: Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes
From the themed collection: Antibiotic resistance
Concise Article

Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity

New dimeric aminoglycosides conjugated to arginine were synthesized and found to efficiently bind to human and bacterial RNA A-site and to evade the activity of resistance enzymes.

Graphical abstract: Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity
From the themed collection: Antibiotic resistance
Concise Article

Patterns of biofilm structure and formation kinetics among Acinetobacter baumannii clinical isolates with different antibiotic resistance profiles

This study evaluates the rates of biofilm formation in light of the different characteristics of twelve A. baumannii clinical isolates.

Graphical abstract: Patterns of biofilm structure and formation kinetics among Acinetobacter baumannii clinical isolates with different antibiotic resistance profiles
From the themed collection: Antibiotic resistance
Open Access Concise Article

Synergistic activity of a short lipidated antimicrobial peptide (lipoAMP) and colistin or tobramycin against Pseudomonas aeruginosa from cystic fibrosis patients

Synergistic effects between a lipoAMP and colistin against clinical P. aeruginosa strains isolated from cystic fibrosis patients are described.

Graphical abstract: Synergistic activity of a short lipidated antimicrobial peptide (lipoAMP) and colistin or tobramycin against Pseudomonas aeruginosa from cystic fibrosis patients
From the themed collection: Antibiotic resistance
Concise Article

Syntheses and biological evaluations of highly functionalized hydroxamate containing and N-methylthio monobactams as anti-tuberculosis and β-lactamase inhibitory agents

Described are the syntheses and evaluations of hydroxamate containing and N-methylthiolated monobactams as a class of potent β-lactamase inhibitors.

Graphical abstract: Syntheses and biological evaluations of highly functionalized hydroxamate containing and N-methylthio monobactams as anti-tuberculosis and β-lactamase inhibitory agents
From the themed collection: Antibiotic resistance
Concise Article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia.

Graphical abstract: Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants
From the themed collection: Phenotypic Drug Discovery
Concise Article

Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis

The glycopeptide antibiotics are important clinical antibiotics that are currently employed against serious Gram-positive bacterial infections.

Graphical abstract: Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis
From the themed collection: Antibiotic resistance
Concise Article

Phase II metabolic pathways of spectinamide antitubercular agents: a comparative study of the reactivity of 4-substituted pyridines to glutathione conjugation

Spectinamides are promising new semisynthetic anti-tubercular agents that are modified with a pyridyl side chain, which blocks native efflux from the tuberculosis cell.

Graphical abstract: Phase II metabolic pathways of spectinamide antitubercular agents: a comparative study of the reactivity of 4-substituted pyridines to glutathione conjugation
From the themed collection: Antibiotic resistance
Concise Article

Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance

Tabtoxinine-β-lactam (TβL) is a phytotoxin produced by plant pathogenic strains of Pseudomonas syringae.

Graphical abstract: Tabtoxinine-β-lactam is a “stealth” β-lactam antibiotic that evades β-lactamase-mediated antibiotic resistance
From the themed collection: Antibiotic resistance
24 items

About this collection

This themed issue, guest edited by Professors Sylvie Garneau-Tsodikova and Gerard D. Wright, showcases some of the top research currently being carried out into the many facets of antibiotic resistance.

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