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Themed collection New Talent

13 items
Cover

Front cover

Graphical abstract: Front cover
From the themed collection: New Talent
Cover

Inside front cover

Graphical abstract: Inside front cover
From the themed collection: New Talent
Profile

Contributors to our ‘New Talent’ Collection

MedChemComm profiles the contributors to the ‘New Talent’ themed collection.

Graphical abstract: Contributors to our ‘New Talent’ Collection
From the themed collection: New Talent
Review Article

Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics

This review provides a detailed examination and comparison of the diverse non-covalent albumin-binding ligands developed until now to extend the half-life of different small biotherapeutics.

Graphical abstract: Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics
From the themed collection: New Talent
Review Article

Targeting S. mutans biofilms: a perspective on preventing dental caries

This review aims to provide an overview of the current small molecule strategies used for targeting S. mutans biofilms, and a perspective of the future for the field.

Graphical abstract: Targeting S. mutans biofilms: a perspective on preventing dental caries
From the themed collection: New Talent
Research Article

Messenger RNA delivery by hydrazone-activated polymers

Here we present the intracellular delivery of mRNA using polyhydrazones prepared in situ under physiological conditions, demonstrating the versatility and adaptability of this technology to more sensitive and therapeutically relevant nucleic acids.

Graphical abstract: Messenger RNA delivery by hydrazone-activated polymers
From the themed collection: New Talent
Research Article

Binding site characterization – similarity, promiscuity, and druggability

Promiscuity as key to drug repurposing, off-target prediction, polypharmacology: What can be learned based on the comparison of binding sites and the description of their properties? Herein, we discuss binding site similarities with a special focus on medicinal chemistry.

Graphical abstract: Binding site characterization – similarity, promiscuity, and druggability
From the themed collection: New Talent
Research Article

Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches

Protein dynamics finely tune the “druggability” of mammalian PAS-B domains, as assessed by atomistic molecular dynamics simulations and hotspot mapping.

Graphical abstract: Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches
From the themed collection: New Talent
Research Article

Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs

B,B-Fluoro-perfluoroalkyl BODIPYs 2 (R = CF3) and 3 (R = C2F5) exhibited higher photo- and chemical stability than B,B-difluoro-BODIPY 1.

Graphical abstract: Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs
From the themed collection: New Talent
Research Article

Computation of protein–ligand binding free energies using quantum mechanical bespoke force fields

A quantum mechanical bespoke molecular mechanics force field is derived for the L99A mutant of T4 lysozyme and used to compute absolute binding free energies of six benzene analogs to the protein.

Graphical abstract: Computation of protein–ligand binding free energies using quantum mechanical bespoke force fields
From the themed collection: New Talent
Research Article

Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry

A solid phase-based strategy gave access to DNA-tagged heterocycles by metal-mediated imine chemistry, exemplified by Cushman- and 1,3-dipolar cycloaddition reactions.

Graphical abstract: Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry
From the themed collection: New Talent
Research Article

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example

A series of adenosine receptor antagonists bearing a reactive linker was developed.

Graphical abstract: Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example
From the themed collection: New Talent
Research Article

Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity

Novel β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity were synthesized.

Graphical abstract: Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity
From the themed collection: New Talent
13 items

About this collection

New Talent in Medicinal Chemistry. This themed collection highlights medicinal chemistry research in its broadest sense, and showcases the strength of research being carried out by tomorrow's leaders in the field.
Articles in this themed issue will be added below as soon as possible after they are published. 
Please return to this page frequently to see the collection grow.

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