Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors
A new class of (aza)indole derivatives have been identified as potent RSV fusion inhibitors.
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.
Expansion of the structure–activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach
The structural diversity of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors was expanded by harnessing diverse building blocks that had been prepared via a unified lead-oriented synthetic approach.
Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions
The nanoscale composite improved β-cell functions in terms of rate of proliferation, glucose-stimulated insulin secretion, resistance to cellular stress and functional maturation.
About this collection
MedChemComm is delighted to publish this collection of articles from presenters at the 25th EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018) held in Ljubljana, Slovenia, September 2018.
Articles in this themed issue will be added below as soon as possible after they are published.
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