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Themed collection Celebrating the 25th EFMC-ISMC

4 items
Research Article

Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors

A new class of (aza)indole derivatives have been identified as potent RSV fusion inhibitors.

Graphical abstract: Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors
From the themed collection: Celebrating the 25th EFMC-ISMC
Open Access Research Article

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.

Graphical abstract: Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
From the themed collection: Celebrating the 25th EFMC-ISMC
Research Article

Expansion of the structure–activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach

The structural diversity of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors was expanded by harnessing diverse building blocks that had been prepared via a unified lead-oriented synthetic approach.

Graphical abstract: Expansion of the structure–activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach
From the themed collection: Celebrating the 25th EFMC-ISMC
Research Article

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions

The nanoscale composite improved β-cell functions in terms of rate of proliferation, glucose-stimulated insulin secretion, resistance to cellular stress and functional maturation.

Graphical abstract: Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions
From the themed collection: Celebrating the 25th EFMC-ISMC
4 items

About this collection

MedChemComm is delighted to publish this collection of articles from presenters at the 25th EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018) held in Ljubljana, Slovenia, September 2018.

Articles in this themed issue will be added below as soon as possible after they are published.

Please return to this page frequently to see the collection grow.

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