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Themed collection Microtechnologies in Medicine and Biology (MMB 2013)

9 items
Paper

Magnetic manipulation of bacterial magnetic nanoparticle-loaded neurospheres

An in vitro model system for regeneration of spinal cord injury was successfully demonstrated using neurospheres labeled with bacterial magnetic nanoparticles.

Graphical abstract: Magnetic manipulation of bacterial magnetic nanoparticle-loaded neurospheres
Open Access Paper

The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues

This in vitro model system, mimicking healthy aligned and diseased disorganized cardiac tissue, shows that matrix disorganization affects the direction and distribution of cardiomyocyte contraction force although it has no effect on contraction force magnitude.

Graphical abstract: The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues
Paper

A lab-on-chip cell-based biosensor for label-free sensing of water toxicants

This paper presents a lab-on-chip biosensor containing an enclosed fluidic cell culturing well seeded with live cells for rapid screening of toxicants in drinking water.

Graphical abstract: A lab-on-chip cell-based biosensor for label-free sensing of water toxicants
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response.

Graphical abstract: A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids
Paper

A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control

A wearable system for intracochlear drug delivery with controllable dosing for small animals, incorporating a novel micropump and drug reservoir.

Graphical abstract: A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control
From the themed collection: Implantable Devices
Paper

Quantifying genetically inserted fluorescent protein in single iPS cells to monitor Nanog expression using electroactive microchamber arrays

We propose a method utilizing a large number of arrayed microchambers to quantitatively measure an intracellular fluorescent protein that is genetically inserted to monitor the expression of a pluripotency marker, Nanog, in iPS cells.

Graphical abstract: Quantifying genetically inserted fluorescent protein in single iPS cells to monitor Nanog expression using electroactive microchamber arrays
Paper

Continuous flow real-time PCR device using multi-channel fluorescence excitation and detection

We have developed a ‘conveyor belt’ analog for real-time quantitative polymerase chain reaction (qPCR) in a continuous flow thermocycler. The device integrates droplet emulsion technology with LED and fiber optic fluorescence excitation in conjunction with a continuous flow thermal cycler to achieve real-time fluorescence detection.

Graphical abstract: Continuous flow real-time PCR device using multi-channel fluorescence excitation and detection
Paper

Continuous-flow cytomorphological staining and analysis

We demonstrate a platform for on-chip colorimetric staining of cells in continuous flows integrated with automated image processing for analysis of cytomorphological parameters of diagnostic interest.

Graphical abstract: Continuous-flow cytomorphological staining and analysis
Technical Innovation

Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium

Understanding the regenerative capacity of small vertebrate models has provided new insights into the plasticity of injured myocardium.

Graphical abstract: Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium
9 items

About this collection

This web collection contains contributions highlighting work presented at the 7th International Conference on Microtechnologies in Medicine and Biology (MMB 2013) on April 10-12, 2013 in Marina del Rey, California, USA. The biennial meeting brings together an interdisciplinary group of biologists and medical researchers, clinicians, chemists, physicists, and engineers for the purpose of fostering interactions that will enhance and strengthen the impact of microtechnologies in the fields of medicine and biology.

The MMB conference series started in 2000 under the leadership of Prof. David Beebe (University of Wisconsin - Madison) and Prof. André Dittmar (University of Lyon) who developed a unique forum to discuss recent developments in microtechnologies to unmet needs in medicine and biology. The next conference will be held in Seoul, South Korea in 2015 and we look forward to the outstanding research and technological contributions from the various stakeholders in the field.

This collection of articles in both Lab on a Chip and Integrative Biology highlights recent progress in microtechnologies with medical and biological applications. We thank the many authors and reviewers who made this web collection possible.

Our Guest Editors for this collection were:

Ellis Meng, Departments of Biomedical and Electrical Engineering, University of Southern California, USA

Shuichi Takayama, Departments of Biomedical Engineering, Macromolecular Science and Engineering, and Biointerfaces Institute, University of Michigan, USA

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