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Themed collection Lab on a Chip Pioneers of Miniaturization Lectureship winners

19 items
Paper

Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo

An interdigitated microelectronic device that applies low voltage (<9 V) electrical field augments hemostasis in vitro and in vivo.

Graphical abstract: Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo
Open Access Paper

On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits

New designs of microfluidic devices can facilitate recording of C. elegans larvae neuronal responses to precise mechanical stimuli, which reveal new understanding of development of mechanosensory neurons and circuits.

Graphical abstract: On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits
From the themed collection: Lab on a Chip Recent Open Access Articles
Paper

Probing blood cell mechanics of hematologic processes at the single micron level

Single-micron PDMS devices provide insight into the biophysical effects that vascular matrices have on platelets, RBCs, and neutrophils.

Graphical abstract: Probing blood cell mechanics of hematologic processes at the single micron level
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Biophysical isolation and identification of circulating tumor cells

The integrated vortex enrichment–deformability cytometry device may enable automated enumeration of circulating tumor cells from blood by mechanophenotyping.

Graphical abstract: Biophysical isolation and identification of circulating tumor cells
Paper

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

A vascularized, perfused organ-on-a-chip platform suitable for large-scale drug efficacy/toxicity screening.

Graphical abstract: A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

Inkjet printing is combined with roll-coating to fabricate digital microfluidic (DMF) devices outside of the cleanroom for inexpensive, miniaturized diagnostic assays, with straightforward scalability towards mass production.

Graphical abstract: An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays
Paper

Bioprinted thrombosis-on-a-chip

A novel bioprinted model of thrombosis was developed to study thrombosis and thrombolysis in vitro.

Graphical abstract: Bioprinted thrombosis-on-a-chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Engineering a perfusable 3D human liver platform from iPS cells

The authors present a human liver model that supports both primary hepatocytes and human iHeps with flexibility for systems integration.

Graphical abstract: Engineering a perfusable 3D human liver platform from iPS cells
Paper

Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics

We report a novel wash-free magnetic immunoassay technique for prostate-specific antigen that uses a surface-enhanced Raman scattering-based microdroplet sensor.

Graphical abstract: Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics
Paper

Surface-tension driven open microfluidic platform for hanging droplet culture

A hanging droplet culture platform enabling culture of shear-sensitive and suspension cells with a high degree of accessibility to culture.

Graphical abstract: Surface-tension driven open microfluidic platform for hanging droplet culture
Paper

A cost-effective fluorescence mini-microscope for biomedical applications

A miniature microscope was designed and fabricated with built-in fluorescence capability for biomedical applications.

Graphical abstract: A cost-effective fluorescence mini-microscope for biomedical applications
Open Access Paper

Photopatterned oil-reservoir micromodels with tailored wetting properties

We present a new method to fabricate oil-reservoir micromodels with heterogeneous wetting properties.

Graphical abstract: Photopatterned oil-reservoir micromodels with tailored wetting properties
Paper

Whole blood human neutrophil trafficking in a microfluidic model of infection and inflammation

Inflammation on a chip.

Graphical abstract: Whole blood human neutrophil trafficking in a microfluidic model of infection and inflammation
Paper

Microfluidic cellular enrichment and separation through differences in viscoelastic deformation

We report a microfluidic approach to separate and enrich a mixture of two cell types based on differences in cell viscoelastic behavior during repeated compressions and relaxation events.

Graphical abstract: Microfluidic cellular enrichment and separation through differences in viscoelastic deformation
Paper

Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control

Microfluidic serial digital to analog pressure converter can generate arbitrary analog pressures on-chip for real time, automated flow control.

Graphical abstract: Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control
Paper

Rapid antibiotic susceptibility testing by tracking single cell growth in a microfluidic agarose channel system

We demonstrate a microfluidic agarose channel system that uses agarose as a fixation material of bacteria and reduces the time taken for antibiotic susceptibility testing.

Graphical abstract: Rapid antibiotic susceptibility testing by tracking single cell growth in a microfluidic agarose channel system
Paper

Immuno-pillar chip: a new platform for rapid and easy-to-use immunoassay

We present a new rapid and easy-to-use immunoassay chip which we have named the immuno-pillar chip. It has hydrogel pillars, fabricated inside a microchannel, with many antibody molecules immobilized onto 1 µm diameter polystyrene beads.

Graphical abstract: Immuno-pillar chip: a new platform for rapid and easy-to-use immunoassay
From the themed collection: 10th Anniversary Issue: Japan
Paper

Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry

Measurement of blood cell mechanics is enabled by flowing cells through a parallel network of microchannels. Here, an acute myeloid leukemia cell from a patient who died of leukostasis, a complication of acute leukemia, occludes a microchannel, mimicking in vivo microvascular occlusion.

Graphical abstract: Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry
Technical Innovation

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

This 3D multiplex in vitro microvascular model of the DLBCL microenvironment incorporates an endothelialized microvessel traversing a hydrogel-based tumor model.

Graphical abstract: 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro
19 items

About this collection

This collection contains papers authored by winners of the Lab on a Chip Pioneers of Miniaturization Lectureship. Nominations for the Lectureship open in spring each year and the winner is announced in late summer. The winner gives a lecture at the annual MicroTAS conference.

2020 winner: Professor Wilbur Lam, Georgia Institute of Technology/Emory University, USA

Professor Lam is a physician-scientist-engineer and clinical pediatric hematologist/oncologist. He is the W. Paul Bowers Research Chair of Pediatrics and Biomedical Engineering at Emory University and Georgia Tech and an attending physician at the Aflac Cancer and Blood Disorders Center of the Children’s Healthcare of Atlanta.

His laboratory focuses on developing microsystems to study and diagnose hematologic diseases including sickle cell disease, thrombotic/bleeding disorders, and leukemia. He is also principal investigator of the Atlanta Center for Microsystems Engineered Point-of-Care Technology (ACME POCT), an integral part of the NIH’s Point-of-Care Technologies Research Network (POCTRN) and RADx COVID-19 initiative.

Professor Lam received his MD from Baylor College of Medicine, going on to earn his PhD in Bioengineering from the University of California, Berkley. He completed his Fellowship in Pediatric Hematology/Oncology and Residency in Pediatrics at the University of California, San Francisco.

Learn about the Lam lab online.

Previous winners of the Pioneers of Miniaturization Lectureship

2019: Professor Hang Lu, Georgia Tech, USA

2018: Professor Sunghoon Kwon, Seoul National University, South Korea

2017: Professor Aaron Wheeler, University of Toronto, Canada

2016: Professor Daniel Irimia, Massachusetts General Hospital, USA

2015: Professor Dino Di Carlo, University of California, Los Angeles, USA

2014: Professor Sangeeta N. Bhatia, Massachusetts Institute of Technology, USA

2013: Professor Shuichi Takayama, University of Michigan, USA

2012: Professor Andrew deMello, ETH Zürich, Switzerland

2011: Professor Ali Khademhosseini, Massachusetts Institute of Technology, USA

2010: Professor Stephen Quake, Stanford University, USA

2009: Professor Abe Lee, University of California, Irvine, USA

2008: Dr Patrick Doyle, Massachusetts Institute of Technology, USA

2007: Dr Manabu Tokeshi, Nagoya University, Japan

2006: Dr David Beebe, University of Wisconsin, USA

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