Accepted Manuscript -
Paper
Investigating the effect of fusion partners on the enzymatic activity and thermodynamic stability of poly(ethylene terephthalate) degrading enzymes
An engineered T7 RNA Polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesis
Accepted Manuscript -
Paper
On synergy between ultrahigh throughput screening and machine learning in biocatalyst engineering
Accepted Manuscript -
Paper
Computation-guided engineering of distal mutations in an artificial enzyme
Enhancement of essential cofactors for in vivo biocatalysis
Accepted Manuscript -
Paper
Harnessing Conformational Dynamics in Enzyme Catalysis to achieve Nature-like catalytic efficiencies: The Shortest Path Map tool for computational enzyme design
Accepted Manuscript -
Paper
Designing Michaelases: Exploration of novel protein scaffolds for iminium biocatalysis
Accepted Manuscript -
Paper
Computational study of the Mechanism of a polyurethane esterase A (PueA) from Pseudomonas chlororaphis
Accepted Manuscript -
Paper
An Efficient Pyrrolysyl-tRNA Synthetase for Economical Production of MeHis-containing Enzymes
Tuning peroxidase activity of artificial P450 peroxygenase by engineering redox-sensitive residues
Accepted Manuscript -
Paper
Degradation of PET microplastic particles to monomers in human serum by PETase
Accepted Manuscript -
Paper
Developing Deprotectase Biocatalysts for Synthesis.
Accepted Manuscript -
Paper
Friends and Relatives: Insight Into Conformational Regulation from Orthologues and Evolutionary Lineages using KIF and KIN
Accepted Manuscript -
Paper
Exploring the Selectivity of Cytochrome P450 for Enhanced Novel Anticancer Agent Synthesis
Accepted Manuscript -
Paper
Oxygen-resistant [FeFe]hydrogenases: new biocatalysis tools for clean energy and cascade reactions
Accepted Manuscript -
Paper
Towards Controlling Activity of a Peptide Asparaginyl Ligase (PAL) by Lumazine Synthetase Compartmentalization
Accepted Manuscript -
Paper
On the Biocatalytic Synthesis of Silicone Polymers
Application of rational enzyme engineering in a new route to Etonogestrel and Levonorgestrel: Carbonyl reductase bioreduction of ethyl secodione
About this collection
We are delighted to share with you a selection of the papers associated with a Faraday Discussion on Biocatalysis. More information about the related event may be found here: http://rsc.li/biocatalysis-fd2024. Additional articles will be added to the collection as they are published. The final versions of all the articles presented and a record of the discussions will be published after the event.
Biocatalysis, a rapidly evolving field with increasing impact in synthesis, chemical manufacturing and medicine, is being transformed by advances in biophysical and computational techniques. It is expanding into new areas of chemistry, facilitated by de novo protein design, directed evolution, incorporation of new catalytic functionality into proteins, genetic data, developing spectroscopic and structural techniques, and informed by modelling, machine learning and artificial intelligence. The four themes of this Discussion will unite researchers working in different fields (for example synthetic biology, computational chemistry and mechanistic organic and organometallic chemistry) to improve our understanding of enzyme catalytic power with a view to engineering hybrid and artificial enzymes.
This meeting will cover 4 main themes: Enzyme evolution, engineering and design: mechanism and dynamics, Biocatalytic pathways, cascades, cells and systems, Biocatalysis for industry, medicine and the circular economy, Artificial, biomimetic and hybrid enzymes.
On behalf of the Scientific Committee, we hope you join us and participate in this exciting event, and that you enjoy these articles and the record of the discussion.