Themed collection 2022 CRSI Medal Winners Collection

This review provides a complete demonstration of amalgamating significant pieces of work in the metal-mediated trifluoromethylation genre of recent past years.

We describe design and syntheses of a new generation of exceptionally highly potent non-peptidic HIV-1 protease inhibitors.

Using periodic DFT calculations, we unveil the mechanism of cooperative CO adsorption in an Fe(II) bistriazolate MOF, where both structural distortion and electronic effects are found to play an active role.

A new class of 5′-morpholino modified nucleoside building blocks was synthesized. Among them, Mo2 exhibited better off-target mitigation for RNAi compared to other analogues Pip and Mo3 and the previously reported morpholino derivative Mo1.

Palladium-catalyzed novel remote meta-C–H olefination of geometrically challenging cinnamates using nitrile directing group derived from 2-cyanobenzoic acid has been described. A variety of bioactive molecules tethered acrylates have been coupled.

A palladium-catalyzed, solvent-dependent, intramolecular oxypalladation-initiated chemodivergent approach was established for the synthesis of functionalized benzazepines and tetrahydroquinolines.

A metal–organic cage exhibits ferro- and piezoelectric properties as visualized by its domain structure using PFM and utility in piezoelectric energy harvesting properties. This is a rare observation in supramolecular metal–organic cages.

An oxoiron(IV) cation radical is generated upon two-electron oxidation of an iron(III) complex bearing an electron-rich methoxy substituted bTAML framework and characterized via multiple spectroscopic techniques and density functional theory (DFT).

Understanding of the energy/charge transfer processes in Mn–CsPbBr₃ NPLs is achieved using temperature-dependent femtosecond TA spectroscopy. Charge transfer process which is efficient at 300 K is seen to be inhibited at 5 K.

A Pd-catalysed 100% atom-economical method has been developed for the synthesis of 1,3-disubstituted indolizine derivatives in good yields through a regiospecific formal [3 + 2]-annulation from 2-pyridinyl-substituted p-quinone methides and terminal alkynes.

Here, we demonstrate the residue-specific transformation of N-Gly into N-Gly-glyoxamide. The aldehyde introduction opens the residue-specific synthetic flexibility for the N-Gly proteome.

Herein, we report a Pd(0)-catalyzed cascade reaction with multifunction of isocyanide as a nucleophile promoter for rearrangement and a hydride source.

Isomeric coordination complexes of different configurations (hour-glass and double-decker) but prepared from regioisomeric tridentate ligands are described.

The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described.