SCHEDULED MAINTENANCE:
Communication
Side-chain dependent direct vs. indirect photoresponse in hydrazone-based supramolecular polymers
Side chain engineering in a hydrazone-based system can alter the aggregate-to-aggregate photoconversion mechanism from indirect to direct.
Communication
An esterase-sensitive persulfide/hydrogen sulfide generating fluorogenic probe enhances antioxidant response
A tool that generates sulfane sulfur species such as persulfides and polysulfides to promote endogenous antioxidant response is reported.
Differentiating α-synuclein aggregates using charge-sensitive gold nanoclusters
Label-free gold nanoclusters (AuNCs) with tailored surface charges distinguish wild type and mutant α-syn monomers from amyloids with pM-level sensitivity.
Dynamical insights into denitrogenation of 1-pyrazoline: exploring pathways via transition states and a second-order saddle
Post-second-order saddle (SOS) dynamics reveal alternative stereoselective pathways in 1-pyrazoline denitrogenation.
Influence of internal electrostatics on reduction potentials in amine-ligated bimetallic copper complexes
In a series of bis-Cu(II) complexes, we quantify the distance dependent electrostatic contributions to the reduction potential, which vary linearly as the reciprocal of the Cu–Cu distance (rCu–Cu), and span more than 0.5 V depending on rCu–Cu.
Elucidating the molecular mechanism of noncompetitive inhibition of acetylcholinesterase by an antidiabetic drug chlorpropamide: identification of new allosteric sites
A new allosteric site has been identified in acetylcholinesterase (AChE) as a potential drug target. Binding of inhibitors modulates the conformational ensemble at the catalytic site.
About this collection
Kaleidoscope: A discussion meeting in chemistry is an annual gathering of Indian investigators working in various fields of in chemistry and allied areas. Started in 2014, this meeting is a platform for young investigators to discuss on contemporary research trends in chemistry and allied areas to identify and seek suggestions and collaborations among the peer group. The primary aim of this meeting is to provide a platform for the exchange of new ideas and fresh perspectives among chemists of all different fields of research.
Guest edited by Professor G. Naresh Patwari (Indian Institute of Technology Bombay), Professor Jyotishman Dasgupta and Professor Vaibhav Prabhudesai (both from Tata Institute of fundamental Research, Mumbai) and Sayan Bagchi (National Chemistry Laboratory, Pune ) this special collection highlights the exciting research by the speakers of the two Kaleidoscope meetings held in 2024 and 2025 in India. We hope you enjoy reading this collection.