By tuning the copper(I)/copper(II) affinity of a novel N-acylhydrazone, a more soluble, hydrolysis resistant and less toxic improved Metal–Protein Attenuating Compound for the bioinorganic management of metal-enhanced aggregopathies was obtained.
Highly fluorinated, water-soluble transition metal complexes serve as both 19F and PARACEST magnetic resonance imaging agents.
Using 5,6-dihydro-5,6-epoxy-1,10-phenanthroline as the ligand L, the X-ray crystal structure of [FeL3](ClO4)2·2H2O is determined.
This review article highlights the recent progress and outlook for small molecule gamma secretase modulators for potential Alzheimer's therapies.
Transition metals and lanthanide ions display unique properties that enable the development of non-invasive diagnostic tools for imaging. In this review, we highlight various metal-based imaging strategies used to interrogate neurodegeneration.