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Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation


Liwen Han, Wenlong Sheng, Xiaobin Li, Attila Sik, Houwen Lin, Kechun Liu and Lizhen Wang
Med. Chem. Commun., 2019,10, 598-605

Abstract

Berberine is a bioactive alkaloid used in Chinese medicine and has numerous positive effects on biological systems.


Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology


Lizhen Wang, Haotian Kong, Meng Jin, Xiaobin Li, Rostyslav Stoika, Houwen Lin and Kechun Liu
Org. Biomol. Chem., 2020,18, 3563-3574
From themed collection: Chemical Biology in OBC

Abstract

Diglucose modified berberine derivatives can dramatically promote the uptake of 2-NBDG in both zebrafish larvae and their eyes.


Novel potential artificial MRSA DNA intercalators: synthesis and biological evaluation of berberine-derived thiazolidinediones


Hang Sun, Mohammad Fawad Ansari, Narsaiah Battini, Rammohan R. Yadav Bheemanaboina and Cheng-He Zhou
Org. Chem. Front., 2019,6, 319-334

Abstract

Novel berberine-derived thiazolidinediones as potential artificial DNA intercalators were synthesized, and the preliminary mechanism suggested that active compound 6b could intercalate into MRSA DNA.


Inhibition of biofilm formation and quorum sensing mediated phenotypes by berberine in Pseudomonas aeruginosa and Salmonella typhimurium


Jamuna Bai Aswathanarayan and Ravishankar Rai Vittal
RSC Adv., 2018,8, 36133-36141

Abstract

Quorum sensing regulates violacein pigment production in C. violaceum.


Retracted Article: Berberine alleviates amyloid beta-induced injury in Alzheimer's disease by miR-107/ZNF217


Jing Wang and Dong Jin
RSC Adv., 2019,9, 25232-25239

Abstract

Berberine plays a neuroprotective role in neurodegenerative disorders, including Alzheimer's disease (AD).


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