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Integrated microfluidic device for the separation, decomposition and detection of low molecular weight S-nitrosothiols


Gerson F. Duarte-Junior, Abdulghani Ismail, Sophie Griveau, Fanny d'Orlyé, José Alberto Fracassi da Silva, Wendell K. T. Coltro, Fethi Bedioui and Anne Varenne
Analyst, 2019,144, 180-185
From themed collection: Analyst Recent HOT articles

Abstract

S-nitrosothiols (RSNOs) are electrokinetically separated and the nitrite generated by decomposition with mercury(II) is detected by amperometry, in an integrated microdevice.


Biological control of S-nitrosothiol reactivity: potential role of sigma-hole interactions


Niloufar Hendinejad and Qadir K. Timerghazin
Phys. Chem. Chem. Phys., 2020,22, 6595-6605

Abstract

S-Nitrosothiols, ubiquitous biological derivatives of nitric oxide, can engage in σ-hole/bonding with Lewis bases, which, in combination with hydrogen bonding with Lewis acids, could be the basis of enzymatic control of S-nitrosothiol reactions.


Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite


Rama Alhasan, Ammar Kharma, Muhammad Jawad Nasim, Ahmad Yaman Abdin, Justine Bonetti, Philippe Giummelly, Chukwunonso E. C. C. Ejike, Pierre Leroy, Caroline Gaucher and Claus Jacob
Med. Chem. Commun., 2018,9, 1994-1999

Abstract

Controlled O2˙− production promotes the decomposition of S-nitrosothiols, forming highly aggressive ONOO−.


Platinum nanoparticles: an avenue for enhancing the release of nitric oxide from S-nitroso-N-acetylpenicillamine and S-nitrosoglutathione


Gao-Juan Cao, Christine M. Fisher, Xiumei Jiang, Yu Chong, Hui Zhang, Hongyu Guo, Qian Zhang, Jiwen Zheng, Ann M. Knolhoff, Timothy R. Croley and Jun-Jie Yin
Nanoscale, 2018,10, 11176-11185

Abstract

Identification of Pt NPs capable of generating NO from S-nitrosothiols donors is an important step in harnessing NO for investigations into its clinical applications.


Endothelial mimetic multifunctional surfaces fabricated via polydopamine mediated copper immobilization


Xin Li, Fangyu Shen, Kebing Wang, Shuang Lin, Lei Zhou, Si Chen, Jin Wang and Nan Huang
J. Mater. Chem. B, 2018,6, 7582-7593

Abstract

Nitric oxide (NO), which is continuously released from the normal healthy endodermis cell layer of the vascular system, plays a crucial role in the stability and health maintenance of blood vessels.


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