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Cationic and hydrolysable branched polymers by RAFT for complexation and controlled release of dsRNA


Alexander B. Cook, Raoul Peltier, Matthias Hartlieb, Richard Whitfield, Guillaume Moriceau, James A. Burns, David M. Haddleton and Sébastien Perrier
Polym. Chem., 2018,9, 4025-4035

Abstract

The complexation and sustained release of dsRNA from highly branched polymers prepared via RAFT polymerisation and copolymerisation of the monomers DMAEA, DMAPA, and DMAEMA, is reported.


Fabrication of low-fouling, high-loading polymeric surfaces through pH-controlled RAFT


Alexander H. Jesmer, Vincent Huynh and Ryan G. Wylie
RSC Adv., 2020,10, 20302-20312

Abstract

pH-Controlled surface-reversible addition–fragmentation chain-transfer (S-RAFT) polymerization yields a one-pot synthesis for bimodal polymeric surfaces for improved capture agent immobilization.


Statistical versus block fluoropolymers in gene delivery


Echuan Tan, Jia Lv, Jingjing Hu, Wanwan Shen, Hui Wang and Yiyun Cheng
J. Mater. Chem. B, 2018,6, 7230-7238
From themed collection: Journal of Materials Chemistry B Emerging Investigators

Abstract

A statistical fluorocopolymer shows dramatically higher transfection efficiency in gene delivery than a block one.


Covalent cell surface recruitment of chemotherapeutic polymers enhances selectivity and activity


Ruben M. F. Tomás and Matthew I. Gibson
Chem. Sci., 2021, Advance Article

Abstract

Chemotherapeutic polymers are targeted to cells by introduction of unnatural glycans to their glycocalyx, enhancing their cytotoxic effect.


Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity


Thaiesha A. Wright, Richard C. Page and Dominik Konkolewicz
Polym. Chem., 2019,10, 434-454

Abstract

This review article discusses the impact of polymer modification on bioconjugate performance, including both activity and stability, with a focus on how the polymer structure and functionality impact these parameters.


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