The complexation and sustained release of dsRNA from highly branched polymers prepared via RAFT polymerisation and copolymerisation of the monomers DMAEA, DMAPA, and DMAEMA, is reported.
pH-Controlled surface-reversible addition–fragmentation chain-transfer (S-RAFT) polymerization yields a one-pot synthesis for bimodal polymeric surfaces for improved capture agent immobilization.
A statistical fluorocopolymer shows dramatically higher transfection efficiency in gene delivery than a block one.
Chemotherapeutic polymers are targeted to cells by introduction of unnatural glycans to their glycocalyx, enhancing their cytotoxic effect.
This review article discusses the impact of polymer modification on bioconjugate performance, including both activity and stability, with a focus on how the polymer structure and functionality impact these parameters.