Sunil Kumar, Maria C. Vogel and Andrew D. Hamilton
Org. Biomol. Chem., 2018,16, 733-741
From themed collection:
Chemical biology in OBC
Abstract
An oligopyrrolamide was identified as a potent antagonist of the aggregation of IAPP, a process associated with type 2 diabetes.
Lei Wang, Pascale Coric, Kexin Zhu, Wang-Qing Liu, Michel Vidal, Serge Bouaziz and Sylvain Broussy
Org. Biomol. Chem., 2018,16, 459-471
From themed collection:
Chemical biology in OBC
Abstract
Macrocyclic peptides mimic tight “non-classical” α-turn type II-αLS found in proteins, as shown by spectroscopic and computational analysis of their equilibrating conformations.
Amandine Xolin, Romain Losa, Aicha Kaid, Cédric Tresse, Jean-Marie Beau, François-Didier Boyer and Stéphanie Norsikian
Org. Biomol. Chem., 2018,16, 325-335
From themed collection:
Chemical biology in OBC
Abstract
Activation of armed glycosyl sulfone donors, using scandium(III) triflate under microwave irradiation, provides a selective preparation of α-mannosides.
S. Daikoku, R. Pendrill, Y. Kanie, Y. Ito, G. Widmalm and O. Kanie
Org. Biomol. Chem., 2018,16, 228-238
From themed collection:
Chemical biology in OBC
Abstract
Gas-phase collision-induced dissociation and acid hydrolysis of mannose-containing oligosaccharides were performed, which revealed the reactivity order of linkage isomers.
Jaeyeon Lee, Jihyun Shim, Philjae Kang, Moon-Gun Choi and Soo Hyuk Choi
Org. Biomol. Chem., 2018,16, 433-438
From themed collection:
Chemical biology in OBC
Abstract
The 11/9-helix propensity of α/β-peptides is dependent on a specific side chain group of α- or β3-residue.
Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Jiang Shimin, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando J. Ferrer-Gago, Prakash Arumugam, Yi Han, Shiying Chen, Laurent Rénia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K. Sawyer, Chandra S. Verma and Anthony W. Partridge
Chem. Sci., 2020,11, 5577-5591
Abstract
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs).
Stephen J. Walsh, Jessica Iegre, Hikaru Seki, Jonathan D. Bargh, Hannah F. Sore, Jeremy S. Parker, Jason S. Carroll and David R. Spring
Org. Biomol. Chem., 2020,18, 4224-4230
From themed collection:
Methodology development for protein modifications
Abstract
A general method that facilitates the modular dual functionalisation of a range of peptides and proteins is reported.
Lotte-Emilie Boyhus, Mia Danielsen, Nina Smidt Bengtson, Micha Ben Achim Kunze, Xavier Kubiak, Tjerk J. Sminia, Jacob Hartvig Løper, Phuong Thu Tran, Kresten Lindorff-Larsen, Søren G. F. Rasmussen, Jesper Mosolff Mathiesen and Daniel Sejer Pedersen
RSC Adv., 2018,8, 2219-2228
From themed collection:
Editors' collection: Chemical Biology
Abstract
A series of Gs protein peptidomimetics were designed and synthesised based on the published X-ray crystal structure of the active state β2-adrenergic receptor (β2AR) in complex with the Gs protein (PDB 3SN6).
Soonsil Hyun, Yoonhwa Choi, Ha Neul Lee, Changki Lee, Donghoon Oh, Dong-Ki Lee, Changjin Lee, Yan Lee and Jaehoon Yu
Chem. Sci., 2018,9, 3820-3827
Abstract
A hydrocarbon stapled peptide, LKH-stEK, promotes delivery of nanomolar siRNAs leading to efficient gene silencing in mouse skin.
Dilraj Lama, Anne-Marie Liberatore, Yuri Frosi, Jessica Nakhle, Natia Tsomaia, Tarig Bashir, David P. Lane, Christopher J. Brown, Chandra S. Verma and Serge Auvin
Chem. Sci., 2019,10, 2489-2500
Abstract
We have revealed a non-canonical recognition feature that can modulate the binding kinetics of hydrocarbon stapled-peptides interactions with the eIF4E protein.