A cyclic iRGD peptide as a dual-functional on–off gatekeeper on the surface of MSNs is prepared for specific NRP-1 targeting and selective drug release by conformational conversion.
We demonstrate tracking of silicon nanoparticles through intrinsic photoluminescence during the course of cellular targeting and uptake.
Biomimetic iRGD-rHDL/ICG nanoparticles exhibited deep tumor targeted shuttling of indocyanine green and enhanced phototherapy.
Conventional optical nanoprobes rely on absolute intensity-dependent signal readout, which can often cause erroneous sensing and imaging results owing to the existence of analyte-independent confounding factors. Ratiometric signal processing provides built-in self-calibration for signal correction, enabling more accurate molecular detection and imaging.
Polypeptides as functional groups continue to garner significant interest in the detection and imaging of breast cancer, working as recognition elements, signal sources, building blocks and therapeutic reagents, etc.