Combining imaging and anticancer properties with new heterobimetallic Pt(II)/M(I) (M = Re, 99mTc) complexes


Letícia Quental, Paula Raposinho, Filipa Mendes, Isabel Santos, Carmen Navarro-Ranninger, Amparo Alvarez-Valdes, Huaiyi Huang, Hui Chao, Riccardo Rubbiani, Gilles Gasser, Adoración G. Quiroga and António Paulo
Dalton Trans., 2017,46, 14523-14536
From themed collection: Frontiers in Radionuclide Imaging and Therapy

Abstract

New metal-based anticancer agents with imaging, chemotherapeutic and photosensitizing properties.


In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99mTc-label


Francisco Silva, Lurdes Gano, Maria Paula Cabral Campello, Rosa Marques, Isabel Prudêncio, Ajit Zambre, Anandhi Upendran, António Paulo and Raghuraman Kannan
Dalton Trans., 2017,46, 14572-14583
From themed collection: Frontiers in Radionuclide Imaging and Therapy

Abstract

The BBN-Au-DTDTPA coating is selectively released upon interaction with glutathione (GSH), rendering this nanoplatform potentially useful for GSH-mediated drug delivery.


Mangiferin functionalized radioactive gold nanoparticles (MGF-198AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy


A. Y. Al-Yasiri, M. Khoobchandani, C. S. Cutler, L. Watkinson, T. Carmack, C. J. Smith, M. Kuchuk, S. K. Loyalka, A. B. Lugão and K. V. Katti
Dalton Trans., 2017,46, 14561-14571
From themed collection: Frontiers in Radionuclide Imaging and Therapy

Abstract

We report here production of MGF-198AuNPs and its application for prostate tumor therapy.


Technetium-99m complexes of L-arginine derivatives for targeting amino acid transporters


Maurício Morais, Vera F. C. Ferreira, Flávio Figueira, Filipa Mendes, Paula Raposinho, Isabel Santos, Bruno L. Oliveira and João D. G. Correia
Dalton Trans., 2017,46, 14537-14547
From themed collection: Frontiers in Radionuclide Imaging and Therapy

Abstract

The metal complex Tc2 exhibits relevant internalization in several cancer cell lines, likely to be mediated by cationic amino acid transporters.


Fluoroquinolones as imaging agents for bacterial infection


Syed Ali Raza Naqvi and Karl Drlica
Dalton Trans., 2017,46, 14452-14460
From themed collection: 2017 Frontier and Perspective articles

Abstract

Three ways to radioactively label fluoroquinolones are available, thereby creating multiple options for developing a diagnostic for deep-seated bacterial infection.


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A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection


Yuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma and Yueqing Gu
Biomater. Sci., 2020,8, 2682-2693

Abstract

The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN7–14.


The core of the matter – arene substitution determines the coordination and catalytic behaviour of tris(1-phosphanyl-1′-ferrocenylene)arene gold(I) complexes


Axel Straube, Peter Coburger, Marvin Michak, Mark R. Ringenberg and Evamarie Hey-Hawkins
Dalton Trans., 2020,49, 16667-16682

Abstract

Four C3-symmetric tris-phosphanes coordinate gold(I) differently depending on their tris(ferrocenyl)arene backbone with implications on electrochemical and catalytic performance.


Synthesis and photophysics of gold(I) alkynyls bearing a benzothiazole-2,7-fluorenyl moiety: a comparative study analyzing influence of ancillary ligand, bridging moiety, and number of metal centers on photophysical properties


Joseph J. Mihaly, Alexis T. Phillips, David J. Stewart, Zachary M. Marsh, Christopher L. McCleese, Joy E. Haley, Matthias Zeller, Tod A. Grusenmeyer and Thomas G. Gray
Phys. Chem. Chem. Phys., 2020,22, 11915-11927

Abstract

Three new gold(I) alkynyl complexes containing a benzothiazole fluorenyl ligand were prepared. Their photophysical properties are compared with previously published dinuclear and mononuclear gold(I) aryl complexes with the same chromophoric ligand.


GRPR-targeted SPECT imaging using a novel bombesin-based peptide for colorectal cancer detection


Peifei Liu, Yuanbiao Tu, Ji Tao, Zicun Liu, Fang Wang, Yi Ma, Zhaolun Li, Zhihao Han and Yueqing Gu
Biomater. Sci., 2020,8, 6764-6772

Abstract

The designed novel targeting peptide GB-6 binding to GRPR possesses more favorable pharmacokinetic properties with lower intestinal activity as well as superior tumor-targeting ability in colorectal cancer models than BBN7–14.


An efficient synthetic method for organometallic radicals: structures and properties of gold(I)-(nitronyl nitroxide)-2-ide complexes


Shuichi Suzuki, Sayaka Kira, Masatoshi Kozaki, Masaki Yamamura, Toru Hasegawa, Tatsuya Nabeshima and Keiji Okada
Dalton Trans., 2017,46, 2653-2659

Abstract

One-pot synthesis of (nitronyl nitroxide)-gold(I)-phosphine (NN-Au-P) complexes has been developed using chloro(tetrahydrothiophene)gold(I), phosphine ligands, nitronyl nitroxide radicals, and sodium hydroxide.


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