We have designed a fluorescent perylene dye with two aromatic units for intracavity folding to afford a high-affinity complex with cucurbit[8]uril. The high affinity allows the complex to act as a fluorescent probe for detection of strong binding guests with nanomolar sensitivity.
A host–guest complex based on a newly designed and synthesized cationic perylene dye and cucurbit[8]uril exhibits red-NIR emission, high affinity and stability, and large Stokes shift. It can serve as a red-NIR fluorescent displacement probe for the detection of drugs in urine.
Cucurbit[7/8]uril–acridine complexes result in striking modulation of the excited state properties of acridine and allowed a tunable upward pKa shift, which is applied for controlled relocation of the dye from the host to live cells.
A new colorimetric and fluorescent dual-modal displacement probe based on a supramolecular host–guest complex involving macrocycle encapsulation that modulated intramolecular charge transfer and deaggregation.
In this study, we report the first supramolecular indicator displacement assay (IDA) based on cucurbit[n]uril (CBn) host and a [2.2]paracyclophane derivative as indicator that is operational in blood serum.