The current study provides a novel remote loading approach utilizing chemically modified cyclodextrins to incorporate hydrophobic drugs into liposomes.
An alternating magnetic field (AMF)-responsive controlled release system has been developed by the binding of mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin (βCD-Ts) onto amine-modified superparamagnetic iron oxide nanoparticles (MNP-NH2), resulting in a MNP-βCD nanocarrier.
The degree of substitution on βCD rims by sulfobutylether groups significantly modulates the binding affinity of the SBEnβCD hosts for the studied cationic guest molecule.
Polyaniline supramolecularly grafted with polyethylene glycol coupled with β-cyclodextrin forming a pseudorotaxane structure shows an extremely high solubility, higher degree of doping, and highly efficient radical cation stabilization.
The main interaction between the synthesized material and the targeted paraben compounds.