Issue 5, 2011
From the journal:

Chemical Society Reviews

Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

Debasis Samantaa  and  Amitabha Sarkar*a  

* Corresponding authors

a Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
E-mail: ocas@iacs.res.in
Fax: (91)3324732805
Tel: (91)3324734971

Abstract

Attachment of biomolecules on gold, silicon or glass surfaces has direct implications for the development of novel biosensors in the context of nanoscale detection of pathogens and other metabolites related to issues of human health. In this critical review, we have highlighted the current developments in various techniques of immobilization of biomolecules, specifically biological macromolecules on surfaces through the modification of a functional self-assembled monolayer. The utility of such immobilized biomolecules in the area of biosensing in nanoscale has been surveyed. Merits and demerits of some of the methods with reference to sensitivity of detection and practical use have been discussed (221 references).

Graphical abstract: Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

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Article information

DOI
https://doi.org/10.1039/C0CS00056F
Article type
Critical Review
Submitted
27 Jul 2010
First published
24 Jan 2011

Chem. Soc. Rev., 2011,40, 2567-2592

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Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

D. Samanta and A. Sarkar, Chem. Soc. Rev., 2011, 40, 2567 DOI: 10.1039/C0CS00056F

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