Membrane partition of bis-(3-hydroxy-4-pyridinonato) zinc(ii) complexes revealed by molecular dynamics simulations

João T. S. Coimbra, Natércia F. Brás, Pedro A. Fernandes, Maria Rangel and Maria J. Ramos

RSC Adv., 2018, 8, 27081
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Looking at new ligands for chelation therapy

Valeria Marina Nurchi, Maria de Guadalupe Jaraquemada-Pelaez, Joanna I. Lachowicz, Maria Antonietta Zoroddu, Massimiliano Peana, Alicia Domínguez-Martín, Duane Choquesillo-Lazarte, Maurizio Remelli, Zbigniew Szewczuk and Guido Crisponi

New J. Chem., 2018, 42, 8021
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para-Aminosalicylic acid in the treatment of manganese toxicity. Complexation of Mn2+ with 4-amino-2-hydroxybenzoic acid and its N-acetylated metabolite

Joanna Izabela Lachowicz, Valeria Marina Nurchi, Guido Crisponi, Ilaria Cappai, Rosita Cappai, Matteo Busato, Andrea Melchior, Marilena Tolazzi, Massimiliano Peana, Eugenio Garribba, Maria Antonietta Zoroddu, Pierpaolo Coni, Giuseppina Pichiri and Jan Aaseth

New J. Chem., 2018, 42, 8035
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New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation

Valeria M. Nurchi, Rosita Cappai, Karam Chand, Sílvia Chaves, Lurdes Gano, Guido Crisponi, Massimiliano Peana, M. Antonietta Zoroddu and M. Amélia Santos

Dalton Trans., 2019, 48, 16167
DOI: 10.1039/C9DT02905B

Metal self-assembly mimosine peptides with enhanced antimicrobial activity: towards a new generation of multitasking chelating agents

Joanna Izabela Lachowicz, Gabriele Dalla Torre, Rosita Cappai, Enrico Randaccio, Valeria M. Nurchi, Remigiusz Bachor, Zbigniew Szewczuk, Lukasz Jaremko, Mariusz Jaremko, Maria Barbara Pisano, Sofia Cosentino, Germano Orrù, Antonella Ibba, Joni Mujika and Xabier Lopez

Dalton Trans., 2020, 49, 2862
DOI: 10.1039/C9DT04545G

Synthesis and characterization of methyl substituted 3-hydroxypyridin-4-ones and their complexes with iron(III)

Chen Cheng, Yulin Chen, Yue Cao, Yongmin Ma and Robert C. Hider

Can. J. Chem., 2018, 96, 293
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New bis-(3-hydroxy-4-pyridinone)-NTA-derivative: Synthesis, binding ability towards Ca2+, Cu2+, Zn2+, Al3+, Fe3+ and biological assays

Anna Irto, Paola Cardiano, Karam Chand, Rosalia Maria Cigala, Francesco Crea, Concetta De Stefano, Lurdes Gano, Giuseppe Gattuso, Silvio Sammartano and Maria Amélia Santos

Journal of Molecular Liquids, 2018, 272, 609
DOI: 10.1016/j.molliq.2018.09.107

Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa

Mariano Andrea Scorciapino, Giuliano Malloci, Ilaria Serra, Stefan Milenkovic, Lucile Moynié, James H. Naismith, Eric Desarbre, Malcolm G. P. Page and Matteo Ceccarelli

Biometals, 2019, 32, 155
DOI: 10.1007/s10534-018-00166-0

A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays

Valeria M. Nurchi, Maria de Guadalupe Jaraquemada-Pelaez, Guido Crisponi, Joanna I. Lachowicz, Rosita Cappai, Lurdes Gano, M. Amelia Santos, Andrea Melchior, Marilena Tolazzi, Massimiliano Peana, Serenella Medici and Maria Antonietta Zoroddu

Journal of Inorganic Biochemistry, 2019, 193, 152
DOI: 10.1016/j.jinorgbio.2019.01.012

Synthesis of a new tetradentate chelator with 1-Hydoroxy-2(1H)-pyridinone (HOPO) as chelating unit: Interaction with Fe (III), solution thermodynamics and DFT studies

Dibyajit Dash, Minati Baral and B.K. Kanungo

Journal of Molecular Structure, 2020, 1222, 128796
DOI: 10.1016/j.molstruc.2020.128796

Evaluation of the Tetrakis(3-Hydroxy-4-Pyridinone) Ligand THPN with Zirconium(IV): Thermodynamic Solution Studies, Bifunctionalization, and in Vivo Assessment of Macromolecular 89Zr-THPN-Conjugates

Christian Buchwalder, María de Guadalupe Jaraquemada-Peláez, Julie Rousseau, Helen Merkens, Cristina Rodríguez-Rodríguez, Chris Orvig, François Bénard, Paul Schaffer, Katayoun Saatchi and Urs O. Häfeli

Inorg. Chem., 2019, 58, 14667
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Interaction of a chelating agent, 5-hydroxy-2-(hydroxymethyl)pyridin-4(1 H )-one, with Al(III), Cu(II) and Zn(II) ions

Massimiliano Peana, Serenella Medici, Valeria Marina Nurchi, Joanna I. Lachowicz, Guido Crisponi, Eugenio Garribba, Daniele Sanna and Maria Antonietta Zoroddu

Journal of Inorganic Biochemistry, 2017, 171, 18
DOI: 10.1016/j.jinorgbio.2017.03.001

Salicylamide derivatives for iron and aluminium sequestration. From synthesis to complexation studies

Joanna I. Lachowicz, Miriam Crespo-Alonso, Claudia Caltagirone, Giancarla Alberti, Raffaela Biesuz, James O. Orton and Valeria M. Nurchi

Journal of Trace Elements in Medicine and Biology, 2018, 50, 580
DOI: 10.1016/j.jtemb.2018.04.010

Reversible Folding of a β-Hairpin Peptide by a Metal-Chelating Amino Acid

Jan Reutzel, Timm M. Diogo and Armin Geyer

Chem. Eur. J., 2017, 23, 8450
DOI: 10.1002/chem.201700698

DFT investigation on the selective complexation of Fe 3+ and Al 3+ with hydroxypyridinones used for treatment of the aluminium and iron overload diseases

Sadegh Kaviani, Mohammad Izadyar and Mohammad Reza Housaindokht

Journal of Molecular Graphics and Modelling, 2018, 80, 182
DOI: 10.1016/j.jmgm.2018.01.003

Thermodynamic investigation on acid-base equilibria of deferiprone and deferasirox at different ionic strengths and various temperatures

Hadi Chahiyan Boroujeni and Farrokh Gharib

The Journal of Chemical Thermodynamics, 2016, 103, 366
DOI: 10.1016/j.jct.2016.08.036

Medical Uses of Silver: History, Myths, and Scientific Evidence

Serenella Medici, Massimiliano Peana, Valeria M. Nurchi and Maria Antonietta Zoroddu

J. Med. Chem., 2019, 62, 5923
DOI: 10.1021/acs.jmedchem.8b01439

A computational study on the redox properties and binding affinities of iron complexes of hydroxypyridinones

João T. S. Coimbra, Natércia F. Brás, Pedro A. Fernandes, Maria Rangel and Maria J. Ramos

J Mol Model, 2019, 25
DOI: 10.1007/s00894-019-4037-0

Synthesis and Mass Spectrometry Analysis of Mimosine-Containing Peptides

Remigiusz Bąchor, Enrico Randaccio, Joanna I. Lachowicz, Piotr Stefanowicz, Valeria M. Nurchi and Zbigniew Szewczuk

Int J Pept Res Ther, 2020
DOI: 10.1007/s10989-020-10092-w

Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities

Xiaoying Jiang, Tao Zhou, Renren Bai and Yuanyuan Xie

J. Med. Chem., 2020, 63, 14470
DOI: 10.1021/acs.jmedchem.0c01480