Manganese Transport, Trafficking and Function in Invertebrates
Nutritional Requirements for Manganese
Olfactory Transport of Manganese: Implications for Neurotoxicity
Manganese Transport Across the Pulmonary Epithelium
Are There Distinguishable Roles for the Different Oxidation States of Manganese in Manganese Toxicity?
Effect of Manganese on Signaling Pathways
Manganese and Oxidative Stress
Mechanism of Manganese-Induced Impairment of Astrocytic Glutamate Transporters
Impairment of Glutamine/Glutamate-γ-aminobutyric Acid Cycle in Manganese Toxicity in the Central Nervous System
Modeling Manganese Kinetics for Human Health Risk Assessment
Significance and Usefulness of Biomarkers of Exposure to Manganese
The Effects of Manganese on Female Pubertal Development
A Decade of Studies on Manganese Neurotoxicity in Non-Human Primates: Novel Findings and Future Directions
Epidemiological Studies of Parkinsonism in Welders
Manganese and Prion Disease
About this book
Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders.
The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases.
Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.
Dr Michael Aschner is currently a Professor of Toxicology, Pharmacology and Pediatrics at Vanderbilt University Medical School. He is a world-known authority on the toxicology of manganese and of other metals. Also world-renowned for his contributions to the field, Dr Lucio Costa is a Professor of Toxicology at the University of Washington with over thirty years of experience in the area of neurotoxicology.