Carbohydrate–Protein Interactions: A 3D View by NMR
NMR as a Tool to Unveil the Molecular Basis of Glycan-mediated Host–Pathogen Interactions
Lipopolysaccharides as Microbe-associated Molecular Patterns: A Structural Perspective
Molecular Basis of
Mycobacterium tuberculosis Recognition by the C-Type Lectin DC-SIGN: from the Modulation of Innate Immune Response to the Design of Innovative Anti-inflammatory Drugs
Glyconanotechnology and Disease: Gold Nanoparticles Coated with Glycosides as Multivalent Systems for Potential Applications in Diagnostics and Therapy
Boosting Humoral Immune Responses to Tumor-associated Carbohydrate Antigens with Virus-like Particles
Synthetic Glycosylated Ether Glycerolipids as Anticancer Agents
Carbohydrates and Glycomimetics in Alzheimer's Disease Therapeutics and Diagnosis
Galactofuranose Biosynthesis: Discovery, Mechanisms and Therapeutic Relevance
Carbohydrate-containing Matrix Metalloproteinase Inhibitors (MMPIs): A Second Childhood for Sulfonamidic Inhibitors?
Amphiphilic Aminoglycoside Antimicrobials in Antibacterial Discovery
From the Capsular Polysaccharide to a Conjugate Vaccine Containing
Haemophilus influenzae Type b Synthetic Oligosaccharide
About this book
In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery.
Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery.
Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.