Fragment-Based Drug Discovery

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique.

This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

From the book series:
Drug Discovery

Fragment-Based Drug Discovery Editors: Steven Howard, Chris Abell

Front Matter

Foreword

Preface

Contents

Personal Essay: Fragments in the Blogosphere

Personal Essay: Adventures and Experiences in Fragment-Based Drug Discovery

Different Flavours of Fragments

Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support

Applications of NMR in Fragment-Based Drug Design

Current Status and Future Direction of Fragment-Based Drug Discovery: A Computational Chemistry Perspective

Fragment Screening of G Protein-Coupled Receptors

Fragment-Based Lead Discovery Applied to Protein–Protein Interactions

Fragment-Based Discovery of Allosteric Ligands

Fragment-Based Discovery of Antibacterials

Exploring Fragment Screening and Optimization Strategies Using Acetylcholine-Binding Protein

Fragment-Based Approaches to Epigenetic Targets

Subject Index

Publication details

About this book