How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance
Role of Solubility, Permeability and Absorption in Drug Discovery and Development
Cytochrome P450 Mediated Drug Metabolism
Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs
Chemically Reactive Versus Stable Drug Metabolites: Role in Adverse Drug Reactions
Metabolomics-Based Approaches to Determine Drug Metabolite Profiles
Drug–Drug Interactions: Regulatory and Theoretical Considerations, and an Industry Perspective
Drug–Drug Interactions: Computational Approaches
Induction of Hepatic Cytochrome P450 Enzymes: Importance in Drug Development and Toxicity
Current Status and Implications of Transporters: QSAR Analysis Method to Evaluate Drug–Drug Interactions of Human Bile Salt Export Pump (ABCB11/BSEP) and Prediction of Intrahepatic Cholestasis Risk
Pharmacokinetic–Pharmacodynamic Modeling in Drug Development with Special Reference to Oncology
About this book
Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk.
Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities.
Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.
Alan G.E. Wilson is an expert in the area of drug metabolism, pharmacokinetics and toxicology. He is a Board Certified Toxicologist with over thirty years of experience working in governmental and industrial companies, conducting ADME, PK, Toxicology and risk assessments. He has over 120 peer reviewed publications, including edited books and book chapters and is a frequently invited speaker at International Symposia. He is currently Vice President of a Department of DMPK, Toxicology and Pathology.