Immunopharmacotherapy for Nicotine Addiction
Carbohydrate Vaccines
Generation and Maturation of Therapeutic Antibodies via In Vitro Somatic Hypermutation
Synthetic Protein Biologics
Recent Advances in Antibody–Drug Conjugates
MicroRNA Biotherapeutics: Key Challenges from a Drug Development Perspective
Phage Selection of Mono- and Bicyclic Peptide Ligands
Chemical Approaches for Localization, Characterization and Mimicry of Peptide Epitopes
Cystine-Knot Micro-Proteins
Subject Index
Publication details
About this book
This book illustrates the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text highlights recent developments from these disciplines that have delivered drugs, clinical candidates or significantly advanced biotherapeutic approaches.
Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area, by explaining and describing the chemical biology technologies that underpin specific therapeutic advances and demonstrating the unique value of molecular design and understanding.
Covering topics such as selective protein modification, immunopharmacotherapy, chemically programmed vaccinations, nanobodies and antibodies, this book provides essential reading for medicinal and pharmaceutical chemists working in both industry and academia.