Overview of Molecular Chaperones in Health and Disease
Structure and Function of Hsp70 Molecular Chaperones
Exploiting the Dependency of Cancer Cells on Molecular Chaperones
Discovery of NVP-AUY922
Discovery and Selection of NVP-HSP990 as a Clinical Candidate
The Cancer Super-chaperone Hsp90: Drug Targeting and Post-translational Regulation
Heat-shock Protein 90 as an Antimalarial Target
Molecular Chaperones as Potential Therapeutic Targets for Neurological Disorders
About this book
This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.
Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.