Inhibitors of Molecular Chaperones as Therapeutic Agents

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.

Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.

From the book series:
Drug Discovery

Inhibitors of Molecular Chaperones as Therapeutic Agents Editors: Timothy D Machajewski, Zhenhai Gao

Front Matter

Preface

Contents

Overview of Molecular Chaperones in Health and Disease

Structural Basis of Hsp90 Function

Structure and Function of Hsp70 Molecular Chaperones

Exploiting the Dependency of Cancer Cells on Molecular Chaperones

The Discovery of BIIB021 and BIIB028

Discovery and Development of Ganetespib

Discovery of the Serenex Hsp90 Inhibitor, SNX5422

Discovery of NVP-AUY922

Discovery and Selection of NVP-HSP990 as a Clinical Candidate

Inhibitors of the Hsp90 C-terminus

Hsp70 Inhibitors

The Cancer Super-chaperone Hsp90: Drug Targeting and Post-translational Regulation

Hsp90 Inhibitors in Clinic

Heat-shock Protein 90 as an Antimalarial Target

Molecular Chaperones as Potential Therapeutic Targets for Neurological Disorders

Subject Index

Publication details

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